DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4201), putative

Species:

Leishmania braziliensis

UniProt:

A4H7N6_LEIBR

TriTrypDb:

LbrM.14.0790 , LBRM2903_140013600

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005856	cytoskeleton	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4H7N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7N6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.532
CLV_NRD_NRD_1	16	18	PF00675	0.604
CLV_NRD_NRD_1	169	171	PF00675	0.610
CLV_NRD_NRD_1	176	178	PF00675	0.572
CLV_NRD_NRD_1	229	231	PF00675	0.583
CLV_NRD_NRD_1	267	269	PF00675	0.752
CLV_NRD_NRD_1	297	299	PF00675	0.549
CLV_NRD_NRD_1	330	332	PF00675	0.326
CLV_NRD_NRD_1	462	464	PF00675	0.292
CLV_NRD_NRD_1	480	482	PF00675	0.500
CLV_NRD_NRD_1	532	534	PF00675	0.617
CLV_NRD_NRD_1	96	98	PF00675	0.705
CLV_PCSK_FUR_1	328	332	PF00082	0.362
CLV_PCSK_FUR_1	393	397	PF00082	0.353
CLV_PCSK_KEX2_1	15	17	PF00082	0.774
CLV_PCSK_KEX2_1	169	171	PF00082	0.609
CLV_PCSK_KEX2_1	175	177	PF00082	0.588
CLV_PCSK_KEX2_1	229	231	PF00082	0.570
CLV_PCSK_KEX2_1	267	269	PF00082	0.766
CLV_PCSK_KEX2_1	297	299	PF00082	0.495
CLV_PCSK_KEX2_1	330	332	PF00082	0.334
CLV_PCSK_KEX2_1	395	397	PF00082	0.334
CLV_PCSK_KEX2_1	480	482	PF00082	0.566
CLV_PCSK_KEX2_1	496	498	PF00082	0.455
CLV_PCSK_KEX2_1	531	533	PF00082	0.603
CLV_PCSK_KEX2_1	96	98	PF00082	0.705
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.353
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.574
CLV_PCSK_PC7_1	293	299	PF00082	0.495
CLV_PCSK_PC7_1	476	482	PF00082	0.581
CLV_PCSK_SKI1_1	208	212	PF00082	0.479
CLV_PCSK_SKI1_1	272	276	PF00082	0.749
CLV_PCSK_SKI1_1	396	400	PF00082	0.334
CLV_PCSK_SKI1_1	456	460	PF00082	0.362
CLV_Separin_Metazoa	290	294	PF03568	0.599
DEG_APCC_DBOX_1	175	183	PF00400	0.678
DEG_SPOP_SBC_1	7	11	PF00917	0.502
DOC_MAPK_gen_1	175	184	PF00069	0.494
DOC_MAPK_gen_1	229	236	PF00069	0.504
DOC_MAPK_MEF2A_6	177	186	PF00069	0.442
DOC_MAPK_MEF2A_6	229	238	PF00069	0.528
DOC_MAPK_MEF2A_6	33	42	PF00069	0.620
DOC_MAPK_MEF2A_6	97	106	PF00069	0.501
DOC_USP7_MATH_1	109	113	PF00917	0.641
DOC_USP7_MATH_1	127	131	PF00917	0.605
DOC_USP7_MATH_1	278	282	PF00917	0.639
DOC_USP7_MATH_1	514	518	PF00917	0.709
DOC_USP7_MATH_1	568	572	PF00917	0.743
DOC_USP7_MATH_1	7	11	PF00917	0.749
DOC_USP7_UBL2_3	395	399	PF12436	0.562
DOC_WW_Pin1_4	266	271	PF00397	0.727
LIG_14-3-3_CanoR_1	169	175	PF00244	0.645
LIG_14-3-3_CanoR_1	176	180	PF00244	0.580
LIG_14-3-3_CanoR_1	297	306	PF00244	0.536
LIG_14-3-3_CanoR_1	480	490	PF00244	0.618
LIG_14-3-3_CanoR_1	497	505	PF00244	0.544
LIG_14-3-3_CanoR_1	6	13	PF00244	0.674
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_FHA_1	133	139	PF00498	0.658
LIG_FHA_1	191	197	PF00498	0.576
LIG_FHA_1	3	9	PF00498	0.517
LIG_FHA_1	369	375	PF00498	0.495
LIG_FHA_1	81	87	PF00498	0.551
LIG_FHA_2	221	227	PF00498	0.397
LIG_FHA_2	284	290	PF00498	0.643
LIG_LIR_Gen_1	183	192	PF02991	0.508
LIG_LIR_Gen_1	335	345	PF02991	0.486
LIG_LIR_Gen_1	34	43	PF02991	0.540
LIG_LIR_LC3C_4	37	40	PF02991	0.369
LIG_LIR_Nem_3	183	188	PF02991	0.517
LIG_LIR_Nem_3	335	340	PF02991	0.482
LIG_LIR_Nem_3	34	38	PF02991	0.550
LIG_PCNA_yPIPBox_3	33	43	PF02747	0.607
LIG_RPA_C_Fungi	319	331	PF08784	0.227
LIG_RPA_C_Fungi	520	532	PF08784	0.561
LIG_SH2_GRB2like	492	495	PF00017	0.678
LIG_SH2_STAP1	43	47	PF00017	0.583
LIG_SH2_STAT3	444	447	PF00017	0.335
LIG_SH2_STAT5	294	297	PF00017	0.522
LIG_SH2_STAT5	404	407	PF00017	0.335
LIG_SH3_3	433	439	PF00018	0.355
LIG_SH3_3	557	563	PF00018	0.712
LIG_Sin3_3	192	199	PF02671	0.354
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.489
LIG_SUMO_SIM_par_1	192	198	PF11976	0.354
LIG_TRAF2_1	204	207	PF00917	0.590
LIG_TRAF2_1	223	226	PF00917	0.334
LIG_TRAF2_1	431	434	PF00917	0.447
LIG_TRAF2_1	78	81	PF00917	0.622
LIG_WRC_WIRS_1	39	44	PF05994	0.575
MOD_CDC14_SPxK_1	269	272	PF00782	0.614
MOD_CDK_SPxK_1	266	272	PF00069	0.621
MOD_CK1_1	110	116	PF00069	0.612
MOD_CK1_1	146	152	PF00069	0.659
MOD_CK1_1	2	8	PF00069	0.720
MOD_CK1_1	20	26	PF00069	0.765
MOD_CK1_1	370	376	PF00069	0.335
MOD_CK1_1	41	47	PF00069	0.573
MOD_CK1_1	555	561	PF00069	0.533
MOD_CK2_1	220	226	PF00069	0.414
MOD_CK2_1	284	290	PF00069	0.641
MOD_CK2_1	397	403	PF00069	0.378
MOD_Cter_Amidation	167	170	PF01082	0.757
MOD_GlcNHglycan	10	13	PF01048	0.705
MOD_GlcNHglycan	109	112	PF01048	0.714
MOD_GlcNHglycan	124	127	PF01048	0.611
MOD_GlcNHglycan	129	132	PF01048	0.508
MOD_GlcNHglycan	152	155	PF01048	0.688
MOD_GlcNHglycan	164	167	PF01048	0.598
MOD_GlcNHglycan	20	23	PF01048	0.510
MOD_GlcNHglycan	247	250	PF01048	0.556
MOD_GlcNHglycan	280	283	PF01048	0.693
MOD_GlcNHglycan	48	51	PF01048	0.646
MOD_GlcNHglycan	553	557	PF01048	0.803
MOD_GlcNHglycan	75	79	PF01048	0.618
MOD_GSK3_1	122	129	PF00069	0.697
MOD_GSK3_1	146	153	PF00069	0.704
MOD_GSK3_1	16	23	PF00069	0.629
MOD_GSK3_1	2	9	PF00069	0.722
MOD_GSK3_1	297	304	PF00069	0.625
MOD_GSK3_1	34	41	PF00069	0.598
MOD_GSK3_1	366	373	PF00069	0.335
MOD_N-GLC_1	107	112	PF02516	0.691
MOD_N-GLC_1	143	148	PF02516	0.552
MOD_N-GLC_1	17	22	PF02516	0.659
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	107	112	PF00069	0.502
MOD_NEK2_1	366	371	PF00069	0.335
MOD_NEK2_1	38	43	PF00069	0.575
MOD_NEK2_1	505	510	PF00069	0.654
MOD_NEK2_1	8	13	PF00069	0.619
MOD_PIKK_1	146	152	PF00454	0.561
MOD_PIKK_1	298	304	PF00454	0.550
MOD_PIKK_1	481	487	PF00454	0.486
MOD_PIKK_1	514	520	PF00454	0.678
MOD_PIKK_1	80	86	PF00454	0.611
MOD_PKA_1	16	22	PF00069	0.591
MOD_PKA_1	175	181	PF00069	0.691
MOD_PKA_1	297	303	PF00069	0.578
MOD_PKA_1	496	502	PF00069	0.649
MOD_PKA_2	16	22	PF00069	0.684
MOD_PKA_2	175	181	PF00069	0.622
MOD_PKA_2	297	303	PF00069	0.578
MOD_PKA_2	496	502	PF00069	0.581
MOD_PKA_2	540	546	PF00069	0.549
MOD_PKB_1	15	23	PF00069	0.691
MOD_Plk_1	132	138	PF00069	0.728
MOD_Plk_1	389	395	PF00069	0.376
MOD_Plk_1	74	80	PF00069	0.611
MOD_Plk_4	190	196	PF00069	0.470
MOD_Plk_4	34	40	PF00069	0.649
MOD_ProDKin_1	266	272	PF00069	0.727
MOD_SUMO_for_1	394	397	PF00179	0.434
MOD_SUMO_for_1	439	442	PF00179	0.349
MOD_SUMO_rev_2	183	193	PF00179	0.615
MOD_SUMO_rev_2	269	277	PF00179	0.531
MOD_SUMO_rev_2	343	352	PF00179	0.384
MOD_SUMO_rev_2	362	369	PF00179	0.186
MOD_SUMO_rev_2	418	427	PF00179	0.360
TRG_DiLeu_BaEn_1	423	428	PF01217	0.227
TRG_DiLeu_BaEn_4	81	87	PF01217	0.543
TRG_ER_diArg_1	15	17	PF00400	0.545
TRG_ER_diArg_1	174	177	PF00400	0.622
TRG_ER_diArg_1	327	330	PF00400	0.355
TRG_ER_diArg_1	480	482	PF00400	0.558
TRG_ER_diArg_1	531	533	PF00400	0.513
TRG_ER_diArg_1	96	98	PF00400	0.738
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T9	Leptomonas seymouri	60%	100%
A0A1X0NNL2	Trypanosomatidae	40%	100%
A0A3Q8IIC4	Leishmania donovani	78%	99%
A0A422N1M9	Trypanosoma rangeli	39%	100%
A4HW26	Leishmania infantum	78%	99%
C9ZT07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9APS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QFQ1	Leishmania major	76%	100%
V5BEA4	Trypanosoma cruzi	42%	100%