PRK domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7Q1_LEIBR

TriTrypDb:

LbrM.14.0950 , LBRM2903_140015200

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7Q1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.618
CLV_NRD_NRD_1	103	105	PF00675	0.483
CLV_NRD_NRD_1	88	90	PF00675	0.383
CLV_PCSK_KEX2_1	102	104	PF00082	0.406
CLV_PCSK_KEX2_1	88	90	PF00082	0.424
CLV_PCSK_SKI1_1	185	189	PF00082	0.407
CLV_PCSK_SKI1_1	34	38	PF00082	0.408
CLV_PCSK_SKI1_1	89	93	PF00082	0.506
DEG_APCC_DBOX_1	87	95	PF00400	0.346
DEG_COP1_1	132	139	PF00400	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.411
DOC_CKS1_1	122	127	PF01111	0.420
DOC_CYCLIN_RxL_1	85	93	PF00134	0.248
DOC_MAPK_DCC_7	3	12	PF00069	0.454
DOC_MAPK_MEF2A_6	3	12	PF00069	0.530
DOC_PP2B_LxvP_1	92	95	PF13499	0.436
DOC_USP7_MATH_1	218	222	PF00917	0.352
DOC_USP7_MATH_1	245	249	PF00917	0.616
DOC_USP7_MATH_1	61	65	PF00917	0.623
DOC_WW_Pin1_4	121	126	PF00397	0.412
DOC_WW_Pin1_4	169	174	PF00397	0.343
LIG_deltaCOP1_diTrp_1	174	182	PF00928	0.357
LIG_FHA_2	122	128	PF00498	0.425
LIG_LIR_Gen_1	172	182	PF02991	0.306
LIG_LIR_Nem_3	163	169	PF02991	0.274
LIG_LIR_Nem_3	172	178	PF02991	0.302
LIG_LIR_Nem_3	82	87	PF02991	0.309
LIG_PDZ_Class_1	245	250	PF00595	0.599
LIG_Pex14_2	135	139	PF04695	0.438
LIG_Rb_pABgroove_1	176	184	PF01858	0.360
LIG_SH2_NCK_1	131	135	PF00017	0.407
LIG_SH2_SRC	131	134	PF00017	0.416
LIG_SH2_STAP1	131	135	PF00017	0.441
LIG_SH2_STAT5	166	169	PF00017	0.310
LIG_SH3_3	131	137	PF00018	0.364
LIG_SH3_3	40	46	PF00018	0.616
LIG_SUMO_SIM_par_1	158	163	PF11976	0.293
LIG_TRAF2_2	46	51	PF00917	0.473
LIG_WRC_WIRS_1	136	141	PF05994	0.347
MOD_CDK_SPxxK_3	121	128	PF00069	0.426
MOD_CK1_1	59	65	PF00069	0.753
MOD_CK2_1	121	127	PF00069	0.422
MOD_CK2_1	207	213	PF00069	0.456
MOD_GlcNHglycan	155	158	PF01048	0.444
MOD_GlcNHglycan	218	221	PF01048	0.509
MOD_GlcNHglycan	30	33	PF01048	0.364
MOD_GlcNHglycan	71	74	PF01048	0.623
MOD_GSK3_1	106	113	PF00069	0.393
MOD_GSK3_1	117	124	PF00069	0.460
MOD_GSK3_1	205	212	PF00069	0.527
MOD_GSK3_1	216	223	PF00069	0.409
MOD_GSK3_1	239	246	PF00069	0.543
MOD_GSK3_1	56	63	PF00069	0.563
MOD_N-GLC_1	243	248	PF02516	0.526
MOD_NEK2_1	28	33	PF00069	0.322
MOD_PKA_2	216	222	PF00069	0.443
MOD_PKA_2	56	62	PF00069	0.588
MOD_Plk_1	106	112	PF00069	0.335
MOD_Plk_1	117	123	PF00069	0.356
MOD_ProDKin_1	121	127	PF00069	0.422
MOD_ProDKin_1	169	175	PF00069	0.335
MOD_SUMO_rev_2	180	187	PF00179	0.421
MOD_SUMO_rev_2	242	250	PF00179	0.572
TRG_ENDOCYTIC_2	131	134	PF00928	0.381
TRG_ER_diArg_1	101	104	PF00400	0.457
TRG_ER_diArg_1	87	89	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.455
TRG_PTS1	247	250	PF00515	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB45	Leptomonas seymouri	65%	85%
A0A0S4JJ70	Bodo saltans	36%	100%
A0A1X0NT00	Trypanosomatidae	52%	93%
A0A3Q8IA01	Leishmania donovani	82%	87%
A0A3R7K1F1	Trypanosoma rangeli	49%	100%
A4HW39	Leishmania infantum	83%	87%
A7A245	Saccharomyces cerevisiae (strain YJM789)	24%	71%
A7TQF3	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	25%	70%
B3LUL5	Saccharomyces cerevisiae (strain RM11-1a)	24%	71%
B5VI33	Saccharomyces cerevisiae (strain AWRI1631)	24%	71%
C5DNG5	Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)	25%	72%
C5DXG0	Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)	28%	67%
C7GYB3	Saccharomyces cerevisiae (strain JAY291)	24%	71%
C8Z7U0	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	24%	71%
E9APU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	87%
P43591	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	71%
Q4QFN8	Leishmania major	84%	100%
Q6CNA8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	71%
Q6FUM2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	72%
Q750K6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	75%
Q9UTC5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
V5AZD0	Trypanosoma cruzi	55%	100%