Ubiquinone biosynthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COQ9, putative

Species:

Leishmania braziliensis

UniProt:

A4H7Q9_LEIBR

TriTrypDb:

LbrM.14.1040

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A4H7Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Q9

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	11
GO:0006744	ubiquinone biosynthetic process	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11
GO:0042181	ketone biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901661	quinone metabolic process	4	11
GO:1901663	quinone biosynthetic process	5	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.569
CLV_NRD_NRD_1	175	177	PF00675	0.538
CLV_PCSK_KEX2_1	175	177	PF00082	0.538
CLV_PCSK_KEX2_1	231	233	PF00082	0.425
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.458
CLV_PCSK_PC7_1	227	233	PF00082	0.287
CLV_PCSK_SKI1_1	102	106	PF00082	0.582
CLV_PCSK_SKI1_1	114	118	PF00082	0.479
CLV_PCSK_SKI1_1	163	167	PF00082	0.538
CLV_PCSK_SKI1_1	175	179	PF00082	0.535
CLV_PCSK_SKI1_1	205	209	PF00082	0.484
CLV_PCSK_SKI1_1	258	262	PF00082	0.448
DEG_APCC_DBOX_1	113	121	PF00400	0.252
DEG_APCC_DBOX_1	204	212	PF00400	0.310
DEG_Nend_UBRbox_4	1	3	PF02207	0.654
DEG_SPOP_SBC_1	241	245	PF00917	0.535
DOC_MAPK_gen_1	231	237	PF00069	0.424
DOC_PP1_RVXF_1	117	123	PF00149	0.250
DOC_PP1_RVXF_1	223	229	PF00149	0.331
DOC_PP2B_LxvP_1	103	106	PF13499	0.566
DOC_PP4_FxxP_1	122	125	PF00568	0.265
DOC_USP7_MATH_1	182	186	PF00917	0.592
DOC_USP7_MATH_1	212	216	PF00917	0.405
DOC_USP7_MATH_1	219	223	PF00917	0.512
DOC_USP7_MATH_1	242	246	PF00917	0.384
DOC_WW_Pin1_4	3	8	PF00397	0.570
LIG_14-3-3_CanoR_1	163	168	PF00244	0.511
LIG_BRCT_BRCA1_1	50	54	PF00533	0.475
LIG_FHA_1	12	18	PF00498	0.434
LIG_FHA_1	162	168	PF00498	0.278
LIG_FHA_1	19	25	PF00498	0.363
LIG_FHA_1	221	227	PF00498	0.570
LIG_FHA_1	241	247	PF00498	0.526
LIG_FHA_1	255	261	PF00498	0.260
LIG_FHA_2	164	170	PF00498	0.551
LIG_LIR_Apic_2	121	125	PF02991	0.270
LIG_NRBOX	166	172	PF00104	0.523
LIG_PAM2_1	129	141	PF00658	0.539
LIG_Pex14_2	203	207	PF04695	0.410
LIG_Pex14_2	54	58	PF04695	0.397
LIG_PTB_Apo_2	52	59	PF02174	0.515
LIG_SH2_CRK	145	149	PF00017	0.427
LIG_SH2_NCK_1	145	149	PF00017	0.427
LIG_SH2_SRC	138	141	PF00017	0.569
LIG_SH2_SRC	218	221	PF00017	0.396
LIG_SH2_STAT5	138	141	PF00017	0.482
LIG_SH2_STAT5	145	148	PF00017	0.481
LIG_SUMO_SIM_par_1	58	64	PF11976	0.370
LIG_TYR_ITIM	143	148	PF00017	0.440
LIG_Vh1_VBS_1	143	161	PF01044	0.528
MOD_CK1_1	18	24	PF00069	0.481
MOD_CK1_1	198	204	PF00069	0.507
MOD_CK1_1	37	43	PF00069	0.507
MOD_CK1_1	90	96	PF00069	0.494
MOD_CK2_1	115	121	PF00069	0.435
MOD_CK2_1	163	169	PF00069	0.513
MOD_GlcNHglycan	131	134	PF01048	0.479
MOD_GlcNHglycan	198	201	PF01048	0.355
MOD_GlcNHglycan	214	217	PF01048	0.446
MOD_GSK3_1	11	18	PF00069	0.467
MOD_GSK3_1	195	202	PF00069	0.428
MOD_GSK3_1	23	30	PF00069	0.323
MOD_GSK3_1	254	261	PF00069	0.469
MOD_N-GLC_1	30	35	PF02516	0.404
MOD_N-GLC_2	71	73	PF02516	0.276
MOD_NEK2_1	153	158	PF00069	0.371
MOD_NEK2_1	161	166	PF00069	0.403
MOD_NEK2_1	34	39	PF00069	0.440
MOD_PKA_2	24	30	PF00069	0.368
MOD_Plk_1	154	160	PF00069	0.393
MOD_Plk_1	219	225	PF00069	0.379
MOD_Plk_1	30	36	PF00069	0.403
MOD_Plk_4	143	149	PF00069	0.518
MOD_Plk_4	154	160	PF00069	0.464
MOD_Plk_4	199	205	PF00069	0.511
MOD_Plk_4	242	248	PF00069	0.414
MOD_ProDKin_1	3	9	PF00069	0.563
MOD_SUMO_rev_2	96	104	PF00179	0.521
TRG_DiLeu_BaEn_1	100	105	PF01217	0.321
TRG_ENDOCYTIC_2	145	148	PF00928	0.515
TRG_ER_diArg_1	175	177	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P430	Leptomonas seymouri	61%	100%
A0A1X0NP57	Trypanosomatidae	35%	96%
A0A3Q8IC23	Leishmania donovani	77%	100%
A0A422MQP2	Trypanosoma rangeli	37%	96%
A4HW47	Leishmania infantum	78%	100%
C9ZSX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	88%
E9APV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QFN0	Leishmania major	76%	100%
V5BEC0	Trypanosoma cruzi	34%	96%