PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3808), putative

Species:

Leishmania braziliensis

UniProt:

A4H7S4_LEIBR

TriTrypDb:

LbrM.14.1210 , LBRM2903_200024800

Length:

805

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A4H7S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	634	638	PF00656	0.369
CLV_C14_Caspase3-7	72	76	PF00656	0.384
CLV_NRD_NRD_1	154	156	PF00675	0.187
CLV_NRD_NRD_1	322	324	PF00675	0.289
CLV_NRD_NRD_1	530	532	PF00675	0.316
CLV_NRD_NRD_1	608	610	PF00675	0.463
CLV_NRD_NRD_1	710	712	PF00675	0.316
CLV_NRD_NRD_1	89	91	PF00675	0.255
CLV_PCSK_KEX2_1	322	324	PF00082	0.184
CLV_PCSK_KEX2_1	439	441	PF00082	0.309
CLV_PCSK_KEX2_1	549	551	PF00082	0.297
CLV_PCSK_KEX2_1	91	93	PF00082	0.184
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.309
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.333
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.184
CLV_PCSK_SKI1_1	302	306	PF00082	0.307
CLV_PCSK_SKI1_1	323	327	PF00082	0.228
CLV_PCSK_SKI1_1	502	506	PF00082	0.184
CLV_PCSK_SKI1_1	532	536	PF00082	0.315
CLV_PCSK_SKI1_1	56	60	PF00082	0.397
CLV_PCSK_SKI1_1	612	616	PF00082	0.321
CLV_PCSK_SKI1_1	698	702	PF00082	0.443
CLV_PCSK_SKI1_1	712	716	PF00082	0.573
DEG_APCC_DBOX_1	301	309	PF00400	0.536
DEG_APCC_KENBOX_2	370	374	PF00400	0.384
DEG_SCF_FBW7_1	652	658	PF00400	0.463
DOC_CKS1_1	652	657	PF01111	0.501
DOC_CKS1_1	722	727	PF01111	0.537
DOC_CYCLIN_RxL_1	439	451	PF00134	0.384
DOC_CYCLIN_RxL_1	499	507	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.596
DOC_MAPK_gen_1	386	396	PF00069	0.498
DOC_MAPK_gen_1	439	447	PF00069	0.536
DOC_MAPK_gen_1	500	508	PF00069	0.451
DOC_MAPK_gen_1	609	616	PF00069	0.401
DOC_MAPK_gen_1	708	717	PF00069	0.457
DOC_MAPK_MEF2A_6	375	383	PF00069	0.486
DOC_MAPK_MEF2A_6	389	398	PF00069	0.444
DOC_MAPK_MEF2A_6	500	508	PF00069	0.384
DOC_MAPK_MEF2A_6	585	592	PF00069	0.265
DOC_MAPK_NFAT4_5	585	593	PF00069	0.479
DOC_PIKK_1	484	492	PF02985	0.384
DOC_PP1_RVXF_1	503	509	PF00149	0.384
DOC_PP1_RVXF_1	521	527	PF00149	0.451
DOC_USP7_MATH_1	205	209	PF00917	0.496
DOC_USP7_MATH_1	250	254	PF00917	0.388
DOC_USP7_MATH_1	333	337	PF00917	0.473
DOC_USP7_MATH_1	347	351	PF00917	0.454
DOC_USP7_MATH_1	648	652	PF00917	0.593
DOC_USP7_MATH_1	664	668	PF00917	0.553
DOC_USP7_MATH_1	669	673	PF00917	0.543
DOC_USP7_UBL2_3	156	160	PF12436	0.384
DOC_USP7_UBL2_3	708	712	PF12436	0.371
DOC_USP7_UBL2_3	801	805	PF12436	0.631
DOC_WW_Pin1_4	162	167	PF00397	0.384
DOC_WW_Pin1_4	18	23	PF00397	0.480
DOC_WW_Pin1_4	246	251	PF00397	0.552
DOC_WW_Pin1_4	329	334	PF00397	0.473
DOC_WW_Pin1_4	56	61	PF00397	0.567
DOC_WW_Pin1_4	6	11	PF00397	0.515
DOC_WW_Pin1_4	627	632	PF00397	0.489
DOC_WW_Pin1_4	651	656	PF00397	0.561
DOC_WW_Pin1_4	660	665	PF00397	0.693
DOC_WW_Pin1_4	672	677	PF00397	0.699
DOC_WW_Pin1_4	721	726	PF00397	0.489
LIG_14-3-3_CanoR_1	110	116	PF00244	0.523
LIG_14-3-3_CanoR_1	204	210	PF00244	0.496
LIG_14-3-3_CanoR_1	277	281	PF00244	0.451
LIG_14-3-3_CanoR_1	323	333	PF00244	0.525
LIG_14-3-3_CanoR_1	45	55	PF00244	0.340
LIG_14-3-3_CanoR_1	531	537	PF00244	0.536
LIG_14-3-3_CanoR_1	711	718	PF00244	0.388
LIG_14-3-3_CanoR_1	730	735	PF00244	0.378
LIG_14-3-3_CanoR_1	81	89	PF00244	0.507
LIG_Actin_WH2_2	181	199	PF00022	0.399
LIG_Actin_WH2_2	290	308	PF00022	0.536
LIG_Actin_WH2_2	489	507	PF00022	0.384
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_BRCT_BRCA1_1	145	149	PF00533	0.519
LIG_BRCT_BRCA1_1	281	285	PF00533	0.384
LIG_BRCT_BRCA1_1	348	352	PF00533	0.384
LIG_BRCT_BRCA1_1	680	684	PF00533	0.412
LIG_BRCT_BRCA1_2	145	151	PF00533	0.496
LIG_DLG_GKlike_1	730	738	PF00625	0.419
LIG_FHA_1	133	139	PF00498	0.427
LIG_FHA_1	265	271	PF00498	0.554
LIG_FHA_1	389	395	PF00498	0.509
LIG_FHA_2	116	122	PF00498	0.445
LIG_FHA_2	172	178	PF00498	0.543
LIG_FHA_2	256	262	PF00498	0.504
LIG_FHA_2	739	745	PF00498	0.270
LIG_GBD_Chelix_1	613	621	PF00786	0.250
LIG_LIR_Apic_2	161	166	PF02991	0.384
LIG_LIR_Apic_2	17	22	PF02991	0.527
LIG_LIR_Gen_1	146	153	PF02991	0.503
LIG_LIR_Gen_1	211	220	PF02991	0.495
LIG_LIR_Gen_1	507	516	PF02991	0.531
LIG_LIR_Nem_3	146	152	PF02991	0.543
LIG_LIR_Nem_3	206	212	PF02991	0.467
LIG_LIR_Nem_3	355	360	PF02991	0.511
LIG_LIR_Nem_3	422	426	PF02991	0.442
LIG_LIR_Nem_3	427	432	PF02991	0.442
LIG_LIR_Nem_3	507	511	PF02991	0.531
LIG_LIR_Nem_3	744	750	PF02991	0.382
LIG_LYPXL_yS_3	605	608	PF13949	0.253
LIG_PCNA_PIPBox_1	71	80	PF02747	0.197
LIG_PCNA_yPIPBox_3	182	196	PF02747	0.557
LIG_PCNA_yPIPBox_3	64	78	PF02747	0.269
LIG_Pex14_1	732	736	PF04695	0.418
LIG_Pex14_2	149	153	PF04695	0.496
LIG_REV1ctd_RIR_1	75	85	PF16727	0.473
LIG_SH2_CRK	19	23	PF00017	0.479
LIG_SH2_CRK	209	213	PF00017	0.480
LIG_SH2_CRK	343	347	PF00017	0.536
LIG_SH2_CRK	459	463	PF00017	0.384
LIG_SH2_CRK	689	693	PF00017	0.381
LIG_SH2_NCK_1	736	740	PF00017	0.376
LIG_SH2_NCK_1	743	747	PF00017	0.331
LIG_SH2_SRC	357	360	PF00017	0.536
LIG_SH2_SRC	459	462	PF00017	0.464
LIG_SH2_SRC	635	638	PF00017	0.357
LIG_SH2_STAP1	426	430	PF00017	0.473
LIG_SH2_STAP1	593	597	PF00017	0.431
LIG_SH2_STAP1	736	740	PF00017	0.404
LIG_SH2_STAP1	743	747	PF00017	0.372
LIG_SH2_STAT3	789	792	PF00017	0.353
LIG_SH2_STAT5	357	360	PF00017	0.536
LIG_SH2_STAT5	461	464	PF00017	0.527
LIG_SH2_STAT5	620	623	PF00017	0.456
LIG_SH2_STAT5	635	638	PF00017	0.498
LIG_SH2_STAT5	69	72	PF00017	0.269
LIG_SH2_STAT5	747	750	PF00017	0.447
LIG_SH2_STAT5	774	777	PF00017	0.260
LIG_SH3_3	244	250	PF00018	0.496
LIG_SH3_3	571	577	PF00018	0.514
LIG_SH3_3	623	629	PF00018	0.414
LIG_SH3_3	663	669	PF00018	0.782
LIG_SH3_5	631	635	PF00018	0.440
LIG_SUMO_SIM_anti_2	395	400	PF11976	0.416
LIG_SUMO_SIM_anti_2	713	719	PF11976	0.505
LIG_SUMO_SIM_par_1	468	473	PF11976	0.502
LIG_TRAF2_1	263	266	PF00917	0.384
LIG_TRAF2_1	36	39	PF00917	0.537
LIG_TRAF2_1	754	757	PF00917	0.311
LIG_UBA3_1	761	767	PF00899	0.517
MOD_CDK_SPxxK_3	721	728	PF00069	0.533
MOD_CK1_1	140	146	PF00069	0.539
MOD_CK1_1	147	153	PF00069	0.545
MOD_CK1_1	191	197	PF00069	0.476
MOD_CK1_1	208	214	PF00069	0.584
MOD_CK1_1	279	285	PF00069	0.384
MOD_CK1_1	449	455	PF00069	0.449
MOD_CK1_1	46	52	PF00069	0.327
MOD_CK1_1	651	657	PF00069	0.614
MOD_CK1_1	660	666	PF00069	0.687
MOD_CK1_1	667	673	PF00069	0.653
MOD_CK1_1	675	681	PF00069	0.525
MOD_CK1_1	9	15	PF00069	0.659
MOD_CK2_1	11	17	PF00069	0.575
MOD_CK2_1	162	168	PF00069	0.536
MOD_CK2_1	171	177	PF00069	0.536
MOD_CK2_1	260	266	PF00069	0.518
MOD_CK2_1	509	515	PF00069	0.465
MOD_CK2_1	635	641	PF00069	0.569
MOD_CK2_1	710	716	PF00069	0.424
MOD_CK2_1	751	757	PF00069	0.453
MOD_CK2_1	80	86	PF00069	0.514
MOD_Cter_Amidation	566	569	PF01082	0.294
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.315
MOD_GlcNHglycan	130	133	PF01048	0.339
MOD_GlcNHglycan	146	149	PF01048	0.328
MOD_GlcNHglycan	335	338	PF01048	0.304
MOD_GlcNHglycan	349	352	PF01048	0.290
MOD_GlcNHglycan	48	51	PF01048	0.431
MOD_GlcNHglycan	648	651	PF01048	0.486
MOD_GlcNHglycan	666	669	PF01048	0.488
MOD_GlcNHglycan	671	674	PF01048	0.550
MOD_GlcNHglycan	677	680	PF01048	0.473
MOD_GlcNHglycan	712	715	PF01048	0.407
MOD_GlcNHglycan	770	773	PF01048	0.634
MOD_GSK3_1	1	8	PF00069	0.742
MOD_GSK3_1	111	118	PF00069	0.443
MOD_GSK3_1	128	135	PF00069	0.472
MOD_GSK3_1	140	147	PF00069	0.491
MOD_GSK3_1	158	165	PF00069	0.363
MOD_GSK3_1	171	178	PF00069	0.557
MOD_GSK3_1	204	211	PF00069	0.534
MOD_GSK3_1	246	253	PF00069	0.529
MOD_GSK3_1	260	267	PF00069	0.580
MOD_GSK3_1	288	295	PF00069	0.425
MOD_GSK3_1	329	336	PF00069	0.536
MOD_GSK3_1	642	649	PF00069	0.530
MOD_GSK3_1	651	658	PF00069	0.610
MOD_GSK3_1	660	667	PF00069	0.614
MOD_GSK3_1	668	675	PF00069	0.538
MOD_N-GLC_1	509	514	PF02516	0.252
MOD_N-GLC_2	402	404	PF02516	0.296
MOD_NEK2_1	1	6	PF00069	0.512
MOD_NEK2_1	115	120	PF00069	0.472
MOD_NEK2_1	127	132	PF00069	0.461
MOD_NEK2_1	144	149	PF00069	0.483
MOD_NEK2_1	188	193	PF00069	0.490
MOD_NEK2_1	264	269	PF00069	0.536
MOD_NEK2_1	292	297	PF00069	0.536
MOD_NEK2_1	353	358	PF00069	0.490
MOD_NEK2_1	448	453	PF00069	0.492
MOD_NEK2_1	504	509	PF00069	0.397
MOD_NEK2_2	635	640	PF00069	0.377
MOD_NEK2_2	85	90	PF00069	0.524
MOD_PIKK_1	115	121	PF00454	0.401
MOD_PIKK_1	132	138	PF00454	0.466
MOD_PIKK_1	171	177	PF00454	0.573
MOD_PKA_1	439	445	PF00069	0.536
MOD_PKA_2	203	209	PF00069	0.384
MOD_PKA_2	276	282	PF00069	0.473
MOD_PKA_2	374	380	PF00069	0.480
MOD_PKA_2	388	394	PF00069	0.423
MOD_PKA_2	439	445	PF00069	0.536
MOD_PKA_2	710	716	PF00069	0.462
MOD_PKA_2	80	86	PF00069	0.543
MOD_PKB_1	640	648	PF00069	0.329
MOD_Plk_1	140	146	PF00069	0.525
MOD_Plk_1	260	266	PF00069	0.520
MOD_Plk_1	37	43	PF00069	0.522
MOD_Plk_1	394	400	PF00069	0.523
MOD_Plk_1	85	91	PF00069	0.440
MOD_Plk_4	140	146	PF00069	0.536
MOD_Plk_4	191	197	PF00069	0.457
MOD_Plk_4	208	214	PF00069	0.529
MOD_Plk_4	292	298	PF00069	0.487
MOD_Plk_4	326	332	PF00069	0.480
MOD_Plk_4	353	359	PF00069	0.487
MOD_Plk_4	374	380	PF00069	0.442
MOD_Plk_4	394	400	PF00069	0.350
MOD_Plk_4	561	567	PF00069	0.429
MOD_Plk_4	612	618	PF00069	0.341
MOD_Plk_4	65	71	PF00069	0.422
MOD_Plk_4	680	686	PF00069	0.535
MOD_Plk_4	696	702	PF00069	0.410
MOD_Plk_4	757	763	PF00069	0.512
MOD_ProDKin_1	162	168	PF00069	0.384
MOD_ProDKin_1	18	24	PF00069	0.482
MOD_ProDKin_1	246	252	PF00069	0.552
MOD_ProDKin_1	329	335	PF00069	0.473
MOD_ProDKin_1	56	62	PF00069	0.567
MOD_ProDKin_1	6	12	PF00069	0.512
MOD_ProDKin_1	627	633	PF00069	0.483
MOD_ProDKin_1	651	657	PF00069	0.566
MOD_ProDKin_1	660	666	PF00069	0.693
MOD_ProDKin_1	672	678	PF00069	0.696
MOD_ProDKin_1	721	727	PF00069	0.488
MOD_SUMO_for_1	31	34	PF00179	0.484
MOD_SUMO_rev_2	242	247	PF00179	0.384
MOD_SUMO_rev_2	499	507	PF00179	0.490
MOD_SUMO_rev_2	705	714	PF00179	0.389
TRG_DiLeu_BaEn_1	316	321	PF01217	0.496
TRG_DiLeu_BaEn_1	484	489	PF01217	0.384
TRG_DiLeu_BaEn_3	756	762	PF01217	0.302
TRG_DiLeu_BaEn_4	265	271	PF01217	0.384
TRG_DiLeu_BaEn_4	484	490	PF01217	0.394
TRG_ENDOCYTIC_2	209	212	PF00928	0.449
TRG_ENDOCYTIC_2	213	216	PF00928	0.451
TRG_ENDOCYTIC_2	343	346	PF00928	0.536
TRG_ENDOCYTIC_2	357	360	PF00928	0.536
TRG_ENDOCYTIC_2	432	435	PF00928	0.495
TRG_ENDOCYTIC_2	459	462	PF00928	0.430
TRG_ENDOCYTIC_2	605	608	PF00928	0.333
TRG_ENDOCYTIC_2	689	692	PF00928	0.384
TRG_ENDOCYTIC_2	697	700	PF00928	0.360
TRG_ER_diArg_1	321	323	PF00400	0.384
TRG_ER_diArg_1	89	92	PF00400	0.536
TRG_NLS_MonoExtC_3	567	573	PF00514	0.477
TRG_NLS_MonoExtC_3	89	95	PF00514	0.384
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I210	Leptomonas seymouri	58%	100%
A0A1X0PAU9	Trypanosomatidae	29%	100%
A0A3Q8IUJ9	Leishmania donovani	74%	100%
A0A3R7K1I3	Trypanosoma rangeli	27%	100%
A4I9W2	Leishmania infantum	74%	100%
C9ZMS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B4X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q352	Leishmania major	73%	99%
V5B3F2	Trypanosoma cruzi	26%	100%