Protein phosphatase 2C-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7P3_LEIBR

TriTrypDb:

LbrM.14.0870 , LBRM2903_140014400

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7P3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.838
CLV_NRD_NRD_1	190	192	PF00675	0.724
CLV_NRD_NRD_1	2	4	PF00675	0.701
CLV_NRD_NRD_1	212	214	PF00675	0.826
CLV_NRD_NRD_1	228	230	PF00675	0.583
CLV_NRD_NRD_1	335	337	PF00675	0.564
CLV_NRD_NRD_1	378	380	PF00675	0.829
CLV_NRD_NRD_1	415	417	PF00675	0.587
CLV_NRD_NRD_1	5	7	PF00675	0.691
CLV_NRD_NRD_1	566	568	PF00675	0.514
CLV_NRD_NRD_1	628	630	PF00675	0.457
CLV_NRD_NRD_1	694	696	PF00675	0.360
CLV_NRD_NRD_1	766	768	PF00675	0.425
CLV_NRD_NRD_1	97	99	PF00675	0.768
CLV_PCSK_KEX2_1	158	160	PF00082	0.576
CLV_PCSK_KEX2_1	212	214	PF00082	0.826
CLV_PCSK_KEX2_1	227	229	PF00082	0.604
CLV_PCSK_KEX2_1	335	337	PF00082	0.564
CLV_PCSK_KEX2_1	378	380	PF00082	0.829
CLV_PCSK_KEX2_1	382	384	PF00082	0.777
CLV_PCSK_KEX2_1	415	417	PF00082	0.666
CLV_PCSK_KEX2_1	566	568	PF00082	0.514
CLV_PCSK_KEX2_1	627	629	PF00082	0.412
CLV_PCSK_KEX2_1	694	696	PF00082	0.381
CLV_PCSK_KEX2_1	766	768	PF00082	0.478
CLV_PCSK_KEX2_1	97	99	PF00082	0.768
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.576
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.566
CLV_PCSK_PC7_1	378	384	PF00082	0.569
CLV_PCSK_PC7_1	411	417	PF00082	0.574
CLV_PCSK_PC7_1	623	629	PF00082	0.286
CLV_PCSK_SKI1_1	228	232	PF00082	0.678
CLV_PCSK_SKI1_1	23	27	PF00082	0.550
CLV_PCSK_SKI1_1	241	245	PF00082	0.756
CLV_PCSK_SKI1_1	305	309	PF00082	0.738
CLV_PCSK_SKI1_1	379	383	PF00082	0.713
CLV_PCSK_SKI1_1	603	607	PF00082	0.412
CLV_PCSK_SKI1_1	669	673	PF00082	0.412
CLV_PCSK_SKI1_1	695	699	PF00082	0.412
CLV_PCSK_SKI1_1	815	819	PF00082	0.412
DEG_APCC_DBOX_1	22	30	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.735
DEG_SCF_FBW7_1	203	210	PF00400	0.581
DEG_SPOP_SBC_1	311	315	PF00917	0.804
DOC_CKS1_1	468	473	PF01111	0.612
DOC_MAPK_gen_1	694	705	PF00069	0.412
DOC_MAPK_MEF2A_6	514	522	PF00069	0.619
DOC_PP2B_LxvP_1	231	234	PF13499	0.606
DOC_PP2B_LxvP_1	308	311	PF13499	0.728
DOC_PP2B_LxvP_1	55	58	PF13499	0.497
DOC_PP4_FxxP_1	63	66	PF00568	0.703
DOC_USP7_MATH_1	19	23	PF00917	0.622
DOC_USP7_MATH_1	312	316	PF00917	0.756
DOC_USP7_MATH_1	40	44	PF00917	0.500
DOC_USP7_MATH_1	437	441	PF00917	0.578
DOC_USP7_MATH_1	760	764	PF00917	0.490
DOC_USP7_UBL2_3	734	738	PF12436	0.256
DOC_WW_Pin1_4	203	208	PF00397	0.595
DOC_WW_Pin1_4	229	234	PF00397	0.593
DOC_WW_Pin1_4	261	266	PF00397	0.768
DOC_WW_Pin1_4	320	325	PF00397	0.732
DOC_WW_Pin1_4	467	472	PF00397	0.570
DOC_WW_Pin1_4	62	67	PF00397	0.795
DOC_WW_Pin1_4	758	763	PF00397	0.362
DOC_WW_Pin1_4	818	823	PF00397	0.412
DOC_WW_Pin1_4	835	840	PF00397	0.183
DOC_WW_Pin1_4	886	891	PF00397	0.539
LIG_14-3-3_CanoR_1	159	165	PF00244	0.712
LIG_14-3-3_CanoR_1	416	422	PF00244	0.585
LIG_14-3-3_CanoR_1	486	494	PF00244	0.657
LIG_14-3-3_CanoR_1	514	519	PF00244	0.497
LIG_14-3-3_CanoR_1	916	920	PF00244	0.749
LIG_Actin_WH2_2	236	253	PF00022	0.801
LIG_Actin_WH2_2	740	756	PF00022	0.256
LIG_BRCT_BRCA1_1	739	743	PF00533	0.514
LIG_Clathr_ClatBox_1	357	361	PF01394	0.555
LIG_EVH1_1	141	145	PF00568	0.567
LIG_FHA_1	114	120	PF00498	0.579
LIG_FHA_1	204	210	PF00498	0.826
LIG_FHA_1	370	376	PF00498	0.835
LIG_FHA_1	445	451	PF00498	0.695
LIG_FHA_1	513	519	PF00498	0.580
LIG_FHA_1	79	85	PF00498	0.560
LIG_FHA_1	809	815	PF00498	0.387
LIG_FHA_1	819	825	PF00498	0.412
LIG_FHA_2	234	240	PF00498	0.801
LIG_FHA_2	275	281	PF00498	0.596
LIG_FHA_2	431	437	PF00498	0.590
LIG_FHA_2	533	539	PF00498	0.412
LIG_FHA_2	599	605	PF00498	0.412
LIG_Integrin_isoDGR_2	934	936	PF01839	0.664
LIG_LIR_Gen_1	538	549	PF02991	0.412
LIG_LIR_Gen_1	604	611	PF02991	0.402
LIG_LIR_Gen_1	634	641	PF02991	0.376
LIG_LIR_Gen_1	791	801	PF02991	0.394
LIG_LIR_Nem_3	538	544	PF02991	0.412
LIG_LIR_Nem_3	604	609	PF02991	0.412
LIG_LIR_Nem_3	791	796	PF02991	0.394
LIG_LIR_Nem_3	799	805	PF02991	0.383
LIG_LIR_Nem_3	816	820	PF02991	0.412
LIG_MYND_1	139	143	PF01753	0.786
LIG_MYND_1	245	249	PF01753	0.709
LIG_Pex14_1	575	579	PF04695	0.412
LIG_Pex14_2	721	725	PF04695	0.412
LIG_Pex14_2	813	817	PF04695	0.412
LIG_SH2_CRK	52	56	PF00017	0.504
LIG_SH2_GRB2like	153	156	PF00017	0.709
LIG_SH2_STAT5	186	189	PF00017	0.793
LIG_SH2_STAT5	579	582	PF00017	0.412
LIG_SH2_STAT5	661	664	PF00017	0.357
LIG_SH2_STAT5	820	823	PF00017	0.412
LIG_SH3_1	137	143	PF00018	0.576
LIG_SH3_3	136	142	PF00018	0.748
LIG_SH3_3	466	472	PF00018	0.836
LIG_SH3_3	756	762	PF00018	0.350
LIG_SH3_3	821	827	PF00018	0.412
LIG_SH3_3	884	890	PF00018	0.510
LIG_Sin3_3	385	392	PF02671	0.559
LIG_SUMO_SIM_anti_2	555	561	PF11976	0.514
LIG_SUMO_SIM_anti_2	864	870	PF11976	0.431
LIG_SUMO_SIM_par_1	555	561	PF11976	0.514
LIG_SUMO_SIM_par_1	710	715	PF11976	0.412
LIG_SxIP_EBH_1	311	325	PF03271	0.824
LIG_TRAF2_1	806	809	PF00917	0.412
LIG_UBA3_1	605	612	PF00899	0.412
LIG_WW_2	139	142	PF00397	0.562
LIG_WW_3	232	236	PF00397	0.570
LIG_WW_3	265	269	PF00397	0.736
MOD_CDC14_SPxK_1	232	235	PF00782	0.567
MOD_CDC14_SPxK_1	889	892	PF00782	0.536
MOD_CDK_SPK_2	320	325	PF00069	0.826
MOD_CDK_SPxK_1	229	235	PF00069	0.579
MOD_CDK_SPxK_1	886	892	PF00069	0.511
MOD_CDK_SPxxK_3	261	268	PF00069	0.787
MOD_CK1_1	113	119	PF00069	0.625
MOD_CK1_1	13	19	PF00069	0.573
MOD_CK1_1	320	326	PF00069	0.723
MOD_CK1_1	339	345	PF00069	0.680
MOD_CK1_1	371	377	PF00069	0.722
MOD_CK1_1	446	452	PF00069	0.723
MOD_CK1_1	480	486	PF00069	0.703
MOD_CK1_1	489	495	PF00069	0.547
MOD_CK1_1	512	518	PF00069	0.634
MOD_CK1_1	835	841	PF00069	0.478
MOD_CK1_1	898	904	PF00069	0.745
MOD_CK1_1	915	921	PF00069	0.748
MOD_CK2_1	430	436	PF00069	0.646
MOD_CK2_1	452	458	PF00069	0.794
MOD_CK2_1	598	604	PF00069	0.412
MOD_CK2_1	803	809	PF00069	0.357
MOD_Cter_Amidation	225	228	PF01082	0.654
MOD_Cter_Amidation	4	7	PF01082	0.715
MOD_Cter_Amidation	564	567	PF01082	0.514
MOD_Cter_Amidation	625	628	PF01082	0.412
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.583
MOD_DYRK1A_RPxSP_1	886	890	PF00069	0.534
MOD_GlcNHglycan	112	115	PF01048	0.560
MOD_GlcNHglycan	12	15	PF01048	0.600
MOD_GlcNHglycan	168	171	PF01048	0.620
MOD_GlcNHglycan	208	212	PF01048	0.769
MOD_GlcNHglycan	216	219	PF01048	0.712
MOD_GlcNHglycan	23	26	PF01048	0.521
MOD_GlcNHglycan	255	258	PF01048	0.630
MOD_GlcNHglycan	308	311	PF01048	0.728
MOD_GlcNHglycan	341	344	PF01048	0.587
MOD_GlcNHglycan	404	407	PF01048	0.664
MOD_GlcNHglycan	454	457	PF01048	0.802
MOD_GlcNHglycan	488	491	PF01048	0.791
MOD_GlcNHglycan	511	514	PF01048	0.626
MOD_GlcNHglycan	525	528	PF01048	0.412
MOD_GlcNHglycan	641	644	PF01048	0.466
MOD_GlcNHglycan	728	731	PF01048	0.256
MOD_GlcNHglycan	755	758	PF01048	0.424
MOD_GlcNHglycan	789	793	PF01048	0.412
MOD_GlcNHglycan	830	833	PF01048	0.412
MOD_GlcNHglycan	883	886	PF01048	0.629
MOD_GlcNHglycan	898	901	PF01048	0.596
MOD_GlcNHglycan	917	920	PF01048	0.744
MOD_GSK3_1	109	116	PF00069	0.707
MOD_GSK3_1	203	210	PF00069	0.784
MOD_GSK3_1	214	221	PF00069	0.706
MOD_GSK3_1	229	236	PF00069	0.702
MOD_GSK3_1	253	260	PF00069	0.635
MOD_GSK3_1	274	281	PF00069	0.664
MOD_GSK3_1	306	313	PF00069	0.784
MOD_GSK3_1	335	342	PF00069	0.801
MOD_GSK3_1	364	371	PF00069	0.639
MOD_GSK3_1	474	481	PF00069	0.668
MOD_GSK3_1	508	515	PF00069	0.615
MOD_GSK3_1	594	601	PF00069	0.357
MOD_GSK3_1	641	648	PF00069	0.438
MOD_GSK3_1	675	682	PF00069	0.370
MOD_GSK3_1	828	835	PF00069	0.478
MOD_GSK3_1	894	901	PF00069	0.785
MOD_GSK3_1	9	16	PF00069	0.605
MOD_N-GLC_1	290	295	PF02516	0.802
MOD_N-GLC_1	688	693	PF02516	0.256
MOD_N-GLC_1	8	13	PF02516	0.641
MOD_N-GLC_1	864	869	PF02516	0.431
MOD_N-GLC_2	847	849	PF02516	0.412
MOD_NEK2_1	443	448	PF00069	0.690
MOD_NEK2_1	594	599	PF00069	0.412
MOD_NEK2_1	712	717	PF00069	0.378
MOD_NEK2_1	753	758	PF00069	0.268
MOD_NEK2_1	774	779	PF00069	0.360
MOD_NEK2_1	910	915	PF00069	0.777
MOD_NEK2_1	923	928	PF00069	0.542
MOD_PIKK_1	336	342	PF00454	0.616
MOD_PIKK_1	444	450	PF00454	0.666
MOD_PIKK_1	610	616	PF00454	0.374
MOD_PIKK_1	925	931	PF00454	0.478
MOD_PK_1	27	33	PF00069	0.547
MOD_PK_1	98	104	PF00069	0.700
MOD_PKA_1	212	218	PF00069	0.818
MOD_PKA_1	335	341	PF00069	0.569
MOD_PKA_2	120	126	PF00069	0.634
MOD_PKA_2	212	218	PF00069	0.737
MOD_PKA_2	335	341	PF00069	0.768
MOD_PKA_2	513	519	PF00069	0.501
MOD_PKA_2	532	538	PF00069	0.392
MOD_PKA_2	748	754	PF00069	0.286
MOD_PKA_2	859	865	PF00069	0.412
MOD_PKA_2	881	887	PF00069	0.615
MOD_PKA_2	915	921	PF00069	0.740
MOD_PKB_1	484	492	PF00069	0.734
MOD_Plk_1	27	33	PF00069	0.547
MOD_Plk_1	290	296	PF00069	0.552
MOD_Plk_1	788	794	PF00069	0.387
MOD_Plk_1	864	870	PF00069	0.431
MOD_Plk_2-3	859	865	PF00069	0.412
MOD_Plk_4	313	319	PF00069	0.828
MOD_Plk_4	446	452	PF00069	0.542
MOD_Plk_4	552	558	PF00069	0.412
MOD_Plk_4	594	600	PF00069	0.373
MOD_Plk_4	646	652	PF00069	0.412
MOD_Plk_4	864	870	PF00069	0.431
MOD_ProDKin_1	203	209	PF00069	0.595
MOD_ProDKin_1	229	235	PF00069	0.591
MOD_ProDKin_1	261	267	PF00069	0.763
MOD_ProDKin_1	320	326	PF00069	0.727
MOD_ProDKin_1	467	473	PF00069	0.572
MOD_ProDKin_1	62	68	PF00069	0.798
MOD_ProDKin_1	758	764	PF00069	0.362
MOD_ProDKin_1	818	824	PF00069	0.412
MOD_ProDKin_1	835	841	PF00069	0.183
MOD_ProDKin_1	886	892	PF00069	0.548
MOD_SUMO_for_1	733	736	PF00179	0.256
MOD_SUMO_rev_2	151	160	PF00179	0.567
MOD_SUMO_rev_2	238	243	PF00179	0.799
MOD_SUMO_rev_2	400	406	PF00179	0.593
MOD_SUMO_rev_2	682	687	PF00179	0.412
MOD_SUMO_rev_2	720	725	PF00179	0.412
MOD_SUMO_rev_2	732	740	PF00179	0.412
MOD_SUMO_rev_2	750	756	PF00179	0.190
TRG_DiLeu_BaEn_3	808	814	PF01217	0.412
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.538
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.822
TRG_ENDOCYTIC_2	52	55	PF00928	0.503
TRG_ER_diArg_1	227	229	PF00400	0.677
TRG_ER_diArg_1	245	248	PF00400	0.716
TRG_ER_diArg_1	334	336	PF00400	0.566
TRG_ER_diArg_1	414	416	PF00400	0.580
TRG_ER_diArg_1	566	568	PF00400	0.514
TRG_ER_diArg_1	627	629	PF00400	0.412
TRG_ER_diArg_1	694	696	PF00400	0.412
TRG_ER_diArg_1	766	768	PF00400	0.478
TRG_ER_diArg_1	96	98	PF00400	0.673
TRG_NLS_MonoExtC_3	2	7	PF00514	0.715
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.795
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	716	720	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L7	Leptomonas seymouri	50%	89%
A0A3Q8ID61	Leishmania donovani	71%	100%
A4HW33	Leishmania infantum	70%	97%
E9APT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	97%
Q4QFP5	Leishmania major	72%	100%