Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7T2_LEIBR

TriTrypDb:

LbrM.14.1290 , LBRM2903_200024000

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.552
CLV_C14_Caspase3-7	240	244	PF00656	0.437
CLV_NRD_NRD_1	28	30	PF00675	0.491
CLV_PCSK_KEX2_1	28	30	PF00082	0.491
CLV_PCSK_SKI1_1	163	167	PF00082	0.468
CLV_PCSK_SKI1_1	196	200	PF00082	0.695
CLV_PCSK_SKI1_1	222	226	PF00082	0.504
CLV_PCSK_SKI1_1	55	59	PF00082	0.585
CLV_PCSK_SKI1_1	77	81	PF00082	0.546
DEG_SPOP_SBC_1	246	250	PF00917	0.493
DEG_SPOP_SBC_1	35	39	PF00917	0.594
DOC_CYCLIN_RxL_1	74	85	PF00134	0.623
DOC_PP1_RVXF_1	75	82	PF00149	0.487
DOC_PP2B_LxvP_1	115	118	PF13499	0.625
DOC_PP4_FxxP_1	31	34	PF00568	0.615
DOC_USP7_MATH_1	118	122	PF00917	0.587
DOC_USP7_MATH_1	139	143	PF00917	0.565
DOC_USP7_MATH_1	246	250	PF00917	0.504
DOC_USP7_MATH_1	36	40	PF00917	0.587
DOC_WW_Pin1_4	175	180	PF00397	0.471
LIG_14-3-3_CanoR_1	222	231	PF00244	0.497
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_BIR_III_2	243	247	PF00653	0.454
LIG_BIR_III_4	232	236	PF00653	0.464
LIG_CAP-Gly_1	275	278	PF01302	0.674
LIG_deltaCOP1_diTrp_1	22	31	PF00928	0.493
LIG_eIF4E_1	15	21	PF01652	0.429
LIG_eIF4E_1	206	212	PF01652	0.581
LIG_EVH1_2	67	71	PF00568	0.511
LIG_FHA_1	125	131	PF00498	0.501
LIG_FHA_1	147	153	PF00498	0.600
LIG_FHA_1	224	230	PF00498	0.546
LIG_FHA_1	94	100	PF00498	0.601
LIG_FHA_2	108	114	PF00498	0.493
LIG_FHA_2	17	23	PF00498	0.553
LIG_FHA_2	198	204	PF00498	0.608
LIG_LIR_Apic_2	203	209	PF02991	0.576
LIG_LIR_Nem_3	52	57	PF02991	0.553
LIG_MYND_1	209	213	PF01753	0.675
LIG_SH2_CRK	206	210	PF00017	0.535
LIG_SH2_CRK	54	58	PF00017	0.530
LIG_SH2_GRB2like	109	112	PF00017	0.678
LIG_SH2_SRC	206	209	PF00017	0.619
LIG_SH2_STAT5	109	112	PF00017	0.653
LIG_SH2_STAT5	167	170	PF00017	0.539
LIG_SH2_STAT5	237	240	PF00017	0.479
LIG_SH2_STAT5	92	95	PF00017	0.558
LIG_WW_3	207	211	PF00397	0.671
MOD_CK1_1	7	13	PF00069	0.530
MOD_CK2_1	107	113	PF00069	0.537
MOD_CK2_1	189	195	PF00069	0.714
MOD_CK2_1	197	203	PF00069	0.600
MOD_GlcNHglycan	12	15	PF01048	0.444
MOD_GlcNHglycan	134	137	PF01048	0.513
MOD_GlcNHglycan	141	144	PF01048	0.572
MOD_GlcNHglycan	155	160	PF01048	0.552
MOD_GlcNHglycan	180	183	PF01048	0.523
MOD_GlcNHglycan	187	190	PF01048	0.775
MOD_GlcNHglycan	191	194	PF01048	0.745
MOD_GlcNHglycan	203	206	PF01048	0.570
MOD_GlcNHglycan	38	41	PF01048	0.621
MOD_GSK3_1	167	174	PF00069	0.529
MOD_GSK3_1	180	187	PF00069	0.644
MOD_GSK3_1	197	204	PF00069	0.608
MOD_GSK3_1	223	230	PF00069	0.499
MOD_GSK3_1	34	41	PF00069	0.649
MOD_GSK3_1	45	52	PF00069	0.390
MOD_GSK3_1	55	62	PF00069	0.425
MOD_N-GLC_1	137	142	PF02516	0.645
MOD_N-GLC_1	227	232	PF02516	0.516
MOD_N-GLC_1	46	51	PF02516	0.461
MOD_NEK2_1	130	135	PF00069	0.525
MOD_NEK2_1	137	142	PF00069	0.548
MOD_NEK2_1	171	176	PF00069	0.569
MOD_NEK2_1	185	190	PF00069	0.713
MOD_NEK2_1	223	228	PF00069	0.502
MOD_NEK2_1	247	252	PF00069	0.579
MOD_NEK2_1	264	269	PF00069	0.385
MOD_PIKK_1	180	186	PF00454	0.697
MOD_PIKK_1	247	253	PF00454	0.539
MOD_PK_1	227	233	PF00069	0.553
MOD_PKB_1	220	228	PF00069	0.574
MOD_Plk_1	227	233	PF00069	0.516
MOD_Plk_1	46	52	PF00069	0.607
MOD_Plk_1	7	13	PF00069	0.492
MOD_Plk_4	16	22	PF00069	0.468
MOD_ProDKin_1	175	181	PF00069	0.473
TRG_DiLeu_BaEn_1	219	224	PF01217	0.571
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.581
TRG_DiLeu_LyEn_5	219	224	PF01217	0.571
TRG_ENDOCYTIC_2	54	57	PF00928	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P396	Leptomonas seymouri	65%	97%
A0A0S4J125	Bodo saltans	33%	100%
A0A0S4J4Y9	Bodo saltans	32%	100%
A0A1X0P9Q3	Trypanosomatidae	40%	100%
A0A3Q8IH55	Leishmania donovani	81%	100%
A0A3R7LYE4	Trypanosoma rangeli	41%	100%
A4I9V4	Leishmania infantum	81%	100%
C9ZMS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q360	Leishmania major	81%	100%
V5DJW1	Trypanosoma cruzi	37%	96%