Putative phosphatidylserine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylserine synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7U0_LEIBR

TriTrypDb:

LbrM.14.1370 , LBRM2903_140018400

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4H7U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7U0

Function

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Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	12
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006658	phosphatidylserine metabolic process	4	12
GO:0006659	phosphatidylserine biosynthetic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003882	CDP-diacylglycerol-serine O-phosphatidyltransferase activity	6	5
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	5
GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	409	411	PF00675	0.345
CLV_PCSK_FUR_1	406	410	PF00082	0.394
CLV_PCSK_KEX2_1	254	256	PF00082	0.282
CLV_PCSK_KEX2_1	408	410	PF00082	0.336
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.304
CLV_PCSK_SKI1_1	180	184	PF00082	0.311
CLV_PCSK_SKI1_1	254	258	PF00082	0.262
CLV_PCSK_SKI1_1	300	304	PF00082	0.443
CLV_PCSK_SKI1_1	315	319	PF00082	0.296
CLV_PCSK_SKI1_1	443	447	PF00082	0.529

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC0	Leptomonas seymouri	77%	88%
A0A0S4ILR0	Bodo saltans	47%	100%
A0A1X0NNG6	Trypanosomatidae	57%	91%
A0A3R7N202	Trypanosoma rangeli	57%	91%
A0A3S7WT59	Leishmania donovani	87%	87%
A4HW66	Leishmania infantum	87%	87%
B1H3H9	Xenopus tropicalis	33%	100%
B2GV22	Rattus norvegicus	35%	98%
C9ZSV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	91%
E1BYA3	Gallus gallus	36%	100%

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