P25-alpha family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p25-alpha, putative

Species:

Leishmania braziliensis

UniProt:

A4H7S1_LEIBR

TriTrypDb:

LbrM.14.1180 , LBRM2903_140017800

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4H7S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7S1

Function

Biological processes
Term	Name	Level	Count
GO:0031334	positive regulation of protein-containing complex assembly	6	2
GO:0032271	regulation of protein polymerization	6	2
GO:0032273	positive regulation of protein polymerization	7	2
GO:0043254	regulation of protein-containing complex assembly	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0044089	positive regulation of cellular component biogenesis	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.441
CLV_C14_Caspase3-7	174	178	PF00656	0.525
CLV_C14_Caspase3-7	57	61	PF00656	0.505
CLV_NRD_NRD_1	153	155	PF00675	0.305
CLV_NRD_NRD_1	182	184	PF00675	0.497
CLV_NRD_NRD_1	74	76	PF00675	0.304
CLV_PCSK_KEX2_1	153	155	PF00082	0.296
CLV_PCSK_KEX2_1	182	184	PF00082	0.497
CLV_PCSK_KEX2_1	74	76	PF00082	0.384
CLV_PCSK_SKI1_1	44	48	PF00082	0.305
CLV_PCSK_SKI1_1	54	58	PF00082	0.302
DOC_MAPK_gen_1	69	78	PF00069	0.525
DOC_PP1_RVXF_1	72	79	PF00149	0.540
DOC_USP7_MATH_1	25	29	PF00917	0.480
DOC_USP7_UBL2_3	50	54	PF12436	0.517
DOC_USP7_UBL2_3	67	71	PF12436	0.505
DOC_WW_Pin1_4	93	98	PF00397	0.558
LIG_14-3-3_CanoR_1	74	79	PF00244	0.517
LIG_FHA_2	112	118	PF00498	0.417
LIG_FHA_2	136	142	PF00498	0.517
LIG_FHA_2	19	25	PF00498	0.354
LIG_FHA_2	55	61	PF00498	0.505
LIG_FHA_2	94	100	PF00498	0.557
LIG_LIR_Gen_1	20	29	PF02991	0.521
LIG_LIR_Gen_1	40	46	PF02991	0.557
LIG_LIR_Gen_1	62	73	PF02991	0.505
LIG_LIR_Gen_1	77	86	PF02991	0.505
LIG_LIR_Nem_3	20	26	PF02991	0.479
LIG_LIR_Nem_3	62	68	PF02991	0.503
LIG_LIR_Nem_3	77	81	PF02991	0.463
LIG_PDZ_Class_3	183	188	PF00595	0.501
LIG_PTB_Apo_2	36	43	PF02174	0.491
LIG_REV1ctd_RIR_1	5	15	PF16727	0.414
LIG_SH2_STAT5	128	131	PF00017	0.505
LIG_SH2_STAT5	14	17	PF00017	0.383
LIG_SH2_STAT5	6	9	PF00017	0.422
LIG_SUMO_SIM_par_1	161	167	PF11976	0.472
LIG_TRAF2_1	96	99	PF00917	0.456
LIG_WRC_WIRS_1	26	31	PF05994	0.470
MOD_CK1_1	111	117	PF00069	0.554
MOD_CK1_1	126	132	PF00069	0.457
MOD_CK1_1	170	176	PF00069	0.506
MOD_CK1_1	28	34	PF00069	0.505
MOD_CK1_1	40	46	PF00069	0.532
MOD_CK2_1	18	24	PF00069	0.354
MOD_CK2_1	74	80	PF00069	0.534
MOD_CK2_1	93	99	PF00069	0.434
MOD_GlcNHglycan	169	172	PF01048	0.490
MOD_GlcNHglycan	30	33	PF01048	0.409
MOD_GSK3_1	167	174	PF00069	0.630
MOD_GSK3_1	52	59	PF00069	0.510
MOD_N-GLC_1	111	116	PF02516	0.257
MOD_NEK2_1	37	42	PF00069	0.523
MOD_NEK2_1	63	68	PF00069	0.567
MOD_NEK2_1	7	12	PF00069	0.540
MOD_PIKK_1	175	181	PF00454	0.722
MOD_PKA_1	74	80	PF00069	0.517
MOD_PKA_2	74	80	PF00069	0.584
MOD_Plk_1	123	129	PF00069	0.529
MOD_Plk_1	37	43	PF00069	0.530
MOD_Plk_2-3	18	24	PF00069	0.209
MOD_Plk_4	18	24	PF00069	0.209
MOD_Plk_4	99	105	PF00069	0.536
MOD_ProDKin_1	93	99	PF00069	0.558
MOD_SUMO_rev_2	117	127	PF00179	0.505
MOD_SUMO_rev_2	43	52	PF00179	0.505
TRG_DiLeu_BaEn_3	98	104	PF01217	0.469
TRG_ER_diArg_1	1	4	PF00400	0.423
TRG_ER_diArg_1	74	76	PF00400	0.589
TRG_ER_diArg_1	8	11	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI7	Leptomonas seymouri	78%	100%
A0A0N1PDJ8	Leptomonas seymouri	75%	100%
A0A0S4IQF6	Bodo saltans	69%	95%
A0A1X0PAD0	Trypanosomatidae	71%	100%
A0A3Q8IEB6	Leishmania donovani	76%	69%
A0A3R7N9A0	Trypanosoma rangeli	67%	100%
A0A3S7X7W0	Leishmania donovani	90%	100%
A4H7S2	Leishmania braziliensis	96%	100%
A4I9W4	Leishmania infantum	86%	100%
A4I9W5	Leishmania infantum	90%	100%
A4IIY2	Xenopus tropicalis	39%	100%
C9ZMR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
D3ZQL7	Rattus norvegicus	37%	86%
E9B4X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O94811	Homo sapiens	34%	86%
Q0P5Y3	Mus musculus	40%	100%
Q27957	Bos taurus	35%	86%
Q2VPM9	Xenopus laevis	40%	100%
Q3T077	Bos taurus	36%	100%
Q3ZCC8	Bos taurus	40%	100%
Q4Q349	Leishmania major	90%	100%
Q4Q350	Leishmania major	86%	100%
Q5PPN5	Rattus norvegicus	41%	100%
Q7TQD2	Mus musculus	37%	86%
Q9BW30	Homo sapiens	39%	100%
Q9CRB6	Mus musculus	40%	100%