Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7R2_LEIBR

TriTrypDb:

LbrM.14.1070 , LBRM2903_140016400

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.526
CLV_C14_Caspase3-7	241	245	PF00656	0.465
CLV_C14_Caspase3-7	52	56	PF00656	0.375
CLV_NRD_NRD_1	201	203	PF00675	0.606
CLV_NRD_NRD_1	24	26	PF00675	0.586
CLV_NRD_NRD_1	279	281	PF00675	0.705
CLV_NRD_NRD_1	28	30	PF00675	0.532
CLV_PCSK_KEX2_1	138	140	PF00082	0.802
CLV_PCSK_KEX2_1	24	26	PF00082	0.586
CLV_PCSK_KEX2_1	28	30	PF00082	0.532
CLV_PCSK_KEX2_1	347	349	PF00082	0.719
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.802
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.719
CLV_PCSK_PC7_1	24	30	PF00082	0.403
CLV_PCSK_SKI1_1	158	162	PF00082	0.655
CLV_PCSK_SKI1_1	326	330	PF00082	0.796
CLV_PCSK_SKI1_1	344	348	PF00082	0.605
CLV_PCSK_SKI1_1	359	363	PF00082	0.594
CLV_PCSK_SKI1_1	396	400	PF00082	0.482
CLV_PCSK_SKI1_1	83	87	PF00082	0.626
CLV_Separin_Metazoa	252	256	PF03568	0.571
DEG_APCC_DBOX_1	201	209	PF00400	0.507
DEG_SCF_FBW7_2	149	156	PF00400	0.546
DOC_CDC14_PxL_1	33	41	PF14671	0.244
DOC_CKS1_1	150	155	PF01111	0.468
DOC_CKS1_1	32	37	PF01111	0.244
DOC_CYCLIN_RxL_1	200	209	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.244
DOC_MAPK_DCC_7	100	109	PF00069	0.582
DOC_MAPK_DCC_7	28	38	PF00069	0.427
DOC_MAPK_FxFP_2	362	365	PF00069	0.439
DOC_MAPK_gen_1	324	331	PF00069	0.439
DOC_MAPK_gen_1	68	78	PF00069	0.413
DOC_MAPK_MEF2A_6	100	109	PF00069	0.582
DOC_MAPK_MEF2A_6	71	80	PF00069	0.413
DOC_PP1_RVXF_1	357	363	PF00149	0.404
DOC_PP2B_LxvP_1	170	173	PF13499	0.575
DOC_PP2B_LxvP_1	175	178	PF13499	0.546
DOC_PP2B_LxvP_1	38	41	PF13499	0.244
DOC_PP4_FxxP_1	150	153	PF00568	0.547
DOC_PP4_FxxP_1	362	365	PF00568	0.439
DOC_USP7_MATH_1	114	118	PF00917	0.501
DOC_USP7_MATH_1	216	220	PF00917	0.527
DOC_USP7_MATH_1	287	291	PF00917	0.617
DOC_USP7_MATH_1	351	355	PF00917	0.494
DOC_USP7_MATH_1	99	103	PF00917	0.522
DOC_WW_Pin1_4	149	154	PF00397	0.475
DOC_WW_Pin1_4	15	20	PF00397	0.608
DOC_WW_Pin1_4	191	196	PF00397	0.442
DOC_WW_Pin1_4	297	302	PF00397	0.458
DOC_WW_Pin1_4	31	36	PF00397	0.575
DOC_WW_Pin1_4	330	335	PF00397	0.614
LIG_14-3-3_CanoR_1	174	178	PF00244	0.572
LIG_14-3-3_CanoR_1	185	191	PF00244	0.550
LIG_14-3-3_CanoR_1	237	243	PF00244	0.522
LIG_14-3-3_CanoR_1	98	108	PF00244	0.569
LIG_Actin_WH2_2	399	416	PF00022	0.304
LIG_FHA_1	167	173	PF00498	0.489
LIG_FHA_1	248	254	PF00498	0.551
LIG_FHA_2	116	122	PF00498	0.450
LIG_FHA_2	239	245	PF00498	0.440
LIG_HP1_1	204	208	PF01393	0.498
LIG_IBAR_NPY_1	256	258	PF08397	0.566
LIG_LIR_Apic_2	31	35	PF02991	0.427
LIG_LIR_Gen_1	232	240	PF02991	0.490
LIG_LIR_Gen_1	314	323	PF02991	0.505
LIG_LIR_Gen_1	339	350	PF02991	0.532
LIG_LIR_Gen_1	387	395	PF02991	0.468
LIG_LIR_Nem_3	130	135	PF02991	0.608
LIG_LIR_Nem_3	152	157	PF02991	0.461
LIG_LIR_Nem_3	232	236	PF02991	0.419
LIG_LIR_Nem_3	314	319	PF02991	0.512
LIG_LIR_Nem_3	339	345	PF02991	0.536
LIG_LIR_Nem_3	387	391	PF02991	0.431
LIG_MYND_1	195	199	PF01753	0.388
LIG_MYND_1	37	41	PF01753	0.492
LIG_Pex14_1	411	415	PF04695	0.433
LIG_Pex14_2	150	154	PF04695	0.542
LIG_REV1ctd_RIR_1	389	396	PF16727	0.487
LIG_SH2_STAT5	235	238	PF00017	0.517
LIG_SH2_STAT5	356	359	PF00017	0.426
LIG_SH2_STAT5	388	391	PF00017	0.429
LIG_SH3_3	13	19	PF00018	0.610
LIG_SH3_3	192	198	PF00018	0.462
LIG_SH3_3	251	257	PF00018	0.570
LIG_SH3_3	93	99	PF00018	0.471
LIG_SUMO_SIM_par_1	203	209	PF11976	0.431
LIG_SUMO_SIM_par_1	269	274	PF11976	0.420
LIG_SUMO_SIM_par_1	45	52	PF11976	0.244
LIG_UBA3_1	270	275	PF00899	0.519
MOD_CDK_SPxK_1	149	155	PF00069	0.589
MOD_CK1_1	193	199	PF00069	0.610
MOD_CK1_1	217	223	PF00069	0.590
MOD_CK1_1	291	297	PF00069	0.814
MOD_CK1_1	51	57	PF00069	0.578
MOD_CK2_1	287	293	PF00069	0.800
MOD_CK2_1	78	84	PF00069	0.501
MOD_GlcNHglycan	144	147	PF01048	0.712
MOD_GlcNHglycan	208	211	PF01048	0.559
MOD_GlcNHglycan	290	293	PF01048	0.717
MOD_GlcNHglycan	294	297	PF01048	0.716
MOD_GSK3_1	124	131	PF00069	0.600
MOD_GSK3_1	133	140	PF00069	0.485
MOD_GSK3_1	216	223	PF00069	0.659
MOD_GSK3_1	287	294	PF00069	0.711
MOD_GSK3_1	314	321	PF00069	0.567
MOD_GSK3_1	332	339	PF00069	0.707
MOD_GSK3_1	377	384	PF00069	0.699
MOD_GSK3_1	5	12	PF00069	0.549
MOD_N-GLC_1	262	267	PF02516	0.493
MOD_N-GLC_1	366	371	PF02516	0.513
MOD_N-GLC_1	87	92	PF02516	0.550
MOD_NEK2_1	271	276	PF00069	0.697
MOD_NEK2_1	398	403	PF00069	0.390
MOD_NEK2_1	49	54	PF00069	0.465
MOD_NEK2_1	62	67	PF00069	0.506
MOD_NEK2_1	78	83	PF00069	0.564
MOD_NEK2_2	133	138	PF00069	0.534
MOD_PIKK_1	302	308	PF00454	0.654
MOD_PIKK_1	381	387	PF00454	0.711
MOD_PIKK_1	5	11	PF00454	0.520
MOD_PK_1	100	106	PF00069	0.536
MOD_PKA_2	173	179	PF00069	0.669
MOD_PKA_2	184	190	PF00069	0.711
MOD_PKA_2	99	105	PF00069	0.744
MOD_PKB_1	98	106	PF00069	0.540
MOD_Plk_1	314	320	PF00069	0.598
MOD_Plk_1	366	372	PF00069	0.488
MOD_Plk_1	377	383	PF00069	0.655
MOD_Plk_1	54	60	PF00069	0.578
MOD_Plk_2-3	124	130	PF00069	0.623
MOD_Plk_2-3	247	253	PF00069	0.654
MOD_Plk_2-3	377	383	PF00069	0.453
MOD_Plk_4	217	223	PF00069	0.407
MOD_Plk_4	238	244	PF00069	0.504
MOD_Plk_4	366	372	PF00069	0.523
MOD_ProDKin_1	149	155	PF00069	0.589
MOD_ProDKin_1	15	21	PF00069	0.497
MOD_ProDKin_1	191	197	PF00069	0.532
MOD_ProDKin_1	297	303	PF00069	0.568
MOD_ProDKin_1	31	37	PF00069	0.451
MOD_ProDKin_1	330	336	PF00069	0.785
TRG_DiLeu_BaEn_1	266	271	PF01217	0.489
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.475
TRG_ENDOCYTIC_2	388	391	PF00928	0.458
TRG_ER_diArg_1	24	26	PF00400	0.747
TRG_ER_diArg_1	28	30	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P428	Leptomonas seymouri	49%	100%
A0A3S7WT47	Leishmania donovani	71%	100%
A4HW50	Leishmania infantum	71%	100%
E9APV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4QFM7	Leishmania major	71%	100%