Mannose-P-dolichol utilization defect 1 protein homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PQ loop repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H7R3_LEIBR

TriTrypDb:

LbrM.14.1080 , LBRM2903_140016500

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H7R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7R3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.377
CLV_NRD_NRD_1	239	241	PF00675	0.324
CLV_NRD_NRD_1	248	250	PF00675	0.358
CLV_PCSK_KEX2_1	125	127	PF00082	0.319
CLV_PCSK_KEX2_1	247	249	PF00082	0.393
CLV_PCSK_PC7_1	244	250	PF00082	0.277
CLV_PCSK_SKI1_1	197	201	PF00082	0.250
CLV_PCSK_SKI1_1	253	257	PF00082	0.453
DEG_APCC_DBOX_1	178	186	PF00400	0.470
DOC_CYCLIN_RxL_1	90	99	PF00134	0.193
DOC_MAPK_gen_1	122	131	PF00069	0.522
DOC_MAPK_gen_1	177	184	PF00069	0.481
DOC_MAPK_gen_1	209	218	PF00069	0.280
DOC_MAPK_MEF2A_6	209	218	PF00069	0.299
DOC_MAPK_MEF2A_6	4	12	PF00069	0.340
DOC_MAPK_RevD_3	227	241	PF00069	0.430
DOC_PP1_SILK_1	51	56	PF00149	0.393
DOC_PP2B_LxvP_1	203	206	PF13499	0.234
DOC_PP2B_LxvP_1	54	57	PF13499	0.266
LIG_14-3-3_CanoR_1	125	130	PF00244	0.574
LIG_14-3-3_CanoR_1	179	185	PF00244	0.533
LIG_14-3-3_CanoR_1	197	207	PF00244	0.138
LIG_14-3-3_CanoR_1	247	255	PF00244	0.485
LIG_14-3-3_CanoR_1	4	9	PF00244	0.399
LIG_APCC_ABBA_1	74	79	PF00400	0.193
LIG_DLG_GKlike_1	125	133	PF00625	0.501
LIG_FHA_1	105	111	PF00498	0.446
LIG_FHA_1	131	137	PF00498	0.514
LIG_FHA_1	184	190	PF00498	0.250
LIG_FHA_1	198	204	PF00498	0.250
LIG_FHA_1	5	11	PF00498	0.343
LIG_FHA_2	147	153	PF00498	0.567
LIG_LIR_Gen_1	102	113	PF02991	0.359
LIG_LIR_Gen_1	183	191	PF02991	0.286
LIG_LIR_Gen_1	44	53	PF02991	0.404
LIG_LIR_Gen_1	75	85	PF02991	0.316
LIG_LIR_Nem_3	102	108	PF02991	0.266
LIG_LIR_Nem_3	183	187	PF02991	0.296
LIG_LIR_Nem_3	40	45	PF02991	0.355
LIG_LIR_Nem_3	75	80	PF02991	0.334
LIG_LIR_Nem_3	86	92	PF02991	0.316
LIG_NRBOX	109	115	PF00104	0.393
LIG_Pex14_2	11	15	PF04695	0.322
LIG_Pex14_2	160	164	PF04695	0.470
LIG_Pex14_2	184	188	PF04695	0.310
LIG_SH2_CRK	45	49	PF00017	0.250
LIG_SH2_GRB2like	171	174	PF00017	0.484
LIG_SH2_SRC	83	86	PF00017	0.385
LIG_SH2_STAP1	45	49	PF00017	0.310
LIG_SH2_STAT5	171	174	PF00017	0.426
LIG_SH2_STAT5	37	40	PF00017	0.262
LIG_SH2_STAT5	42	45	PF00017	0.305
LIG_SH2_STAT5	83	86	PF00017	0.357
LIG_SH3_5	96	100	PF00018	0.266
LIG_SUMO_SIM_anti_2	133	139	PF11976	0.505
LIG_TYR_ITIM	43	48	PF00017	0.268
LIG_WRC_WIRS_1	184	189	PF05994	0.275
MOD_CK1_1	17	23	PF00069	0.626
MOD_CK1_1	183	189	PF00069	0.266
MOD_CK1_1	30	36	PF00069	0.365
MOD_CK1_1	72	78	PF00069	0.302
MOD_CK2_1	146	152	PF00069	0.528
MOD_CK2_1	239	245	PF00069	0.475
MOD_Cter_Amidation	238	241	PF01082	0.413
MOD_GlcNHglycan	142	145	PF01048	0.297
MOD_GSK3_1	121	128	PF00069	0.563
MOD_GSK3_1	169	176	PF00069	0.390
MOD_GSK3_1	247	254	PF00069	0.526
MOD_GSK3_1	27	34	PF00069	0.433
MOD_GSK3_1	37	44	PF00069	0.387
MOD_GSK3_1	79	86	PF00069	0.333
MOD_N-GLC_1	27	32	PF02516	0.469
MOD_NEK2_1	104	109	PF00069	0.285
MOD_NEK2_1	14	19	PF00069	0.367
MOD_NEK2_1	140	145	PF00069	0.507
MOD_NEK2_1	3	8	PF00069	0.353
MOD_PKA_1	125	131	PF00069	0.499
MOD_PKA_1	247	253	PF00069	0.612
MOD_PKA_2	125	131	PF00069	0.517
MOD_PKA_2	239	245	PF00069	0.519
MOD_PKA_2	247	253	PF00069	0.507
MOD_PKA_2	3	9	PF00069	0.375
MOD_Plk_1	27	33	PF00069	0.314
MOD_Plk_4	125	131	PF00069	0.475
MOD_Plk_4	180	186	PF00069	0.419
MOD_Plk_4	49	55	PF00069	0.215
MOD_Plk_4	72	78	PF00069	0.344
MOD_Plk_4	79	85	PF00069	0.344
MOD_SUMO_rev_2	245	255	PF00179	0.482
TRG_ENDOCYTIC_2	234	237	PF00928	0.543
TRG_ENDOCYTIC_2	45	48	PF00928	0.268
TRG_ER_diArg_1	247	249	PF00400	0.617
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I8	Leptomonas seymouri	70%	100%
A0A0S4JQ57	Bodo saltans	45%	92%
A0A1X0NQ59	Trypanosomatidae	45%	100%
A0A3S7WT35	Leishmania donovani	78%	100%
A0A422MWP8	Trypanosoma rangeli	46%	100%
A4HW51	Leishmania infantum	78%	100%
C9ZSW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9APV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
O75352	Homo sapiens	31%	100%
Q20157	Caenorhabditis elegans	29%	100%
Q4QFM6	Leishmania major	78%	100%
Q60441	Cricetulus griseus	28%	100%
Q8C6U2	Mus musculus	27%	100%
Q8VY63	Arabidopsis thaliana	31%	100%
Q9LTI3	Arabidopsis thaliana	27%	100%
Q9R0Q9	Mus musculus	29%	100%
Q9VMW8	Drosophila melanogaster	28%	100%
V5BJ03	Trypanosoma cruzi	47%	100%