Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7P1_LEIBR

TriTrypDb:

LbrM.14.0850 , LBRM2903_140014200

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.605
CLV_C14_Caspase3-7	584	588	PF00656	0.563
CLV_MEL_PAP_1	14	20	PF00089	0.545
CLV_NRD_NRD_1	100	102	PF00675	0.669
CLV_NRD_NRD_1	162	164	PF00675	0.558
CLV_NRD_NRD_1	250	252	PF00675	0.602
CLV_NRD_NRD_1	307	309	PF00675	0.554
CLV_NRD_NRD_1	370	372	PF00675	0.584
CLV_NRD_NRD_1	425	427	PF00675	0.700
CLV_NRD_NRD_1	446	448	PF00675	0.551
CLV_NRD_NRD_1	649	651	PF00675	0.629
CLV_NRD_NRD_1	67	69	PF00675	0.565
CLV_PCSK_KEX2_1	102	104	PF00082	0.586
CLV_PCSK_KEX2_1	162	164	PF00082	0.558
CLV_PCSK_KEX2_1	250	252	PF00082	0.598
CLV_PCSK_KEX2_1	409	411	PF00082	0.620
CLV_PCSK_KEX2_1	424	426	PF00082	0.572
CLV_PCSK_KEX2_1	67	69	PF00082	0.565
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.531
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.707
CLV_PCSK_PC7_1	98	104	PF00082	0.538
CLV_PCSK_SKI1_1	138	142	PF00082	0.618
CLV_PCSK_SKI1_1	288	292	PF00082	0.538
CLV_PCSK_SKI1_1	320	324	PF00082	0.553
CLV_PCSK_SKI1_1	345	349	PF00082	0.541
CLV_PCSK_SKI1_1	412	416	PF00082	0.688
DEG_APCC_DBOX_1	250	258	PF00400	0.610
DEG_APCC_DBOX_1	67	75	PF00400	0.413
DEG_Nend_UBRbox_1	1	4	PF02207	0.392
DEG_SPOP_SBC_1	330	334	PF00917	0.544
DEG_SPOP_SBC_1	510	514	PF00917	0.574
DOC_CKS1_1	235	240	PF01111	0.644
DOC_CYCLIN_RxL_1	271	282	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.514
DOC_MAPK_gen_1	101	109	PF00069	0.534
DOC_MAPK_gen_1	342	352	PF00069	0.658
DOC_MAPK_gen_1	424	431	PF00069	0.706
DOC_MAPK_gen_1	67	74	PF00069	0.553
DOC_MAPK_MEF2A_6	17	25	PF00069	0.535
DOC_PP1_RVXF_1	491	497	PF00149	0.551
DOC_PP2B_LxvP_1	213	216	PF13499	0.665
DOC_PP2B_LxvP_1	217	220	PF13499	0.621
DOC_PP2B_LxvP_1	337	340	PF13499	0.548
DOC_PP2B_LxvP_1	567	570	PF13499	0.653
DOC_PP2B_LxvP_1	636	639	PF13499	0.635
DOC_PP2B_LxvP_1	671	674	PF13499	0.646
DOC_PP4_FxxP_1	18	21	PF00568	0.541
DOC_USP7_MATH_1	175	179	PF00917	0.574
DOC_USP7_MATH_1	202	206	PF00917	0.531
DOC_USP7_MATH_1	330	334	PF00917	0.569
DOC_USP7_MATH_1	354	358	PF00917	0.503
DOC_USP7_MATH_1	391	395	PF00917	0.715
DOC_USP7_MATH_1	404	408	PF00917	0.598
DOC_USP7_MATH_1	463	467	PF00917	0.567
DOC_USP7_MATH_1	505	509	PF00917	0.603
DOC_USP7_MATH_1	750	754	PF00917	0.467
DOC_USP7_MATH_2	465	471	PF00917	0.584
DOC_WW_Pin1_4	182	187	PF00397	0.711
DOC_WW_Pin1_4	234	239	PF00397	0.498
DOC_WW_Pin1_4	326	331	PF00397	0.629
DOC_WW_Pin1_4	382	387	PF00397	0.640
DOC_WW_Pin1_4	389	394	PF00397	0.654
DOC_WW_Pin1_4	506	511	PF00397	0.726
DOC_WW_Pin1_4	610	615	PF00397	0.606
DOC_WW_Pin1_4	88	93	PF00397	0.666
LIG_14-3-3_CanoR_1	162	170	PF00244	0.548
LIG_14-3-3_CanoR_1	2	6	PF00244	0.531
LIG_14-3-3_CanoR_1	231	238	PF00244	0.638
LIG_14-3-3_CanoR_1	250	258	PF00244	0.438
LIG_14-3-3_CanoR_1	342	352	PF00244	0.645
LIG_14-3-3_CanoR_1	410	419	PF00244	0.600
LIG_14-3-3_CanoR_1	511	519	PF00244	0.646
LIG_14-3-3_CanoR_1	58	62	PF00244	0.532
LIG_14-3-3_CanoR_1	594	603	PF00244	0.615
LIG_14-3-3_CanoR_1	660	669	PF00244	0.588
LIG_14-3-3_CanoR_1	714	723	PF00244	0.548
LIG_Actin_WH2_2	157	173	PF00022	0.536
LIG_Actin_WH2_2	542	560	PF00022	0.583
LIG_Actin_WH2_2	723	740	PF00022	0.547
LIG_deltaCOP1_diTrp_1	26	30	PF00928	0.566
LIG_eIF4E_1	717	723	PF01652	0.544
LIG_EVH1_1	567	571	PF00568	0.658
LIG_FHA_1	121	127	PF00498	0.525
LIG_FHA_1	231	237	PF00498	0.497
LIG_FHA_1	347	353	PF00498	0.644
LIG_FHA_1	363	369	PF00498	0.449
LIG_FHA_1	414	420	PF00498	0.562
LIG_FHA_1	430	436	PF00498	0.513
LIG_FHA_1	545	551	PF00498	0.588
LIG_FHA_1	576	582	PF00498	0.706
LIG_FHA_1	58	64	PF00498	0.535
LIG_FHA_1	623	629	PF00498	0.590
LIG_FHA_1	652	658	PF00498	0.648
LIG_FHA_1	694	700	PF00498	0.592
LIG_FHA_2	106	112	PF00498	0.660
LIG_FHA_2	167	173	PF00498	0.580
LIG_FHA_2	225	231	PF00498	0.632
LIG_FHA_2	46	52	PF00498	0.442
LIG_FHA_2	466	472	PF00498	0.568
LIG_FHA_2	574	580	PF00498	0.622
LIG_FHA_2	595	601	PF00498	0.704
LIG_FHA_2	640	646	PF00498	0.608
LIG_FHA_2	95	101	PF00498	0.611
LIG_GBD_Chelix_1	628	636	PF00786	0.494
LIG_GBD_Chelix_1	726	734	PF00786	0.399
LIG_Integrin_RGD_1	98	100	PF01839	0.544
LIG_LIR_Gen_1	137	147	PF02991	0.625
LIG_LIR_Gen_1	536	546	PF02991	0.614
LIG_LIR_Gen_1	55	64	PF02991	0.533
LIG_LIR_Gen_1	643	652	PF02991	0.618
LIG_LIR_Nem_3	135	139	PF02991	0.626
LIG_LIR_Nem_3	536	542	PF02991	0.628
LIG_LIR_Nem_3	55	59	PF02991	0.527
LIG_LIR_Nem_3	604	610	PF02991	0.557
LIG_LIR_Nem_3	643	649	PF02991	0.611
LIG_NRBOX	253	259	PF00104	0.615
LIG_PCNA_PIPBox_1	287	296	PF02747	0.551
LIG_PCNA_yPIPBox_3	287	296	PF02747	0.551
LIG_Pex14_2	132	136	PF04695	0.642
LIG_RPA_C_Fungi	53	65	PF08784	0.536
LIG_SH2_CRK	139	143	PF00017	0.615
LIG_SH2_CRK	539	543	PF00017	0.614
LIG_SH2_CRK	56	60	PF00017	0.534
LIG_SH2_CRK	646	650	PF00017	0.620
LIG_SH2_STAT3	10	13	PF00017	0.511
LIG_SH2_STAT5	10	13	PF00017	0.511
LIG_SH2_STAT5	275	278	PF00017	0.537
LIG_SH2_STAT5	545	548	PF00017	0.581
LIG_SH2_STAT5	691	694	PF00017	0.574
LIG_SH2_STAT5	717	720	PF00017	0.545
LIG_SH3_2	340	345	PF14604	0.519
LIG_SH3_3	178	184	PF00018	0.671
LIG_SH3_3	185	191	PF00018	0.685
LIG_SH3_3	213	219	PF00018	0.661
LIG_SH3_3	337	343	PF00018	0.534
LIG_SH3_3	387	393	PF00018	0.611
LIG_SH3_3	394	400	PF00018	0.558
LIG_SH3_3	459	465	PF00018	0.561
LIG_SH3_3	565	571	PF00018	0.652
LIG_SUMO_SIM_par_1	21	26	PF11976	0.523
LIG_SUMO_SIM_par_1	669	676	PF11976	0.643
LIG_TRAF2_1	227	230	PF00917	0.634
LIG_TRAF2_1	434	437	PF00917	0.534
LIG_TRAF2_1	48	51	PF00917	0.553
LIG_TRAF2_1	580	583	PF00917	0.640
LIG_TRAF2_1	642	645	PF00917	0.533
LIG_WRC_WIRS_1	133	138	PF05994	0.633
LIG_WW_3	342	346	PF00397	0.660
MOD_CDC14_SPxK_1	392	395	PF00782	0.716
MOD_CDK_SPK_2	506	511	PF00069	0.647
MOD_CDK_SPxK_1	389	395	PF00069	0.717
MOD_CDK_SPxxK_3	88	95	PF00069	0.630
MOD_CK1_1	166	172	PF00069	0.560
MOD_CK1_1	182	188	PF00069	0.683
MOD_CK1_1	193	199	PF00069	0.604
MOD_CK1_1	205	211	PF00069	0.560
MOD_CK1_1	329	335	PF00069	0.664
MOD_CK1_1	346	352	PF00069	0.533
MOD_CK1_1	413	419	PF00069	0.586
MOD_CK1_1	470	476	PF00069	0.643
MOD_CK1_1	509	515	PF00069	0.601
MOD_CK1_1	520	526	PF00069	0.651
MOD_CK1_1	528	534	PF00069	0.632
MOD_CK1_1	631	637	PF00069	0.635
MOD_CK1_1	672	678	PF00069	0.649
MOD_CK2_1	105	111	PF00069	0.681
MOD_CK2_1	166	172	PF00069	0.530
MOD_CK2_1	224	230	PF00069	0.636
MOD_CK2_1	30	36	PF00069	0.549
MOD_CK2_1	431	437	PF00069	0.619
MOD_CK2_1	45	51	PF00069	0.576
MOD_CK2_1	450	456	PF00069	0.530
MOD_CK2_1	465	471	PF00069	0.646
MOD_CK2_1	594	600	PF00069	0.709
MOD_CK2_1	639	645	PF00069	0.611
MOD_Cter_Amidation	422	425	PF01082	0.707
MOD_GlcNHglycan	113	116	PF01048	0.613
MOD_GlcNHglycan	152	157	PF01048	0.531
MOD_GlcNHglycan	166	169	PF01048	0.513
MOD_GlcNHglycan	196	199	PF01048	0.698
MOD_GlcNHglycan	204	207	PF01048	0.594
MOD_GlcNHglycan	32	35	PF01048	0.535
MOD_GlcNHglycan	345	348	PF01048	0.542
MOD_GlcNHglycan	382	385	PF01048	0.613
MOD_GlcNHglycan	412	415	PF01048	0.610
MOD_GlcNHglycan	421	424	PF01048	0.622
MOD_GlcNHglycan	604	607	PF01048	0.660
MOD_GlcNHglycan	633	636	PF01048	0.611
MOD_GlcNHglycan	694	699	PF01048	0.440
MOD_GlcNHglycan	85	89	PF01048	0.543
MOD_GSK3_1	1	8	PF00069	0.496
MOD_GSK3_1	148	155	PF00069	0.522
MOD_GSK3_1	175	182	PF00069	0.710
MOD_GSK3_1	189	196	PF00069	0.581
MOD_GSK3_1	230	237	PF00069	0.634
MOD_GSK3_1	311	318	PF00069	0.650
MOD_GSK3_1	326	333	PF00069	0.588
MOD_GSK3_1	362	369	PF00069	0.463
MOD_GSK3_1	391	398	PF00069	0.621
MOD_GSK3_1	400	407	PF00069	0.596
MOD_GSK3_1	463	470	PF00069	0.638
MOD_GSK3_1	505	512	PF00069	0.699
MOD_GSK3_1	590	597	PF00069	0.571
MOD_GSK3_1	669	676	PF00069	0.496
MOD_GSK3_1	84	91	PF00069	0.670
MOD_N-GLC_1	595	600	PF02516	0.615
MOD_NEK2_1	1	6	PF00069	0.394
MOD_NEK2_1	142	147	PF00069	0.625
MOD_NEK2_1	200	205	PF00069	0.532
MOD_NEK2_1	278	283	PF00069	0.380
MOD_NEK2_1	609	614	PF00069	0.557
MOD_NEK2_2	366	371	PF00069	0.454
MOD_NEK2_2	5	10	PF00069	0.511
MOD_PIKK_1	179	185	PF00454	0.719
MOD_PIKK_1	404	410	PF00454	0.715
MOD_PIKK_1	525	531	PF00454	0.701
MOD_PIKK_1	715	721	PF00454	0.549
MOD_PKA_1	102	108	PF00069	0.682
MOD_PKA_1	738	744	PF00069	0.543
MOD_PKA_2	1	7	PF00069	0.533
MOD_PKA_2	102	108	PF00069	0.594
MOD_PKA_2	230	236	PF00069	0.634
MOD_PKA_2	249	255	PF00069	0.433
MOD_PKA_2	28	34	PF00069	0.453
MOD_PKA_2	314	320	PF00069	0.642
MOD_PKA_2	510	516	PF00069	0.661
MOD_PKA_2	517	523	PF00069	0.678
MOD_PKA_2	57	63	PF00069	0.536
MOD_PKA_2	94	100	PF00069	0.633
MOD_PKB_1	410	418	PF00069	0.651
MOD_PKB_1	501	509	PF00069	0.598
MOD_Plk_1	324	330	PF00069	0.536
MOD_Plk_1	366	372	PF00069	0.456
MOD_Plk_1	535	541	PF00069	0.633
MOD_Plk_1	694	700	PF00069	0.592
MOD_Plk_4	175	181	PF00069	0.708
MOD_Plk_4	237	243	PF00069	0.489
MOD_Plk_4	541	547	PF00069	0.445
MOD_Plk_4	705	711	PF00069	0.567
MOD_ProDKin_1	182	188	PF00069	0.710
MOD_ProDKin_1	234	240	PF00069	0.502
MOD_ProDKin_1	326	332	PF00069	0.631
MOD_ProDKin_1	382	388	PF00069	0.644
MOD_ProDKin_1	389	395	PF00069	0.656
MOD_ProDKin_1	506	512	PF00069	0.724
MOD_ProDKin_1	610	616	PF00069	0.600
MOD_ProDKin_1	88	94	PF00069	0.667
MOD_SUMO_for_1	492	495	PF00179	0.554
TRG_DiLeu_BaEn_4	644	650	PF01217	0.547
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.556
TRG_ENDOCYTIC_2	139	142	PF00928	0.614
TRG_ENDOCYTIC_2	275	278	PF00928	0.537
TRG_ENDOCYTIC_2	539	542	PF00928	0.617
TRG_ENDOCYTIC_2	56	59	PF00928	0.534
TRG_ENDOCYTIC_2	646	649	PF00928	0.617
TRG_ER_diArg_1	101	104	PF00400	0.600
TRG_ER_diArg_1	161	163	PF00400	0.553
TRG_ER_diArg_1	424	426	PF00400	0.560
TRG_ER_diArg_1	516	519	PF00400	0.696
TRG_ER_diArg_1	66	68	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6S2	Leishmania donovani	71%	69%
A4HW31	Leishmania infantum	71%	69%
E9APT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	70%
Q4QFP7	Leishmania major	72%	100%