Putative phosphatidylserine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylserine synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7U0_LEIBR

TriTrypDb:

LbrM.14.1370 , LBRM2903_140018400

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H7U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7U0

Function

Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	12
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006658	phosphatidylserine metabolic process	4	12
GO:0006659	phosphatidylserine biosynthetic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0042398	cellular modified amino acid biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003882	CDP-diacylglycerol-serine O-phosphatidyltransferase activity	6	5
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	5
GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	409	411	PF00675	0.345
CLV_PCSK_FUR_1	406	410	PF00082	0.394
CLV_PCSK_KEX2_1	254	256	PF00082	0.282
CLV_PCSK_KEX2_1	408	410	PF00082	0.336
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.304
CLV_PCSK_SKI1_1	180	184	PF00082	0.311
CLV_PCSK_SKI1_1	254	258	PF00082	0.262
CLV_PCSK_SKI1_1	300	304	PF00082	0.443
CLV_PCSK_SKI1_1	315	319	PF00082	0.296
CLV_PCSK_SKI1_1	443	447	PF00082	0.529
CLV_PCSK_SKI1_1	455	459	PF00082	0.514
CLV_PCSK_SKI1_1	94	98	PF00082	0.296
DEG_APCC_DBOX_1	314	322	PF00400	0.353
DEG_MDM2_SWIB_1	203	211	PF02201	0.243
DOC_CDC14_PxL_1	433	441	PF14671	0.430
DOC_CDC14_PxL_1	49	57	PF14671	0.355
DOC_CYCLIN_RxL_1	169	178	PF00134	0.353
DOC_MAPK_gen_1	177	187	PF00069	0.442
DOC_MAPK_gen_1	408	417	PF00069	0.589
DOC_MAPK_HePTP_8	45	57	PF00069	0.449
DOC_MAPK_MEF2A_6	180	189	PF00069	0.292
DOC_MAPK_MEF2A_6	410	419	PF00069	0.548
DOC_MAPK_MEF2A_6	48	57	PF00069	0.340
DOC_MAPK_MEF2A_6	94	101	PF00069	0.311
DOC_PP1_RVXF_1	17	24	PF00149	0.624
DOC_PP1_RVXF_1	60	66	PF00149	0.264
DOC_PP4_FxxP_1	273	276	PF00568	0.454
DOC_USP7_MATH_1	27	31	PF00917	0.462
DOC_USP7_MATH_1	323	327	PF00917	0.190
DOC_USP7_MATH_1	445	449	PF00917	0.391
DOC_USP7_UBL2_3	250	254	PF12436	0.514
DOC_WW_Pin1_4	272	277	PF00397	0.497
DOC_WW_Pin1_4	9	14	PF00397	0.643
LIG_14-3-3_CanoR_1	143	151	PF00244	0.237
LIG_14-3-3_CanoR_1	180	189	PF00244	0.296
LIG_AP2alpha_2	149	151	PF02296	0.320
LIG_APCC_ABBA_1	109	114	PF00400	0.416
LIG_BIR_II_1	1	5	PF00653	0.538
LIG_BRCT_BRCA1_1	185	189	PF00533	0.296
LIG_deltaCOP1_diTrp_1	148	158	PF00928	0.328
LIG_EH1_1	168	176	PF00400	0.330
LIG_EH1_1	279	287	PF00400	0.382
LIG_EH1_1	296	304	PF00400	0.197
LIG_eIF4E_1	124	130	PF01652	0.327
LIG_eIF4E_1	169	175	PF01652	0.353
LIG_eIF4E_1	369	375	PF01652	0.237
LIG_eIF4E_1	414	420	PF01652	0.362
LIG_eIF4E_1	52	58	PF01652	0.249
LIG_FHA_1	106	112	PF00498	0.416
LIG_FHA_1	30	36	PF00498	0.298
LIG_FHA_1	306	312	PF00498	0.273
LIG_FHA_1	322	328	PF00498	0.258
LIG_FHA_1	343	349	PF00498	0.319
LIG_FHA_1	355	361	PF00498	0.287
LIG_FHA_2	144	150	PF00498	0.268
LIG_FHA_2	154	160	PF00498	0.243
LIG_GBD_Chelix_1	282	290	PF00786	0.325
LIG_GBD_Chelix_1	388	396	PF00786	0.190
LIG_HCF-1_HBM_1	25	28	PF13415	0.474
LIG_LIR_Gen_1	108	116	PF02991	0.298
LIG_LIR_Gen_1	156	164	PF02991	0.301
LIG_LIR_Gen_1	186	196	PF02991	0.296
LIG_LIR_Gen_1	205	216	PF02991	0.112
LIG_LIR_Gen_1	32	41	PF02991	0.389
LIG_LIR_Gen_1	329	339	PF02991	0.464
LIG_LIR_Gen_1	344	355	PF02991	0.210
LIG_LIR_Gen_1	390	401	PF02991	0.265
LIG_LIR_Gen_1	69	78	PF02991	0.237
LIG_LIR_LC3C_4	308	313	PF02991	0.168
LIG_LIR_Nem_3	108	112	PF02991	0.327
LIG_LIR_Nem_3	148	154	PF02991	0.237
LIG_LIR_Nem_3	156	161	PF02991	0.157
LIG_LIR_Nem_3	178	182	PF02991	0.504
LIG_LIR_Nem_3	186	192	PF02991	0.296
LIG_LIR_Nem_3	193	199	PF02991	0.296
LIG_LIR_Nem_3	205	211	PF02991	0.112
LIG_LIR_Nem_3	264	268	PF02991	0.446
LIG_LIR_Nem_3	277	282	PF02991	0.436
LIG_LIR_Nem_3	32	37	PF02991	0.389
LIG_LIR_Nem_3	344	350	PF02991	0.420
LIG_LIR_Nem_3	390	396	PF02991	0.265
LIG_LIR_Nem_3	454	459	PF02991	0.373
LIG_LIR_Nem_3	69	75	PF02991	0.237
LIG_LYPXL_yS_3	52	55	PF13949	0.376
LIG_NRBOX	286	292	PF00104	0.361
LIG_NRBOX	317	323	PF00104	0.416
LIG_NRP_CendR_1	461	463	PF00754	0.500
LIG_Pex14_1	393	397	PF04695	0.296
LIG_Pex14_2	203	207	PF04695	0.243
LIG_PTB_Apo_2	415	422	PF02174	0.330
LIG_REV1ctd_RIR_1	456	463	PF16727	0.384
LIG_SH2_CRK	414	418	PF00017	0.248
LIG_SH2_SRC	125	128	PF00017	0.197
LIG_SH2_STAP1	422	426	PF00017	0.416
LIG_SH2_STAP1	453	457	PF00017	0.328
LIG_SH2_STAT5	103	106	PF00017	0.265
LIG_SH2_STAT5	169	172	PF00017	0.324
LIG_SH2_STAT5	28	31	PF00017	0.573
LIG_SH2_STAT5	369	372	PF00017	0.319
LIG_SH2_STAT5	397	400	PF00017	0.376
LIG_SH2_STAT5	50	53	PF00017	0.330
LIG_SH3_3	10	16	PF00018	0.659
LIG_SH3_3	376	382	PF00018	0.320
LIG_SH3_3	75	81	PF00018	0.416
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.414
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.373
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.244
LIG_SUMO_SIM_par_1	172	178	PF11976	0.296
LIG_SUMO_SIM_par_1	190	195	PF11976	0.296
LIG_SUMO_SIM_par_1	399	404	PF11976	0.526
LIG_TYR_ITIM	395	400	PF00017	0.381
LIG_UBA3_1	229	236	PF00899	0.381
LIG_UBA3_1	302	306	PF00899	0.197
LIG_WRC_WIRS_1	106	111	PF05994	0.298
MOD_CDC14_SPxK_1	275	278	PF00782	0.504
MOD_CDK_SPxK_1	272	278	PF00069	0.504
MOD_CK1_1	66	72	PF00069	0.227
MOD_CK2_1	142	148	PF00069	0.280
MOD_CK2_1	323	329	PF00069	0.325
MOD_GlcNHglycan	1	4	PF01048	0.456
MOD_GlcNHglycan	389	392	PF01048	0.190
MOD_GlcNHglycan	447	450	PF01048	0.596
MOD_GlcNHglycan	65	68	PF01048	0.337
MOD_GSK3_1	317	324	PF00069	0.359
MOD_GSK3_1	35	42	PF00069	0.390
MOD_GSK3_1	354	361	PF00069	0.382
MOD_N-GLC_1	335	340	PF02516	0.267
MOD_NEK2_1	1	6	PF00069	0.553
MOD_NEK2_1	153	158	PF00069	0.243
MOD_NEK2_1	163	168	PF00069	0.291
MOD_NEK2_1	321	326	PF00069	0.406
MOD_NEK2_1	387	392	PF00069	0.422
MOD_NEK2_2	323	328	PF00069	0.190
MOD_PKA_2	142	148	PF00069	0.268
MOD_Plk_1	134	140	PF00069	0.280
MOD_Plk_1	192	198	PF00069	0.296
MOD_Plk_1	335	341	PF00069	0.368
MOD_Plk_1	53	59	PF00069	0.270
MOD_Plk_4	105	111	PF00069	0.346
MOD_Plk_4	125	131	PF00069	0.276
MOD_Plk_4	281	287	PF00069	0.306
MOD_Plk_4	29	35	PF00069	0.487
MOD_Plk_4	354	360	PF00069	0.311
MOD_Plk_4	39	45	PF00069	0.277
MOD_Plk_4	53	59	PF00069	0.291
MOD_Plk_4	66	72	PF00069	0.265
MOD_Plk_4	80	86	PF00069	0.519
MOD_ProDKin_1	272	278	PF00069	0.497
MOD_ProDKin_1	9	15	PF00069	0.642
TRG_DiLeu_BaEn_2	328	334	PF01217	0.464
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.529
TRG_ENDOCYTIC_2	103	106	PF00928	0.296
TRG_ENDOCYTIC_2	238	241	PF00928	0.461
TRG_ENDOCYTIC_2	331	334	PF00928	0.443
TRG_ENDOCYTIC_2	397	400	PF00928	0.376
TRG_ENDOCYTIC_2	414	417	PF00928	0.381
TRG_ENDOCYTIC_2	456	459	PF00928	0.383
TRG_ENDOCYTIC_2	52	55	PF00928	0.337
TRG_ER_diArg_1	406	409	PF00400	0.534
TRG_ER_diArg_1	460	463	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC0	Leptomonas seymouri	77%	88%
A0A0S4ILR0	Bodo saltans	47%	100%
A0A1X0NNG6	Trypanosomatidae	57%	91%
A0A3R7N202	Trypanosoma rangeli	57%	91%
A0A3S7WT59	Leishmania donovani	87%	87%
A4HW66	Leishmania infantum	87%	87%
B1H3H9	Xenopus tropicalis	33%	100%
B2GV22	Rattus norvegicus	35%	98%
C9ZSV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	91%
E1BYA3	Gallus gallus	36%	100%
E7EY42	Danio rerio	35%	100%
E9APW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	87%
F4HXY7	Arabidopsis thaliana	37%	100%
O08888	Cricetulus griseus	36%	98%
P48651	Homo sapiens	33%	98%
Q00576	Cricetulus griseus	33%	98%
Q08D11	Xenopus tropicalis	36%	98%
Q0JR55	Oryza sativa subsp. japonica	37%	100%
Q2KHY9	Bos taurus	33%	98%
Q4QFL4	Leishmania major	86%	100%
Q5N8Q3	Oryza sativa subsp. japonica	39%	100%
Q5PQL5	Rattus norvegicus	34%	98%
Q5ZM65	Gallus gallus	33%	98%
Q6I628	Oryza sativa subsp. japonica	35%	100%
Q803C9	Danio rerio	33%	100%
Q99LH2	Mus musculus	34%	98%
Q9BVG9	Homo sapiens	39%	95%
Q9VPD3	Drosophila melanogaster	35%	93%
Q9Z1X2	Mus musculus	36%	98%
V5DC50	Trypanosoma cruzi	57%	91%