R3H-assoc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

R3H-associated N-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7S9_LEIBR

TriTrypDb:

LbrM.14.1260 , LBRM2903_200024300

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.468
CLV_C14_Caspase3-7	232	236	PF00656	0.507
CLV_C14_Caspase3-7	456	460	PF00656	0.460
CLV_C14_Caspase3-7	537	541	PF00656	0.520
CLV_C14_Caspase3-7	629	633	PF00656	0.583
CLV_NRD_NRD_1	239	241	PF00675	0.377
CLV_NRD_NRD_1	256	258	PF00675	0.464
CLV_NRD_NRD_1	267	269	PF00675	0.183
CLV_NRD_NRD_1	288	290	PF00675	0.343
CLV_NRD_NRD_1	315	317	PF00675	0.248
CLV_NRD_NRD_1	474	476	PF00675	0.583
CLV_NRD_NRD_1	496	498	PF00675	0.517
CLV_NRD_NRD_1	653	655	PF00675	0.554
CLV_NRD_NRD_1	657	659	PF00675	0.567
CLV_PCSK_FUR_1	254	258	PF00082	0.455
CLV_PCSK_FUR_1	494	498	PF00082	0.481
CLV_PCSK_KEX2_1	205	207	PF00082	0.546
CLV_PCSK_KEX2_1	241	243	PF00082	0.451
CLV_PCSK_KEX2_1	256	258	PF00082	0.464
CLV_PCSK_KEX2_1	474	476	PF00082	0.777
CLV_PCSK_KEX2_1	493	495	PF00082	0.341
CLV_PCSK_KEX2_1	496	498	PF00082	0.517
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.546
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.451
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.520
CLV_PCSK_SKI1_1	257	261	PF00082	0.478
CLV_PCSK_SKI1_1	306	310	PF00082	0.305
CLV_PCSK_SKI1_1	316	320	PF00082	0.236
DEG_SPOP_SBC_1	32	36	PF00917	0.539
DOC_CKS1_1	141	146	PF01111	0.434
DOC_CKS1_1	165	170	PF01111	0.486
DOC_CKS1_1	508	513	PF01111	0.581
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.564
DOC_MAPK_DCC_7	479	488	PF00069	0.489
DOC_MAPK_gen_1	421	430	PF00069	0.379
DOC_MAPK_MEF2A_6	479	488	PF00069	0.438
DOC_PP2B_LxvP_1	550	553	PF13499	0.601
DOC_PP2B_LxvP_1	96	99	PF13499	0.546
DOC_PP4_FxxP_1	79	82	PF00568	0.554
DOC_USP7_MATH_1	26	30	PF00917	0.543
DOC_USP7_MATH_1	3	7	PF00917	0.560
DOC_USP7_MATH_1	397	401	PF00917	0.431
DOC_USP7_MATH_1	501	505	PF00917	0.547
DOC_USP7_MATH_1	554	558	PF00917	0.715
DOC_USP7_MATH_1	666	670	PF00917	0.564
DOC_USP7_MATH_1	82	86	PF00917	0.569
DOC_USP7_UBL2_3	419	423	PF12436	0.545
DOC_USP7_UBL2_3	655	659	PF12436	0.527
DOC_WW_Pin1_4	105	110	PF00397	0.618
DOC_WW_Pin1_4	126	131	PF00397	0.705
DOC_WW_Pin1_4	140	145	PF00397	0.393
DOC_WW_Pin1_4	164	169	PF00397	0.486
DOC_WW_Pin1_4	375	380	PF00397	0.305
DOC_WW_Pin1_4	4	9	PF00397	0.561
DOC_WW_Pin1_4	421	426	PF00397	0.481
DOC_WW_Pin1_4	507	512	PF00397	0.585
DOC_WW_Pin1_4	513	518	PF00397	0.609
DOC_WW_Pin1_4	543	548	PF00397	0.683
DOC_WW_Pin1_4	636	641	PF00397	0.622
DOC_WW_Pin1_4	68	73	PF00397	0.528
DOC_WW_Pin1_4	87	92	PF00397	0.550
LIG_14-3-3_CanoR_1	114	121	PF00244	0.668
LIG_14-3-3_CanoR_1	135	142	PF00244	0.455
LIG_14-3-3_CanoR_1	240	248	PF00244	0.377
LIG_14-3-3_CanoR_1	256	264	PF00244	0.491
LIG_14-3-3_CanoR_1	616	620	PF00244	0.741
LIG_APCC_ABBA_1	356	361	PF00400	0.305
LIG_APCC_ABBAyCdc20_2	355	361	PF00400	0.305
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BRCT_BRCA1_1	426	430	PF00533	0.419
LIG_BRCT_BRCA1_1	49	53	PF00533	0.526
LIG_BRCT_BRCA1_1	63	67	PF00533	0.511
LIG_Clathr_ClatBox_1	350	354	PF01394	0.371
LIG_CtBP_PxDLS_1	425	429	PF00389	0.431
LIG_CtBP_PxDLS_1	523	527	PF00389	0.538
LIG_FHA_1	127	133	PF00498	0.625
LIG_FHA_1	134	140	PF00498	0.440
LIG_FHA_1	195	201	PF00498	0.416
LIG_FHA_1	38	44	PF00498	0.549
LIG_FHA_1	402	408	PF00498	0.418
LIG_FHA_1	508	514	PF00498	0.660
LIG_FHA_1	616	622	PF00498	0.658
LIG_FHA_2	165	171	PF00498	0.410
LIG_FHA_2	23	29	PF00498	0.539
LIG_FHA_2	247	253	PF00498	0.420
LIG_FHA_2	258	264	PF00498	0.443
LIG_FHA_2	454	460	PF00498	0.447
LIG_FHA_2	535	541	PF00498	0.633
LIG_LIR_Apic_2	226	231	PF02991	0.414
LIG_LIR_Apic_2	78	82	PF02991	0.557
LIG_LIR_Gen_1	330	339	PF02991	0.313
LIG_LIR_Gen_1	352	360	PF02991	0.305
LIG_LIR_Gen_1	411	418	PF02991	0.397
LIG_LIR_Gen_1	466	471	PF02991	0.418
LIG_LIR_Gen_1	593	603	PF02991	0.556
LIG_LIR_LC3C_4	618	621	PF02991	0.522
LIG_LIR_Nem_3	100	105	PF02991	0.524
LIG_LIR_Nem_3	192	198	PF02991	0.413
LIG_LIR_Nem_3	330	334	PF02991	0.313
LIG_LIR_Nem_3	352	356	PF02991	0.308
LIG_LIR_Nem_3	380	386	PF02991	0.305
LIG_LIR_Nem_3	411	417	PF02991	0.399
LIG_LIR_Nem_3	434	439	PF02991	0.381
LIG_LIR_Nem_3	466	470	PF02991	0.414
LIG_LIR_Nem_3	593	598	PF02991	0.598
LIG_LYPXL_yS_3	280	283	PF13949	0.305
LIG_MYND_1	130	134	PF01753	0.499
LIG_MYND_1	511	515	PF01753	0.539
LIG_MYND_1	640	644	PF01753	0.678
LIG_MYND_1	95	99	PF01753	0.534
LIG_PCNA_yPIPBox_3	287	300	PF02747	0.305
LIG_PTB_Apo_2	294	301	PF02174	0.305
LIG_SH2_CRK	102	106	PF00017	0.527
LIG_SH2_CRK	436	440	PF00017	0.355
LIG_SH2_GRB2like	549	552	PF00017	0.539
LIG_SH2_NCK_1	228	232	PF00017	0.425
LIG_SH2_PTP2	467	470	PF00017	0.418
LIG_SH2_SRC	549	552	PF00017	0.539
LIG_SH2_STAP1	189	193	PF00017	0.479
LIG_SH2_STAT5	110	113	PF00017	0.533
LIG_SH2_STAT5	299	302	PF00017	0.229
LIG_SH2_STAT5	448	451	PF00017	0.338
LIG_SH2_STAT5	467	470	PF00017	0.586
LIG_SH2_STAT5	549	552	PF00017	0.539
LIG_SH2_STAT5	611	614	PF00017	0.699
LIG_SH3_3	128	134	PF00018	0.504
LIG_SH3_3	247	253	PF00018	0.443
LIG_SH3_3	359	365	PF00018	0.307
LIG_SH3_3	367	373	PF00018	0.361
LIG_SH3_3	465	471	PF00018	0.420
LIG_SH3_3	478	484	PF00018	0.473
LIG_SH3_3	5	11	PF00018	0.559
LIG_SH3_3	517	523	PF00018	0.592
LIG_SH3_3	541	547	PF00018	0.656
LIG_SH3_3	550	556	PF00018	0.585
LIG_SH3_3	70	76	PF00018	0.535
LIG_SH3_3	85	91	PF00018	0.550
LIG_SH3_3	92	98	PF00018	0.537
LIG_SUMO_SIM_par_1	617	622	PF11976	0.658
LIG_TYR_ITIM	465	470	PF00017	0.417
LIG_UBA3_1	488	493	PF00899	0.473
MOD_CDK_SPK_2	140	145	PF00069	0.423
MOD_CDK_SPxxK_3	375	382	PF00069	0.305
MOD_CK1_1	115	121	PF00069	0.607
MOD_CK1_1	161	167	PF00069	0.596
MOD_CK1_1	21	27	PF00069	0.638
MOD_CK1_1	229	235	PF00069	0.467
MOD_CK1_1	246	252	PF00069	0.392
MOD_CK1_1	424	430	PF00069	0.489
MOD_CK1_1	506	512	PF00069	0.581
MOD_CK1_1	534	540	PF00069	0.609
MOD_CK1_1	6	12	PF00069	0.559
MOD_CK2_1	164	170	PF00069	0.429
MOD_CK2_1	22	28	PF00069	0.540
MOD_CK2_1	257	263	PF00069	0.512
MOD_Cter_Amidation	203	206	PF01082	0.543
MOD_DYRK1A_RPxSP_1	421	425	PF00069	0.408
MOD_DYRK1A_RPxSP_1	68	72	PF00069	0.521
MOD_GlcNHglycan	1	4	PF01048	0.569
MOD_GlcNHglycan	122	125	PF01048	0.608
MOD_GlcNHglycan	20	23	PF01048	0.494
MOD_GlcNHglycan	459	463	PF01048	0.493
MOD_GlcNHglycan	47	50	PF01048	0.537
MOD_GlcNHglycan	505	508	PF01048	0.594
MOD_GlcNHglycan	63	66	PF01048	0.474
MOD_GlcNHglycan	634	637	PF01048	0.633
MOD_GlcNHglycan	664	667	PF01048	0.616
MOD_GlcNHglycan	78	82	PF01048	0.535
MOD_GlcNHglycan	84	87	PF01048	0.549
MOD_GSK3_1	112	119	PF00069	0.604
MOD_GSK3_1	154	161	PF00069	0.436
MOD_GSK3_1	174	181	PF00069	0.432
MOD_GSK3_1	18	25	PF00069	0.508
MOD_GSK3_1	209	216	PF00069	0.414
MOD_GSK3_1	28	35	PF00069	0.516
MOD_GSK3_1	3	10	PF00069	0.560
MOD_GSK3_1	323	330	PF00069	0.341
MOD_GSK3_1	37	44	PF00069	0.497
MOD_GSK3_1	397	404	PF00069	0.446
MOD_GSK3_1	449	456	PF00069	0.408
MOD_GSK3_1	466	473	PF00069	0.444
MOD_GSK3_1	503	510	PF00069	0.562
MOD_GSK3_1	590	597	PF00069	0.564
MOD_GSK3_1	632	639	PF00069	0.637
MOD_GSK3_1	643	650	PF00069	0.653
MOD_GSK3_1	662	669	PF00069	0.696
MOD_GSK3_1	77	84	PF00069	0.591
MOD_GSK3_1	87	94	PF00069	0.722
MOD_LATS_1	112	118	PF00433	0.537
MOD_N-GLC_1	112	117	PF02516	0.536
MOD_N-GLC_1	37	42	PF02516	0.562
MOD_NEK2_1	18	23	PF00069	0.551
MOD_NEK2_1	41	46	PF00069	0.593
MOD_NEK2_1	458	463	PF00069	0.573
MOD_NEK2_1	53	58	PF00069	0.499
MOD_NEK2_1	615	620	PF00069	0.689
MOD_NEK2_1	647	652	PF00069	0.615
MOD_PIKK_1	161	167	PF00454	0.541
MOD_PIKK_1	401	407	PF00454	0.413
MOD_PIKK_1	531	537	PF00454	0.528
MOD_PIKK_1	649	655	PF00454	0.583
MOD_PIKK_1	666	672	PF00454	0.605
MOD_PKA_1	240	246	PF00069	0.357
MOD_PKA_2	113	119	PF00069	0.668
MOD_PKA_2	134	140	PF00069	0.397
MOD_PKA_2	178	184	PF00069	0.503
MOD_PKA_2	615	621	PF00069	0.654
MOD_PKA_2	82	88	PF00069	0.555
MOD_Plk_1	323	329	PF00069	0.371
MOD_Plk_1	37	43	PF00069	0.560
MOD_Plk_2-3	453	459	PF00069	0.483
MOD_Plk_4	246	252	PF00069	0.631
MOD_Plk_4	424	430	PF00069	0.427
MOD_Plk_4	463	469	PF00069	0.481
MOD_Plk_4	590	596	PF00069	0.561
MOD_Plk_4	615	621	PF00069	0.519
MOD_Plk_4	97	103	PF00069	0.534
MOD_ProDKin_1	105	111	PF00069	0.558
MOD_ProDKin_1	126	132	PF00069	0.698
MOD_ProDKin_1	140	146	PF00069	0.400
MOD_ProDKin_1	164	170	PF00069	0.488
MOD_ProDKin_1	375	381	PF00069	0.305
MOD_ProDKin_1	4	10	PF00069	0.559
MOD_ProDKin_1	421	427	PF00069	0.472
MOD_ProDKin_1	507	513	PF00069	0.590
MOD_ProDKin_1	543	549	PF00069	0.685
MOD_ProDKin_1	636	642	PF00069	0.620
MOD_ProDKin_1	68	74	PF00069	0.532
MOD_ProDKin_1	87	93	PF00069	0.553
TRG_AP2beta_CARGO_1	411	421	PF09066	0.345
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.374
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.305
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.366
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.348
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.557
TRG_ENDOCYTIC_2	102	105	PF00928	0.527
TRG_ENDOCYTIC_2	280	283	PF00928	0.305
TRG_ENDOCYTIC_2	436	439	PF00928	0.362
TRG_ENDOCYTIC_2	447	450	PF00928	0.359
TRG_ENDOCYTIC_2	467	470	PF00928	0.296
TRG_ENDOCYTIC_2	611	614	PF00928	0.577
TRG_ER_diArg_1	239	242	PF00400	0.380
TRG_ER_diArg_1	253	256	PF00400	0.481
TRG_ER_diArg_1	274	277	PF00400	0.313
TRG_ER_diArg_1	291	294	PF00400	0.447
TRG_ER_diArg_1	355	358	PF00400	0.371
TRG_ER_diArg_1	494	497	PF00400	0.482
TRG_NES_CRM1_1	333	348	PF08389	0.305
TRG_NES_CRM1_1	349	361	PF08389	0.305
TRG_NES_CRM1_1	401	416	PF08389	0.389
TRG_NLS_Bipartite_1	278	293	PF00514	0.305
TRG_NLS_MonoExtC_3	492	497	PF00514	0.502
TRG_NLS_MonoExtC_3	653	658	PF00514	0.522
TRG_NLS_MonoExtN_4	286	293	PF00514	0.305
TRG_NLS_MonoExtN_4	654	659	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P399	Leptomonas seymouri	67%	100%
A0A3S7X7Q4	Leishmania donovani	82%	100%
A4I9V7	Leishmania infantum	82%	100%
E9B4X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q357	Leishmania major	81%	100%