Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7R6_LEIBR

TriTrypDb:

LbrM.14.1130 , LBRM2903_140017200

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H7R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7R6

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.562
CLV_C14_Caspase3-7	160	164	PF00656	0.522
CLV_C14_Caspase3-7	765	769	PF00656	0.474
CLV_C14_Caspase3-7	804	808	PF00656	0.572
CLV_C14_Caspase3-7	809	813	PF00656	0.547
CLV_NRD_NRD_1	119	121	PF00675	0.536
CLV_NRD_NRD_1	149	151	PF00675	0.553
CLV_NRD_NRD_1	190	192	PF00675	0.470
CLV_NRD_NRD_1	267	269	PF00675	0.518
CLV_NRD_NRD_1	356	358	PF00675	0.578
CLV_NRD_NRD_1	437	439	PF00675	0.515
CLV_NRD_NRD_1	655	657	PF00675	0.677
CLV_PCSK_FUR_1	187	191	PF00082	0.415
CLV_PCSK_KEX2_1	119	121	PF00082	0.570
CLV_PCSK_KEX2_1	189	191	PF00082	0.473
CLV_PCSK_KEX2_1	267	269	PF00082	0.518
CLV_PCSK_KEX2_1	437	439	PF00082	0.515
CLV_PCSK_KEX2_1	655	657	PF00082	0.677
CLV_PCSK_SKI1_1	120	124	PF00082	0.522
CLV_PCSK_SKI1_1	191	195	PF00082	0.470
CLV_PCSK_SKI1_1	437	441	PF00082	0.477
CLV_PCSK_SKI1_1	5	9	PF00082	0.612
CLV_PCSK_SKI1_1	558	562	PF00082	0.559
CLV_PCSK_SKI1_1	702	706	PF00082	0.337
DEG_SCF_FBW7_1	745	751	PF00400	0.417
DEG_SPOP_SBC_1	575	579	PF00917	0.557
DEG_SPOP_SBC_1	642	646	PF00917	0.602
DOC_CKS1_1	125	130	PF01111	0.519
DOC_CKS1_1	49	54	PF01111	0.685
DOC_CKS1_1	612	617	PF01111	0.524
DOC_CKS1_1	745	750	PF01111	0.418
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	454	457	PF00134	0.438
DOC_MAPK_gen_1	187	194	PF00069	0.402
DOC_MAPK_gen_1	666	674	PF00069	0.487
DOC_MAPK_MEF2A_6	336	343	PF00069	0.387
DOC_PP1_RVXF_1	419	426	PF00149	0.370
DOC_PP2B_LxvP_1	453	456	PF13499	0.431
DOC_PP4_FxxP_1	346	349	PF00568	0.361
DOC_PP4_FxxP_1	465	468	PF00568	0.464
DOC_USP7_MATH_1	11	15	PF00917	0.649
DOC_USP7_MATH_1	216	220	PF00917	0.685
DOC_USP7_MATH_1	231	235	PF00917	0.395
DOC_USP7_MATH_1	35	39	PF00917	0.690
DOC_USP7_MATH_1	460	464	PF00917	0.426
DOC_USP7_MATH_1	509	513	PF00917	0.386
DOC_USP7_MATH_1	521	525	PF00917	0.401
DOC_USP7_MATH_1	575	579	PF00917	0.561
DOC_USP7_MATH_1	597	601	PF00917	0.628
DOC_USP7_MATH_1	626	630	PF00917	0.533
DOC_USP7_MATH_1	641	645	PF00917	0.686
DOC_USP7_MATH_1	713	717	PF00917	0.391
DOC_USP7_MATH_1	750	754	PF00917	0.317
DOC_USP7_MATH_1	824	828	PF00917	0.444
DOC_USP7_MATH_2	706	712	PF00917	0.424
DOC_WW_Pin1_4	105	110	PF00397	0.660
DOC_WW_Pin1_4	124	129	PF00397	0.511
DOC_WW_Pin1_4	18	23	PF00397	0.595
DOC_WW_Pin1_4	335	340	PF00397	0.402
DOC_WW_Pin1_4	39	44	PF00397	0.613
DOC_WW_Pin1_4	45	50	PF00397	0.632
DOC_WW_Pin1_4	464	469	PF00397	0.452
DOC_WW_Pin1_4	611	616	PF00397	0.537
DOC_WW_Pin1_4	66	71	PF00397	0.804
DOC_WW_Pin1_4	702	707	PF00397	0.455
DOC_WW_Pin1_4	717	722	PF00397	0.382
DOC_WW_Pin1_4	744	749	PF00397	0.421
DOC_WW_Pin1_4	78	83	PF00397	0.495
LIG_14-3-3_CanoR_1	119	126	PF00244	0.523
LIG_14-3-3_CanoR_1	267	277	PF00244	0.679
LIG_14-3-3_CanoR_1	304	308	PF00244	0.570
LIG_14-3-3_CanoR_1	325	329	PF00244	0.436
LIG_14-3-3_CanoR_1	459	468	PF00244	0.474
LIG_14-3-3_CanoR_1	58	62	PF00244	0.627
LIG_14-3-3_CanoR_1	668	673	PF00244	0.404
LIG_14-3-3_CanoR_1	762	772	PF00244	0.525
LIG_APCC_ABBA_1	478	483	PF00400	0.380
LIG_APCC_ABBAyCdc20_2	477	483	PF00400	0.383
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BIR_III_4	731	735	PF00653	0.464
LIG_BRCT_BRCA1_1	825	829	PF00533	0.360
LIG_deltaCOP1_diTrp_1	833	838	PF00928	0.374
LIG_FHA_1	125	131	PF00498	0.596
LIG_FHA_1	164	170	PF00498	0.467
LIG_FHA_1	342	348	PF00498	0.289
LIG_FHA_1	399	405	PF00498	0.359
LIG_FHA_1	448	454	PF00498	0.478
LIG_FHA_1	581	587	PF00498	0.518
LIG_FHA_1	615	621	PF00498	0.663
LIG_FHA_1	741	747	PF00498	0.469
LIG_FHA_1	749	755	PF00498	0.375
LIG_FHA_1	846	852	PF00498	0.452
LIG_FHA_2	154	160	PF00498	0.465
LIG_FHA_2	303	309	PF00498	0.495
LIG_FHA_2	324	330	PF00498	0.536
LIG_FHA_2	703	709	PF00498	0.335
LIG_FHA_2	74	80	PF00498	0.530
LIG_FHA_2	763	769	PF00498	0.480
LIG_LIR_Apic_2	196	202	PF02991	0.335
LIG_LIR_Apic_2	344	349	PF02991	0.300
LIG_LIR_Apic_2	463	468	PF02991	0.446
LIG_LIR_Apic_2	564	570	PF02991	0.420
LIG_LIR_Gen_1	143	153	PF02991	0.425
LIG_LIR_Gen_1	386	395	PF02991	0.300
LIG_LIR_Gen_1	500	509	PF02991	0.315
LIG_LIR_Nem_3	143	149	PF02991	0.423
LIG_LIR_Nem_3	344	348	PF02991	0.292
LIG_LIR_Nem_3	386	390	PF02991	0.324
LIG_LIR_Nem_3	500	504	PF02991	0.321
LIG_LIR_Nem_3	510	516	PF02991	0.425
LIG_MLH1_MIPbox_1	826	830	PF16413	0.361
LIG_MYND_1	660	664	PF01753	0.442
LIG_PDZ_Class_1	851	856	PF00595	0.444
LIG_SH2_CRK	568	572	PF00017	0.447
LIG_SH2_CRK	637	641	PF00017	0.511
LIG_SH2_PTP2	387	390	PF00017	0.308
LIG_SH2_STAP1	847	851	PF00017	0.288
LIG_SH2_STAT5	199	202	PF00017	0.331
LIG_SH2_STAT5	311	314	PF00017	0.558
LIG_SH2_STAT5	387	390	PF00017	0.308
LIG_SH2_STAT5	513	516	PF00017	0.396
LIG_SH2_STAT5	845	848	PF00017	0.371
LIG_SH3_1	567	573	PF00018	0.375
LIG_SH3_3	122	128	PF00018	0.529
LIG_SH3_3	168	174	PF00018	0.424
LIG_SH3_3	345	351	PF00018	0.396
LIG_SH3_3	404	410	PF00018	0.568
LIG_SH3_3	454	460	PF00018	0.439
LIG_SH3_3	46	52	PF00018	0.640
LIG_SH3_3	503	509	PF00018	0.401
LIG_SH3_3	567	573	PF00018	0.375
LIG_SH3_3	609	615	PF00018	0.544
LIG_SH3_3	654	660	PF00018	0.509
LIG_SH3_3	718	724	PF00018	0.322
LIG_SH3_3	771	777	PF00018	0.459
LIG_SUMO_SIM_anti_2	386	392	PF11976	0.388
LIG_SUMO_SIM_par_1	582	587	PF11976	0.521
LIG_SUMO_SIM_par_1	750	756	PF11976	0.408
LIG_SUMO_SIM_par_1	86	91	PF11976	0.511
LIG_TYR_ITIM	514	519	PF00017	0.412
LIG_WW_3	569	573	PF00397	0.476
MOD_CDC14_SPxK_1	720	723	PF00782	0.420
MOD_CDK_SPK_2	78	83	PF00069	0.514
MOD_CDK_SPxK_1	717	723	PF00069	0.397
MOD_CDK_SPxxK_3	105	112	PF00069	0.601
MOD_CK1_1	104	110	PF00069	0.616
MOD_CK1_1	214	220	PF00069	0.487
MOD_CK1_1	234	240	PF00069	0.544
MOD_CK1_1	285	291	PF00069	0.641
MOD_CK1_1	3	9	PF00069	0.677
MOD_CK1_1	315	321	PF00069	0.519
MOD_CK1_1	38	44	PF00069	0.633
MOD_CK1_1	398	404	PF00069	0.391
MOD_CK1_1	464	470	PF00069	0.441
MOD_CK1_1	48	54	PF00069	0.723
MOD_CK1_1	512	518	PF00069	0.492
MOD_CK1_1	600	606	PF00069	0.680
MOD_CK1_1	644	650	PF00069	0.686
MOD_CK1_1	673	679	PF00069	0.577
MOD_CK1_1	689	695	PF00069	0.494
MOD_CK1_1	712	718	PF00069	0.395
MOD_CK1_1	744	750	PF00069	0.416
MOD_CK1_1	775	781	PF00069	0.634
MOD_CK1_1	81	87	PF00069	0.516
MOD_CK1_1	91	97	PF00069	0.541
MOD_CK2_1	323	329	PF00069	0.544
MOD_CK2_1	702	708	PF00069	0.333
MOD_CK2_1	750	756	PF00069	0.418
MOD_DYRK1A_RPxSP_1	702	706	PF00069	0.337
MOD_GlcNHglycan	120	123	PF01048	0.633
MOD_GlcNHglycan	142	145	PF01048	0.472
MOD_GlcNHglycan	195	198	PF01048	0.350
MOD_GlcNHglycan	213	216	PF01048	0.454
MOD_GlcNHglycan	268	271	PF01048	0.717
MOD_GlcNHglycan	329	332	PF01048	0.517
MOD_GlcNHglycan	37	40	PF01048	0.691
MOD_GlcNHglycan	426	429	PF01048	0.338
MOD_GlcNHglycan	5	8	PF01048	0.798
MOD_GlcNHglycan	548	551	PF01048	0.376
MOD_GlcNHglycan	628	631	PF01048	0.661
MOD_GlcNHglycan	688	691	PF01048	0.342
MOD_GlcNHglycan	711	714	PF01048	0.470
MOD_GlcNHglycan	731	735	PF01048	0.258
MOD_GlcNHglycan	774	777	PF01048	0.563
MOD_GlcNHglycan	98	101	PF01048	0.766
MOD_GSK3_1	101	108	PF00069	0.521
MOD_GSK3_1	114	121	PF00069	0.672
MOD_GSK3_1	154	161	PF00069	0.494
MOD_GSK3_1	181	188	PF00069	0.531
MOD_GSK3_1	214	221	PF00069	0.483
MOD_GSK3_1	278	285	PF00069	0.597
MOD_GSK3_1	31	38	PF00069	0.607
MOD_GSK3_1	314	321	PF00069	0.625
MOD_GSK3_1	323	330	PF00069	0.555
MOD_GSK3_1	395	402	PF00069	0.361
MOD_GSK3_1	443	450	PF00069	0.461
MOD_GSK3_1	460	467	PF00069	0.591
MOD_GSK3_1	521	528	PF00069	0.465
MOD_GSK3_1	534	541	PF00069	0.452
MOD_GSK3_1	576	583	PF00069	0.538
MOD_GSK3_1	597	604	PF00069	0.593
MOD_GSK3_1	643	650	PF00069	0.616
MOD_GSK3_1	708	715	PF00069	0.423
MOD_GSK3_1	730	737	PF00069	0.377
MOD_GSK3_1	740	747	PF00069	0.420
MOD_GSK3_1	824	831	PF00069	0.350
MOD_GSK3_1	88	95	PF00069	0.557
MOD_N-GLC_1	741	746	PF02516	0.397
MOD_N-GLC_1	763	768	PF02516	0.642
MOD_N-GLC_2	376	378	PF02516	0.507
MOD_NEK2_1	118	123	PF00069	0.691
MOD_NEK2_1	140	145	PF00069	0.492
MOD_NEK2_1	153	158	PF00069	0.488
MOD_NEK2_1	218	223	PF00069	0.430
MOD_NEK2_1	241	246	PF00069	0.503
MOD_NEK2_1	25	30	PF00069	0.674
MOD_NEK2_1	286	291	PF00069	0.549
MOD_NEK2_1	312	317	PF00069	0.504
MOD_NEK2_1	341	346	PF00069	0.282
MOD_NEK2_1	414	419	PF00069	0.378
MOD_NEK2_1	444	449	PF00069	0.466
MOD_NEK2_1	544	549	PF00069	0.382
MOD_NEK2_1	584	589	PF00069	0.531
MOD_NEK2_1	643	648	PF00069	0.521
MOD_NEK2_1	700	705	PF00069	0.414
MOD_NEK2_1	837	842	PF00069	0.367
MOD_NEK2_1	851	856	PF00069	0.444
MOD_NEK2_2	482	487	PF00069	0.418
MOD_NEK2_2	750	755	PF00069	0.323
MOD_NEK2_2	824	829	PF00069	0.455
MOD_NEK2_2	845	850	PF00069	0.376
MOD_PIKK_1	163	169	PF00454	0.570
MOD_PIKK_1	234	240	PF00454	0.435
MOD_PIKK_1	490	496	PF00454	0.358
MOD_PK_1	488	494	PF00069	0.278
MOD_PKA_2	118	124	PF00069	0.527
MOD_PKA_2	153	159	PF00069	0.607
MOD_PKA_2	266	272	PF00069	0.516
MOD_PKA_2	303	309	PF00069	0.576
MOD_PKA_2	324	330	PF00069	0.439
MOD_PKA_2	57	63	PF00069	0.715
MOD_PKB_1	666	674	PF00069	0.487
MOD_PKB_1	760	768	PF00069	0.492
MOD_Plk_1	247	253	PF00069	0.667
MOD_Plk_1	379	385	PF00069	0.691
MOD_Plk_1	398	404	PF00069	0.299
MOD_Plk_1	700	706	PF00069	0.492
MOD_Plk_1	741	747	PF00069	0.398
MOD_Plk_1	811	817	PF00069	0.502
MOD_Plk_1	92	98	PF00069	0.531
MOD_Plk_2-3	559	565	PF00069	0.423
MOD_Plk_4	172	178	PF00069	0.532
MOD_Plk_4	195	201	PF00069	0.392
MOD_Plk_4	219	225	PF00069	0.472
MOD_Plk_4	341	347	PF00069	0.433
MOD_Plk_4	399	405	PF00069	0.404
MOD_Plk_4	409	415	PF00069	0.440
MOD_Plk_4	449	455	PF00069	0.437
MOD_Plk_4	509	515	PF00069	0.428
MOD_Plk_4	576	582	PF00069	0.540
MOD_Plk_4	734	740	PF00069	0.368
MOD_Plk_4	741	747	PF00069	0.425
MOD_Plk_4	824	830	PF00069	0.364
MOD_ProDKin_1	105	111	PF00069	0.663
MOD_ProDKin_1	124	130	PF00069	0.514
MOD_ProDKin_1	18	24	PF00069	0.586
MOD_ProDKin_1	335	341	PF00069	0.395
MOD_ProDKin_1	39	45	PF00069	0.617
MOD_ProDKin_1	464	470	PF00069	0.441
MOD_ProDKin_1	48	54	PF00069	0.629
MOD_ProDKin_1	611	617	PF00069	0.538
MOD_ProDKin_1	66	72	PF00069	0.745
MOD_ProDKin_1	702	708	PF00069	0.460
MOD_ProDKin_1	717	723	PF00069	0.382
MOD_ProDKin_1	744	750	PF00069	0.416
MOD_ProDKin_1	78	84	PF00069	0.495
MOD_SUMO_rev_2	491	498	PF00179	0.356
TRG_DiLeu_BaEn_1	337	342	PF01217	0.379
TRG_DiLeu_BaEn_1	399	404	PF01217	0.366
TRG_DiLeu_BaEn_1	435	440	PF01217	0.430
TRG_DiLeu_LyEn_5	435	440	PF01217	0.430
TRG_ENDOCYTIC_2	387	390	PF00928	0.308
TRG_ENDOCYTIC_2	516	519	PF00928	0.424
TRG_ENDOCYTIC_2	637	640	PF00928	0.513
TRG_ER_diArg_1	118	120	PF00400	0.538
TRG_ER_diArg_1	187	190	PF00400	0.495
TRG_ER_diArg_1	436	438	PF00400	0.520
TRG_ER_diArg_1	655	657	PF00400	0.677
TRG_ER_diArg_1	666	669	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHJ0	Leptomonas seymouri	54%	85%
A0A3S7WT61	Leishmania donovani	76%	92%
A4HW59	Leishmania infantum	75%	92%
E9APV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	91%
Q4QFM1	Leishmania major	73%	100%