ADP/ATP translocase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ADP/ATP translocase

Gene product:

ADP/ATP mitochondrial carrier-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7Q2_LEIBR

TriTrypDb:

LbrM.14.0970 , LBRM2903_140015400

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	14
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	14
GO:0031090	organelle membrane	3	14
GO:0031966	mitochondrial membrane	4	14
GO:0110165	cellular anatomical entity	1	14
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H7Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Q2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0006811	monoatomic ion transport	4	14
GO:0006820	monoatomic anion transport	5	14
GO:0006862	nucleotide transport	6	14
GO:0009987	cellular process	1	14
GO:0015711	organic anion transport	5	14
GO:0015748	organophosphate ester transport	5	14
GO:0015865	purine nucleotide transport	7	14
GO:0015866	ADP transport	6	14
GO:0015867	ATP transport	6	14
GO:0015868	purine ribonucleotide transport	6	14
GO:0015931	nucleobase-containing compound transport	5	14
GO:0034220	monoatomic ion transmembrane transport	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051503	adenine nucleotide transport	8	14
GO:0055085	transmembrane transport	2	14
GO:0071702	organic substance transport	4	14
GO:0071705	nitrogen compound transport	4	14
GO:0072530	purine-containing compound transmembrane transport	3	14
GO:0098656	monoatomic anion transmembrane transport	4	14
GO:0140021	mitochondrial ADP transmembrane transport	4	14
GO:1901264	carbohydrate derivative transport	5	14
GO:1901679	nucleotide transmembrane transport	3	14
GO:1990542	mitochondrial transmembrane transport	3	14
GO:1990544	mitochondrial ATP transmembrane transport	4	14

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	14
GO:0005215	transporter activity	1	14
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	14
GO:0005347	ATP transmembrane transporter activity	5	14
GO:0005471	ATP:ADP antiporter activity	5	14
GO:0008509	monoatomic anion transmembrane transporter activity	4	14
GO:0008514	organic anion transmembrane transporter activity	5	14
GO:0015075	monoatomic ion transmembrane transporter activity	3	14
GO:0015215	nucleotide transmembrane transporter activity	4	14
GO:0015216	purine nucleotide transmembrane transporter activity	5	14
GO:0015217	ADP transmembrane transporter activity	5	14
GO:0015291	secondary active transmembrane transporter activity	4	14
GO:0015297	antiporter activity	5	14
GO:0015605	organophosphate ester transmembrane transporter activity	3	14
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	14
GO:0022804	active transmembrane transporter activity	3	14
GO:0022853	active monoatomic ion transmembrane transporter activity	4	14
GO:0022857	transmembrane transporter activity	2	14
GO:0140323	obsolete solute:monoatomic anion antiporter activity	6	14
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.349
CLV_NRD_NRD_1	178	180	PF00675	0.364
CLV_NRD_NRD_1	248	250	PF00675	0.309
CLV_NRD_NRD_1	312	314	PF00675	0.224
CLV_PCSK_KEX2_1	248	250	PF00082	0.321
CLV_PCSK_KEX2_1	312	314	PF00082	0.225
CLV_PCSK_KEX2_1	325	327	PF00082	0.178
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.254
CLV_PCSK_SKI1_1	109	113	PF00082	0.276
CLV_PCSK_SKI1_1	313	317	PF00082	0.282
CLV_PCSK_SKI1_1	364	368	PF00082	0.538
CLV_PCSK_SKI1_1	54	58	PF00082	0.370
CLV_Separin_Metazoa	80	84	PF03568	0.495
DEG_APCC_DBOX_1	108	116	PF00400	0.435
DOC_CKS1_1	152	157	PF01111	0.329
DOC_CKS1_1	171	176	PF01111	0.365
DOC_CYCLIN_RxL_1	267	277	PF00134	0.416
DOC_CYCLIN_RxL_1	309	320	PF00134	0.492
DOC_CYCLIN_RxL_1	361	371	PF00134	0.309
DOC_CYCLIN_yCln2_LP_2	152	158	PF00134	0.229
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.392
DOC_MAPK_DCC_7	257	266	PF00069	0.534
DOC_MAPK_gen_1	351	358	PF00069	0.365
DOC_MAPK_MEF2A_6	351	358	PF00069	0.405
DOC_MAPK_RevD_3	297	313	PF00069	0.362
DOC_PP2B_LxvP_1	121	124	PF13499	0.270
DOC_USP7_MATH_1	163	167	PF00917	0.388
DOC_USP7_MATH_2	306	312	PF00917	0.286
DOC_WW_Pin1_4	151	156	PF00397	0.295
DOC_WW_Pin1_4	16	21	PF00397	0.728
DOC_WW_Pin1_4	170	175	PF00397	0.384
DOC_WW_Pin1_4	224	229	PF00397	0.756
DOC_WW_Pin1_4	4	9	PF00397	0.796
LIG_14-3-3_CanoR_1	353	359	PF00244	0.286
LIG_AP2alpha_1	127	131	PF02296	0.322
LIG_BH_BH3_1	288	304	PF00452	0.323
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_eIF4E_1	269	275	PF01652	0.345
LIG_EVH1_2	88	92	PF00568	0.440
LIG_FHA_1	131	137	PF00498	0.425
LIG_FHA_1	152	158	PF00498	0.333
LIG_FHA_1	196	202	PF00498	0.672
LIG_FHA_1	302	308	PF00498	0.401
LIG_FHA_2	195	201	PF00498	0.519
LIG_FHA_2	236	242	PF00498	0.535
LIG_FHA_2	315	321	PF00498	0.492
LIG_FHA_2	41	47	PF00498	0.546
LIG_FHA_2	73	79	PF00498	0.504
LIG_LIR_Gen_1	173	183	PF02991	0.551
LIG_LIR_Nem_3	173	178	PF02991	0.564
LIG_LIR_Nem_3	268	272	PF02991	0.333
LIG_LIR_Nem_3	28	34	PF02991	0.663
LIG_LIR_Nem_3	324	330	PF02991	0.484
LIG_LIR_Nem_3	344	350	PF02991	0.425
LIG_Pex14_1	252	256	PF04695	0.577
LIG_Pex14_2	127	131	PF04695	0.410
LIG_Pex14_2	92	96	PF04695	0.510
LIG_SH2_CRK	175	179	PF00017	0.557
LIG_SH2_CRK	269	273	PF00017	0.422
LIG_SH2_CRK	327	331	PF00017	0.469
LIG_SH2_NCK_1	236	240	PF00017	0.528
LIG_SH2_SRC	273	276	PF00017	0.491
LIG_SH2_STAT5	273	276	PF00017	0.437
LIG_SH3_3	14	20	PF00018	0.639
LIG_SH3_3	168	174	PF00018	0.350
LIG_SH3_3	61	67	PF00018	0.428
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.527
LIG_SUMO_SIM_par_1	118	125	PF11976	0.357
LIG_SUMO_SIM_par_1	156	161	PF11976	0.277
LIG_SUMO_SIM_par_1	262	268	PF11976	0.298
LIG_SUMO_SIM_par_1	304	311	PF11976	0.405
LIG_SUMO_SIM_par_1	354	360	PF11976	0.373
LIG_TRAF2_1	228	231	PF00917	0.688
LIG_TRAF2_1	36	39	PF00917	0.622
LIG_TYR_ITSM	171	178	PF00017	0.459
LIG_WRC_WIRS_1	128	133	PF05994	0.322
MOD_CK1_1	130	136	PF00069	0.365
MOD_CK1_1	237	243	PF00069	0.417
MOD_CK1_1	357	363	PF00069	0.423
MOD_CK1_1	370	376	PF00069	0.460
MOD_CK1_1	7	13	PF00069	0.693
MOD_CK2_1	235	241	PF00069	0.511
MOD_CK2_1	33	39	PF00069	0.698
MOD_CK2_1	72	78	PF00069	0.501
MOD_GlcNHglycan	124	127	PF01048	0.298
MOD_GlcNHglycan	165	168	PF01048	0.337
MOD_GlcNHglycan	23	26	PF01048	0.516
MOD_GlcNHglycan	347	350	PF01048	0.242
MOD_GlcNHglycan	35	38	PF01048	0.382
MOD_GlcNHglycan	372	375	PF01048	0.685
MOD_GSK3_1	158	165	PF00069	0.290
MOD_GSK3_1	204	211	PF00069	0.713
MOD_GSK3_1	235	242	PF00069	0.517
MOD_GSK3_1	274	281	PF00069	0.511
MOD_GSK3_1	3	10	PF00069	0.678
MOD_GSK3_1	341	348	PF00069	0.485
MOD_NEK2_1	127	132	PF00069	0.310
MOD_NEK2_1	162	167	PF00069	0.246
MOD_NEK2_1	274	279	PF00069	0.491
MOD_NEK2_1	314	319	PF00069	0.444
MOD_NEK2_1	354	359	PF00069	0.258
MOD_NEK2_1	40	45	PF00069	0.617
MOD_NEK2_1	60	65	PF00069	0.388
MOD_NEK2_1	72	77	PF00069	0.448
MOD_NEK2_2	362	367	PF00069	0.322
MOD_PIKK_1	301	307	PF00454	0.286
MOD_PKA_2	178	184	PF00069	0.553
MOD_PKA_2	234	240	PF00069	0.605
MOD_PKA_2	26	32	PF00069	0.582
MOD_Plk_1	27	33	PF00069	0.658
MOD_Plk_4	178	184	PF00069	0.451
MOD_Plk_4	274	280	PF00069	0.383
MOD_ProDKin_1	151	157	PF00069	0.294
MOD_ProDKin_1	16	22	PF00069	0.727
MOD_ProDKin_1	170	176	PF00069	0.380
MOD_ProDKin_1	224	230	PF00069	0.753
MOD_ProDKin_1	4	10	PF00069	0.796
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.332
TRG_ENDOCYTIC_2	175	178	PF00928	0.545
TRG_ENDOCYTIC_2	269	272	PF00928	0.323
TRG_ENDOCYTIC_2	327	330	PF00928	0.426
TRG_ENDOCYTIC_2	99	102	PF00928	0.509
TRG_ER_diArg_1	247	249	PF00400	0.530
TRG_ER_diArg_1	312	314	PF00400	0.411
TRG_NES_CRM1_1	305	320	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD69	Leptomonas seymouri	68%	100%
A0A0S4J2G4	Bodo saltans	32%	100%
A0A1X0NP33	Trypanosomatidae	28%	100%
A0A1X0NQ13	Trypanosomatidae	42%	100%
A0A3R7NBU8	Trypanosoma rangeli	32%	100%
A0A3S7WT37	Leishmania donovani	84%	100%
A0A422N466	Trypanosoma rangeli	43%	100%
A4HW41	Leishmania infantum	84%	100%
C9ZSY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9APU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QFN6	Leishmania major	81%	100%
Q7PQV7	Anopheles gambiae	21%	100%
V5BNE7	Trypanosoma cruzi	42%	100%