Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7S6_LEIBR

TriTrypDb:

LbrM.14.1230 , LBRM2903_200024600

Length:

1021

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.594
CLV_C14_Caspase3-7	255	259	PF00656	0.595
CLV_C14_Caspase3-7	475	479	PF00656	0.618
CLV_C14_Caspase3-7	787	791	PF00656	0.818
CLV_NRD_NRD_1	301	303	PF00675	0.792
CLV_NRD_NRD_1	667	669	PF00675	0.828
CLV_NRD_NRD_1	693	695	PF00675	0.723
CLV_NRD_NRD_1	806	808	PF00675	0.600
CLV_NRD_NRD_1	9	11	PF00675	0.808
CLV_NRD_NRD_1	994	996	PF00675	0.696
CLV_PCSK_FUR_1	992	996	PF00082	0.694
CLV_PCSK_KEX2_1	301	303	PF00082	0.831
CLV_PCSK_KEX2_1	600	602	PF00082	0.707
CLV_PCSK_KEX2_1	667	669	PF00082	0.828
CLV_PCSK_KEX2_1	730	732	PF00082	0.471
CLV_PCSK_KEX2_1	756	758	PF00082	0.580
CLV_PCSK_KEX2_1	806	808	PF00082	0.600
CLV_PCSK_KEX2_1	855	857	PF00082	0.629
CLV_PCSK_KEX2_1	992	994	PF00082	0.696
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.797
CLV_PCSK_PC1ET2_1	730	732	PF00082	0.471
CLV_PCSK_PC1ET2_1	756	758	PF00082	0.580
CLV_PCSK_PC1ET2_1	855	857	PF00082	0.541
CLV_PCSK_SKI1_1	1016	1020	PF00082	0.732
CLV_PCSK_SKI1_1	328	332	PF00082	0.594
CLV_PCSK_SKI1_1	461	465	PF00082	0.668
CLV_PCSK_SKI1_1	573	577	PF00082	0.766
CLV_PCSK_SKI1_1	727	731	PF00082	0.708
CLV_PCSK_SKI1_1	757	761	PF00082	0.571
CLV_PCSK_SKI1_1	994	998	PF00082	0.489
CLV_Separin_Metazoa	422	426	PF03568	0.550
CLV_Separin_Metazoa	886	890	PF03568	0.580
DEG_APCC_DBOX_1	572	580	PF00400	0.777
DEG_APCC_DBOX_1	681	689	PF00400	0.734
DEG_APCC_DBOX_1	722	730	PF00400	0.708
DEG_ODPH_VHL_1	452	465	PF01847	0.567
DEG_SCF_FBW7_1	414	420	PF00400	0.538
DEG_SCF_FBW7_1	813	819	PF00400	0.584
DEG_SPOP_SBC_1	220	224	PF00917	0.574
DEG_SPOP_SBC_1	409	413	PF00917	0.559
DEG_SPOP_SBC_1	892	896	PF00917	0.555
DOC_CKS1_1	342	347	PF01111	0.579
DOC_CKS1_1	414	419	PF01111	0.540
DOC_CKS1_1	583	588	PF01111	0.587
DOC_CKS1_1	813	818	PF01111	0.583
DOC_CYCLIN_RxL_1	370	384	PF00134	0.803
DOC_MAPK_gen_1	10	17	PF00069	0.810
DOC_PP1_RVXF_1	374	381	PF00149	0.800
DOC_PP1_RVXF_1	954	960	PF00149	0.526
DOC_PP2B_LxvP_1	439	442	PF13499	0.593
DOC_PP4_FxxP_1	438	441	PF00568	0.662
DOC_PP4_FxxP_1	944	947	PF00568	0.554
DOC_USP7_MATH_1	106	110	PF00917	0.609
DOC_USP7_MATH_1	118	122	PF00917	0.491
DOC_USP7_MATH_1	159	163	PF00917	0.654
DOC_USP7_MATH_1	263	267	PF00917	0.663
DOC_USP7_MATH_1	318	322	PF00917	0.651
DOC_USP7_MATH_1	446	450	PF00917	0.773
DOC_USP7_MATH_1	561	565	PF00917	0.793
DOC_USP7_MATH_1	581	585	PF00917	0.552
DOC_USP7_MATH_1	779	783	PF00917	0.820
DOC_USP7_MATH_1	816	820	PF00917	0.579
DOC_USP7_MATH_1	870	874	PF00917	0.737
DOC_USP7_MATH_1	892	896	PF00917	0.748
DOC_USP7_MATH_1	9	13	PF00917	0.622
DOC_USP7_MATH_1	913	917	PF00917	0.576
DOC_USP7_MATH_1	930	934	PF00917	0.516
DOC_USP7_UBL2_3	756	760	PF12436	0.712
DOC_WW_Pin1_4	102	107	PF00397	0.693
DOC_WW_Pin1_4	112	117	PF00397	0.729
DOC_WW_Pin1_4	127	132	PF00397	0.498
DOC_WW_Pin1_4	157	162	PF00397	0.846
DOC_WW_Pin1_4	174	179	PF00397	0.531
DOC_WW_Pin1_4	232	237	PF00397	0.647
DOC_WW_Pin1_4	27	32	PF00397	0.706
DOC_WW_Pin1_4	281	286	PF00397	0.806
DOC_WW_Pin1_4	293	298	PF00397	0.628
DOC_WW_Pin1_4	341	346	PF00397	0.680
DOC_WW_Pin1_4	36	41	PF00397	0.778
DOC_WW_Pin1_4	4	9	PF00397	0.786
DOC_WW_Pin1_4	413	418	PF00397	0.542
DOC_WW_Pin1_4	442	447	PF00397	0.709
DOC_WW_Pin1_4	47	52	PF00397	0.636
DOC_WW_Pin1_4	582	587	PF00397	0.579
DOC_WW_Pin1_4	624	629	PF00397	0.568
DOC_WW_Pin1_4	704	709	PF00397	0.643
DOC_WW_Pin1_4	712	717	PF00397	0.593
DOC_WW_Pin1_4	812	817	PF00397	0.610
DOC_WW_Pin1_4	918	923	PF00397	0.665
DOC_WW_Pin1_4	92	97	PF00397	0.843
LIG_14-3-3_CanoR_1	10	14	PF00244	0.595
LIG_14-3-3_CanoR_1	107	112	PF00244	0.645
LIG_14-3-3_CanoR_1	201	207	PF00244	0.596
LIG_14-3-3_CanoR_1	269	278	PF00244	0.833
LIG_14-3-3_CanoR_1	425	430	PF00244	0.540
LIG_14-3-3_CanoR_1	617	626	PF00244	0.590
LIG_14-3-3_CanoR_1	650	658	PF00244	0.710
LIG_14-3-3_CanoR_1	668	674	PF00244	0.665
LIG_14-3-3_CanoR_1	682	686	PF00244	0.509
LIG_14-3-3_CanoR_1	806	814	PF00244	0.587
LIG_14-3-3_CanoR_1	842	847	PF00244	0.757
LIG_14-3-3_CanoR_1	876	885	PF00244	0.735
LIG_14-3-3_CanoR_1	993	999	PF00244	0.604
LIG_APCC_ABBA_1	380	385	PF00400	0.554
LIG_APCC_ABBAyCdc20_2	379	385	PF00400	0.554
LIG_BRCT_BRCA1_1	168	172	PF00533	0.818
LIG_BRCT_BRCA1_1	256	260	PF00533	0.809
LIG_BRCT_BRCA1_1	706	710	PF00533	0.795
LIG_BRCT_BRCA1_2	256	262	PF00533	0.808
LIG_CaM_IQ_9	749	765	PF13499	0.570
LIG_Clathr_ClatBox_1	277	281	PF01394	0.590
LIG_Clathr_ClatBox_1	685	689	PF01394	0.727
LIG_DCNL_PONY_1	1	4	PF03556	0.797
LIG_FHA_1	135	141	PF00498	0.587
LIG_FHA_1	187	193	PF00498	0.590
LIG_FHA_1	273	279	PF00498	0.603
LIG_FHA_1	329	335	PF00498	0.602
LIG_FHA_1	36	42	PF00498	0.552
LIG_FHA_1	363	369	PF00498	0.542
LIG_FHA_1	382	388	PF00498	0.500
LIG_FHA_1	409	415	PF00498	0.557
LIG_FHA_1	66	72	PF00498	0.624
LIG_FHA_1	681	687	PF00498	0.510
LIG_FHA_1	81	87	PF00498	0.732
LIG_FHA_1	813	819	PF00498	0.614
LIG_FHA_1	826	832	PF00498	0.480
LIG_FHA_1	834	840	PF00498	0.512
LIG_FHA_1	894	900	PF00498	0.597
LIG_FHA_2	143	149	PF00498	0.590
LIG_FHA_2	188	194	PF00498	0.731
LIG_FHA_2	691	697	PF00498	0.465
LIG_FHA_2	971	977	PF00498	0.635
LIG_LIR_Gen_1	30	41	PF02991	0.794
LIG_LIR_Gen_1	498	509	PF02991	0.558
LIG_LIR_Nem_3	30	36	PF02991	0.794
LIG_LIR_Nem_3	498	504	PF02991	0.562
LIG_LIR_Nem_3	523	528	PF02991	0.566
LIG_MYND_1	437	441	PF01753	0.553
LIG_PCNA_TLS_4	120	127	PF02747	0.574
LIG_PCNA_TLS_4	180	187	PF02747	0.697
LIG_PTAP_UEV_1	799	804	PF05743	0.559
LIG_SH2_CRK	443	447	PF00017	0.576
LIG_SH2_CRK	626	630	PF00017	0.558
LIG_SH2_NCK_1	33	37	PF00017	0.590
LIG_SH2_NCK_1	443	447	PF00017	0.576
LIG_SH2_STAP1	960	964	PF00017	0.517
LIG_SH2_STAT3	1001	1004	PF00017	0.439
LIG_SH2_STAT3	602	605	PF00017	0.807
LIG_SH2_STAT5	126	129	PF00017	0.583
LIG_SH2_STAT5	139	142	PF00017	0.556
LIG_SH2_STAT5	182	185	PF00017	0.693
LIG_SH2_STAT5	383	386	PF00017	0.648
LIG_SH2_STAT5	426	429	PF00017	0.587
LIG_SH2_STAT5	602	605	PF00017	0.593
LIG_SH2_STAT5	657	660	PF00017	0.827
LIG_SH3_1	580	586	PF00018	0.570
LIG_SH3_3	110	116	PF00018	0.823
LIG_SH3_3	212	218	PF00018	0.599
LIG_SH3_3	233	239	PF00018	0.724
LIG_SH3_3	282	288	PF00018	0.838
LIG_SH3_3	327	333	PF00018	0.624
LIG_SH3_3	339	345	PF00018	0.532
LIG_SH3_3	48	54	PF00018	0.577
LIG_SH3_3	505	511	PF00018	0.569
LIG_SH3_3	539	545	PF00018	0.738
LIG_SH3_3	580	586	PF00018	0.578
LIG_SH3_3	610	616	PF00018	0.567
LIG_SH3_3	672	678	PF00018	0.570
LIG_SH3_3	794	800	PF00018	0.778
LIG_SH3_3	810	816	PF00018	0.615
LIG_SH3_3	962	968	PF00018	0.523
LIG_SUMO_SIM_par_1	12	20	PF11976	0.807
LIG_TRAF2_1	16	19	PF00917	0.555
LIG_TYR_ITIM	424	429	PF00017	0.539
LIG_TYR_ITSM	521	528	PF00017	0.570
LIG_UBA3_1	685	692	PF00899	0.623
LIG_WW_3	614	618	PF00397	0.835
MOD_CDC14_SPxK_1	117	120	PF00782	0.710
MOD_CDC14_SPxK_1	921	924	PF00782	0.589
MOD_CDK_SPK_2	102	107	PF00069	0.611
MOD_CDK_SPK_2	27	32	PF00069	0.567
MOD_CDK_SPxK_1	114	120	PF00069	0.723
MOD_CDK_SPxK_1	174	180	PF00069	0.561
MOD_CDK_SPxK_1	4	10	PF00069	0.791
MOD_CDK_SPxK_1	918	924	PF00069	0.588
MOD_CDK_SPxxK_3	4	11	PF00069	0.793
MOD_CDK_SPxxK_3	92	99	PF00069	0.599
MOD_CK1_1	142	148	PF00069	0.676
MOD_CK1_1	162	168	PF00069	0.832
MOD_CK1_1	222	228	PF00069	0.580
MOD_CK1_1	246	252	PF00069	0.834
MOD_CK1_1	272	278	PF00069	0.722
MOD_CK1_1	284	290	PF00069	0.746
MOD_CK1_1	359	365	PF00069	0.667
MOD_CK1_1	444	450	PF00069	0.614
MOD_CK1_1	47	53	PF00069	0.630
MOD_CK1_1	55	61	PF00069	0.755
MOD_CK1_1	571	577	PF00069	0.622
MOD_CK1_1	584	590	PF00069	0.614
MOD_CK1_1	627	633	PF00069	0.558
MOD_CK1_1	651	657	PF00069	0.797
MOD_CK1_1	715	721	PF00069	0.490
MOD_CK1_1	782	788	PF00069	0.764
MOD_CK1_1	825	831	PF00069	0.534
MOD_CK1_1	868	874	PF00069	0.686
MOD_CK1_1	916	922	PF00069	0.704
MOD_CK1_1	94	100	PF00069	0.786
MOD_CK2_1	142	148	PF00069	0.588
MOD_CK2_1	151	157	PF00069	0.586
MOD_CK2_1	31	37	PF00069	0.779
MOD_CK2_1	467	473	PF00069	0.572
MOD_CK2_1	690	696	PF00069	0.462
MOD_CK2_1	782	788	PF00069	0.821
MOD_CK2_1	970	976	PF00069	0.657
MOD_GlcNHglycan	109	112	PF01048	0.690
MOD_GlcNHglycan	281	284	PF01048	0.777
MOD_GlcNHglycan	393	396	PF01048	0.622
MOD_GlcNHglycan	469	472	PF01048	0.663
MOD_GlcNHglycan	565	568	PF01048	0.773
MOD_GlcNHglycan	57	60	PF01048	0.740
MOD_GlcNHglycan	717	720	PF01048	0.736
MOD_GlcNHglycan	800	803	PF01048	0.551
MOD_GlcNHglycan	808	811	PF01048	0.559
MOD_GlcNHglycan	868	871	PF01048	0.752
MOD_GlcNHglycan	872	875	PF01048	0.706
MOD_GlcNHglycan	928	931	PF01048	0.639
MOD_GlcNHglycan	933	936	PF01048	0.633
MOD_GlcNHglycan	960	963	PF01048	0.520
MOD_GSK3_1	102	109	PF00069	0.600
MOD_GSK3_1	114	121	PF00069	0.576
MOD_GSK3_1	134	141	PF00069	0.546
MOD_GSK3_1	157	164	PF00069	0.720
MOD_GSK3_1	22	29	PF00069	0.797
MOD_GSK3_1	242	249	PF00069	0.830
MOD_GSK3_1	250	257	PF00069	0.733
MOD_GSK3_1	284	291	PF00069	0.609
MOD_GSK3_1	31	38	PF00069	0.683
MOD_GSK3_1	355	362	PF00069	0.638
MOD_GSK3_1	409	416	PF00069	0.554
MOD_GSK3_1	442	449	PF00069	0.819
MOD_GSK3_1	46	53	PF00069	0.763
MOD_GSK3_1	472	479	PF00069	0.736
MOD_GSK3_1	516	523	PF00069	0.575
MOD_GSK3_1	527	534	PF00069	0.533
MOD_GSK3_1	706	713	PF00069	0.680
MOD_GSK3_1	72	79	PF00069	0.737
MOD_GSK3_1	779	786	PF00069	0.756
MOD_GSK3_1	808	815	PF00069	0.606
MOD_GSK3_1	818	825	PF00069	0.545
MOD_GSK3_1	865	872	PF00069	0.691
MOD_GSK3_1	87	94	PF00069	0.573
MOD_GSK3_1	914	921	PF00069	0.746
MOD_GSK3_1	926	933	PF00069	0.544
MOD_LATS_1	326	332	PF00433	0.569
MOD_N-GLC_1	211	216	PF02516	0.602
MOD_N-GLC_1	354	359	PF02516	0.670
MOD_N-GLC_1	618	623	PF02516	0.839
MOD_NEK2_1	163	168	PF00069	0.813
MOD_NEK2_1	172	177	PF00069	0.687
MOD_NEK2_1	354	359	PF00069	0.572
MOD_NEK2_1	527	532	PF00069	0.812
MOD_NEK2_1	562	567	PF00069	0.596
MOD_NEK2_1	669	674	PF00069	0.676
MOD_NEK2_1	688	693	PF00069	0.649
MOD_NEK2_1	72	77	PF00069	0.793
MOD_NEK2_1	729	734	PF00069	0.579
MOD_NEK2_1	808	813	PF00069	0.745
MOD_NEK2_1	824	829	PF00069	0.515
MOD_NEK2_1	831	836	PF00069	0.542
MOD_NEK2_1	893	898	PF00069	0.595
MOD_NEK2_1	996	1001	PF00069	0.493
MOD_NEK2_2	520	525	PF00069	0.570
MOD_PIKK_1	134	140	PF00454	0.701
MOD_PIKK_1	163	169	PF00454	0.596
MOD_PIKK_1	263	269	PF00454	0.795
MOD_PIKK_1	288	294	PF00454	0.589
MOD_PIKK_1	403	409	PF00454	0.632
MOD_PIKK_1	484	490	PF00454	0.557
MOD_PIKK_1	601	607	PF00454	0.807
MOD_PIKK_1	749	755	PF00454	0.732
MOD_PIKK_1	808	814	PF00454	0.584
MOD_PIKK_1	857	863	PF00454	0.637
MOD_PIKK_1	900	906	PF00454	0.719
MOD_PIKK_1	947	953	PF00454	0.547
MOD_PK_1	425	431	PF00069	0.541
MOD_PK_1	568	574	PF00069	0.680
MOD_PKA_1	301	307	PF00069	0.575
MOD_PKA_1	568	574	PF00069	0.680
MOD_PKA_1	667	673	PF00069	0.710
MOD_PKA_1	806	812	PF00069	0.592
MOD_PKA_1	994	1000	PF00069	0.441
MOD_PKA_2	106	112	PF00069	0.856
MOD_PKA_2	134	140	PF00069	0.732
MOD_PKA_2	301	307	PF00069	0.685
MOD_PKA_2	355	361	PF00069	0.730
MOD_PKA_2	65	71	PF00069	0.749
MOD_PKA_2	667	673	PF00069	0.814
MOD_PKA_2	681	687	PF00069	0.511
MOD_PKA_2	806	812	PF00069	0.609
MOD_PKA_2	875	881	PF00069	0.593
MOD_PKA_2	9	15	PF00069	0.556
MOD_PKA_2	994	1000	PF00069	0.554
MOD_PKB_1	644	652	PF00069	0.576
MOD_PKB_1	840	848	PF00069	0.545
MOD_PKB_1	992	1000	PF00069	0.440
MOD_Plk_1	272	278	PF00069	0.647
MOD_Plk_1	773	779	PF00069	0.722
MOD_Plk_1	857	863	PF00069	0.561
MOD_Plk_2-3	151	157	PF00069	0.610
MOD_Plk_4	295	301	PF00069	0.571
MOD_Plk_4	320	326	PF00069	0.566
MOD_Plk_4	520	526	PF00069	0.571
MOD_Plk_4	681	687	PF00069	0.737
MOD_Plk_4	72	78	PF00069	0.539
MOD_Plk_4	735	741	PF00069	0.550
MOD_Plk_4	773	779	PF00069	0.595
MOD_Plk_4	9	15	PF00069	0.556
MOD_ProDKin_1	102	108	PF00069	0.692
MOD_ProDKin_1	112	118	PF00069	0.724
MOD_ProDKin_1	127	133	PF00069	0.501
MOD_ProDKin_1	157	163	PF00069	0.846
MOD_ProDKin_1	174	180	PF00069	0.532
MOD_ProDKin_1	232	238	PF00069	0.648
MOD_ProDKin_1	27	33	PF00069	0.705
MOD_ProDKin_1	281	287	PF00069	0.806
MOD_ProDKin_1	293	299	PF00069	0.628
MOD_ProDKin_1	341	347	PF00069	0.680
MOD_ProDKin_1	36	42	PF00069	0.778
MOD_ProDKin_1	4	10	PF00069	0.791
MOD_ProDKin_1	413	419	PF00069	0.542
MOD_ProDKin_1	442	448	PF00069	0.705
MOD_ProDKin_1	47	53	PF00069	0.635
MOD_ProDKin_1	582	588	PF00069	0.582
MOD_ProDKin_1	624	630	PF00069	0.564
MOD_ProDKin_1	704	710	PF00069	0.645
MOD_ProDKin_1	712	718	PF00069	0.583
MOD_ProDKin_1	812	818	PF00069	0.613
MOD_ProDKin_1	918	924	PF00069	0.666
MOD_ProDKin_1	92	98	PF00069	0.844
MOD_SUMO_for_1	854	857	PF00179	0.533
MOD_SUMO_rev_2	724	732	PF00179	0.708
TRG_DiLeu_BaEn_1	273	278	PF01217	0.585
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.815
TRG_DiLeu_LyEn_5	938	943	PF01217	0.616
TRG_ENDOCYTIC_2	33	36	PF00928	0.802
TRG_ENDOCYTIC_2	426	429	PF00928	0.540
TRG_ENDOCYTIC_2	525	528	PF00928	0.629
TRG_ENDOCYTIC_2	626	629	PF00928	0.562
TRG_ER_diArg_1	300	302	PF00400	0.791
TRG_ER_diArg_1	643	646	PF00400	0.585
TRG_ER_diArg_1	667	669	PF00400	0.811
TRG_ER_diArg_1	805	807	PF00400	0.594
TRG_ER_diArg_1	839	842	PF00400	0.510
TRG_ER_diArg_1	992	995	PF00400	0.534
TRG_NES_CRM1_1	979	991	PF08389	0.454
TRG_NLS_MonoExtN_4	727	734	PF00514	0.472
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	650	655	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	986	991	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHG2	Leishmania donovani	52%	100%
A4I9W0	Leishmania infantum	52%	100%
E9B4X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4Q354	Leishmania major	52%	97%