CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7R7_LEIBR

TriTrypDb:

LbrM.14.1140 , LBRM2903_140017400

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7R7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.626
CLV_NRD_NRD_1	162	164	PF00675	0.702
CLV_NRD_NRD_1	171	173	PF00675	0.557
CLV_NRD_NRD_1	260	262	PF00675	0.513
CLV_NRD_NRD_1	342	344	PF00675	0.487
CLV_NRD_NRD_1	467	469	PF00675	0.684
CLV_NRD_NRD_1	68	70	PF00675	0.461
CLV_NRD_NRD_1	88	90	PF00675	0.429
CLV_PCSK_KEX2_1	162	164	PF00082	0.719
CLV_PCSK_KEX2_1	260	262	PF00082	0.513
CLV_PCSK_KEX2_1	342	344	PF00082	0.486
CLV_PCSK_KEX2_1	467	469	PF00082	0.755
CLV_PCSK_KEX2_1	68	70	PF00082	0.463
CLV_PCSK_KEX2_1	87	89	PF00082	0.551
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.470
CLV_PCSK_SKI1_1	103	107	PF00082	0.517
CLV_PCSK_SKI1_1	126	130	PF00082	0.426
CLV_PCSK_SKI1_1	132	136	PF00082	0.364
DOC_CYCLIN_RxL_1	343	355	PF00134	0.650
DOC_MAPK_DCC_7	229	238	PF00069	0.412
DOC_MAPK_gen_1	423	431	PF00069	0.388
DOC_MAPK_gen_1	87	93	PF00069	0.554
DOC_PP1_RVXF_1	144	150	PF00149	0.509
DOC_PP1_RVXF_1	239	246	PF00149	0.493
DOC_PP1_RVXF_1	287	294	PF00149	0.369
DOC_PP1_RVXF_1	32	38	PF00149	0.700
DOC_USP7_MATH_1	165	169	PF00917	0.585
DOC_USP7_MATH_1	271	275	PF00917	0.479
DOC_USP7_MATH_1	300	304	PF00917	0.532
DOC_USP7_MATH_1	317	321	PF00917	0.430
DOC_USP7_MATH_1	51	55	PF00917	0.532
DOC_USP7_MATH_1	6	10	PF00917	0.645
DOC_USP7_UBL2_3	122	126	PF12436	0.375
DOC_USP7_UBL2_3	419	423	PF12436	0.420
DOC_WW_Pin1_4	149	154	PF00397	0.431
DOC_WW_Pin1_4	16	21	PF00397	0.664
DOC_WW_Pin1_4	190	195	PF00397	0.704
DOC_WW_Pin1_4	228	233	PF00397	0.396
LIG_14-3-3_CanoR_1	146	150	PF00244	0.446
LIG_14-3-3_CanoR_1	22	30	PF00244	0.725
LIG_14-3-3_CanoR_1	269	279	PF00244	0.430
LIG_14-3-3_CanoR_1	407	411	PF00244	0.547
LIG_BIR_III_2	355	359	PF00653	0.571
LIG_BIR_III_4	377	381	PF00653	0.283
LIG_BIR_III_4	455	459	PF00653	0.525
LIG_BRCT_BRCA1_1	305	309	PF00533	0.477
LIG_BRCT_BRCA1_1	389	393	PF00533	0.356
LIG_FHA_1	407	413	PF00498	0.516
LIG_FHA_1	6	12	PF00498	0.655
LIG_FHA_2	140	146	PF00498	0.519
LIG_FHA_2	225	231	PF00498	0.447
LIG_LIR_Gen_1	477	484	PF02991	0.520
LIG_LIR_Nem_3	237	242	PF02991	0.371
LIG_LIR_Nem_3	364	370	PF02991	0.431
LIG_LIR_Nem_3	377	382	PF02991	0.303
LIG_LIR_Nem_3	389	395	PF02991	0.374
LIG_LIR_Nem_3	477	483	PF02991	0.519
LIG_MLH1_MIPbox_1	389	393	PF16413	0.356
LIG_REV1ctd_RIR_1	126	136	PF16727	0.485
LIG_SH2_CRK	239	243	PF00017	0.473
LIG_SH2_CRK	427	431	PF00017	0.386
LIG_SH2_CRK	71	75	PF00017	0.336
LIG_SH2_PTP2	90	93	PF00017	0.636
LIG_SH2_STAP1	427	431	PF00017	0.386
LIG_SH2_STAT5	140	143	PF00017	0.382
LIG_SH2_STAT5	290	293	PF00017	0.391
LIG_SH2_STAT5	410	413	PF00017	0.492
LIG_SH2_STAT5	90	93	PF00017	0.692
LIG_SH3_1	229	235	PF00018	0.428
LIG_SH3_2	153	158	PF14604	0.476
LIG_SH3_2	82	87	PF14604	0.410
LIG_SH3_3	150	156	PF00018	0.541
LIG_SH3_3	229	235	PF00018	0.433
LIG_SH3_3	265	271	PF00018	0.554
LIG_SH3_3	294	300	PF00018	0.428
LIG_SH3_3	344	350	PF00018	0.487
LIG_SH3_3	42	48	PF00018	0.567
LIG_SH3_3	79	85	PF00018	0.470
LIG_SUMO_SIM_par_1	349	355	PF11976	0.669
LIG_TRFH_1	293	297	PF08558	0.508
LIG_TYR_ITSM	235	242	PF00017	0.455
MOD_CDK_SPxK_1	149	155	PF00069	0.330
MOD_CDK_SPxK_1	16	22	PF00069	0.615
MOD_CK1_1	168	174	PF00069	0.618
MOD_CK1_1	190	196	PF00069	0.692
MOD_CK1_1	202	208	PF00069	0.648
MOD_CK1_1	234	240	PF00069	0.511
MOD_CK1_1	303	309	PF00069	0.585
MOD_CK1_1	387	393	PF00069	0.514
MOD_CK1_1	396	402	PF00069	0.550
MOD_CK1_1	9	15	PF00069	0.690
MOD_CK2_1	139	145	PF00069	0.514
MOD_CK2_1	224	230	PF00069	0.446
MOD_Cter_Amidation	421	424	PF01082	0.415
MOD_GlcNHglycan	132	135	PF01048	0.523
MOD_GlcNHglycan	25	28	PF01048	0.673
MOD_GlcNHglycan	302	305	PF01048	0.555
MOD_GlcNHglycan	319	322	PF01048	0.735
MOD_GlcNHglycan	384	389	PF01048	0.472
MOD_GlcNHglycan	396	399	PF01048	0.545
MOD_GlcNHglycan	53	56	PF01048	0.557
MOD_GlcNHglycan	8	11	PF01048	0.660
MOD_GSK3_1	1	8	PF00069	0.687
MOD_GSK3_1	145	152	PF00069	0.371
MOD_GSK3_1	195	202	PF00069	0.713
MOD_GSK3_1	224	231	PF00069	0.474
MOD_GSK3_1	303	310	PF00069	0.684
MOD_GSK3_1	393	400	PF00069	0.471
MOD_NEK2_1	1	6	PF00069	0.654
MOD_NEK2_1	128	133	PF00069	0.460
MOD_NEK2_1	23	28	PF00069	0.608
MOD_NEK2_1	30	35	PF00069	0.659
MOD_NEK2_1	309	314	PF00069	0.486
MOD_NEK2_1	393	398	PF00069	0.411
MOD_NEK2_1	58	63	PF00069	0.451
MOD_NEK2_2	165	170	PF00069	0.490
MOD_NMyristoyl	1	7	PF02799	0.529
MOD_PIKK_1	206	212	PF00454	0.767
MOD_PKA_2	145	151	PF00069	0.442
MOD_PKA_2	206	212	PF00069	0.476
MOD_PKA_2	406	412	PF00069	0.435
MOD_PKA_2	466	472	PF00069	0.747
MOD_Plk_1	187	193	PF00069	0.655
MOD_Plk_1	336	342	PF00069	0.523
MOD_Plk_2-3	195	201	PF00069	0.644
MOD_Plk_4	234	240	PF00069	0.462
MOD_Plk_4	387	393	PF00069	0.385
MOD_Plk_4	406	412	PF00069	0.403
MOD_ProDKin_1	149	155	PF00069	0.442
MOD_ProDKin_1	16	22	PF00069	0.665
MOD_ProDKin_1	190	196	PF00069	0.705
MOD_ProDKin_1	228	234	PF00069	0.407
MOD_SUMO_rev_2	102	107	PF00179	0.467
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.399
TRG_ENDOCYTIC_2	239	242	PF00928	0.459
TRG_ENDOCYTIC_2	290	293	PF00928	0.391
TRG_ENDOCYTIC_2	427	430	PF00928	0.387
TRG_ENDOCYTIC_2	71	74	PF00928	0.331
TRG_ENDOCYTIC_2	90	93	PF00928	0.560
TRG_ER_diArg_1	162	164	PF00400	0.717
TRG_ER_diArg_1	169	172	PF00400	0.603
TRG_ER_diArg_1	88	90	PF00400	0.477
TRG_LysEnd_GGAAcLL_1	479	484	PF00790	0.534
TRG_NLS_MonoExtN_4	85	91	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L8	Leptomonas seymouri	49%	88%
A0A1X0NNT6	Trypanosomatidae	35%	100%
A0A3R7R786	Trypanosoma rangeli	37%	100%
A0A3S7WTB0	Leishmania donovani	73%	100%
A4HW60	Leishmania infantum	73%	100%
C9ZSW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9APW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QFM0	Leishmania major	72%	98%
V5DC73	Trypanosoma cruzi	36%	100%