Spc7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7S3_LEIBR

TriTrypDb:

LbrM.14.1200 , LBRM2903_200024900

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.620
CLV_C14_Caspase3-7	257	261	PF00656	0.630
CLV_C14_Caspase3-7	450	454	PF00656	0.535
CLV_PCSK_KEX2_1	131	133	PF00082	0.510
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.510
CLV_PCSK_SKI1_1	274	278	PF00082	0.619
CLV_PCSK_SKI1_1	518	522	PF00082	0.463
CLV_PCSK_SKI1_1	93	97	PF00082	0.500
DEG_APCC_KENBOX_2	316	320	PF00400	0.554
DEG_Nend_UBRbox_2	1	3	PF02207	0.547
DEG_SPOP_SBC_1	261	265	PF00917	0.546
DEG_SPOP_SBC_1	288	292	PF00917	0.442
DEG_SPOP_SBC_1	35	39	PF00917	0.550
DOC_CYCLIN_RxL_1	532	540	PF00134	0.480
DOC_CYCLIN_yClb5_NLxxxL_5	200	209	PF00134	0.536
DOC_MAPK_gen_1	131	137	PF00069	0.516
DOC_MAPK_gen_1	93	102	PF00069	0.496
DOC_MAPK_MEF2A_6	96	104	PF00069	0.496
DOC_PP4_FxxP_1	387	390	PF00568	0.516
DOC_USP7_MATH_1	368	372	PF00917	0.529
DOC_USP7_MATH_1	380	384	PF00917	0.495
DOC_USP7_MATH_1	411	415	PF00917	0.601
DOC_USP7_MATH_1	42	46	PF00917	0.534
DOC_USP7_MATH_1	61	65	PF00917	0.477
DOC_USP7_UBL2_3	121	125	PF12436	0.527
DOC_WW_Pin1_4	188	193	PF00397	0.594
DOC_WW_Pin1_4	329	334	PF00397	0.536
DOC_WW_Pin1_4	36	41	PF00397	0.543
DOC_WW_Pin1_4	415	420	PF00397	0.518
DOC_WW_Pin1_4	432	437	PF00397	0.553
DOC_WW_Pin1_4	45	50	PF00397	0.573
LIG_14-3-3_CanoR_1	182	186	PF00244	0.547
LIG_14-3-3_CanoR_1	194	199	PF00244	0.651
LIG_14-3-3_CanoR_1	236	241	PF00244	0.592
LIG_14-3-3_CanoR_1	272	281	PF00244	0.492
LIG_BRCT_BRCA1_1	115	119	PF00533	0.497
LIG_BRCT_BRCA1_2	115	121	PF00533	0.501
LIG_Clathr_ClatBox_1	218	222	PF01394	0.501
LIG_FHA_1	195	201	PF00498	0.592
LIG_FHA_1	239	245	PF00498	0.603
LIG_FHA_1	262	268	PF00498	0.533
LIG_FHA_1	292	298	PF00498	0.489
LIG_FHA_1	3	9	PF00498	0.559
LIG_FHA_1	353	359	PF00498	0.512
LIG_FHA_1	90	96	PF00498	0.649
LIG_FHA_2	125	131	PF00498	0.530
LIG_FHA_2	282	288	PF00498	0.488
LIG_FHA_2	416	422	PF00498	0.647
LIG_FHA_2	481	487	PF00498	0.759
LIG_FHA_2	497	503	PF00498	0.538
LIG_FHA_2	549	555	PF00498	0.466
LIG_LIR_Apic_2	193	199	PF02991	0.516
LIG_LIR_Apic_2	386	390	PF02991	0.517
LIG_LIR_Gen_1	25	35	PF02991	0.537
LIG_LIR_Gen_1	53	63	PF02991	0.521
LIG_LIR_Nem_3	109	115	PF02991	0.560
LIG_LIR_Nem_3	116	122	PF02991	0.571
LIG_LIR_Nem_3	21	27	PF02991	0.644
LIG_LIR_Nem_3	519	524	PF02991	0.463
LIG_PCNA_PIPBox_1	541	550	PF02747	0.479
LIG_PTB_Apo_2	437	444	PF02174	0.601
LIG_SH2_GRB2like	161	164	PF00017	0.632
LIG_SH2_NCK_1	27	31	PF00017	0.533
LIG_SH2_SRC	27	30	PF00017	0.535
LIG_SH2_STAP1	115	119	PF00017	0.494
LIG_SH2_STAT3	438	441	PF00017	0.545
LIG_SH2_STAT5	112	115	PF00017	0.556
LIG_SH2_STAT5	196	199	PF00017	0.510
LIG_SH2_STAT5	56	59	PF00017	0.529
LIG_SH3_3	186	192	PF00018	0.591
LIG_SH3_3	330	336	PF00018	0.542
LIG_SH3_3	387	393	PF00018	0.514
LIG_SH3_3	417	423	PF00018	0.560
LIG_SH3_3	433	439	PF00018	0.567
LIG_SUMO_SIM_anti_2	133	139	PF11976	0.513
LIG_SUMO_SIM_par_1	263	271	PF11976	0.531
LIG_UBA3_1	513	522	PF00899	0.394
LIG_WRC_WIRS_1	384	389	PF05994	0.647
MOD_CDC14_SPxK_1	191	194	PF00782	0.651
MOD_CDK_SPK_2	45	50	PF00069	0.532
MOD_CDK_SPxK_1	188	194	PF00069	0.647
MOD_CDK_SPxK_1	329	335	PF00069	0.538
MOD_CK1_1	136	142	PF00069	0.580
MOD_CK1_1	162	168	PF00069	0.579
MOD_CK1_1	228	234	PF00069	0.556
MOD_CK1_1	290	296	PF00069	0.546
MOD_CK1_1	31	37	PF00069	0.532
MOD_CK1_1	329	335	PF00069	0.538
MOD_CK1_1	354	360	PF00069	0.613
MOD_CK1_1	383	389	PF00069	0.644
MOD_CK1_1	414	420	PF00069	0.599
MOD_CK1_1	45	51	PF00069	0.550
MOD_CK1_1	484	490	PF00069	0.664
MOD_CK1_1	55	61	PF00069	0.543
MOD_CK1_1	94	100	PF00069	0.495
MOD_CK2_1	124	130	PF00069	0.534
MOD_CK2_1	260	266	PF00069	0.583
MOD_CK2_1	3	9	PF00069	0.530
MOD_CK2_1	357	363	PF00069	0.605
MOD_CK2_1	61	67	PF00069	0.563
MOD_GlcNHglycan	21	24	PF01048	0.520
MOD_GlcNHglycan	274	277	PF01048	0.495
MOD_GlcNHglycan	328	331	PF01048	0.542
MOD_GlcNHglycan	359	362	PF01048	0.597
MOD_GlcNHglycan	375	378	PF01048	0.781
MOD_GlcNHglycan	397	400	PF01048	0.645
MOD_GlcNHglycan	406	410	PF01048	0.573
MOD_GlcNHglycan	50	53	PF01048	0.552
MOD_GSK3_1	190	197	PF00069	0.646
MOD_GSK3_1	244	251	PF00069	0.647
MOD_GSK3_1	262	269	PF00069	0.499
MOD_GSK3_1	272	279	PF00069	0.698
MOD_GSK3_1	287	294	PF00069	0.587
MOD_GSK3_1	31	38	PF00069	0.532
MOD_GSK3_1	347	354	PF00069	0.519
MOD_GSK3_1	364	371	PF00069	0.684
MOD_GSK3_1	379	386	PF00069	0.527
MOD_GSK3_1	395	402	PF00069	0.548
MOD_GSK3_1	4	11	PF00069	0.563
MOD_GSK3_1	411	418	PF00069	0.621
MOD_GSK3_1	48	55	PF00069	0.636
MOD_GSK3_1	480	487	PF00069	0.629
MOD_LATS_1	478	484	PF00433	0.661
MOD_N-GLC_1	162	167	PF02516	0.629
MOD_N-GLC_1	236	241	PF02516	0.592
MOD_N-GLC_1	31	36	PF02516	0.529
MOD_N-GLC_1	352	357	PF02516	0.495
MOD_N-GLC_1	399	404	PF02516	0.620
MOD_N-GLC_1	491	496	PF02516	0.589
MOD_NEK2_1	373	378	PF00069	0.723
MOD_NEK2_1	394	399	PF00069	0.559
MOD_NEK2_1	443	448	PF00069	0.538
MOD_NEK2_1	548	553	PF00069	0.466
MOD_NEK2_1	91	96	PF00069	0.564
MOD_NEK2_2	296	301	PF00069	0.626
MOD_NEK2_2	411	416	PF00069	0.601
MOD_PIKK_1	347	353	PF00454	0.509
MOD_PIKK_1	443	449	PF00454	0.538
MOD_PKA_2	181	187	PF00069	0.510
MOD_PKA_2	235	241	PF00069	0.528
MOD_Plk_1	133	139	PF00069	0.587
MOD_Plk_1	162	168	PF00069	0.630
MOD_Plk_1	236	242	PF00069	0.562
MOD_Plk_1	245	251	PF00069	0.514
MOD_Plk_1	3	9	PF00069	0.559
MOD_Plk_1	308	314	PF00069	0.770
MOD_Plk_1	31	37	PF00069	0.532
MOD_Plk_1	405	411	PF00069	0.525
MOD_Plk_1	491	497	PF00069	0.615
MOD_Plk_1	529	535	PF00069	0.468
MOD_Plk_2-3	181	187	PF00069	0.586
MOD_Plk_2-3	4	10	PF00069	0.536
MOD_Plk_4	156	162	PF00069	0.507
MOD_Plk_4	238	244	PF00069	0.646
MOD_Plk_4	248	254	PF00069	0.563
MOD_Plk_4	341	347	PF00069	0.525
MOD_Plk_4	491	497	PF00069	0.587
MOD_Plk_4	52	58	PF00069	0.523
MOD_ProDKin_1	188	194	PF00069	0.596
MOD_ProDKin_1	329	335	PF00069	0.538
MOD_ProDKin_1	36	42	PF00069	0.544
MOD_ProDKin_1	415	421	PF00069	0.520
MOD_ProDKin_1	432	438	PF00069	0.554
MOD_ProDKin_1	45	51	PF00069	0.573
TRG_DiLeu_BaEn_1	519	524	PF01217	0.462
TRG_ENDOCYTIC_2	27	30	PF00928	0.524
TRG_ENDOCYTIC_2	56	59	PF00928	0.525
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	535	540	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X2	Leptomonas seymouri	53%	100%
A0A3S7X7T0	Leishmania donovani	76%	100%
A4I9W3	Leishmania infantum	76%	100%
E9B4X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q351	Leishmania major	76%	100%