EAP30/Vps36 family-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EAP30/Vps36 family, putative

Species:

Leishmania braziliensis

UniProt:

A4H7S7_LEIBR

TriTrypDb:

LbrM.14.1240 , LBRM2903_200024500

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000814	ESCRT II complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0036452	ESCRT complex	2	12
GO:0098796	membrane protein complex	2	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0071985	multivesicular body sorting pathway	5	12
GO:0006886	intracellular protein transport	4	1
GO:0007034	vacuolar transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	5	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072665	protein localization to vacuole	6	1
GO:0072666	establishment of protein localization to vacuole	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.457
CLV_NRD_NRD_1	110	112	PF00675	0.249
CLV_NRD_NRD_1	3	5	PF00675	0.503
CLV_NRD_NRD_1	324	326	PF00675	0.184
CLV_PCSK_KEX2_1	163	165	PF00082	0.324
CLV_PCSK_KEX2_1	171	173	PF00082	0.293
CLV_PCSK_KEX2_1	2	4	PF00082	0.556
CLV_PCSK_KEX2_1	236	238	PF00082	0.273
CLV_PCSK_KEX2_1	324	326	PF00082	0.339
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.291
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.268
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.273
CLV_PCSK_PC7_1	167	173	PF00082	0.240
CLV_PCSK_PC7_1	320	326	PF00082	0.339
CLV_PCSK_SKI1_1	320	324	PF00082	0.339
CLV_PCSK_SKI1_1	359	363	PF00082	0.679
CLV_PCSK_SKI1_1	83	87	PF00082	0.271
DEG_APCC_DBOX_1	319	327	PF00400	0.539
DEG_Nend_UBRbox_1	1	4	PF02207	0.523
DOC_CKS1_1	206	211	PF01111	0.448
DOC_MAPK_MEF2A_6	186	194	PF00069	0.379
DOC_PP1_RVXF_1	120	126	PF00149	0.539
DOC_PP1_RVXF_1	367	373	PF00149	0.438
DOC_USP7_MATH_1	248	252	PF00917	0.555
DOC_USP7_MATH_1	355	359	PF00917	0.732
DOC_USP7_UBL2_3	369	373	PF12436	0.633
DOC_WW_Pin1_4	144	149	PF00397	0.379
DOC_WW_Pin1_4	205	210	PF00397	0.451
DOC_WW_Pin1_4	351	356	PF00397	0.666
LIG_14-3-3_CanoR_1	172	181	PF00244	0.456
LIG_APCC_ABBAyCdc20_2	82	88	PF00400	0.491
LIG_BIR_III_4	88	92	PF00653	0.491
LIG_eIF4E_1	131	137	PF01652	0.491
LIG_FHA_1	247	253	PF00498	0.414
LIG_FHA_1	329	335	PF00498	0.517
LIG_FHA_2	205	211	PF00498	0.448
LIG_FHA_2	255	261	PF00498	0.431
LIG_GBD_Chelix_1	70	78	PF00786	0.304
LIG_LIR_Gen_1	363	371	PF02991	0.436
LIG_LIR_Nem_3	363	368	PF02991	0.432
LIG_LIR_Nem_3	387	393	PF02991	0.431
LIG_PALB2_WD40_1	387	395	PF16756	0.483
LIG_PCNA_yPIPBox_3	213	224	PF02747	0.379
LIG_PDZ_Class_1	394	399	PF00595	0.355
LIG_PTB_Apo_2	91	98	PF02174	0.396
LIG_PTB_Phospho_1	91	97	PF10480	0.396
LIG_REV1ctd_RIR_1	123	133	PF16727	0.539
LIG_SH2_GRB2like	131	134	PF00017	0.379
LIG_SH2_PTP2	117	120	PF00017	0.448
LIG_SH2_SRC	131	134	PF00017	0.379
LIG_SH2_STAT5	117	120	PF00017	0.439
LIG_SH2_STAT5	204	207	PF00017	0.437
LIG_SH2_STAT5	223	226	PF00017	0.504
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.555
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.506
LIG_TRAF2_1	239	242	PF00917	0.578
LIG_TRAF2_1	364	367	PF00917	0.727
LIG_TYR_ITIM	388	393	PF00017	0.517
LIG_UBA3_1	180	186	PF00899	0.539
LIG_WRC_WIRS_1	362	367	PF05994	0.438
MOD_CDC14_SPxK_1	147	150	PF00782	0.379
MOD_CDC14_SPxK_1	354	357	PF00782	0.655
MOD_CDK_SPxK_1	144	150	PF00069	0.379
MOD_CDK_SPxK_1	351	357	PF00069	0.665
MOD_CK1_1	153	159	PF00069	0.531
MOD_CK1_1	185	191	PF00069	0.518
MOD_CK1_1	246	252	PF00069	0.435
MOD_CK1_1	255	261	PF00069	0.415
MOD_CK1_1	55	61	PF00069	0.521
MOD_CK2_1	254	260	PF00069	0.407
MOD_CK2_1	360	366	PF00069	0.736
MOD_Cter_Amidation	161	164	PF01082	0.182
MOD_Cter_Amidation	169	172	PF01082	0.276
MOD_GlcNHglycan	153	156	PF01048	0.329
MOD_GlcNHglycan	157	160	PF01048	0.338
MOD_GlcNHglycan	309	312	PF01048	0.391
MOD_GSK3_1	127	134	PF00069	0.512
MOD_GSK3_1	140	147	PF00069	0.522
MOD_GSK3_1	150	157	PF00069	0.529
MOD_GSK3_1	243	250	PF00069	0.545
MOD_GSK3_1	303	310	PF00069	0.491
MOD_GSK3_1	351	358	PF00069	0.684
MOD_N-GLC_1	132	137	PF02516	0.301
MOD_N-GLC_1	252	257	PF02516	0.179
MOD_NEK2_1	70	75	PF00069	0.441
MOD_NEK2_1	78	83	PF00069	0.431
MOD_PIKK_1	285	291	PF00454	0.406
MOD_PIKK_1	334	340	PF00454	0.710
MOD_PKA_2	303	309	PF00069	0.491
MOD_PKA_2	343	349	PF00069	0.799
MOD_Plk_1	131	137	PF00069	0.539
MOD_Plk_1	252	258	PF00069	0.388
MOD_Plk_4	132	138	PF00069	0.564
MOD_Plk_4	185	191	PF00069	0.529
MOD_ProDKin_1	144	150	PF00069	0.379
MOD_ProDKin_1	205	211	PF00069	0.451
MOD_ProDKin_1	351	357	PF00069	0.665
MOD_SUMO_rev_2	105	113	PF00179	0.448
MOD_SUMO_rev_2	168	173	PF00179	0.482
MOD_SUMO_rev_2	363	371	PF00179	0.593
TRG_ENDOCYTIC_2	117	120	PF00928	0.457
TRG_ENDOCYTIC_2	390	393	PF00928	0.389
TRG_ENDOCYTIC_2	96	99	PF00928	0.448
TRG_ER_diArg_1	1	4	PF00400	0.549
TRG_ER_diArg_1	323	325	PF00400	0.480
TRG_ER_diArg_1	63	66	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.280
TRG_PTS2	1	39	PF00400	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSW5	Leptomonas seymouri	67%	100%
A0A0S4J518	Bodo saltans	28%	97%
A0A1X0P9K2	Trypanosomatidae	44%	100%
A0A3Q8IKY6	Leishmania donovani	78%	100%
A0A3R7NWX2	Trypanosoma rangeli	42%	100%
A4I9V9	Leishmania infantum	78%	100%
C9ZMT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B4X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q355	Leishmania major	77%	99%
V5BT20	Trypanosoma cruzi	46%	100%