Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania braziliensis

UniProt:

A4H7T7_LEIBR

TriTrypDb:

LbrM.14.1340 , LBRM2903_140018000 , LBRM2903_140018100

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7T7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0003924	GTPase activity	7	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.262
CLV_NRD_NRD_1	145	147	PF00675	0.337
CLV_NRD_NRD_1	16	18	PF00675	0.560
CLV_NRD_NRD_1	224	226	PF00675	0.468
CLV_NRD_NRD_1	313	315	PF00675	0.641
CLV_NRD_NRD_1	452	454	PF00675	0.579
CLV_NRD_NRD_1	514	516	PF00675	0.337
CLV_NRD_NRD_1	546	548	PF00675	0.337
CLV_NRD_NRD_1	563	565	PF00675	0.337
CLV_NRD_NRD_1	75	77	PF00675	0.567
CLV_NRD_NRD_1	809	811	PF00675	0.548
CLV_NRD_NRD_1	837	839	PF00675	0.615
CLV_NRD_NRD_1	864	866	PF00675	0.560
CLV_PCSK_KEX2_1	16	18	PF00082	0.560
CLV_PCSK_KEX2_1	224	226	PF00082	0.500
CLV_PCSK_KEX2_1	312	314	PF00082	0.645
CLV_PCSK_KEX2_1	433	435	PF00082	0.556
CLV_PCSK_KEX2_1	452	454	PF00082	0.579
CLV_PCSK_KEX2_1	514	516	PF00082	0.337
CLV_PCSK_KEX2_1	546	548	PF00082	0.337
CLV_PCSK_KEX2_1	631	633	PF00082	0.701
CLV_PCSK_KEX2_1	75	77	PF00082	0.567
CLV_PCSK_KEX2_1	809	811	PF00082	0.548
CLV_PCSK_KEX2_1	836	838	PF00082	0.627
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.556
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.603
CLV_PCSK_SKI1_1	107	111	PF00082	0.576
CLV_PCSK_SKI1_1	3	7	PF00082	0.612
CLV_PCSK_SKI1_1	324	328	PF00082	0.451
CLV_PCSK_SKI1_1	470	474	PF00082	0.432
CLV_PCSK_SKI1_1	478	482	PF00082	0.337
CLV_PCSK_SKI1_1	494	498	PF00082	0.262
CLV_PCSK_SKI1_1	515	519	PF00082	0.314
CLV_PCSK_SKI1_1	564	568	PF00082	0.447
CLV_Separin_Metazoa	372	376	PF03568	0.570
DEG_APCC_DBOX_1	315	323	PF00400	0.573
DEG_Nend_UBRbox_2	1	3	PF02207	0.533
DEG_SCF_FBW7_2	765	772	PF00400	0.570
DEG_SPOP_SBC_1	100	104	PF00917	0.589
DEG_SPOP_SBC_1	176	180	PF00917	0.468
DEG_SPOP_SBC_1	719	723	PF00917	0.523
DEG_SPOP_SBC_1	735	739	PF00917	0.477
DEG_SPOP_SBC_1	787	791	PF00917	0.518
DOC_CDC14_PxL_1	231	239	PF14671	0.262
DOC_CKS1_1	659	664	PF01111	0.528
DOC_CYCLIN_yCln2_LP_2	473	479	PF00134	0.402
DOC_MAPK_DCC_7	16	26	PF00069	0.539
DOC_MAPK_gen_1	514	521	PF00069	0.337
DOC_MAPK_MEF2A_6	17	26	PF00069	0.532
DOC_MAPK_MEF2A_6	514	521	PF00069	0.468
DOC_PP1_RVXF_1	390	397	PF00149	0.520
DOC_USP7_MATH_1	176	180	PF00917	0.468
DOC_USP7_MATH_1	185	189	PF00917	0.338
DOC_USP7_MATH_1	196	200	PF00917	0.235
DOC_USP7_MATH_1	230	234	PF00917	0.401
DOC_USP7_MATH_1	239	243	PF00917	0.458
DOC_USP7_MATH_1	264	268	PF00917	0.319
DOC_USP7_MATH_1	275	279	PF00917	0.327
DOC_USP7_MATH_1	292	296	PF00917	0.307
DOC_USP7_MATH_1	340	344	PF00917	0.446
DOC_USP7_MATH_1	368	372	PF00917	0.467
DOC_USP7_MATH_1	383	387	PF00917	0.620
DOC_USP7_MATH_1	398	402	PF00917	0.539
DOC_USP7_MATH_1	404	408	PF00917	0.727
DOC_USP7_MATH_1	597	601	PF00917	0.540
DOC_USP7_MATH_1	61	65	PF00917	0.600
DOC_USP7_MATH_1	673	677	PF00917	0.757
DOC_USP7_MATH_1	71	75	PF00917	0.532
DOC_USP7_MATH_1	719	723	PF00917	0.520
DOC_USP7_MATH_1	735	739	PF00917	0.623
DOC_USP7_MATH_1	788	792	PF00917	0.603
DOC_USP7_MATH_1	801	805	PF00917	0.533
DOC_USP7_MATH_1	839	843	PF00917	0.575
DOC_USP7_MATH_1	84	88	PF00917	0.500
DOC_USP7_MATH_1	89	93	PF00917	0.554
DOC_USP7_MATH_1	99	103	PF00917	0.618
DOC_WW_Pin1_4	192	197	PF00397	0.364
DOC_WW_Pin1_4	226	231	PF00397	0.323
DOC_WW_Pin1_4	273	278	PF00397	0.324
DOC_WW_Pin1_4	472	477	PF00397	0.424
DOC_WW_Pin1_4	658	663	PF00397	0.527
DOC_WW_Pin1_4	669	674	PF00397	0.766
DOC_WW_Pin1_4	721	726	PF00397	0.742
DOC_WW_Pin1_4	765	770	PF00397	0.576
DOC_WW_Pin1_4	80	85	PF00397	0.563
DOC_WW_Pin1_4	95	100	PF00397	0.623
LIG_14-3-3_CanoR_1	155	165	PF00244	0.365
LIG_14-3-3_CanoR_1	289	298	PF00244	0.337
LIG_14-3-3_CanoR_1	375	380	PF00244	0.674
LIG_14-3-3_CanoR_1	406	410	PF00244	0.700
LIG_14-3-3_CanoR_1	434	439	PF00244	0.537
LIG_14-3-3_CanoR_1	441	450	PF00244	0.483
LIG_14-3-3_CanoR_1	470	476	PF00244	0.431
LIG_14-3-3_CanoR_1	48	56	PF00244	0.643
LIG_14-3-3_CanoR_1	514	520	PF00244	0.319
LIG_14-3-3_CanoR_1	523	533	PF00244	0.369
LIG_14-3-3_CanoR_1	564	569	PF00244	0.447
LIG_14-3-3_CanoR_1	598	607	PF00244	0.548
LIG_14-3-3_CanoR_1	755	764	PF00244	0.465
LIG_14-3-3_CanoR_1	810	820	PF00244	0.541
LIG_BIR_III_4	748	752	PF00653	0.504
LIG_BRCT_BRCA1_1	345	349	PF00533	0.474
LIG_BRCT_BRCA1_1	38	42	PF00533	0.595
LIG_FHA_1	200	206	PF00498	0.286
LIG_FHA_1	443	449	PF00498	0.469
LIG_FHA_1	488	494	PF00498	0.246
LIG_FHA_1	516	522	PF00498	0.417
LIG_FHA_1	525	531	PF00498	0.282
LIG_FHA_1	60	66	PF00498	0.539
LIG_FHA_1	648	654	PF00498	0.549
LIG_FHA_1	682	688	PF00498	0.566
LIG_FHA_1	709	715	PF00498	0.520
LIG_FHA_1	788	794	PF00498	0.521
LIG_FHA_1	95	101	PF00498	0.601
LIG_FHA_2	302	308	PF00498	0.590
LIG_FHA_2	333	339	PF00498	0.568
LIG_FHA_2	790	796	PF00498	0.551
LIG_LIR_Gen_1	332	340	PF02991	0.435
LIG_LIR_Gen_1	443	451	PF02991	0.477
LIG_LIR_Gen_1	768	779	PF02991	0.526
LIG_LIR_LC3C_4	249	252	PF02991	0.262
LIG_LIR_LC3C_4	297	302	PF02991	0.640
LIG_LIR_Nem_3	140	144	PF02991	0.340
LIG_LIR_Nem_3	192	197	PF02991	0.262
LIG_LIR_Nem_3	332	336	PF02991	0.436
LIG_LIR_Nem_3	443	447	PF02991	0.493
LIG_LIR_Nem_3	540	545	PF02991	0.337
LIG_LIR_Nem_3	768	774	PF02991	0.526
LIG_MYND_1	235	239	PF01753	0.262
LIG_MYND_1	727	731	PF01753	0.545
LIG_MYND_1	763	767	PF01753	0.553
LIG_NRBOX	858	864	PF00104	0.486
LIG_RPA_C_Fungi	518	530	PF08784	0.406
LIG_SH2_CRK	194	198	PF00017	0.262
LIG_SH2_NCK_1	194	198	PF00017	0.262
LIG_SH2_SRC	167	170	PF00017	0.468
LIG_SH2_SRC	560	563	PF00017	0.337
LIG_SH2_STAP1	296	300	PF00017	0.337
LIG_SH2_STAP1	444	448	PF00017	0.470
LIG_SH2_STAT3	296	299	PF00017	0.337
LIG_SH2_STAT5	167	170	PF00017	0.337
LIG_SH2_STAT5	194	197	PF00017	0.290
LIG_SH2_STAT5	350	353	PF00017	0.576
LIG_SH2_STAT5	444	447	PF00017	0.479
LIG_SH3_3	163	169	PF00018	0.468
LIG_SH3_3	274	280	PF00018	0.249
LIG_SH3_3	502	508	PF00018	0.468
LIG_SH3_3	590	596	PF00018	0.386
LIG_SH3_3	638	644	PF00018	0.555
LIG_SH3_3	724	730	PF00018	0.638
LIG_SUMO_SIM_par_1	108	113	PF11976	0.674
LIG_SxIP_EBH_1	58	71	PF03271	0.547
LIG_TRAF2_1	304	307	PF00917	0.590
LIG_TYR_ITSM	190	197	PF00017	0.262
LIG_WRC_WIRS_1	330	335	PF05994	0.560
LIG_WRC_WIRS_1	462	467	PF05994	0.490
LIG_WW_3	595	599	PF00397	0.505
MOD_CDC14_SPxK_1	475	478	PF00782	0.402
MOD_CDC14_SPxK_1	83	86	PF00782	0.540
MOD_CDK_SPxK_1	472	478	PF00069	0.409
MOD_CDK_SPxK_1	80	86	PF00069	0.544
MOD_CK1_1	178	184	PF00069	0.337
MOD_CK1_1	199	205	PF00069	0.442
MOD_CK1_1	217	223	PF00069	0.325
MOD_CK1_1	229	235	PF00069	0.390
MOD_CK1_1	276	282	PF00069	0.360
MOD_CK1_1	343	349	PF00069	0.484
MOD_CK1_1	378	384	PF00069	0.562
MOD_CK1_1	400	406	PF00069	0.714
MOD_CK1_1	463	469	PF00069	0.478
MOD_CK1_1	601	607	PF00069	0.758
MOD_CK1_1	636	642	PF00069	0.612
MOD_CK1_1	667	673	PF00069	0.569
MOD_CK1_1	676	682	PF00069	0.521
MOD_CK1_1	688	694	PF00069	0.541
MOD_CK1_1	721	727	PF00069	0.542
MOD_CK1_1	738	744	PF00069	0.604
MOD_CK1_1	789	795	PF00069	0.567
MOD_CK1_1	804	810	PF00069	0.563
MOD_CK1_1	813	819	PF00069	0.805
MOD_CK1_1	821	827	PF00069	0.705
MOD_CK1_1	87	93	PF00069	0.623
MOD_CK2_1	301	307	PF00069	0.581
MOD_CK2_1	312	318	PF00069	0.623
MOD_CK2_1	378	384	PF00069	0.486
MOD_CK2_1	405	411	PF00069	0.526
MOD_CK2_1	424	430	PF00069	0.566
MOD_CK2_1	789	795	PF00069	0.517
MOD_Cter_Amidation	807	810	PF01082	0.536
MOD_GlcNHglycan	18	21	PF01048	0.545
MOD_GlcNHglycan	198	201	PF01048	0.428
MOD_GlcNHglycan	215	219	PF01048	0.443
MOD_GlcNHglycan	232	235	PF01048	0.415
MOD_GlcNHglycan	262	265	PF01048	0.377
MOD_GlcNHglycan	345	348	PF01048	0.483
MOD_GlcNHglycan	400	403	PF01048	0.705
MOD_GlcNHglycan	415	418	PF01048	0.535
MOD_GlcNHglycan	535	539	PF01048	0.309
MOD_GlcNHglycan	601	604	PF01048	0.755
MOD_GlcNHglycan	67	70	PF01048	0.667
MOD_GlcNHglycan	687	690	PF01048	0.631
MOD_GlcNHglycan	738	741	PF01048	0.588
MOD_GlcNHglycan	743	747	PF01048	0.446
MOD_GlcNHglycan	795	799	PF01048	0.572
MOD_GlcNHglycan	803	806	PF01048	0.612
MOD_GlcNHglycan	815	818	PF01048	0.492
MOD_GlcNHglycan	820	823	PF01048	0.556
MOD_GSK3_1	185	192	PF00069	0.328
MOD_GSK3_1	195	202	PF00069	0.383
MOD_GSK3_1	226	233	PF00069	0.340
MOD_GSK3_1	260	267	PF00069	0.365
MOD_GSK3_1	269	276	PF00069	0.285
MOD_GSK3_1	278	285	PF00069	0.392
MOD_GSK3_1	374	381	PF00069	0.561
MOD_GSK3_1	38	45	PF00069	0.595
MOD_GSK3_1	392	399	PF00069	0.669
MOD_GSK3_1	4	11	PF00069	0.545
MOD_GSK3_1	400	407	PF00069	0.673
MOD_GSK3_1	48	55	PF00069	0.535
MOD_GSK3_1	560	567	PF00069	0.337
MOD_GSK3_1	597	604	PF00069	0.741
MOD_GSK3_1	61	68	PF00069	0.589
MOD_GSK3_1	612	619	PF00069	0.553
MOD_GSK3_1	647	654	PF00069	0.603
MOD_GSK3_1	669	676	PF00069	0.762
MOD_GSK3_1	677	684	PF00069	0.667
MOD_GSK3_1	704	711	PF00069	0.558
MOD_GSK3_1	730	737	PF00069	0.600
MOD_GSK3_1	738	745	PF00069	0.523
MOD_GSK3_1	783	790	PF00069	0.498
MOD_GSK3_1	80	87	PF00069	0.587
MOD_GSK3_1	809	816	PF00069	0.583
MOD_GSK3_1	821	828	PF00069	0.647
MOD_GSK3_1	95	102	PF00069	0.528
MOD_N-GLC_1	340	345	PF02516	0.581
MOD_N-GLC_1	362	367	PF02516	0.452
MOD_N-GLC_1	667	672	PF02516	0.600
MOD_N-GLC_1	78	83	PF02516	0.545
MOD_N-GLC_1	810	815	PF02516	0.578
MOD_N-GLC_1	850	855	PF02516	0.476
MOD_N-GLC_1	94	99	PF02516	0.550
MOD_NEK2_1	110	115	PF00069	0.594
MOD_NEK2_1	157	162	PF00069	0.337
MOD_NEK2_1	300	305	PF00069	0.560
MOD_NEK2_1	413	418	PF00069	0.682
MOD_NEK2_1	42	47	PF00069	0.609
MOD_NEK2_1	617	622	PF00069	0.563
MOD_NEK2_1	624	629	PF00069	0.660
MOD_NEK2_1	674	679	PF00069	0.668
MOD_NEK2_1	720	725	PF00069	0.530
MOD_NEK2_1	850	855	PF00069	0.436
MOD_OFUCOSY	288	294	PF10250	0.337
MOD_PIKK_1	110	116	PF00454	0.507
MOD_PIKK_1	224	230	PF00454	0.323
MOD_PIKK_1	279	285	PF00454	0.468
MOD_PIKK_1	385	391	PF00454	0.484
MOD_PIKK_1	442	448	PF00454	0.483
MOD_PIKK_1	499	505	PF00454	0.337
MOD_PK_1	489	495	PF00069	0.262
MOD_PKA_1	16	22	PF00069	0.547
MOD_PKA_1	224	230	PF00069	0.303
MOD_PKA_1	312	318	PF00069	0.623
MOD_PKA_1	564	570	PF00069	0.447
MOD_PKA_1	809	815	PF00069	0.547
MOD_PKA_2	16	22	PF00069	0.547
MOD_PKA_2	224	230	PF00069	0.303
MOD_PKA_2	312	318	PF00069	0.631
MOD_PKA_2	374	380	PF00069	0.695
MOD_PKA_2	405	411	PF00069	0.700
MOD_PKA_2	440	446	PF00069	0.425
MOD_PKA_2	47	53	PF00069	0.636
MOD_PKA_2	506	512	PF00069	0.337
MOD_PKA_2	597	603	PF00069	0.535
MOD_PKA_2	685	691	PF00069	0.630
MOD_PKA_2	809	815	PF00069	0.547
MOD_PKA_2	826	832	PF00069	0.499
MOD_PKB_1	76	84	PF00069	0.542
MOD_Plk_1	110	116	PF00069	0.507
MOD_Plk_1	340	346	PF00069	0.582
MOD_Plk_1	362	368	PF00069	0.455
MOD_Plk_1	783	789	PF00069	0.506
MOD_Plk_1	794	800	PF00069	0.575
MOD_Plk_1	850	856	PF00069	0.481
MOD_Plk_4	246	252	PF00069	0.423
MOD_Plk_4	264	270	PF00069	0.184
MOD_Plk_4	329	335	PF00069	0.433
MOD_Plk_4	340	346	PF00069	0.467
MOD_Plk_4	38	44	PF00069	0.537
MOD_Plk_4	392	398	PF00069	0.581
MOD_Plk_4	4	10	PF00069	0.560
MOD_Plk_4	564	570	PF00069	0.337
MOD_Plk_4	583	589	PF00069	0.303
MOD_Plk_4	774	780	PF00069	0.528
MOD_ProDKin_1	192	198	PF00069	0.364
MOD_ProDKin_1	226	232	PF00069	0.323
MOD_ProDKin_1	273	279	PF00069	0.324
MOD_ProDKin_1	472	478	PF00069	0.419
MOD_ProDKin_1	658	664	PF00069	0.528
MOD_ProDKin_1	669	675	PF00069	0.769
MOD_ProDKin_1	721	727	PF00069	0.743
MOD_ProDKin_1	765	771	PF00069	0.570
MOD_ProDKin_1	80	86	PF00069	0.565
MOD_ProDKin_1	95	101	PF00069	0.624
MOD_SUMO_for_1	630	633	PF00179	0.659
MOD_SUMO_rev_2	315	322	PF00179	0.583
TRG_DiLeu_BaEn_2	543	549	PF01217	0.468
TRG_DiLeu_BaLyEn_6	760	765	PF01217	0.552
TRG_ENDOCYTIC_2	194	197	PF00928	0.334
TRG_ENDOCYTIC_2	444	447	PF00928	0.479
TRG_ENDOCYTIC_2	542	545	PF00928	0.337
TRG_ER_diArg_1	223	225	PF00400	0.468
TRG_ER_diArg_1	311	314	PF00400	0.635
TRG_ER_diArg_1	545	547	PF00400	0.337
TRG_ER_diArg_1	75	78	PF00400	0.547
TRG_ER_diArg_1	835	838	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	843	847	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I177	Leptomonas seymouri	57%	99%
A0A3S7WT46	Leishmania donovani	73%	100%
E9APW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QFL7	Leishmania major	71%	99%