Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Q5_LEIBR

TriTrypDb:

LbrM.14.1000 , LBRM2903_140015900

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.537
CLV_NRD_NRD_1	207	209	PF00675	0.623
CLV_NRD_NRD_1	273	275	PF00675	0.707
CLV_NRD_NRD_1	314	316	PF00675	0.487
CLV_PCSK_KEX2_1	126	128	PF00082	0.614
CLV_PCSK_KEX2_1	20	22	PF00082	0.537
CLV_PCSK_KEX2_1	313	315	PF00082	0.484
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.574
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.484
CLV_PCSK_SKI1_1	105	109	PF00082	0.670
CLV_PCSK_SKI1_1	127	131	PF00082	0.563
DOC_CYCLIN_RxL_1	121	132	PF00134	0.552
DOC_MAPK_gen_1	215	224	PF00069	0.625
DOC_MAPK_gen_1	253	260	PF00069	0.633
DOC_MAPK_gen_1	274	281	PF00069	0.694
DOC_MAPK_JIP1_4	218	224	PF00069	0.685
DOC_USP7_MATH_1	306	310	PF00917	0.618
DOC_USP7_UBL2_3	205	209	PF12436	0.591
DOC_USP7_UBL2_3	290	294	PF12436	0.598
DOC_WW_Pin1_4	144	149	PF00397	0.787
LIG_14-3-3_CanoR_1	127	137	PF00244	0.622
LIG_14-3-3_CanoR_1	208	212	PF00244	0.671
LIG_14-3-3_CanoR_1	253	259	PF00244	0.600
LIG_APCC_ABBAyCdc20_2	126	132	PF00400	0.616
LIG_BRCT_BRCA1_1	40	44	PF00533	0.551
LIG_FHA_1	185	191	PF00498	0.673
LIG_FHA_1	296	302	PF00498	0.609
LIG_FHA_1	317	323	PF00498	0.482
LIG_LIR_Apic_2	254	259	PF02991	0.559
LIG_LIR_Gen_1	24	30	PF02991	0.548
LIG_LIR_Gen_1	291	297	PF02991	0.453
LIG_LIR_Gen_1	41	49	PF02991	0.503
LIG_LIR_Nem_3	210	214	PF02991	0.718
LIG_LIR_Nem_3	24	29	PF02991	0.546
LIG_LIR_Nem_3	291	295	PF02991	0.463
LIG_LIR_Nem_3	41	47	PF02991	0.506
LIG_LYPXL_yS_3	133	136	PF13949	0.589
LIG_MYND_1	259	263	PF01753	0.473
LIG_Pex14_1	26	30	PF04695	0.553
LIG_SH2_CRK	292	296	PF00017	0.508
LIG_SH2_CRK	63	67	PF00017	0.701
LIG_SH2_SRC	55	58	PF00017	0.706
LIG_SH2_STAT5	161	164	PF00017	0.699
LIG_SH2_STAT5	96	99	PF00017	0.529
LIG_SH3_1	63	69	PF00018	0.705
LIG_SH3_2	103	108	PF14604	0.644
LIG_SH3_3	100	106	PF00018	0.638
LIG_SH3_3	257	263	PF00018	0.649
LIG_SH3_3	63	69	PF00018	0.598
MOD_CDK_SPK_2	144	149	PF00069	0.636
MOD_CK1_1	285	291	PF00069	0.589
MOD_CK1_1	308	314	PF00069	0.481
MOD_CMANNOS	23	26	PF00535	0.537
MOD_GlcNHglycan	40	43	PF01048	0.631
MOD_GlcNHglycan	56	60	PF01048	0.536
MOD_GlcNHglycan	74	78	PF01048	0.722
MOD_GSK3_1	113	120	PF00069	0.571
MOD_GSK3_1	140	147	PF00069	0.673
MOD_GSK3_1	263	270	PF00069	0.572
MOD_GSK3_1	305	312	PF00069	0.568
MOD_GSK3_1	316	323	PF00069	0.617
MOD_N-GLC_1	295	300	PF02516	0.584
MOD_NEK2_1	297	302	PF00069	0.653
MOD_PIKK_1	295	301	PF00454	0.618
MOD_PK_1	320	326	PF00069	0.487
MOD_PKA_2	113	119	PF00069	0.713
MOD_PKA_2	207	213	PF00069	0.725
MOD_PKA_2	38	44	PF00069	0.550
MOD_PKA_2	86	92	PF00069	0.631
MOD_Plk_1	282	288	PF00069	0.663
MOD_ProDKin_1	144	150	PF00069	0.786
MOD_SUMO_rev_2	202	207	PF00179	0.693
TRG_ENDOCYTIC_2	133	136	PF00928	0.589
TRG_ENDOCYTIC_2	211	214	PF00928	0.668
TRG_ENDOCYTIC_2	292	295	PF00928	0.506
TRG_ENDOCYTIC_2	96	99	PF00928	0.529
TRG_ER_diArg_1	179	182	PF00400	0.537
TRG_ER_diArg_1	314	316	PF00400	0.487
TRG_NES_CRM1_1	90	102	PF08389	0.626
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK5	Leptomonas seymouri	75%	100%
A0A0S4J633	Bodo saltans	40%	81%
A0A1X0NNI6	Trypanosomatidae	58%	100%
A0A3Q8ID70	Leishmania donovani	90%	100%
A0A422N494	Trypanosoma rangeli	58%	100%
A4HW44	Leishmania infantum	89%	100%
C9ZSX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9APU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFN3	Leishmania major	92%	100%
V5BJ00	Trypanosoma cruzi	58%	100%