Sulfatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7S5_LEIBR

TriTrypDb:

LbrM.14.1220 , LBRM2903_200024700

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H7S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.324
CLV_NRD_NRD_1	187	189	PF00675	0.685
CLV_NRD_NRD_1	197	199	PF00675	0.608
CLV_NRD_NRD_1	270	272	PF00675	0.525
CLV_NRD_NRD_1	36	38	PF00675	0.406
CLV_NRD_NRD_1	59	61	PF00675	0.624
CLV_NRD_NRD_1	85	87	PF00675	0.447
CLV_PCSK_KEX2_1	149	151	PF00082	0.463
CLV_PCSK_KEX2_1	270	272	PF00082	0.576
CLV_PCSK_KEX2_1	36	38	PF00082	0.406
CLV_PCSK_KEX2_1	85	87	PF00082	0.447
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.463
CLV_PCSK_SKI1_1	199	203	PF00082	0.602
CLV_PCSK_SKI1_1	27	31	PF00082	0.433
CLV_PCSK_SKI1_1	37	41	PF00082	0.336
CLV_PCSK_SKI1_1	70	74	PF00082	0.474
CLV_PCSK_SKI1_1	86	90	PF00082	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.669
DEG_SPOP_SBC_1	135	139	PF00917	0.432
DOC_MAPK_gen_1	33	41	PF00069	0.599
DOC_MAPK_RevD_3	71	86	PF00069	0.221
DOC_PP4_FxxP_1	168	171	PF00568	0.328
DOC_PP4_MxPP_1	12	15	PF00568	0.583
DOC_USP7_MATH_1	154	158	PF00917	0.345
DOC_USP7_MATH_1	260	264	PF00917	0.285
DOC_USP7_UBL2_3	101	105	PF12436	0.302
DOC_USP7_UBL2_3	145	149	PF12436	0.346
DOC_WW_Pin1_4	65	70	PF00397	0.241
DOC_WW_Pin1_4	90	95	PF00397	0.458
LIG_14-3-3_CanoR_1	36	40	PF00244	0.558
LIG_14-3-3_CanoR_1	60	64	PF00244	0.419
LIG_Actin_WH2_2	23	38	PF00022	0.672
LIG_Clathr_ClatBox_1	215	219	PF01394	0.340
LIG_eIF4E_1	210	216	PF01652	0.354
LIG_eIF4E_1	301	307	PF01652	0.270
LIG_FHA_1	135	141	PF00498	0.356
LIG_FHA_1	291	297	PF00498	0.223
LIG_FHA_1	316	322	PF00498	0.322
LIG_FHA_1	334	340	PF00498	0.268
LIG_FHA_1	36	42	PF00498	0.461
LIG_FHA_1	66	72	PF00498	0.413
LIG_FHA_2	131	137	PF00498	0.477
LIG_FHA_2	20	26	PF00498	0.714
LIG_FHA_2	200	206	PF00498	0.410
LIG_FHA_2	300	306	PF00498	0.353
LIG_FHA_2	342	348	PF00498	0.406
LIG_FHA_2	60	66	PF00498	0.407
LIG_GBD_Chelix_1	44	52	PF00786	0.327
LIG_LIR_Gen_1	277	283	PF02991	0.302
LIG_LIR_Gen_1	93	102	PF02991	0.400
LIG_LIR_Nem_3	227	233	PF02991	0.332
LIG_LIR_Nem_3	277	282	PF02991	0.364
LIG_LIR_Nem_3	93	98	PF02991	0.397
LIG_PDZ_Class_1	351	356	PF00595	0.398
LIG_SH2_STAT5	193	196	PF00017	0.322
LIG_SH2_STAT5	200	203	PF00017	0.320
LIG_SH2_STAT5	230	233	PF00017	0.329
LIG_SH2_STAT5	301	304	PF00017	0.329
LIG_SH3_3	150	156	PF00018	0.339
LIG_SH3_3	238	244	PF00018	0.402
LIG_SH3_3	8	14	PF00018	0.688
LIG_SUMO_SIM_par_1	296	302	PF11976	0.218
LIG_SUMO_SIM_par_1	37	42	PF11976	0.478
LIG_UBA3_1	140	149	PF00899	0.351
LIG_UBA3_1	71	77	PF00899	0.210
MOD_CDK_SPK_2	65	70	PF00069	0.241
MOD_CDK_SPxxK_3	90	97	PF00069	0.363
MOD_CK1_1	269	275	PF00069	0.356
MOD_CK1_1	290	296	PF00069	0.293
MOD_CK1_1	90	96	PF00069	0.390
MOD_CK2_1	130	136	PF00069	0.336
MOD_CK2_1	19	25	PF00069	0.726
MOD_CK2_1	232	238	PF00069	0.334
MOD_CK2_1	271	277	PF00069	0.386
MOD_CK2_1	299	305	PF00069	0.367
MOD_CK2_1	341	347	PF00069	0.385
MOD_GlcNHglycan	109	112	PF01048	0.469
MOD_GlcNHglycan	125	128	PF01048	0.536
MOD_GlcNHglycan	161	164	PF01048	0.623
MOD_GlcNHglycan	179	183	PF01048	0.617
MOD_GlcNHglycan	190	193	PF01048	0.527
MOD_GlcNHglycan	224	227	PF01048	0.577
MOD_GlcNHglycan	258	261	PF01048	0.562
MOD_GlcNHglycan	344	347	PF01048	0.580
MOD_GlcNHglycan	353	356	PF01048	0.542
MOD_GSK3_1	107	114	PF00069	0.350
MOD_GSK3_1	123	130	PF00069	0.372
MOD_GSK3_1	154	161	PF00069	0.362
MOD_GSK3_1	256	263	PF00069	0.375
MOD_GSK3_1	329	336	PF00069	0.446
MOD_GSK3_1	35	42	PF00069	0.492
MOD_GSK3_1	55	62	PF00069	0.600
MOD_N-GLC_1	111	116	PF02516	0.485
MOD_N-GLC_1	222	227	PF02516	0.570
MOD_N-GLC_1	334	339	PF02516	0.563
MOD_N-GLC_1	90	95	PF02516	0.645
MOD_NEK2_1	123	128	PF00069	0.354
MOD_NEK2_1	134	139	PF00069	0.381
MOD_NEK2_1	158	163	PF00069	0.468
MOD_NEK2_1	231	236	PF00069	0.369
MOD_NEK2_1	256	261	PF00069	0.322
MOD_NEK2_1	266	271	PF00069	0.321
MOD_NEK2_1	329	334	PF00069	0.389
MOD_NEK2_1	35	40	PF00069	0.560
MOD_PK_1	105	111	PF00069	0.334
MOD_PKA_1	148	154	PF00069	0.229
MOD_PKA_1	188	194	PF00069	0.282
MOD_PKA_2	269	275	PF00069	0.354
MOD_PKA_2	35	41	PF00069	0.522
MOD_PKA_2	59	65	PF00069	0.411
MOD_Plk_1	135	141	PF00069	0.433
MOD_Plk_1	334	340	PF00069	0.358
MOD_Plk_4	136	142	PF00069	0.327
MOD_Plk_4	154	160	PF00069	0.432
MOD_Plk_4	321	327	PF00069	0.254
MOD_Plk_4	50	56	PF00069	0.347
MOD_ProDKin_1	65	71	PF00069	0.236
MOD_ProDKin_1	90	96	PF00069	0.452
MOD_SUMO_rev_2	181	191	PF00179	0.479
MOD_SUMO_rev_2	311	319	PF00179	0.252
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.248
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.368
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.401
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.394
TRG_ENDOCYTIC_2	230	233	PF00928	0.335
TRG_ER_diArg_1	35	37	PF00400	0.630
TRG_ER_diArg_1	84	86	PF00400	0.246
TRG_NLS_MonoExtN_4	145	152	PF00514	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAP6	Leptomonas seymouri	64%	100%
A0A0S4IM03	Bodo saltans	30%	97%
A0A1X0PAG1	Trypanosomatidae	36%	99%
A0A3S7X7R9	Leishmania donovani	82%	100%
A0A422N0E3	Trypanosoma rangeli	37%	100%
A4I9W1	Leishmania infantum	82%	100%
C9ZMS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B4X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q353	Leishmania major	81%	100%