Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7S8_LEIBR

TriTrypDb:

LbrM.14.1250 , LBRM2903_200024400

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	704	708	PF00656	0.603
CLV_NRD_NRD_1	121	123	PF00675	0.464
CLV_NRD_NRD_1	17	19	PF00675	0.626
CLV_NRD_NRD_1	176	178	PF00675	0.524
CLV_NRD_NRD_1	198	200	PF00675	0.343
CLV_NRD_NRD_1	284	286	PF00675	0.468
CLV_NRD_NRD_1	557	559	PF00675	0.484
CLV_NRD_NRD_1	570	572	PF00675	0.315
CLV_NRD_NRD_1	588	590	PF00675	0.358
CLV_NRD_NRD_1	694	696	PF00675	0.516
CLV_NRD_NRD_1	721	723	PF00675	0.499
CLV_NRD_NRD_1	8	10	PF00675	0.701
CLV_PCSK_FUR_1	555	559	PF00082	0.358
CLV_PCSK_KEX2_1	121	123	PF00082	0.464
CLV_PCSK_KEX2_1	17	19	PF00082	0.565
CLV_PCSK_KEX2_1	176	178	PF00082	0.467
CLV_PCSK_KEX2_1	198	200	PF00082	0.458
CLV_PCSK_KEX2_1	284	286	PF00082	0.529
CLV_PCSK_KEX2_1	347	349	PF00082	0.508
CLV_PCSK_KEX2_1	533	535	PF00082	0.797
CLV_PCSK_KEX2_1	557	559	PF00082	0.503
CLV_PCSK_KEX2_1	570	572	PF00082	0.301
CLV_PCSK_KEX2_1	599	601	PF00082	0.370
CLV_PCSK_KEX2_1	688	690	PF00082	0.426
CLV_PCSK_KEX2_1	721	723	PF00082	0.523
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.429
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.688
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.370
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.426
CLV_PCSK_SKI1_1	146	150	PF00082	0.472
CLV_PCSK_SKI1_1	176	180	PF00082	0.492
CLV_PCSK_SKI1_1	225	229	PF00082	0.400
CLV_PCSK_SKI1_1	258	262	PF00082	0.427
CLV_PCSK_SKI1_1	347	351	PF00082	0.481
CLV_PCSK_SKI1_1	412	416	PF00082	0.477
CLV_PCSK_SKI1_1	465	469	PF00082	0.519
CLV_PCSK_SKI1_1	483	487	PF00082	0.445
DEG_APCC_DBOX_1	224	232	PF00400	0.391
DEG_APCC_DBOX_1	445	453	PF00400	0.363
DEG_SCF_FBW7_2	629	636	PF00400	0.554
DEG_SCF_FBW7_2	96	102	PF00400	0.347
DEG_SPOP_SBC_1	525	529	PF00917	0.450
DEG_SPOP_SBC_1	82	86	PF00917	0.671
DOC_CKS1_1	484	489	PF01111	0.276
DOC_CKS1_1	630	635	PF01111	0.519
DOC_CKS1_1	96	101	PF01111	0.349
DOC_CYCLIN_RxL_1	143	151	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	710	716	PF00134	0.631
DOC_MAPK_gen_1	176	185	PF00069	0.392
DOC_MAPK_gen_1	553	562	PF00069	0.487
DOC_MAPK_gen_1	599	605	PF00069	0.464
DOC_MAPK_MEF2A_6	219	228	PF00069	0.442
DOC_MAPK_MEF2A_6	599	607	PF00069	0.332
DOC_MAPK_MEF2A_6	656	664	PF00069	0.490
DOC_PP1_RVXF_1	346	353	PF00149	0.466
DOC_PP1_RVXF_1	686	693	PF00149	0.410
DOC_PP2B_LxvP_1	710	713	PF13499	0.549
DOC_USP7_MATH_1	133	137	PF00917	0.435
DOC_USP7_MATH_1	189	193	PF00917	0.529
DOC_USP7_MATH_1	239	243	PF00917	0.489
DOC_USP7_MATH_1	270	274	PF00917	0.567
DOC_USP7_MATH_1	309	313	PF00917	0.684
DOC_USP7_MATH_1	362	366	PF00917	0.561
DOC_USP7_MATH_1	422	426	PF00917	0.501
DOC_USP7_MATH_1	524	528	PF00917	0.588
DOC_USP7_MATH_1	547	551	PF00917	0.539
DOC_USP7_MATH_1	680	684	PF00917	0.374
DOC_USP7_MATH_1	702	706	PF00917	0.611
DOC_USP7_MATH_1	81	85	PF00917	0.734
DOC_WW_Pin1_4	266	271	PF00397	0.637
DOC_WW_Pin1_4	30	35	PF00397	0.448
DOC_WW_Pin1_4	355	360	PF00397	0.390
DOC_WW_Pin1_4	439	444	PF00397	0.456
DOC_WW_Pin1_4	483	488	PF00397	0.452
DOC_WW_Pin1_4	629	634	PF00397	0.512
DOC_WW_Pin1_4	69	74	PF00397	0.722
DOC_WW_Pin1_4	95	100	PF00397	0.529
LIG_14-3-3_CanoR_1	146	156	PF00244	0.413
LIG_14-3-3_CanoR_1	167	175	PF00244	0.358
LIG_14-3-3_CanoR_1	412	417	PF00244	0.443
LIG_14-3-3_CanoR_1	515	521	PF00244	0.533
LIG_14-3-3_CanoR_1	53	59	PF00244	0.632
LIG_14-3-3_CanoR_1	60	64	PF00244	0.618
LIG_14-3-3_CanoR_1	608	614	PF00244	0.373
LIG_14-3-3_CanoR_1	71	81	PF00244	0.473
LIG_14-3-3_CanoR_1	9	15	PF00244	0.606
LIG_APCC_ABBA_1	660	665	PF00400	0.496
LIG_deltaCOP1_diTrp_1	323	329	PF00928	0.338
LIG_deltaCOP1_diTrp_1	343	352	PF00928	0.409
LIG_eIF4E_1	125	131	PF01652	0.487
LIG_FHA_1	232	238	PF00498	0.496
LIG_FHA_1	270	276	PF00498	0.668
LIG_FHA_1	322	328	PF00498	0.444
LIG_FHA_1	462	468	PF00498	0.511
LIG_FHA_1	484	490	PF00498	0.274
LIG_FHA_1	53	59	PF00498	0.645
LIG_FHA_1	672	678	PF00498	0.532
LIG_FHA_1	735	741	PF00498	0.534
LIG_FHA_2	169	175	PF00498	0.334
LIG_FHA_2	218	224	PF00498	0.525
LIG_FHA_2	593	599	PF00498	0.505
LIG_LIR_Apic_2	38	42	PF02991	0.438
LIG_LIR_Apic_2	488	494	PF02991	0.438
LIG_LIR_Gen_1	180	190	PF02991	0.418
LIG_LIR_Gen_1	207	217	PF02991	0.364
LIG_LIR_Gen_1	242	251	PF02991	0.315
LIG_LIR_Gen_1	323	333	PF02991	0.411
LIG_LIR_Gen_1	582	593	PF02991	0.411
LIG_LIR_Gen_1	675	682	PF02991	0.459
LIG_LIR_Nem_3	112	117	PF02991	0.358
LIG_LIR_Nem_3	180	185	PF02991	0.459
LIG_LIR_Nem_3	207	212	PF02991	0.334
LIG_LIR_Nem_3	242	247	PF02991	0.310
LIG_LIR_Nem_3	323	328	PF02991	0.339
LIG_LIR_Nem_3	343	349	PF02991	0.356
LIG_LIR_Nem_3	492	498	PF02991	0.382
LIG_LIR_Nem_3	582	588	PF02991	0.393
LIG_LIR_Nem_3	675	681	PF02991	0.438
LIG_LIR_Nem_3	684	690	PF02991	0.500
LIG_LYPXL_SIV_4	382	390	PF13949	0.324
LIG_NRBOX	144	150	PF00104	0.433
LIG_NRBOX	644	650	PF00104	0.421
LIG_PCNA_PIPBox_1	141	150	PF02747	0.303
LIG_PCNA_yPIPBox_3	138	146	PF02747	0.307
LIG_Pex14_1	325	329	PF04695	0.330
LIG_Pex14_1	345	349	PF04695	0.204
LIG_Pex14_2	248	252	PF04695	0.434
LIG_RPA_C_Fungi	717	729	PF08784	0.505
LIG_SH2_CRK	209	213	PF00017	0.357
LIG_SH2_CRK	646	650	PF00017	0.329
LIG_SH2_CRK	687	691	PF00017	0.579
LIG_SH2_GRB2like	405	408	PF00017	0.487
LIG_SH2_NCK_1	244	248	PF00017	0.218
LIG_SH2_PTP2	114	117	PF00017	0.269
LIG_SH2_STAP1	209	213	PF00017	0.445
LIG_SH2_STAP1	244	248	PF00017	0.379
LIG_SH2_STAT3	125	128	PF00017	0.302
LIG_SH2_STAT5	114	117	PF00017	0.407
LIG_SH2_STAT5	201	204	PF00017	0.512
LIG_SH2_STAT5	405	408	PF00017	0.497
LIG_SH2_STAT5	491	494	PF00017	0.490
LIG_SH2_STAT5	610	613	PF00017	0.457
LIG_SH3_3	421	427	PF00018	0.566
LIG_SUMO_SIM_anti_2	601	607	PF11976	0.333
LIG_TYR_ITIM	403	408	PF00017	0.283
LIG_TYR_ITIM	644	649	PF00017	0.475
LIG_UBA3_1	341	347	PF00899	0.425
LIG_UBA3_1	456	465	PF00899	0.340
LIG_UBA3_1	584	590	PF00899	0.402
MOD_CDK_SPK_2	69	74	PF00069	0.513
MOD_CDK_SPxxK_3	439	446	PF00069	0.324
MOD_CK1_1	269	275	PF00069	0.650
MOD_CK1_1	304	310	PF00069	0.662
MOD_CK1_1	425	431	PF00069	0.606
MOD_CK1_1	441	447	PF00069	0.544
MOD_CK1_1	463	469	PF00069	0.514
MOD_CK1_1	503	509	PF00069	0.346
MOD_CK1_1	518	524	PF00069	0.490
MOD_CK1_1	527	533	PF00069	0.708
MOD_CK1_1	56	62	PF00069	0.665
MOD_CK1_1	652	658	PF00069	0.281
MOD_CK1_1	72	78	PF00069	0.758
MOD_CK1_1	84	90	PF00069	0.709
MOD_CK2_1	148	154	PF00069	0.497
MOD_CK2_1	217	223	PF00069	0.433
MOD_CK2_1	239	245	PF00069	0.450
MOD_CK2_1	592	598	PF00069	0.513
MOD_Cter_Amidation	555	558	PF01082	0.462
MOD_GlcNHglycan	185	188	PF01048	0.503
MOD_GlcNHglycan	191	194	PF01048	0.545
MOD_GlcNHglycan	214	217	PF01048	0.395
MOD_GlcNHglycan	263	267	PF01048	0.705
MOD_GlcNHglycan	276	279	PF01048	0.669
MOD_GlcNHglycan	311	314	PF01048	0.773
MOD_GlcNHglycan	360	363	PF01048	0.746
MOD_GlcNHglycan	373	376	PF01048	0.616
MOD_GlcNHglycan	502	505	PF01048	0.343
MOD_GlcNHglycan	508	511	PF01048	0.378
MOD_GlcNHglycan	520	523	PF01048	0.580
MOD_GlcNHglycan	549	552	PF01048	0.760
MOD_GlcNHglycan	619	622	PF01048	0.359
MOD_GlcNHglycan	651	654	PF01048	0.435
MOD_GSK3_1	208	215	PF00069	0.351
MOD_GSK3_1	226	233	PF00069	0.442
MOD_GSK3_1	258	265	PF00069	0.666
MOD_GSK3_1	266	273	PF00069	0.436
MOD_GSK3_1	301	308	PF00069	0.483
MOD_GSK3_1	358	365	PF00069	0.665
MOD_GSK3_1	412	419	PF00069	0.496
MOD_GSK3_1	438	445	PF00069	0.460
MOD_GSK3_1	52	59	PF00069	0.693
MOD_GSK3_1	524	531	PF00069	0.665
MOD_GSK3_1	72	79	PF00069	0.767
MOD_GSK3_1	82	89	PF00069	0.761
MOD_N-GLC_1	30	35	PF02516	0.448
MOD_N-GLC_1	309	314	PF02516	0.480
MOD_N-GLC_1	67	72	PF02516	0.559
MOD_NEK2_1	148	153	PF00069	0.518
MOD_NEK2_1	178	183	PF00069	0.521
MOD_NEK2_1	212	217	PF00069	0.378
MOD_NEK2_1	303	308	PF00069	0.510
MOD_NEK2_1	328	333	PF00069	0.414
MOD_NEK2_1	416	421	PF00069	0.524
MOD_NEK2_1	460	465	PF00069	0.339
MOD_NEK2_1	609	614	PF00069	0.309
MOD_NEK2_1	681	686	PF00069	0.530
MOD_NEK2_1	733	738	PF00069	0.534
MOD_NEK2_2	239	244	PF00069	0.452
MOD_PIKK_1	682	688	PF00454	0.594
MOD_PKA_2	52	58	PF00069	0.710
MOD_PKA_2	59	65	PF00069	0.680
MOD_Plk_1	239	245	PF00069	0.454
MOD_Plk_4	10	16	PF00069	0.689
MOD_Plk_4	140	146	PF00069	0.333
MOD_Plk_4	178	184	PF00069	0.289
MOD_Plk_4	208	214	PF00069	0.488
MOD_Plk_4	239	245	PF00069	0.335
MOD_Plk_4	35	41	PF00069	0.625
MOD_Plk_4	564	570	PF00069	0.352
MOD_Plk_4	580	586	PF00069	0.386
MOD_Plk_4	59	65	PF00069	0.594
MOD_ProDKin_1	266	272	PF00069	0.630
MOD_ProDKin_1	30	36	PF00069	0.448
MOD_ProDKin_1	355	361	PF00069	0.399
MOD_ProDKin_1	439	445	PF00069	0.464
MOD_ProDKin_1	483	489	PF00069	0.446
MOD_ProDKin_1	629	635	PF00069	0.520
MOD_ProDKin_1	69	75	PF00069	0.721
MOD_ProDKin_1	95	101	PF00069	0.527
MOD_SUMO_for_1	637	640	PF00179	0.313
MOD_SUMO_rev_2	634	639	PF00179	0.363
TRG_DiLeu_BaEn_1	598	603	PF01217	0.415
TRG_DiLeu_BaEn_2	558	564	PF01217	0.429
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.502
TRG_ENDOCYTIC_2	114	117	PF00928	0.432
TRG_ENDOCYTIC_2	209	212	PF00928	0.312
TRG_ENDOCYTIC_2	244	247	PF00928	0.310
TRG_ENDOCYTIC_2	405	408	PF00928	0.308
TRG_ENDOCYTIC_2	610	613	PF00928	0.491
TRG_ENDOCYTIC_2	646	649	PF00928	0.339
TRG_ENDOCYTIC_2	687	690	PF00928	0.581
TRG_ER_diArg_1	121	123	PF00400	0.467
TRG_ER_diArg_1	175	177	PF00400	0.531
TRG_ER_diArg_1	197	199	PF00400	0.353
TRG_ER_diArg_1	283	285	PF00400	0.451
TRG_ER_diArg_1	555	558	PF00400	0.537
TRG_ER_diArg_1	569	571	PF00400	0.316
TRG_ER_diArg_1	720	722	PF00400	0.527
TRG_ER_diArg_1	726	729	PF00400	0.529
TRG_NES_CRM1_1	398	411	PF08389	0.374
TRG_NES_CRM1_1	582	598	PF08389	0.414
TRG_NLS_MonoExtC_3	531	536	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA97	Leptomonas seymouri	54%	100%
A0A1X0P9G0	Trypanosomatidae	37%	100%
A0A3R7MA99	Trypanosoma rangeli	40%	100%
A0A3S7X7S0	Leishmania donovani	77%	100%
A4I9V8	Leishmania infantum	77%	100%
C9ZMS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B4X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q356	Leishmania major	77%	100%
V5BT29	Trypanosoma cruzi	39%	100%