Tyrosine phosphatase isoform

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phosphatase isoform

Species:

Leishmania braziliensis

UniProt:

A4H7T1_LEIBR

TriTrypDb:

LbrM.14.1280 , LBRM2903_200024100

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4H7T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7T1

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	5
GO:0006629	lipid metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	8	4
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	7	4
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	5
GO:0140096	catalytic activity, acting on a protein	2	8
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.415
CLV_NRD_NRD_1	197	199	PF00675	0.322
CLV_NRD_NRD_1	242	244	PF00675	0.396
CLV_NRD_NRD_1	382	384	PF00675	0.350
CLV_NRD_NRD_1	385	387	PF00675	0.357
CLV_NRD_NRD_1	416	418	PF00675	0.380
CLV_PCSK_FUR_1	383	387	PF00082	0.383
CLV_PCSK_KEX2_1	197	199	PF00082	0.321
CLV_PCSK_KEX2_1	242	244	PF00082	0.356
CLV_PCSK_KEX2_1	382	384	PF00082	0.309
CLV_PCSK_KEX2_1	385	387	PF00082	0.317
CLV_PCSK_KEX2_1	416	418	PF00082	0.382
CLV_PCSK_SKI1_1	214	218	PF00082	0.280
CLV_PCSK_SKI1_1	424	428	PF00082	0.408
CLV_PCSK_SKI1_1	445	449	PF00082	0.413
CLV_PCSK_SKI1_1	507	511	PF00082	0.221
DEG_APCC_DBOX_1	385	393	PF00400	0.497
DEG_Nend_UBRbox_3	1	3	PF02207	0.700
DEG_SCF_FBW7_2	353	359	PF00400	0.498
DOC_CDC14_PxL_1	389	397	PF14671	0.552
DOC_CKS1_1	353	358	PF01111	0.473
DOC_CYCLIN_yCln2_LP_2	518	521	PF00134	0.498
DOC_MAPK_gen_1	25	33	PF00069	0.660
DOC_MAPK_gen_1	382	389	PF00069	0.507
DOC_PP1_RVXF_1	422	429	PF00149	0.594
DOC_PP2B_LxvP_1	518	521	PF13499	0.497
DOC_PP2B_LxvP_1	91	94	PF13499	0.371
DOC_USP7_MATH_1	265	269	PF00917	0.623
DOC_USP7_MATH_1	464	468	PF00917	0.753
DOC_WW_Pin1_4	106	111	PF00397	0.408
DOC_WW_Pin1_4	352	357	PF00397	0.473
LIG_14-3-3_CanoR_1	179	183	PF00244	0.315
LIG_14-3-3_CanoR_1	247	255	PF00244	0.570
LIG_14-3-3_CanoR_1	259	263	PF00244	0.612
LIG_14-3-3_CanoR_1	336	341	PF00244	0.503
LIG_14-3-3_CanoR_1	424	429	PF00244	0.699
LIG_14-3-3_CanoR_1	554	561	PF00244	0.498
LIG_Actin_RPEL_3	322	341	PF02755	0.384
LIG_BRCT_BRCA1_1	108	112	PF00533	0.336
LIG_BRCT_BRCA1_1	555	559	PF00533	0.384
LIG_eIF4E_1	211	217	PF01652	0.411
LIG_eIF4E_1	86	92	PF01652	0.410
LIG_EVH1_2	520	524	PF00568	0.498
LIG_FHA_1	109	115	PF00498	0.228
LIG_FHA_1	211	217	PF00498	0.525
LIG_FHA_1	26	32	PF00498	0.495
LIG_FHA_1	267	273	PF00498	0.567
LIG_FHA_1	40	46	PF00498	0.645
LIG_FHA_1	405	411	PF00498	0.625
LIG_FHA_1	533	539	PF00498	0.528
LIG_FHA_1	548	554	PF00498	0.543
LIG_FHA_1	6	12	PF00498	0.739
LIG_FHA_2	13	19	PF00498	0.633
LIG_FHA_2	526	532	PF00498	0.473
LIG_LIR_Apic_2	227	233	PF02991	0.506
LIG_LIR_Gen_1	109	120	PF02991	0.280
LIG_LIR_Gen_1	14	24	PF02991	0.546
LIG_LIR_Gen_1	143	154	PF02991	0.398
LIG_LIR_Gen_1	28	38	PF02991	0.614
LIG_LIR_Gen_1	402	412	PF02991	0.559
LIG_LIR_Gen_1	95	104	PF02991	0.410
LIG_LIR_Nem_3	109	115	PF02991	0.261
LIG_LIR_Nem_3	14	20	PF02991	0.558
LIG_LIR_Nem_3	143	149	PF02991	0.398
LIG_LIR_Nem_3	28	33	PF02991	0.623
LIG_LIR_Nem_3	359	364	PF02991	0.558
LIG_LIR_Nem_3	402	408	PF02991	0.556
LIG_LIR_Nem_3	478	482	PF02991	0.522
LIG_LIR_Nem_3	503	509	PF02991	0.497
LIG_LIR_Nem_3	95	101	PF02991	0.381
LIG_LYPXL_L_2	159	168	PF13949	0.184
LIG_MYND_1	517	521	PF01753	0.384
LIG_NRBOX	164	170	PF00104	0.482
LIG_NRBOX	95	101	PF00104	0.355
LIG_Pex14_1	468	472	PF04695	0.541
LIG_Pex14_2	506	510	PF04695	0.451
LIG_PTB_Apo_2	46	53	PF02174	0.518
LIG_PTB_Phospho_1	46	52	PF10480	0.518
LIG_REV1ctd_RIR_1	506	514	PF16727	0.536
LIG_REV1ctd_RIR_1	79	88	PF16727	0.479
LIG_RPA_C_Fungi	339	351	PF08784	0.355
LIG_SH2_CRK	116	120	PF00017	0.357
LIG_SH2_CRK	245	249	PF00017	0.499
LIG_SH2_NCK_1	17	21	PF00017	0.311
LIG_SH2_PTP2	52	55	PF00017	0.517
LIG_SH2_SRC	30	33	PF00017	0.600
LIG_SH2_SRC	456	459	PF00017	0.520
LIG_SH2_STAP1	116	120	PF00017	0.410
LIG_SH2_STAP1	555	559	PF00017	0.292
LIG_SH2_STAT3	324	327	PF00017	0.355
LIG_SH2_STAT5	200	203	PF00017	0.427
LIG_SH2_STAT5	211	214	PF00017	0.339
LIG_SH2_STAT5	23	26	PF00017	0.440
LIG_SH2_STAT5	293	296	PF00017	0.410
LIG_SH2_STAT5	30	33	PF00017	0.512
LIG_SH2_STAT5	321	324	PF00017	0.322
LIG_SH2_STAT5	361	364	PF00017	0.346
LIG_SH2_STAT5	420	423	PF00017	0.392
LIG_SH2_STAT5	52	55	PF00017	0.517
LIG_SH2_STAT5	86	89	PF00017	0.343
LIG_SH3_2	378	383	PF14604	0.508
LIG_SH3_3	155	161	PF00018	0.292
LIG_SH3_3	350	356	PF00018	0.302
LIG_SH3_3	375	381	PF00018	0.512
LIG_SH3_3	429	435	PF00018	0.445
LIG_SH3_3	514	520	PF00018	0.410
LIG_SH3_3	52	58	PF00018	0.505
LIG_SH3_3	7	13	PF00018	0.632
LIG_SUMO_SIM_anti_2	121	126	PF11976	0.335
LIG_SUMO_SIM_par_1	117	123	PF11976	0.342
LIG_SUMO_SIM_par_1	249	258	PF11976	0.448
LIG_SUMO_SIM_par_1	279	285	PF11976	0.355
LIG_SUMO_SIM_par_1	36	42	PF11976	0.347
LIG_TRAF2_1	356	359	PF00917	0.357
LIG_TRAF2_1	450	453	PF00917	0.495
LIG_TYR_ITIM	114	119	PF00017	0.402
LIG_TYR_ITSM	13	20	PF00017	0.559
LIG_TYR_ITSM	26	33	PF00017	0.572
LIG_UBA3_1	216	224	PF00899	0.224
LIG_WRC_WIRS_1	283	288	PF05994	0.410
MOD_CK1_1	467	473	PF00069	0.653
MOD_CK1_1	547	553	PF00069	0.197
MOD_CK2_1	12	18	PF00069	0.553
MOD_CK2_1	447	453	PF00069	0.455
MOD_CK2_1	525	531	PF00069	0.322
MOD_GlcNHglycan	329	332	PF01048	0.338
MOD_GlcNHglycan	429	432	PF01048	0.555
MOD_GlcNHglycan	555	558	PF01048	0.459
MOD_GlcNHglycan	65	68	PF01048	0.672
MOD_GSK3_1	247	254	PF00069	0.459
MOD_GSK3_1	336	343	PF00069	0.428
MOD_GSK3_1	59	66	PF00069	0.620
MOD_N-GLC_1	422	427	PF02516	0.487
MOD_NEK2_1	114	119	PF00069	0.378
MOD_NEK2_1	282	287	PF00069	0.428
MOD_NEK2_1	340	345	PF00069	0.396
MOD_NEK2_1	39	44	PF00069	0.483
MOD_NEK2_1	404	409	PF00069	0.391
MOD_NEK2_1	61	66	PF00069	0.686
MOD_PIKK_1	354	360	PF00454	0.274
MOD_PIKK_1	439	445	PF00454	0.633
MOD_PKA_2	178	184	PF00069	0.389
MOD_PKA_2	246	252	PF00069	0.482
MOD_PKA_2	258	264	PF00069	0.501
MOD_PKA_2	553	559	PF00069	0.393
MOD_Plk_1	422	428	PF00069	0.586
MOD_Plk_1	59	65	PF00069	0.587
MOD_Plk_4	108	114	PF00069	0.322
MOD_Plk_4	12	18	PF00069	0.442
MOD_Plk_4	123	129	PF00069	0.335
MOD_Plk_4	313	319	PF00069	0.357
MOD_Plk_4	404	410	PF00069	0.520
MOD_Plk_4	92	98	PF00069	0.374
MOD_ProDKin_1	106	112	PF00069	0.509
MOD_ProDKin_1	352	358	PF00069	0.322
MOD_SUMO_rev_2	544	553	PF00179	0.197
TRG_DiLeu_BaEn_1	143	148	PF01217	0.444
TRG_DiLeu_BaLyEn_6	514	519	PF01217	0.306
TRG_ENDOCYTIC_2	116	119	PF00928	0.322
TRG_ENDOCYTIC_2	17	20	PF00928	0.544
TRG_ENDOCYTIC_2	245	248	PF00928	0.477
TRG_ENDOCYTIC_2	30	33	PF00928	0.589
TRG_ENDOCYTIC_2	52	55	PF00928	0.517
TRG_ENDOCYTIC_2	79	82	PF00928	0.525
TRG_ER_diArg_1	241	243	PF00400	0.515
TRG_ER_diArg_1	341	344	PF00400	0.369
TRG_ER_diArg_1	381	383	PF00400	0.413
TRG_ER_diArg_1	384	386	PF00400	0.407
TRG_ER_diArg_1	416	418	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N6	Leptomonas seymouri	69%	95%
A0A0S4J8D3	Bodo saltans	29%	100%
A0A0S4JNQ3	Bodo saltans	26%	66%
A0A1X0PAB6	Trypanosomatidae	40%	92%
A0A3S7X7V0	Leishmania donovani	85%	100%
A4I9V5	Leishmania infantum	85%	100%
E9B4W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q359	Leishmania major	84%	100%
V5BT25	Trypanosoma cruzi	40%	92%