Tub family protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tub family protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7R8_LEIBR

TriTrypDb:

LbrM.14.1150 , LBRM2903_140017500

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7R8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.632
CLV_NRD_NRD_1	107	109	PF00675	0.417
CLV_NRD_NRD_1	179	181	PF00675	0.505
CLV_NRD_NRD_1	196	198	PF00675	0.506
CLV_NRD_NRD_1	311	313	PF00675	0.420
CLV_NRD_NRD_1	398	400	PF00675	0.555
CLV_NRD_NRD_1	82	84	PF00675	0.540
CLV_NRD_NRD_1	92	94	PF00675	0.530
CLV_PCSK_FUR_1	80	84	PF00082	0.481
CLV_PCSK_KEX2_1	179	181	PF00082	0.507
CLV_PCSK_KEX2_1	299	301	PF00082	0.391
CLV_PCSK_KEX2_1	311	313	PF00082	0.342
CLV_PCSK_KEX2_1	82	84	PF00082	0.540
CLV_PCSK_KEX2_1	92	94	PF00082	0.530
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.378
CLV_PCSK_SKI1_1	15	19	PF00082	0.505
CLV_PCSK_SKI1_1	198	202	PF00082	0.570
CLV_PCSK_SKI1_1	374	378	PF00082	0.411
CLV_PCSK_SKI1_1	83	87	PF00082	0.386
CLV_PCSK_SKI1_1	93	97	PF00082	0.445
DEG_APCC_DBOX_1	379	387	PF00400	0.411
DEG_APCC_DBOX_1	91	99	PF00400	0.446
DEG_Nend_UBRbox_3	1	3	PF02207	0.514
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.603
DOC_MAPK_FxFP_2	379	382	PF00069	0.411
DOC_MAPK_gen_1	128	136	PF00069	0.457
DOC_MAPK_gen_1	194	203	PF00069	0.496
DOC_MAPK_gen_1	92	100	PF00069	0.521
DOC_MAPK_MEF2A_6	197	205	PF00069	0.470
DOC_MAPK_MEF2A_6	312	321	PF00069	0.411
DOC_PP1_RVXF_1	335	341	PF00149	0.411
DOC_PP2B_PxIxI_1	316	322	PF00149	0.411
DOC_PP4_FxxP_1	379	382	PF00568	0.411
DOC_USP7_MATH_1	17	21	PF00917	0.587
DOC_USP7_MATH_1	209	213	PF00917	0.684
DOC_USP7_MATH_1	269	273	PF00917	0.607
DOC_USP7_MATH_1	287	291	PF00917	0.692
DOC_USP7_MATH_1	32	36	PF00917	0.628
DOC_USP7_UBL2_3	194	198	PF12436	0.531
DOC_USP7_UBL2_3	346	350	PF12436	0.513
DOC_WW_Pin1_4	310	315	PF00397	0.356
DOC_WW_Pin1_4	323	328	PF00397	0.346
LIG_14-3-3_CanoR_1	108	112	PF00244	0.574
LIG_14-3-3_CanoR_1	281	288	PF00244	0.564
LIG_14-3-3_CanoR_1	300	306	PF00244	0.191
LIG_14-3-3_CanoR_1	8	14	PF00244	0.530
LIG_Actin_RPEL_3	85	104	PF02755	0.550
LIG_APCC_ABBA_1	186	191	PF00400	0.500
LIG_BRCT_BRCA1_1	109	113	PF00533	0.468
LIG_FHA_1	215	221	PF00498	0.473
LIG_FHA_1	8	14	PF00498	0.615
LIG_FHA_1	99	105	PF00498	0.525
LIG_FHA_2	194	200	PF00498	0.390
LIG_FHA_2	49	55	PF00498	0.615
LIG_LIR_Apic_2	227	232	PF02991	0.549
LIG_LIR_Apic_2	378	382	PF02991	0.411
LIG_LIR_Apic_2	75	81	PF02991	0.501
LIG_LIR_Gen_1	110	115	PF02991	0.452
LIG_LIR_Gen_1	349	360	PF02991	0.396
LIG_LIR_Nem_3	110	114	PF02991	0.451
LIG_LIR_Nem_3	326	332	PF02991	0.513
LIG_LIR_Nem_3	349	355	PF02991	0.402
LIG_NRBOX	200	206	PF00104	0.574
LIG_Pex14_2	375	379	PF04695	0.411
LIG_SH2_PTP2	229	232	PF00017	0.549
LIG_SH2_STAT5	229	232	PF00017	0.549
LIG_SH2_STAT5	263	266	PF00017	0.550
LIG_SH2_STAT5	89	92	PF00017	0.464
LIG_SH3_1	311	317	PF00018	0.411
LIG_SH3_3	215	221	PF00018	0.473
LIG_SH3_3	311	317	PF00018	0.411
LIG_SH3_3	67	73	PF00018	0.567
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.567
LIG_SUMO_SIM_anti_2	214	220	PF11976	0.333
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.261
LIG_SUMO_SIM_par_1	318	324	PF11976	0.513
MOD_CK1_1	129	135	PF00069	0.722
MOD_CK1_1	141	147	PF00069	0.537
MOD_CK1_1	190	196	PF00069	0.548
MOD_CK1_1	212	218	PF00069	0.506
MOD_CK1_1	25	31	PF00069	0.630
MOD_CK1_1	290	296	PF00069	0.704
MOD_CK1_1	313	319	PF00069	0.325
MOD_CK1_1	60	66	PF00069	0.743
MOD_CK2_1	193	199	PF00069	0.437
MOD_CK2_1	48	54	PF00069	0.552
MOD_GlcNHglycan	140	143	PF01048	0.736
MOD_GlcNHglycan	226	229	PF01048	0.565
MOD_GlcNHglycan	267	270	PF01048	0.662
MOD_GlcNHglycan	27	30	PF01048	0.638
MOD_GlcNHglycan	283	286	PF01048	0.737
MOD_GlcNHglycan	289	292	PF01048	0.796
MOD_GlcNHglycan	34	37	PF01048	0.666
MOD_GlcNHglycan	40	43	PF01048	0.734
MOD_GSK3_1	137	144	PF00069	0.603
MOD_GSK3_1	208	215	PF00069	0.574
MOD_GSK3_1	265	272	PF00069	0.732
MOD_GSK3_1	277	284	PF00069	0.675
MOD_GSK3_1	390	397	PF00069	0.411
MOD_GSK3_1	53	60	PF00069	0.636
MOD_NEK2_1	208	213	PF00069	0.586
MOD_NEK2_1	264	269	PF00069	0.555
MOD_NEK2_1	64	69	PF00069	0.612
MOD_NEK2_1	98	103	PF00069	0.527
MOD_OFUCOSY	45	52	PF10250	0.431
MOD_PIKK_1	148	154	PF00454	0.601
MOD_PIKK_1	209	215	PF00454	0.451
MOD_PIKK_1	62	68	PF00454	0.508
MOD_PK_1	43	49	PF00069	0.450
MOD_PKA_1	299	305	PF00069	0.261
MOD_PKA_2	107	113	PF00069	0.345
MOD_PKA_2	244	250	PF00069	0.802
MOD_PKA_2	299	305	PF00069	0.282
MOD_PKA_2	342	348	PF00069	0.411
MOD_PKA_2	7	13	PF00069	0.530
MOD_Plk_4	214	220	PF00069	0.328
MOD_Plk_4	315	321	PF00069	0.261
MOD_Plk_4	391	397	PF00069	0.411
MOD_Plk_4	43	49	PF00069	0.633
MOD_Plk_4	57	63	PF00069	0.621
MOD_Plk_4	64	70	PF00069	0.599
MOD_Plk_4	99	105	PF00069	0.637
MOD_ProDKin_1	310	316	PF00069	0.356
MOD_ProDKin_1	323	329	PF00069	0.346
MOD_SUMO_for_1	134	137	PF00179	0.482
MOD_SUMO_rev_2	234	241	PF00179	0.505
TRG_ER_diArg_1	130	133	PF00400	0.475
TRG_ER_diArg_1	310	312	PF00400	0.420
TRG_ER_diArg_1	79	82	PF00400	0.495
TRG_NLS_Bipartite_1	82	97	PF00514	0.511
TRG_NLS_MonoExtN_4	296	302	PF00514	0.261
TRG_NLS_MonoExtN_4	92	97	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC07	Leptomonas seymouri	66%	83%
A0A3Q8I9W0	Leishmania donovani	77%	100%
A4HW61	Leishmania infantum	73%	78%
E9APW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QFL9	Leishmania major	77%	100%