P25-alpha family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p25-alpha, putative

Species:

Leishmania braziliensis

UniProt:

A4H7S2_LEIBR

TriTrypDb:

LbrM.14.1190 , LBRM2903_140017900

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4H7S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S2

Function

Biological processes
Term	Name	Level	Count
GO:0031334	positive regulation of protein-containing complex assembly	6	2
GO:0032271	regulation of protein polymerization	6	2
GO:0032273	positive regulation of protein polymerization	7	2
GO:0043254	regulation of protein-containing complex assembly	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0044089	positive regulation of cellular component biogenesis	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.496
CLV_C14_Caspase3-7	99	103	PF00656	0.435
CLV_NRD_NRD_1	138	140	PF00675	0.296
CLV_NRD_NRD_1	59	61	PF00675	0.297
CLV_PCSK_KEX2_1	138	140	PF00082	0.296
CLV_PCSK_KEX2_1	59	61	PF00082	0.242
CLV_PCSK_SKI1_1	29	33	PF00082	0.296
CLV_PCSK_SKI1_1	39	43	PF00082	0.296
DOC_MAPK_gen_1	54	63	PF00069	0.521
DOC_PP1_RVXF_1	57	64	PF00149	0.538
DOC_USP7_MATH_1	10	14	PF00917	0.469
DOC_USP7_UBL2_3	35	39	PF12436	0.506
DOC_USP7_UBL2_3	52	56	PF12436	0.443
DOC_WW_Pin1_4	78	83	PF00397	0.550
LIG_14-3-3_CanoR_1	146	153	PF00244	0.794
LIG_14-3-3_CanoR_1	59	64	PF00244	0.507
LIG_BIR_II_1	1	5	PF00653	0.398
LIG_FHA_2	121	127	PF00498	0.507
LIG_FHA_2	40	46	PF00498	0.496
LIG_FHA_2	79	85	PF00498	0.605
LIG_FHA_2	97	103	PF00498	0.411
LIG_LIR_Gen_1	25	31	PF02991	0.567
LIG_LIR_Gen_1	47	58	PF02991	0.496
LIG_LIR_Gen_1	62	71	PF02991	0.496
LIG_LIR_Gen_1	7	14	PF02991	0.511
LIG_LIR_Nem_3	47	53	PF02991	0.496
LIG_LIR_Nem_3	62	66	PF02991	0.496
LIG_LIR_Nem_3	7	11	PF02991	0.473
LIG_Pex14_2	4	8	PF04695	0.318
LIG_PTB_Apo_2	21	28	PF02174	0.479
LIG_SH2_STAT5	113	116	PF00017	0.496
LIG_TRAF2_1	81	84	PF00917	0.462
LIG_WRC_WIRS_1	11	16	PF05994	0.460
MOD_CK1_1	111	117	PF00069	0.449
MOD_CK1_1	13	19	PF00069	0.495
MOD_CK1_1	25	31	PF00069	0.524
MOD_CK1_1	96	102	PF00069	0.546
MOD_CK2_1	59	65	PF00069	0.534
MOD_CK2_1	78	84	PF00069	0.395
MOD_GlcNHglycan	15	18	PF01048	0.405
MOD_GSK3_1	37	44	PF00069	0.508
MOD_N-GLC_1	96	101	PF02516	0.251
MOD_NEK2_1	22	27	PF00069	0.513
MOD_NEK2_1	48	53	PF00069	0.603
MOD_PKA_1	59	65	PF00069	0.506
MOD_PKA_2	145	151	PF00069	0.506
MOD_PKA_2	59	65	PF00069	0.442
MOD_Plk_1	108	114	PF00069	0.521
MOD_Plk_1	22	28	PF00069	0.521
MOD_Plk_4	84	90	PF00069	0.529
MOD_ProDKin_1	78	84	PF00069	0.550
MOD_SUMO_rev_2	102	112	PF00179	0.496
MOD_SUMO_rev_2	28	37	PF00179	0.496
TRG_DiLeu_BaEn_3	83	89	PF01217	0.462
TRG_ER_diArg_1	59	61	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI7	Leptomonas seymouri	79%	99%
A0A0N1PDJ8	Leptomonas seymouri	76%	99%
A0A0S4IQF6	Bodo saltans	67%	77%
A0A1X0PAD0	Trypanosomatidae	68%	100%
A0A3R7N9A0	Trypanosoma rangeli	64%	100%
A0A3S7X7W0	Leishmania donovani	91%	100%
A4H7S1	Leishmania braziliensis	96%	100%
A4I9W4	Leishmania infantum	91%	100%
A4I9W5	Leishmania infantum	91%	100%
A4IIY2	Xenopus tropicalis	37%	87%
C9ZMR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D3ZQL7	Rattus norvegicus	36%	70%
E9B4X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O94811	Homo sapiens	33%	70%
P59282	Homo sapiens	40%	90%
Q0P5Y3	Mus musculus	39%	90%
Q27957	Bos taurus	34%	70%
Q2VPM9	Xenopus laevis	39%	87%
Q3T077	Bos taurus	36%	89%
Q3ZCC8	Bos taurus	38%	87%
Q4Q349	Leishmania major	90%	100%
Q4Q350	Leishmania major	91%	100%
Q5PPN5	Rattus norvegicus	39%	87%
Q7TQD2	Mus musculus	36%	70%
Q9BW30	Homo sapiens	38%	87%
Q9CRB6	Mus musculus	39%	87%