Glutathione synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutathione synthetase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7P4_LEIBR

TriTrypDb:

LbrM.14.0880 , LBRM2903_140014600

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H7P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7P4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000287	magnesium ion binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004363	glutathione synthase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	12
GO:0016881	acid-amino acid ligase activity	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0033218	amide binding	2	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042277	peptide binding	3	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0043295	glutathione binding	3	12
GO:0046872	metal ion binding	4	12
GO:0072341	modified amino acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1900750	oligopeptide binding	4	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:1901681	sulfur compound binding	2	12
GO:1904091	non-ribosomal peptide synthetase activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.196
CLV_C14_Caspase3-7	592	596	PF00656	0.446
CLV_NRD_NRD_1	321	323	PF00675	0.318
CLV_NRD_NRD_1	527	529	PF00675	0.353
CLV_NRD_NRD_1	533	535	PF00675	0.337
CLV_PCSK_KEX2_1	321	323	PF00082	0.318
CLV_PCSK_KEX2_1	527	529	PF00082	0.326
CLV_PCSK_SKI1_1	306	310	PF00082	0.400
CLV_PCSK_SKI1_1	460	464	PF00082	0.451
CLV_PCSK_SKI1_1	490	494	PF00082	0.279
CLV_PCSK_SKI1_1	542	546	PF00082	0.196
CLV_PCSK_SKI1_1	98	102	PF00082	0.406
CLV_Separin_Metazoa	60	64	PF03568	0.196
DEG_APCC_DBOX_1	320	328	PF00400	0.314
DEG_SPOP_SBC_1	225	229	PF00917	0.196
DOC_CKS1_1	113	118	PF01111	0.422
DOC_CYCLIN_RxL_1	303	313	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.449
DOC_MAPK_DCC_7	281	291	PF00069	0.449
DOC_MAPK_gen_1	285	294	PF00069	0.196
DOC_MAPK_JIP1_4	287	293	PF00069	0.422
DOC_MAPK_MEF2A_6	285	294	PF00069	0.221
DOC_MAPK_MEF2A_6	29	37	PF00069	0.337
DOC_MAPK_MEF2A_6	53	61	PF00069	0.397
DOC_MAPK_RevD_3	307	322	PF00069	0.362
DOC_PP1_RVXF_1	174	181	PF00149	0.196
DOC_PP1_RVXF_1	540	547	PF00149	0.309
DOC_PP2B_LxvP_1	357	360	PF13499	0.449
DOC_USP7_MATH_1	153	157	PF00917	0.340
DOC_USP7_MATH_1	225	229	PF00917	0.384
DOC_USP7_MATH_1	264	268	PF00917	0.411
DOC_USP7_MATH_1	581	585	PF00917	0.352
DOC_USP7_MATH_1	604	608	PF00917	0.302
DOC_WW_Pin1_4	112	117	PF00397	0.389
DOC_WW_Pin1_4	143	148	PF00397	0.196
DOC_WW_Pin1_4	188	193	PF00397	0.318
DOC_WW_Pin1_4	221	226	PF00397	0.395
DOC_WW_Pin1_4	231	236	PF00397	0.411
LIG_14-3-3_CanoR_1	110	116	PF00244	0.196
LIG_14-3-3_CanoR_1	316	321	PF00244	0.356
LIG_14-3-3_CanoR_1	376	380	PF00244	0.318
LIG_Actin_WH2_2	305	323	PF00022	0.371
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BRCT_BRCA1_1	183	187	PF00533	0.302
LIG_deltaCOP1_diTrp_1	387	395	PF00928	0.196
LIG_FHA_1	225	231	PF00498	0.408
LIG_FHA_1	312	318	PF00498	0.395
LIG_FHA_1	328	334	PF00498	0.302
LIG_FHA_1	347	353	PF00498	0.332
LIG_FHA_1	40	46	PF00498	0.439
LIG_FHA_1	99	105	PF00498	0.308
LIG_FHA_2	112	118	PF00498	0.365
LIG_FHA_2	321	327	PF00498	0.217
LIG_FHA_2	514	520	PF00498	0.415
LIG_FHA_2	9	15	PF00498	0.443
LIG_LIR_Gen_1	179	188	PF02991	0.196
LIG_LIR_Gen_1	406	417	PF02991	0.318
LIG_LIR_Gen_1	520	531	PF02991	0.343
LIG_LIR_Nem_3	179	183	PF02991	0.314
LIG_LIR_Nem_3	184	190	PF02991	0.337
LIG_LIR_Nem_3	303	308	PF02991	0.337
LIG_LIR_Nem_3	520	526	PF02991	0.422
LIG_NRBOX	307	313	PF00104	0.449
LIG_PCNA_APIM_2	488	494	PF02747	0.196
LIG_PTB_Apo_2	452	459	PF02174	0.196
LIG_PTB_Phospho_1	452	458	PF10480	0.196
LIG_REV1ctd_RIR_1	543	551	PF16727	0.371
LIG_SH2_CRK	124	128	PF00017	0.307
LIG_SH2_CRK	305	309	PF00017	0.387
LIG_SH2_CRK	523	527	PF00017	0.318
LIG_SH2_STAT3	379	382	PF00017	0.196
LIG_SH2_STAT3	66	69	PF00017	0.422
LIG_SH2_STAT5	200	203	PF00017	0.368
LIG_SH2_STAT5	242	245	PF00017	0.417
LIG_SH2_STAT5	368	371	PF00017	0.327
LIG_SH2_STAT5	374	377	PF00017	0.275
LIG_SH2_STAT5	379	382	PF00017	0.264
LIG_SH2_STAT5	491	494	PF00017	0.337
LIG_SH2_STAT5	530	533	PF00017	0.288
LIG_SH2_STAT5	576	579	PF00017	0.339
LIG_SH3_3	120	126	PF00018	0.422
LIG_SH3_3	144	150	PF00018	0.196
LIG_SH3_3	249	255	PF00018	0.272
LIG_SH3_3	399	405	PF00018	0.311
LIG_SH3_3	42	48	PF00018	0.248
LIG_SH3_3	424	430	PF00018	0.318
LIG_SH3_3	489	495	PF00018	0.280
LIG_SUMO_SIM_par_1	103	109	PF11976	0.449
LIG_SUMO_SIM_par_1	307	314	PF11976	0.448
LIG_SUMO_SIM_par_1	368	373	PF11976	0.264
LIG_TRAF2_1	21	24	PF00917	0.491
LIG_TRFH_1	491	495	PF08558	0.302
LIG_WRC_WIRS_1	411	416	PF05994	0.318
LIG_WW_1	40	43	PF00397	0.196
MOD_CDK_SPxK_1	112	118	PF00069	0.196
MOD_CK1_1	139	145	PF00069	0.360
MOD_CK1_1	146	152	PF00069	0.422
MOD_CK1_1	223	229	PF00069	0.442
MOD_CK1_1	346	352	PF00069	0.449
MOD_CK1_1	422	428	PF00069	0.419
MOD_CK1_1	556	562	PF00069	0.340
MOD_CK1_1	621	627	PF00069	0.465
MOD_CK1_1	89	95	PF00069	0.429
MOD_CK2_1	103	109	PF00069	0.351
MOD_CK2_1	146	152	PF00069	0.400
MOD_CK2_1	19	25	PF00069	0.489
MOD_CK2_1	320	326	PF00069	0.217
MOD_CK2_1	89	95	PF00069	0.400
MOD_GlcNHglycan	138	141	PF01048	0.376
MOD_GlcNHglycan	159	162	PF01048	0.375
MOD_GlcNHglycan	239	242	PF01048	0.362
MOD_GlcNHglycan	249	252	PF01048	0.317
MOD_GlcNHglycan	266	269	PF01048	0.387
MOD_GlcNHglycan	620	623	PF01048	0.720
MOD_GSK3_1	1	8	PF00069	0.673
MOD_GSK3_1	131	138	PF00069	0.429
MOD_GSK3_1	139	146	PF00069	0.385
MOD_GSK3_1	153	160	PF00069	0.323
MOD_GSK3_1	179	186	PF00069	0.297
MOD_GSK3_1	220	227	PF00069	0.401
MOD_GSK3_1	316	323	PF00069	0.318
MOD_GSK3_1	339	346	PF00069	0.314
MOD_GSK3_1	370	377	PF00069	0.377
MOD_GSK3_1	39	46	PF00069	0.400
MOD_GSK3_1	553	560	PF00069	0.331
MOD_GSK3_1	86	93	PF00069	0.416
MOD_N-GLC_1	343	348	PF02516	0.196
MOD_N-GLC_1	422	427	PF02516	0.422
MOD_N-GLC_1	556	561	PF02516	0.274
MOD_N-GLC_1	76	81	PF02516	0.344
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	247	252	PF00069	0.219
MOD_NEK2_1	311	316	PF00069	0.358
MOD_NEK2_1	320	325	PF00069	0.312
MOD_NEK2_1	327	332	PF00069	0.204
MOD_NEK2_1	338	343	PF00069	0.219
MOD_NEK2_1	375	380	PF00069	0.307
MOD_NEK2_1	513	518	PF00069	0.288
MOD_NEK2_1	86	91	PF00069	0.350
MOD_NEK2_2	458	463	PF00069	0.196
MOD_NEK2_2	48	53	PF00069	0.422
MOD_PK_1	103	109	PF00069	0.313
MOD_PK_1	403	409	PF00069	0.318
MOD_PKA_2	320	326	PF00069	0.318
MOD_PKA_2	375	381	PF00069	0.318
MOD_PKA_2	513	519	PF00069	0.246
MOD_PKA_2	86	92	PF00069	0.283
MOD_Plk_2-3	515	521	PF00069	0.449
MOD_Plk_4	103	109	PF00069	0.397
MOD_Plk_4	226	232	PF00069	0.429
MOD_Plk_4	370	376	PF00069	0.306
MOD_Plk_4	581	587	PF00069	0.395
MOD_ProDKin_1	112	118	PF00069	0.389
MOD_ProDKin_1	143	149	PF00069	0.196
MOD_ProDKin_1	188	194	PF00069	0.318
MOD_ProDKin_1	221	227	PF00069	0.395
MOD_ProDKin_1	231	237	PF00069	0.411
MOD_SUMO_for_1	57	60	PF00179	0.331
MOD_SUMO_rev_2	342	352	PF00179	0.196
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.387
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.423
TRG_ENDOCYTIC_2	124	127	PF00928	0.337
TRG_ENDOCYTIC_2	305	308	PF00928	0.387
TRG_ENDOCYTIC_2	409	412	PF00928	0.318
TRG_ENDOCYTIC_2	523	526	PF00928	0.302
TRG_ENDOCYTIC_2	530	533	PF00928	0.302
TRG_ER_diArg_1	320	322	PF00400	0.305
TRG_ER_diArg_1	526	528	PF00400	0.337
TRG_NES_CRM1_1	60	74	PF08389	0.196
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.199
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHC1	Leptomonas seymouri	64%	99%
A0A0S4J7U4	Bodo saltans	36%	100%
A0A1X0NNJ6	Trypanosomatidae	42%	100%
A0A3Q8IC15	Leishmania donovani	76%	100%
A0A3R7LQL5	Trypanosoma rangeli	45%	100%
A4HW34	Leishmania infantum	76%	100%
C9ZSZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9APT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
O22494	Solanum lycopersicum	29%	100%
O23732	Brassica juncea	29%	100%
P35668	Xenopus laevis	28%	100%
P35669	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P46413	Rattus norvegicus	26%	100%
P46416	Arabidopsis thaliana	30%	100%
P48637	Homo sapiens	28%	100%
P51855	Mus musculus	27%	100%
Q08220	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q4QFP4	Leishmania major	75%	100%
Q54E83	Dictyostelium discoideum	26%	100%
Q5EAC2	Bos taurus	26%	100%
Q8HXX5	Macaca fascicularis	28%	100%
V5BNE3	Trypanosoma cruzi	46%	100%