DUF1656 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H7Q8_LEIBR

TriTrypDb:

LbrM.14.1030

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H7Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.387
DOC_CKS1_1	188	193	PF01111	0.535
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.573
DOC_MAPK_DCC_7	98	106	PF00069	0.579
DOC_MAPK_MEF2A_6	166	173	PF00069	0.196
DOC_PP1_RVXF_1	155	162	PF00149	0.314
DOC_USP7_MATH_1	184	188	PF00917	0.655
DOC_WW_Pin1_4	187	192	PF00397	0.601
DOC_WW_Pin1_4	86	91	PF00397	0.583
LIG_14-3-3_CanoR_1	166	172	PF00244	0.241
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BRCT_BRCA1_1	122	126	PF00533	0.315
LIG_FHA_1	127	133	PF00498	0.373
LIG_FHA_1	168	174	PF00498	0.351
LIG_FHA_1	18	24	PF00498	0.471
LIG_FHA_1	183	189	PF00498	0.679
LIG_FHA_1	53	59	PF00498	0.319
LIG_FHA_1	62	68	PF00498	0.271
LIG_FHA_1	79	85	PF00498	0.637
LIG_FHA_2	191	197	PF00498	0.566
LIG_LIR_Gen_1	24	33	PF02991	0.359
LIG_LIR_Gen_1	64	72	PF02991	0.408
LIG_LIR_Gen_1	9	19	PF02991	0.637
LIG_LIR_LC3C_4	129	132	PF02991	0.343
LIG_LIR_Nem_3	162	168	PF02991	0.283
LIG_LIR_Nem_3	24	28	PF02991	0.299
LIG_LIR_Nem_3	64	68	PF02991	0.436
LIG_LIR_Nem_3	9	15	PF02991	0.593
LIG_NRBOX	12	18	PF00104	0.505
LIG_NRBOX	120	126	PF00104	0.241
LIG_PCNA_PIPBox_1	152	161	PF02747	0.338
LIG_PCNA_yPIPBox_3	152	166	PF02747	0.291
LIG_Pex14_1	59	63	PF04695	0.196
LIG_Pex14_2	21	25	PF04695	0.288
LIG_PTB_Apo_2	144	151	PF02174	0.324
LIG_PTB_Phospho_1	144	150	PF10480	0.283
LIG_SH2_CRK	122	126	PF00017	0.374
LIG_SH2_STAP1	122	126	PF00017	0.352
LIG_SH2_STAT5	158	161	PF00017	0.367
LIG_SH2_STAT5	178	181	PF00017	0.256
LIG_SH2_STAT5	37	40	PF00017	0.319
LIG_SH3_3	185	191	PF00018	0.652
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.218
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.362
LIG_SUMO_SIM_par_1	29	35	PF11976	0.196
LIG_TRFH_1	3	7	PF08558	0.563
LIG_TYR_ITIM	120	125	PF00017	0.374
LIG_WRC_WIRS_1	62	67	PF05994	0.337
MOD_CDK_SPxxK_3	86	93	PF00069	0.599
MOD_CK1_1	187	193	PF00069	0.718
MOD_CK1_1	26	32	PF00069	0.349
MOD_CK1_1	75	81	PF00069	0.628
MOD_CK2_1	39	45	PF00069	0.365
MOD_GlcNHglycan	47	50	PF01048	0.649
MOD_GSK3_1	17	24	PF00069	0.461
MOD_GSK3_1	40	47	PF00069	0.354
MOD_GSK3_1	66	73	PF00069	0.323
MOD_GSK3_1	74	81	PF00069	0.597
MOD_GSK3_1	92	99	PF00069	0.593
MOD_N-GLC_1	45	50	PF02516	0.642
MOD_NEK2_1	120	125	PF00069	0.232
MOD_NEK2_1	159	164	PF00069	0.398
MOD_NEK2_1	167	172	PF00069	0.431
MOD_NEK2_1	21	26	PF00069	0.383
MOD_NEK2_1	63	68	PF00069	0.371
MOD_NEK2_1	72	77	PF00069	0.433
MOD_PIKK_1	107	113	PF00454	0.475
MOD_PIKK_1	182	188	PF00454	0.596
MOD_PIKK_1	75	81	PF00454	0.645
MOD_PKA_2	17	23	PF00069	0.514
MOD_Plk_1	39	45	PF00069	0.349
MOD_Plk_2-3	40	46	PF00069	0.329
MOD_Plk_4	102	108	PF00069	0.571
MOD_Plk_4	120	126	PF00069	0.264
MOD_Plk_4	184	190	PF00069	0.637
MOD_Plk_4	27	33	PF00069	0.333
MOD_Plk_4	8	14	PF00069	0.598
MOD_ProDKin_1	187	193	PF00069	0.608
MOD_ProDKin_1	86	92	PF00069	0.579
TRG_DiLeu_BaEn_2	7	13	PF01217	0.511
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.196
TRG_ENDOCYTIC_2	122	125	PF00928	0.366
TRG_ENDOCYTIC_2	150	153	PF00928	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I195	Leptomonas seymouri	67%	95%
A0A0S4IKP2	Bodo saltans	28%	91%
A0A0S4JKJ4	Bodo saltans	24%	86%
A0A3Q8I8V9	Leishmania donovani	79%	95%
E9ACR4	Leishmania major	81%	100%
E9AGL4	Leishmania infantum	79%	95%
E9APV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	95%