Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7N7_LEIBR

TriTrypDb:

LbrM.14.0800 , LBRM2903_140013700

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7N7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0051301	cell division	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	512	516	PF00656	0.320
CLV_NRD_NRD_1	173	175	PF00675	0.460
CLV_NRD_NRD_1	211	213	PF00675	0.428
CLV_NRD_NRD_1	564	566	PF00675	0.381
CLV_NRD_NRD_1	87	89	PF00675	0.631
CLV_PCSK_KEX2_1	440	442	PF00082	0.428
CLV_PCSK_KEX2_1	566	568	PF00082	0.373
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.460
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.402
CLV_PCSK_SKI1_1	174	178	PF00082	0.453
CLV_PCSK_SKI1_1	196	200	PF00082	0.434
CLV_PCSK_SKI1_1	220	224	PF00082	0.367
CLV_PCSK_SKI1_1	583	587	PF00082	0.530
CLV_PCSK_SKI1_1	75	79	PF00082	0.595
DEG_SCF_FBW7_1	476	483	PF00400	0.419
DOC_CYCLIN_RxL_1	217	226	PF00134	0.373
DOC_CYCLIN_RxL_1	72	80	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.645
DOC_MAPK_gen_1	375	384	PF00069	0.360
DOC_MAPK_HePTP_8	127	139	PF00069	0.460
DOC_MAPK_HePTP_8	372	384	PF00069	0.360
DOC_MAPK_MEF2A_6	130	139	PF00069	0.460
DOC_MAPK_MEF2A_6	180	187	PF00069	0.460
DOC_MAPK_MEF2A_6	202	210	PF00069	0.460
DOC_MAPK_MEF2A_6	375	384	PF00069	0.360
DOC_MAPK_NFAT4_5	180	188	PF00069	0.460
DOC_PP1_RVXF_1	251	258	PF00149	0.460
DOC_PP2B_LxvP_1	495	498	PF13499	0.460
DOC_PP2B_LxvP_1	614	617	PF13499	0.616
DOC_PP2B_LxvP_1	79	82	PF13499	0.621
DOC_PP4_FxxP_1	578	581	PF00568	0.488
DOC_PP4_MxPP_1	1	4	PF00568	0.634
DOC_USP7_MATH_1	10	14	PF00917	0.672
DOC_USP7_MATH_1	15	19	PF00917	0.641
DOC_USP7_MATH_1	247	251	PF00917	0.431
DOC_USP7_MATH_1	25	29	PF00917	0.401
DOC_USP7_MATH_1	289	293	PF00917	0.741
DOC_USP7_MATH_1	325	329	PF00917	0.681
DOC_USP7_MATH_1	34	38	PF00917	0.354
DOC_USP7_MATH_1	455	459	PF00917	0.320
DOC_USP7_MATH_1	462	466	PF00917	0.225
DOC_USP7_MATH_1	480	484	PF00917	0.460
DOC_USP7_MATH_1	5	9	PF00917	0.703
DOC_USP7_MATH_1	584	588	PF00917	0.574
DOC_USP7_MATH_1	591	595	PF00917	0.627
DOC_WW_Pin1_4	17	22	PF00397	0.628
DOC_WW_Pin1_4	278	283	PF00397	0.580
DOC_WW_Pin1_4	313	318	PF00397	0.715
DOC_WW_Pin1_4	376	381	PF00397	0.402
DOC_WW_Pin1_4	435	440	PF00397	0.367
DOC_WW_Pin1_4	476	481	PF00397	0.402
DOC_WW_Pin1_4	488	493	PF00397	0.443
DOC_WW_Pin1_4	515	520	PF00397	0.390
LIG_14-3-3_CanoR_1	196	201	PF00244	0.431
LIG_14-3-3_CanoR_1	394	398	PF00244	0.412
LIG_14-3-3_CanoR_1	565	574	PF00244	0.336
LIG_14-3-3_CanoR_1	588	596	PF00244	0.592
LIG_BIR_III_2	473	477	PF00653	0.460
LIG_BRCT_BRCA1_1	490	494	PF00533	0.460
LIG_Clathr_ClatBox_1	222	226	PF01394	0.460
LIG_deltaCOP1_diTrp_1	393	400	PF00928	0.329
LIG_eIF4E_1	72	78	PF01652	0.601
LIG_FHA_1	28	34	PF00498	0.591
LIG_FHA_1	317	323	PF00498	0.665
LIG_FHA_1	325	331	PF00498	0.669
LIG_FHA_1	387	393	PF00498	0.460
LIG_FHA_1	422	428	PF00498	0.339
LIG_FHA_1	445	451	PF00498	0.320
LIG_FHA_1	51	57	PF00498	0.622
LIG_FHA_1	595	601	PF00498	0.659
LIG_FHA_2	388	394	PF00498	0.460
LIG_FHA_2	510	516	PF00498	0.454
LIG_LIR_Apic_2	374	380	PF02991	0.304
LIG_LIR_Gen_1	546	556	PF02991	0.460
LIG_LIR_Gen_1	62	72	PF02991	0.579
LIG_LIR_Nem_3	119	123	PF02991	0.355
LIG_LIR_Nem_3	191	195	PF02991	0.360
LIG_LIR_Nem_3	201	206	PF02991	0.412
LIG_LIR_Nem_3	546	552	PF02991	0.395
LIG_LIR_Nem_3	62	67	PF02991	0.580
LIG_LIR_Nem_3	94	100	PF02991	0.492
LIG_MLH1_MIPbox_1	490	494	PF16413	0.460
LIG_MYND_1	476	480	PF01753	0.460
LIG_MYND_1	577	581	PF01753	0.460
LIG_REV1ctd_RIR_1	491	497	PF16727	0.460
LIG_SH2_CRK	195	199	PF00017	0.460
LIG_SH2_CRK	203	207	PF00017	0.402
LIG_SH2_CRK	216	220	PF00017	0.333
LIG_SH2_CRK	446	450	PF00017	0.320
LIG_SH2_NCK_1	64	68	PF00017	0.581
LIG_SH2_NCK_1	90	94	PF00017	0.565
LIG_SH2_SRC	90	93	PF00017	0.563
LIG_SH2_STAP1	388	392	PF00017	0.460
LIG_SH2_STAT3	262	265	PF00017	0.460
LIG_SH2_STAT5	109	112	PF00017	0.250
LIG_SH2_STAT5	145	148	PF00017	0.437
LIG_SH2_STAT5	371	374	PF00017	0.360
LIG_SH2_STAT5	388	391	PF00017	0.360
LIG_SH2_STAT5	422	425	PF00017	0.434
LIG_SH2_STAT5	446	449	PF00017	0.425
LIG_SH2_STAT5	97	100	PF00017	0.531
LIG_SH3_1	446	452	PF00018	0.320
LIG_SH3_2	409	414	PF14604	0.402
LIG_SH3_3	183	189	PF00018	0.460
LIG_SH3_3	272	278	PF00018	0.607
LIG_SH3_3	311	317	PF00018	0.767
LIG_SH3_3	327	333	PF00018	0.754
LIG_SH3_3	406	412	PF00018	0.360
LIG_SH3_3	423	429	PF00018	0.360
LIG_SH3_3	446	452	PF00018	0.369
LIG_SH3_5	429	433	PF00018	0.460
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.549
LIG_SUMO_SIM_par_1	182	188	PF11976	0.460
LIG_SUMO_SIM_par_1	196	201	PF11976	0.215
LIG_SUMO_SIM_par_1	220	226	PF11976	0.460
LIG_SUMO_SIM_par_1	518	525	PF11976	0.460
LIG_SUMO_SIM_par_1	52	57	PF11976	0.621
LIG_TRAF2_1	101	104	PF00917	0.546
LIG_TRAF2_1	522	525	PF00917	0.443
LIG_TYR_ITSM	199	206	PF00017	0.460
LIG_UBA3_1	197	202	PF00899	0.460
MOD_CDC14_SPxK_1	438	441	PF00782	0.460
MOD_CDK_SPK_2	435	440	PF00069	0.460
MOD_CDK_SPxK_1	435	441	PF00069	0.431
MOD_CDK_SPxxK_3	17	24	PF00069	0.628
MOD_CK1_1	119	125	PF00069	0.460
MOD_CK1_1	281	287	PF00069	0.672
MOD_CK1_1	316	322	PF00069	0.693
MOD_CK1_1	347	353	PF00069	0.686
MOD_CK1_1	37	43	PF00069	0.533
MOD_CK1_1	589	595	PF00069	0.598
MOD_CK1_1	612	618	PF00069	0.620
MOD_CK2_1	245	251	PF00069	0.379
MOD_CK2_1	455	461	PF00069	0.414
MOD_CK2_1	519	525	PF00069	0.443
MOD_CK2_1	59	65	PF00069	0.586
MOD_GlcNHglycan	12	15	PF01048	0.675
MOD_GlcNHglycan	141	144	PF01048	0.460
MOD_GlcNHglycan	17	20	PF01048	0.678
MOD_GlcNHglycan	258	261	PF01048	0.406
MOD_GlcNHglycan	285	288	PF01048	0.631
MOD_GlcNHglycan	327	330	PF01048	0.669
MOD_GlcNHglycan	346	349	PF01048	0.742
MOD_GlcNHglycan	36	39	PF01048	0.341
MOD_GlcNHglycan	457	460	PF01048	0.395
MOD_GlcNHglycan	464	467	PF01048	0.325
MOD_GlcNHglycan	482	485	PF01048	0.460
MOD_GlcNHglycan	5	8	PF01048	0.678
MOD_GlcNHglycan	593	596	PF01048	0.640
MOD_GlcNHglycan	607	610	PF01048	0.722
MOD_GlcNHglycan	91	96	PF01048	0.411
MOD_GSK3_1	15	22	PF00069	0.629
MOD_GSK3_1	204	211	PF00069	0.440
MOD_GSK3_1	276	283	PF00069	0.600
MOD_GSK3_1	290	297	PF00069	0.553
MOD_GSK3_1	337	344	PF00069	0.714
MOD_GSK3_1	435	442	PF00069	0.443
MOD_GSK3_1	451	458	PF00069	0.351
MOD_GSK3_1	476	483	PF00069	0.406
MOD_GSK3_1	50	57	PF00069	0.624
MOD_GSK3_1	509	516	PF00069	0.383
MOD_GSK3_1	605	612	PF00069	0.719
MOD_N-GLC_1	455	460	PF02516	0.419
MOD_N-GLC_1	513	518	PF02516	0.366
MOD_NEK2_1	190	195	PF00069	0.460
MOD_NEK2_1	208	213	PF00069	0.379
MOD_NEK2_1	386	391	PF00069	0.346
MOD_NEK2_1	444	449	PF00069	0.460
MOD_NEK2_1	77	82	PF00069	0.621
MOD_NEK2_2	66	71	PF00069	0.582
MOD_PIKK_1	145	151	PF00454	0.460
MOD_PIKK_1	19	25	PF00454	0.705
MOD_PIKK_1	439	445	PF00454	0.402
MOD_PIKK_1	54	60	PF00454	0.604
MOD_PIKK_1	589	595	PF00454	0.574
MOD_PK_1	586	592	PF00069	0.494
MOD_PKA_1	566	572	PF00069	0.402
MOD_PKA_2	393	399	PF00069	0.417
MOD_PKA_2	50	56	PF00069	0.624
MOD_PKA_2	566	572	PF00069	0.304
MOD_Plk_4	119	125	PF00069	0.460
MOD_Plk_4	422	428	PF00069	0.379
MOD_Plk_4	59	65	PF00069	0.586
MOD_Plk_4	609	615	PF00069	0.615
MOD_Plk_4	66	72	PF00069	0.458
MOD_ProDKin_1	17	23	PF00069	0.628
MOD_ProDKin_1	278	284	PF00069	0.587
MOD_ProDKin_1	313	319	PF00069	0.715
MOD_ProDKin_1	376	382	PF00069	0.402
MOD_ProDKin_1	435	441	PF00069	0.367
MOD_ProDKin_1	476	482	PF00069	0.402
MOD_ProDKin_1	488	494	PF00069	0.443
MOD_ProDKin_1	515	521	PF00069	0.390
MOD_SUMO_for_1	237	240	PF00179	0.360
TRG_DiLeu_BaEn_1	74	79	PF01217	0.602
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.460
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.525
TRG_ENDOCYTIC_2	195	198	PF00928	0.428
TRG_ENDOCYTIC_2	203	206	PF00928	0.402
TRG_ENDOCYTIC_2	216	219	PF00928	0.333
TRG_ENDOCYTIC_2	549	552	PF00928	0.412
TRG_ENDOCYTIC_2	64	67	PF00928	0.588
TRG_ENDOCYTIC_2	90	93	PF00928	0.557
TRG_ER_diArg_1	564	567	PF00400	0.422
TRG_NLS_MonoExtN_4	564	569	PF00514	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J5U4	Bodo saltans	25%	100%
A0A0S4KIN4	Bodo saltans	25%	91%
A0A1X0NZD5	Trypanosomatidae	23%	100%
A0A3S5IQV1	Trypanosoma rangeli	24%	100%
A4HW27	Leishmania infantum	83%	100%
C9ZW07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q01917	Crithidia fasciculata	23%	100%