Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Q3_LEIBR

TriTrypDb:

LbrM.14.0980 , LBRM2903_140015500

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005743	mitochondrial inner membrane	5	3
GO:0019866	organelle inner membrane	4	3
GO:0031090	organelle membrane	3	3
GO:0031966	mitochondrial membrane	4	3

Expansion

Sequence features

A4H7Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006820	monoatomic anion transport	5	3
GO:0006862	nucleotide transport	6	3
GO:0009987	cellular process	1	3
GO:0015711	organic anion transport	5	3
GO:0015748	organophosphate ester transport	5	3
GO:0015865	purine nucleotide transport	7	3
GO:0015866	ADP transport	6	3
GO:0015867	ATP transport	6	3
GO:0015868	purine ribonucleotide transport	6	3
GO:0015931	nucleobase-containing compound transport	5	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051503	adenine nucleotide transport	8	3
GO:0055085	transmembrane transport	2	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0072530	purine-containing compound transmembrane transport	3	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0140021	mitochondrial ADP transmembrane transport	4	3
GO:1901264	carbohydrate derivative transport	5	3
GO:1901679	nucleotide transmembrane transport	3	3
GO:1990542	mitochondrial transmembrane transport	3	3
GO:1990544	mitochondrial ATP transmembrane transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	3
GO:0005215	transporter activity	1	3
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	3
GO:0005347	ATP transmembrane transporter activity	5	3
GO:0005471	ATP:ADP antiporter activity	5	3
GO:0008509	monoatomic anion transmembrane transporter activity	4	3
GO:0008514	organic anion transmembrane transporter activity	5	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015215	nucleotide transmembrane transporter activity	4	3
GO:0015216	purine nucleotide transmembrane transporter activity	5	3
GO:0015217	ADP transmembrane transporter activity	5	3
GO:0015291	secondary active transmembrane transporter activity	4	3
GO:0015297	antiporter activity	5	3
GO:0015605	organophosphate ester transmembrane transporter activity	3	3
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	3
GO:0022804	active transmembrane transporter activity	3	3
GO:0022853	active monoatomic ion transmembrane transporter activity	4	3
GO:0022857	transmembrane transporter activity	2	3
GO:0140323	obsolete solute:monoatomic anion antiporter activity	6	3
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.590
CLV_NRD_NRD_1	254	256	PF00675	0.558
CLV_NRD_NRD_1	331	333	PF00675	0.531
CLV_NRD_NRD_1	37	39	PF00675	0.374
CLV_NRD_NRD_1	389	391	PF00675	0.435
CLV_NRD_NRD_1	406	408	PF00675	0.349
CLV_PCSK_KEX2_1	177	179	PF00082	0.575
CLV_PCSK_KEX2_1	22	24	PF00082	0.595
CLV_PCSK_KEX2_1	254	256	PF00082	0.561
CLV_PCSK_KEX2_1	37	39	PF00082	0.368
CLV_PCSK_KEX2_1	389	391	PF00082	0.435
CLV_PCSK_KEX2_1	406	408	PF00082	0.349
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.513
CLV_PCSK_PC7_1	173	179	PF00082	0.503
CLV_PCSK_SKI1_1	267	271	PF00082	0.382
CLV_PCSK_SKI1_1	276	280	PF00082	0.402
CLV_PCSK_SKI1_1	325	329	PF00082	0.240
CLV_PCSK_SKI1_1	362	366	PF00082	0.387
CLV_PCSK_SKI1_1	37	41	PF00082	0.514
CLV_PCSK_SKI1_1	393	397	PF00082	0.339
CLV_PCSK_SKI1_1	85	89	PF00082	0.408
DEG_APCC_DBOX_1	324	332	PF00400	0.411
DOC_CDC14_PxL_1	203	211	PF14671	0.240
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	352	358	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.654
DOC_MAPK_gen_1	149	157	PF00069	0.623
DOC_MAPK_gen_1	177	184	PF00069	0.332
DOC_MAPK_gen_1	219	227	PF00069	0.629
DOC_USP7_MATH_1	106	110	PF00917	0.740
DOC_USP7_MATH_1	111	115	PF00917	0.782
DOC_USP7_MATH_1	126	130	PF00917	0.503
DOC_USP7_MATH_1	171	175	PF00917	0.594
DOC_USP7_MATH_1	193	197	PF00917	0.473
DOC_USP7_MATH_1	438	442	PF00917	0.349
DOC_USP7_MATH_1	5	9	PF00917	0.611
DOC_USP7_MATH_1	54	58	PF00917	0.714
DOC_USP7_MATH_1	76	80	PF00917	0.674
DOC_WW_Pin1_4	117	122	PF00397	0.793
DOC_WW_Pin1_4	16	21	PF00397	0.703
LIG_14-3-3_CanoR_1	127	131	PF00244	0.548
LIG_14-3-3_CanoR_1	200	206	PF00244	0.406
LIG_14-3-3_CanoR_1	219	229	PF00244	0.604
LIG_14-3-3_CanoR_1	258	266	PF00244	0.629
LIG_14-3-3_CanoR_1	290	295	PF00244	0.659
LIG_14-3-3_CanoR_1	37	44	PF00244	0.739
LIG_14-3-3_CanoR_1	58	62	PF00244	0.726
LIG_Actin_WH2_2	206	221	PF00022	0.489
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_BRCT_BRCA1_1	78	82	PF00533	0.511
LIG_Clathr_ClatBox_1	88	92	PF01394	0.630
LIG_FHA_1	206	212	PF00498	0.333
LIG_FHA_1	222	228	PF00498	0.558
LIG_FHA_1	232	238	PF00498	0.682
LIG_FHA_1	421	427	PF00498	0.492
LIG_FHA_1	63	69	PF00498	0.670
LIG_FHA_2	114	120	PF00498	0.614
LIG_FHA_2	159	165	PF00498	0.366
LIG_FHA_2	394	400	PF00498	0.465
LIG_FHA_2	58	64	PF00498	0.724
LIG_GBD_Chelix_1	168	176	PF00786	0.450
LIG_LIR_Gen_1	196	206	PF02991	0.290
LIG_LIR_Nem_3	129	134	PF02991	0.621
LIG_LIR_Nem_3	196	201	PF02991	0.290
LIG_LIR_Nem_3	263	269	PF02991	0.626
LIG_LIR_Nem_3	305	310	PF02991	0.610
LIG_LIR_Nem_3	432	436	PF02991	0.429
LIG_LYPXL_yS_3	436	439	PF13949	0.349
LIG_PCNA_yPIPBox_3	267	279	PF02747	0.501
LIG_RPA_C_Fungi	330	342	PF08784	0.240
LIG_SH2_CRK	310	314	PF00017	0.476
LIG_SH2_NCK_1	10	14	PF00017	0.520
LIG_SH2_NCK_1	259	263	PF00017	0.490
LIG_SH2_SRC	10	13	PF00017	0.521
LIG_SH2_STAP1	10	14	PF00017	0.520
LIG_SH2_STAP1	310	314	PF00017	0.240
LIG_SH3_3	234	240	PF00018	0.688
LIG_SH3_3	297	303	PF00018	0.591
LIG_SH3_3	434	440	PF00018	0.668
LIG_SUMO_SIM_anti_2	65	72	PF11976	0.525
LIG_SUMO_SIM_par_1	180	185	PF11976	0.514
LIG_SUMO_SIM_par_1	207	212	PF11976	0.331
LIG_SUMO_SIM_par_1	65	72	PF11976	0.491
LIG_UBA3_1	328	333	PF00899	0.405
LIG_WRC_WIRS_1	159	164	PF05994	0.490
LIG_WRC_WIRS_1	430	435	PF05994	0.526
LIG_WRC_WIRS_1	439	444	PF05994	0.453
MOD_CDC14_SPxK_1	19	22	PF00782	0.508
MOD_CDK_SPxK_1	16	22	PF00069	0.510
MOD_CDK_SPxxK_3	117	124	PF00069	0.720
MOD_CDK_SPxxK_3	16	23	PF00069	0.511
MOD_CK1_1	212	218	PF00069	0.538
MOD_CK1_1	241	247	PF00069	0.622
MOD_CK1_1	323	329	PF00069	0.279
MOD_CK1_1	57	63	PF00069	0.629
MOD_CK1_1	74	80	PF00069	0.478
MOD_CK2_1	113	119	PF00069	0.513
MOD_CK2_1	158	164	PF00069	0.436
MOD_CK2_1	258	264	PF00069	0.497
MOD_GlcNHglycan	1	4	PF01048	0.717
MOD_GlcNHglycan	140	145	PF01048	0.593
MOD_GlcNHglycan	186	189	PF01048	0.490
MOD_GlcNHglycan	260	263	PF01048	0.529
MOD_GlcNHglycan	442	445	PF01048	0.683
MOD_GlcNHglycan	78	81	PF01048	0.491
MOD_GSK3_1	113	120	PF00069	0.697
MOD_GSK3_1	201	208	PF00069	0.395
MOD_GSK3_1	217	224	PF00069	0.450
MOD_GSK3_1	238	245	PF00069	0.619
MOD_GSK3_1	53	60	PF00069	0.622
MOD_GSK3_1	74	81	PF00069	0.510
MOD_N-GLC_1	314	319	PF02516	0.376
MOD_N-GLC_1	375	380	PF02516	0.498
MOD_NEK2_1	182	187	PF00069	0.526
MOD_NEK2_1	199	204	PF00069	0.399
MOD_NEK2_1	209	214	PF00069	0.334
MOD_NEK2_1	230	235	PF00069	0.588
MOD_NEK2_1	296	301	PF00069	0.534
MOD_NEK2_1	314	319	PF00069	0.357
MOD_NEK2_1	382	387	PF00069	0.712
MOD_NEK2_1	421	426	PF00069	0.391
MOD_NEK2_1	429	434	PF00069	0.528
MOD_NEK2_1	71	76	PF00069	0.542
MOD_NEK2_2	126	131	PF00069	0.613
MOD_NEK2_2	217	222	PF00069	0.291
MOD_NEK2_2	320	325	PF00069	0.413
MOD_PIKK_1	242	248	PF00454	0.524
MOD_PKA_1	37	43	PF00069	0.693
MOD_PKA_2	126	132	PF00069	0.424
MOD_PKA_2	199	205	PF00069	0.240
MOD_PKA_2	221	227	PF00069	0.485
MOD_PKA_2	241	247	PF00069	0.448
MOD_PKA_2	37	43	PF00069	0.693
MOD_PKA_2	57	63	PF00069	0.352
MOD_Plk_1	231	237	PF00069	0.618
MOD_Plk_1	40	46	PF00069	0.693
MOD_Plk_4	126	132	PF00069	0.384
MOD_Plk_4	158	164	PF00069	0.406
MOD_Plk_4	193	199	PF00069	0.476
MOD_Plk_4	205	211	PF00069	0.453
MOD_Plk_4	422	428	PF00069	0.492
MOD_Plk_4	78	84	PF00069	0.555
MOD_ProDKin_1	117	123	PF00069	0.763
MOD_ProDKin_1	16	22	PF00069	0.641
TRG_DiLeu_BaEn_1	164	169	PF01217	0.240
TRG_DiLeu_BaEn_4	34	40	PF01217	0.664
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.568
TRG_ENDOCYTIC_2	310	313	PF00928	0.386
TRG_ENDOCYTIC_2	436	439	PF00928	0.423
TRG_ER_diArg_1	21	23	PF00400	0.769
TRG_ER_diArg_1	254	256	PF00400	0.713
TRG_ER_diArg_1	329	332	PF00400	0.402
TRG_ER_diArg_1	359	362	PF00400	0.394
TRG_ER_diArg_1	37	39	PF00400	0.434
TRG_ER_diArg_1	388	390	PF00400	0.514
TRG_ER_diArg_1	405	407	PF00400	0.425
TRG_NLS_MonoExtN_4	330	336	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD69	Leptomonas seymouri	25%	100%
A0A1X0NP33	Trypanosomatidae	24%	100%
A0A3Q8I9V0	Leishmania donovani	72%	100%
A4HW42	Leishmania infantum	71%	100%
C9ZSY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9APU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QFN5	Leishmania major	72%	100%