Putative immunodominant antigen

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tc40 antigen-like

Species:

Leishmania braziliensis

UniProt:

A4H7P6_LEIBR

TriTrypDb:

LbrM.14.0900 , LBRM2903_140014800

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	481	483	PF00675	0.565
CLV_NRD_NRD_1	50	52	PF00675	0.469
CLV_NRD_NRD_1	606	608	PF00675	0.600
CLV_NRD_NRD_1	653	655	PF00675	0.540
CLV_NRD_NRD_1	835	837	PF00675	0.546
CLV_PCSK_KEX2_1	481	483	PF00082	0.565
CLV_PCSK_KEX2_1	50	52	PF00082	0.469
CLV_PCSK_KEX2_1	605	607	PF00082	0.594
CLV_PCSK_KEX2_1	835	837	PF00082	0.558
CLV_PCSK_PC7_1	831	837	PF00082	0.410
CLV_PCSK_SKI1_1	16	20	PF00082	0.520
CLV_PCSK_SKI1_1	291	295	PF00082	0.457
CLV_PCSK_SKI1_1	297	301	PF00082	0.457
CLV_PCSK_SKI1_1	351	355	PF00082	0.482
CLV_PCSK_SKI1_1	386	390	PF00082	0.658
CLV_PCSK_SKI1_1	453	457	PF00082	0.647
CLV_PCSK_SKI1_1	492	496	PF00082	0.512
CLV_PCSK_SKI1_1	601	605	PF00082	0.531
CLV_PCSK_SKI1_1	63	67	PF00082	0.524
CLV_PCSK_SKI1_1	718	722	PF00082	0.518
CLV_PCSK_SKI1_1	807	811	PF00082	0.614
CLV_PCSK_SKI1_1	835	839	PF00082	0.576
CLV_Separin_Metazoa	602	606	PF03568	0.590
DEG_APCC_DBOX_1	604	612	PF00400	0.464
DEG_APCC_DBOX_1	675	683	PF00400	0.566
DEG_APCC_DBOX_1	834	842	PF00400	0.522
DEG_SPOP_SBC_1	527	531	PF00917	0.479
DOC_CKS1_1	499	504	PF01111	0.538
DOC_CKS1_1	613	618	PF01111	0.601
DOC_MAPK_gen_1	48	55	PF00069	0.485
DOC_PP1_RVXF_1	75	82	PF00149	0.471
DOC_PP2B_LxvP_1	560	563	PF13499	0.560
DOC_PP4_FxxP_1	142	145	PF00568	0.489
DOC_PP4_FxxP_1	404	407	PF00568	0.675
DOC_USP7_MATH_1	145	149	PF00917	0.389
DOC_USP7_MATH_1	192	196	PF00917	0.611
DOC_USP7_MATH_1	210	214	PF00917	0.418
DOC_USP7_MATH_1	252	256	PF00917	0.696
DOC_USP7_MATH_1	261	265	PF00917	0.613
DOC_USP7_MATH_1	269	273	PF00917	0.386
DOC_USP7_MATH_1	375	379	PF00917	0.761
DOC_USP7_MATH_1	418	422	PF00917	0.681
DOC_USP7_MATH_1	431	435	PF00917	0.590
DOC_USP7_MATH_1	543	547	PF00917	0.673
DOC_USP7_MATH_1	551	555	PF00917	0.559
DOC_USP7_MATH_1	563	567	PF00917	0.369
DOC_USP7_MATH_1	591	595	PF00917	0.547
DOC_USP7_MATH_1	644	648	PF00917	0.490
DOC_USP7_MATH_1	685	689	PF00917	0.609
DOC_USP7_MATH_1	87	91	PF00917	0.372
DOC_USP7_UBL2_3	125	129	PF12436	0.453
DOC_USP7_UBL2_3	16	20	PF12436	0.514
DOC_USP7_UBL2_3	806	810	PF12436	0.579
DOC_USP7_UBL2_3	839	843	PF12436	0.524
DOC_WW_Pin1_4	225	230	PF00397	0.527
DOC_WW_Pin1_4	371	376	PF00397	0.650
DOC_WW_Pin1_4	399	404	PF00397	0.627
DOC_WW_Pin1_4	498	503	PF00397	0.573
DOC_WW_Pin1_4	612	617	PF00397	0.606
DOC_WW_Pin1_4	68	73	PF00397	0.485
DOC_WW_Pin1_4	703	708	PF00397	0.658
DOC_WW_Pin1_4	779	784	PF00397	0.418
LIG_14-3-3_CanoR_1	121	125	PF00244	0.485
LIG_14-3-3_CanoR_1	198	208	PF00244	0.425
LIG_14-3-3_CanoR_1	224	229	PF00244	0.542
LIG_14-3-3_CanoR_1	291	296	PF00244	0.466
LIG_14-3-3_CanoR_1	297	302	PF00244	0.457
LIG_14-3-3_CanoR_1	340	345	PF00244	0.458
LIG_14-3-3_CanoR_1	351	356	PF00244	0.469
LIG_14-3-3_CanoR_1	547	555	PF00244	0.586
LIG_14-3-3_CanoR_1	641	647	PF00244	0.550
LIG_14-3-3_CanoR_1	724	732	PF00244	0.579
LIG_14-3-3_CanoR_1	747	753	PF00244	0.560
LIG_Actin_WH2_2	184	200	PF00022	0.375
LIG_Actin_WH2_2	466	483	PF00022	0.641
LIG_Actin_WH2_2	668	685	PF00022	0.557
LIG_APCC_ABBA_1	23	28	PF00400	0.451
LIG_APCC_ABBA_1	308	313	PF00400	0.457
LIG_APCC_ABBA_1	401	406	PF00400	0.546
LIG_BRCT_BRCA1_1	348	352	PF00533	0.544
LIG_BRCT_BRCA1_1	38	42	PF00533	0.410
LIG_BRCT_BRCA1_1	548	552	PF00533	0.586
LIG_BRCT_BRCA1_1	588	592	PF00533	0.434
LIG_BRCT_BRCA1_1	790	794	PF00533	0.490
LIG_BRCT_BRCA1_1	90	94	PF00533	0.454
LIG_eIF4E_1	555	561	PF01652	0.569
LIG_FHA_1	157	163	PF00498	0.418
LIG_FHA_1	172	178	PF00498	0.495
LIG_FHA_1	352	358	PF00498	0.480
LIG_FHA_1	400	406	PF00498	0.590
LIG_FHA_1	443	449	PF00498	0.508
LIG_FHA_1	493	499	PF00498	0.469
LIG_FHA_1	571	577	PF00498	0.564
LIG_FHA_1	659	665	PF00498	0.649
LIG_FHA_2	182	188	PF00498	0.389
LIG_FHA_2	580	586	PF00498	0.596
LIG_FHA_2	709	715	PF00498	0.589
LIG_FHA_2	780	786	PF00498	0.570
LIG_GBD_Chelix_1	490	498	PF00786	0.417
LIG_GBD_Chelix_1	789	797	PF00786	0.479
LIG_LIR_Apic_2	402	407	PF02991	0.665
LIG_LIR_Gen_1	138	145	PF02991	0.472
LIG_LIR_Gen_1	205	215	PF02991	0.470
LIG_LIR_Gen_1	349	360	PF02991	0.482
LIG_LIR_Gen_1	730	738	PF02991	0.504
LIG_LIR_Gen_1	75	86	PF02991	0.498
LIG_LIR_Gen_1	764	774	PF02991	0.502
LIG_LIR_Gen_1	791	801	PF02991	0.501
LIG_LIR_Gen_1	92	101	PF02991	0.425
LIG_LIR_Nem_3	138	142	PF02991	0.545
LIG_LIR_Nem_3	205	211	PF02991	0.512
LIG_LIR_Nem_3	292	298	PF02991	0.479
LIG_LIR_Nem_3	349	355	PF02991	0.495
LIG_LIR_Nem_3	39	45	PF02991	0.423
LIG_LIR_Nem_3	549	555	PF02991	0.579
LIG_LIR_Nem_3	75	81	PF02991	0.496
LIG_LIR_Nem_3	764	770	PF02991	0.507
LIG_LIR_Nem_3	791	797	PF02991	0.486
LIG_LIR_Nem_3	92	98	PF02991	0.415
LIG_NRBOX	556	562	PF00104	0.565
LIG_Pex14_1	626	630	PF04695	0.553
LIG_Pex14_1	97	101	PF04695	0.597
LIG_Pex14_2	204	208	PF04695	0.490
LIG_SH2_PTP2	95	98	PF00017	0.430
LIG_SH2_STAP1	172	176	PF00017	0.506
LIG_SH2_STAT5	127	130	PF00017	0.377
LIG_SH2_STAT5	45	48	PF00017	0.460
LIG_SH2_STAT5	630	633	PF00017	0.577
LIG_SH2_STAT5	719	722	PF00017	0.465
LIG_SH2_STAT5	731	734	PF00017	0.421
LIG_SH2_STAT5	95	98	PF00017	0.565
LIG_SH3_3	281	287	PF00018	0.552
LIG_SH3_3	412	418	PF00018	0.803
LIG_SH3_3	533	539	PF00018	0.654
LIG_SH3_4	125	132	PF00018	0.454
LIG_SUMO_SIM_par_1	264	272	PF11976	0.458
LIG_SUMO_SIM_par_1	353	358	PF11976	0.436
LIG_SxIP_EBH_1	3	16	PF03271	0.385
LIG_SxIP_EBH_1	407	417	PF03271	0.680
LIG_TRAF2_1	648	651	PF00917	0.536
LIG_UBA3_1	152	158	PF00899	0.456
LIG_WRC_WIRS_1	136	141	PF05994	0.434
LIG_WRC_WIRS_1	789	794	PF05994	0.488
MOD_CDK_SPK_2	612	617	PF00069	0.606
MOD_CK1_1	170	176	PF00069	0.526
MOD_CK1_1	182	188	PF00069	0.525
MOD_CK1_1	196	202	PF00069	0.482
MOD_CK1_1	213	219	PF00069	0.470
MOD_CK1_1	379	385	PF00069	0.703
MOD_CK1_1	399	405	PF00069	0.734
MOD_CK1_1	408	414	PF00069	0.629
MOD_CK1_1	5	11	PF00069	0.629
MOD_CK1_1	546	552	PF00069	0.596
MOD_CK1_1	708	714	PF00069	0.595
MOD_CK1_1	755	761	PF00069	0.399
MOD_CK1_1	763	769	PF00069	0.359
MOD_CK1_1	88	94	PF00069	0.444
MOD_CK2_1	172	178	PF00069	0.526
MOD_CK2_1	181	187	PF00069	0.445
MOD_CK2_1	229	235	PF00069	0.495
MOD_CK2_1	644	650	PF00069	0.544
MOD_CK2_1	708	714	PF00069	0.555
MOD_CK2_1	755	761	PF00069	0.536
MOD_CK2_1	779	785	PF00069	0.575
MOD_Cter_Amidation	833	836	PF01082	0.477
MOD_GlcNHglycan	112	117	PF01048	0.542
MOD_GlcNHglycan	204	207	PF01048	0.510
MOD_GlcNHglycan	231	234	PF01048	0.478
MOD_GlcNHglycan	254	257	PF01048	0.720
MOD_GlcNHglycan	264	267	PF01048	0.644
MOD_GlcNHglycan	381	384	PF01048	0.734
MOD_GlcNHglycan	431	434	PF01048	0.721
MOD_GlcNHglycan	438	441	PF01048	0.691
MOD_GlcNHglycan	453	456	PF01048	0.799
MOD_GlcNHglycan	470	473	PF01048	0.528
MOD_GlcNHglycan	530	533	PF01048	0.619
MOD_GlcNHglycan	588	591	PF01048	0.435
MOD_GlcNHglycan	646	649	PF01048	0.544
MOD_GlcNHglycan	665	668	PF01048	0.495
MOD_GlcNHglycan	687	690	PF01048	0.608
MOD_GlcNHglycan	7	10	PF01048	0.402
MOD_GlcNHglycan	87	90	PF01048	0.568
MOD_GSK3_1	14	21	PF00069	0.432
MOD_GSK3_1	163	170	PF00069	0.412
MOD_GSK3_1	192	199	PF00069	0.512
MOD_GSK3_1	200	207	PF00069	0.430
MOD_GSK3_1	209	216	PF00069	0.352
MOD_GSK3_1	219	226	PF00069	0.427
MOD_GSK3_1	240	247	PF00069	0.508
MOD_GSK3_1	297	304	PF00069	0.430
MOD_GSK3_1	347	354	PF00069	0.551
MOD_GSK3_1	367	374	PF00069	0.397
MOD_GSK3_1	375	382	PF00069	0.708
MOD_GSK3_1	405	412	PF00069	0.659
MOD_GSK3_1	457	464	PF00069	0.678
MOD_GSK3_1	563	570	PF00069	0.645
MOD_GSK3_1	579	586	PF00069	0.609
MOD_GSK3_1	723	730	PF00069	0.487
MOD_GSK3_1	755	762	PF00069	0.525
MOD_GSK3_1	85	92	PF00069	0.440
MOD_N-GLC_1	224	229	PF02516	0.542
MOD_N-GLC_1	375	380	PF02516	0.668
MOD_N-GLC_1	399	404	PF02516	0.626
MOD_N-GLC_1	457	462	PF02516	0.649
MOD_N-GLC_1	492	497	PF02516	0.516
MOD_N-GLC_1	5	10	PF02516	0.500
MOD_N-GLC_1	642	647	PF02516	0.550
MOD_NEK2_1	163	168	PF00069	0.428
MOD_NEK2_1	181	186	PF00069	0.461
MOD_NEK2_1	204	209	PF00069	0.485
MOD_NEK2_1	219	224	PF00069	0.548
MOD_NEK2_1	244	249	PF00069	0.587
MOD_NEK2_1	268	273	PF00069	0.524
MOD_NEK2_1	289	294	PF00069	0.415
MOD_NEK2_1	301	306	PF00069	0.538
MOD_NEK2_1	328	333	PF00069	0.488
MOD_NEK2_1	443	448	PF00069	0.672
MOD_NEK2_1	468	473	PF00069	0.685
MOD_NEK2_1	635	640	PF00069	0.572
MOD_NEK2_1	642	647	PF00069	0.682
MOD_NEK2_1	841	846	PF00069	0.648
MOD_NEK2_2	120	125	PF00069	0.499
MOD_PIKK_1	492	498	PF00454	0.516
MOD_PIKK_1	546	552	PF00454	0.498
MOD_PIKK_1	658	664	PF00454	0.540
MOD_PIKK_1	723	729	PF00454	0.505
MOD_PK_1	340	346	PF00069	0.487
MOD_PKA_2	120	126	PF00069	0.488
MOD_PKA_2	223	229	PF00069	0.536
MOD_PKA_2	339	345	PF00069	0.489
MOD_PKA_2	480	486	PF00069	0.427
MOD_PKA_2	546	552	PF00069	0.591
MOD_PKA_2	576	582	PF00069	0.571
MOD_PKA_2	723	729	PF00069	0.586
MOD_PKA_2	746	752	PF00069	0.561
MOD_Plk_1	193	199	PF00069	0.522
MOD_Plk_1	213	219	PF00069	0.290
MOD_Plk_1	328	334	PF00069	0.500
MOD_Plk_1	347	353	PF00069	0.621
MOD_Plk_1	457	463	PF00069	0.647
MOD_Plk_1	492	498	PF00069	0.498
MOD_Plk_1	5	11	PF00069	0.386
MOD_Plk_1	642	648	PF00069	0.554
MOD_Plk_1	763	769	PF00069	0.513
MOD_Plk_2-3	746	752	PF00069	0.579
MOD_Plk_2-3	795	801	PF00069	0.441
MOD_Plk_4	14	20	PF00069	0.579
MOD_Plk_4	172	178	PF00069	0.526
MOD_Plk_4	204	210	PF00069	0.483
MOD_Plk_4	240	246	PF00069	0.466
MOD_Plk_4	297	303	PF00069	0.473
MOD_Plk_4	328	334	PF00069	0.487
MOD_Plk_4	351	357	PF00069	0.500
MOD_Plk_4	405	411	PF00069	0.682
MOD_Plk_4	708	714	PF00069	0.496
MOD_Plk_4	727	733	PF00069	0.427
MOD_Plk_4	752	758	PF00069	0.580
MOD_Plk_4	763	769	PF00069	0.515
MOD_Plk_4	788	794	PF00069	0.497
MOD_ProDKin_1	225	231	PF00069	0.519
MOD_ProDKin_1	371	377	PF00069	0.655
MOD_ProDKin_1	399	405	PF00069	0.625
MOD_ProDKin_1	498	504	PF00069	0.573
MOD_ProDKin_1	612	618	PF00069	0.602
MOD_ProDKin_1	68	74	PF00069	0.481
MOD_ProDKin_1	703	709	PF00069	0.649
MOD_ProDKin_1	779	785	PF00069	0.412
MOD_SUMO_for_1	26	29	PF00179	0.529
MOD_SUMO_rev_2	173	182	PF00179	0.522
TRG_DiLeu_BaEn_1	164	169	PF01217	0.475
TRG_DiLeu_BaEn_2	37	43	PF01217	0.459
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.456
TRG_ENDOCYTIC_2	127	130	PF00928	0.377
TRG_ENDOCYTIC_2	731	734	PF00928	0.495
TRG_ENDOCYTIC_2	95	98	PF00928	0.430
TRG_ER_diArg_1	480	482	PF00400	0.596
TRG_ER_diArg_1	604	607	PF00400	0.598
TRG_ER_diArg_1	835	837	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	633	637	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P333	Leptomonas seymouri	68%	97%
A0A0S4JBI5	Bodo saltans	28%	100%
A0A3S5H6S3	Leishmania donovani	85%	98%
A4HW35	Leishmania infantum	85%	98%
E9APT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4QFP2	Leishmania major	84%	100%