Mucin-5AC

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mucin-5AC

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7N5_LEIBR

TriTrypDb:

LbrM.14.0780 , LBRM2903_140013500

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7N5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.679
CLV_PCSK_KEX2_1	106	108	PF00082	0.633
CLV_PCSK_KEX2_1	422	424	PF00082	0.673
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.633
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.663
CLV_PCSK_SKI1_1	147	151	PF00082	0.717
CLV_PCSK_SKI1_1	160	164	PF00082	0.686
CLV_PCSK_SKI1_1	17	21	PF00082	0.586
CLV_PCSK_SKI1_1	178	182	PF00082	0.460
CLV_PCSK_SKI1_1	46	50	PF00082	0.646
CLV_PCSK_SKI1_1	91	95	PF00082	0.536
DEG_Nend_UBRbox_2	1	3	PF02207	0.494
DEG_SPOP_SBC_1	239	243	PF00917	0.592
DEG_SPOP_SBC_1	244	248	PF00917	0.586
DEG_SPOP_SBC_1	279	283	PF00917	0.521
DEG_SPOP_SBC_1	301	305	PF00917	0.490
DEG_SPOP_SBC_1	358	362	PF00917	0.490
DOC_CDC14_PxL_1	188	196	PF14671	0.667
DOC_CKS1_1	333	338	PF01111	0.583
DOC_MAPK_MEF2A_6	73	82	PF00069	0.670
DOC_PP1_RVXF_1	148	155	PF00149	0.490
DOC_PP2B_LxvP_1	68	71	PF13499	0.655
DOC_USP7_MATH_1	217	221	PF00917	0.683
DOC_USP7_MATH_1	239	243	PF00917	0.661
DOC_USP7_MATH_1	259	263	PF00917	0.714
DOC_USP7_MATH_1	278	282	PF00917	0.701
DOC_USP7_MATH_1	290	294	PF00917	0.554
DOC_USP7_MATH_1	302	306	PF00917	0.685
DOC_USP7_MATH_1	320	324	PF00917	0.706
DOC_USP7_MATH_1	331	335	PF00917	0.685
DOC_USP7_MATH_1	346	350	PF00917	0.624
DOC_USP7_MATH_1	374	378	PF00917	0.550
DOC_USP7_MATH_1	38	42	PF00917	0.661
DOC_USP7_MATH_1	410	414	PF00917	0.743
DOC_USP7_MATH_1	61	65	PF00917	0.663
DOC_USP7_MATH_2	236	242	PF00917	0.599
DOC_USP7_UBL2_3	16	20	PF12436	0.569
DOC_USP7_UBL2_3	418	422	PF12436	0.641
DOC_USP7_UBL2_3	9	13	PF12436	0.523
DOC_WW_Pin1_4	138	143	PF00397	0.676
DOC_WW_Pin1_4	204	209	PF00397	0.594
DOC_WW_Pin1_4	240	245	PF00397	0.586
DOC_WW_Pin1_4	266	271	PF00397	0.663
DOC_WW_Pin1_4	272	277	PF00397	0.720
DOC_WW_Pin1_4	332	337	PF00397	0.662
DOC_WW_Pin1_4	63	68	PF00397	0.682
LIG_14-3-3_CanoR_1	300	309	PF00244	0.492
LIG_14-3-3_CanoR_1	357	366	PF00244	0.651
LIG_14-3-3_CanoR_1	91	97	PF00244	0.648
LIG_BRCT_BRCA1_1	82	86	PF00533	0.482
LIG_FHA_1	161	167	PF00498	0.583
LIG_FHA_1	181	187	PF00498	0.640
LIG_FHA_1	88	94	PF00498	0.605
LIG_FHA_2	191	197	PF00498	0.574
LIG_FHA_2	262	268	PF00498	0.597
LIG_FHA_2	345	351	PF00498	0.704
LIG_LIR_Apic_2	283	289	PF02991	0.536
LIG_LIR_Apic_2	306	312	PF02991	0.701
LIG_LIR_Apic_2	314	320	PF02991	0.648
LIG_LIR_Apic_2	326	331	PF02991	0.632
LIG_LIR_Apic_2	340	346	PF02991	0.591
LIG_LIR_Apic_2	354	359	PF02991	0.601
LIG_LIR_Apic_2	364	369	PF02991	0.695
LIG_LIR_Apic_2	380	384	PF02991	0.520
LIG_LIR_Apic_2	391	395	PF02991	0.588
LIG_LIR_Apic_2	415	420	PF02991	0.702
LIG_MYND_3	191	195	PF01753	0.573
LIG_SH2_CRK	286	290	PF00017	0.505
LIG_SH2_CRK	299	303	PF00017	0.587
LIG_SH2_CRK	309	313	PF00017	0.558
LIG_SH2_CRK	317	321	PF00017	0.628
LIG_SH2_CRK	328	332	PF00017	0.623
LIG_SH2_CRK	343	347	PF00017	0.704
LIG_SH2_CRK	356	360	PF00017	0.635
LIG_SH2_CRK	366	370	PF00017	0.636
LIG_SH2_CRK	381	385	PF00017	0.525
LIG_SH2_CRK	392	396	PF00017	0.686
LIG_SH2_CRK	405	409	PF00017	0.691
LIG_SH2_CRK	417	421	PF00017	0.623
LIG_SH2_PTP2	256	259	PF00017	0.655
LIG_SH2_SRC	256	259	PF00017	0.655
LIG_SH2_STAT5	256	259	PF00017	0.655
LIG_SH3_3	295	301	PF00018	0.566
LIG_SH3_3	313	319	PF00018	0.544
LIG_SH3_3	327	333	PF00018	0.681
LIG_SH3_3	339	345	PF00018	0.683
LIG_SH3_3	365	371	PF00018	0.567
LIG_SH3_4	418	425	PF00018	0.650
LIG_SUMO_SIM_par_1	78	83	PF11976	0.489
LIG_TRAF2_1	119	122	PF00917	0.671
LIG_TRAF2_1	193	196	PF00917	0.616
LIG_TRAF2_1	235	238	PF00917	0.587
MOD_CDK_SPK_2	142	147	PF00069	0.669
MOD_CK1_1	141	147	PF00069	0.683
MOD_CK1_1	220	226	PF00069	0.767
MOD_CK1_1	227	233	PF00069	0.650
MOD_CK1_1	242	248	PF00069	0.714
MOD_CK1_1	262	268	PF00069	0.602
MOD_CK1_1	274	280	PF00069	0.663
MOD_CK1_1	303	309	PF00069	0.679
MOD_CK1_1	334	340	PF00069	0.715
MOD_CK1_1	349	355	PF00069	0.561
MOD_CK1_1	377	383	PF00069	0.501
MOD_CK1_1	385	391	PF00069	0.511
MOD_CK1_1	396	402	PF00069	0.536
MOD_CK1_1	413	419	PF00069	0.738
MOD_CK1_1	56	62	PF00069	0.774
MOD_CK1_1	63	69	PF00069	0.572
MOD_CK1_1	92	98	PF00069	0.667
MOD_CK2_1	142	148	PF00069	0.709
MOD_CK2_1	190	196	PF00069	0.575
MOD_CK2_1	261	267	PF00069	0.709
MOD_CK2_1	320	326	PF00069	0.782
MOD_CK2_1	358	364	PF00069	0.649
MOD_Cter_Amidation	126	129	PF01082	0.488
MOD_GlcNHglycan	22	25	PF01048	0.770
MOD_GlcNHglycan	225	229	PF01048	0.760
MOD_GlcNHglycan	249	252	PF01048	0.631
MOD_GlcNHglycan	290	293	PF01048	0.707
MOD_GlcNHglycan	294	297	PF01048	0.641
MOD_GlcNHglycan	305	308	PF01048	0.557
MOD_GlcNHglycan	313	316	PF01048	0.511
MOD_GlcNHglycan	322	325	PF01048	0.628
MOD_GlcNHglycan	337	340	PF01048	0.651
MOD_GlcNHglycan	350	354	PF01048	0.629
MOD_GlcNHglycan	376	379	PF01048	0.697
MOD_GlcNHglycan	385	388	PF01048	0.725
MOD_GlcNHglycan	400	403	PF01048	0.585
MOD_GlcNHglycan	408	411	PF01048	0.781
MOD_GlcNHglycan	412	415	PF01048	0.686
MOD_GlcNHglycan	57	61	PF01048	0.771
MOD_GlcNHglycan	63	66	PF01048	0.541
MOD_GSK3_1	134	141	PF00069	0.720
MOD_GSK3_1	180	187	PF00069	0.688
MOD_GSK3_1	190	197	PF00069	0.615
MOD_GSK3_1	202	209	PF00069	0.644
MOD_GSK3_1	216	223	PF00069	0.650
MOD_GSK3_1	238	245	PF00069	0.673
MOD_GSK3_1	257	264	PF00069	0.639
MOD_GSK3_1	266	273	PF00069	0.596
MOD_GSK3_1	274	281	PF00069	0.742
MOD_GSK3_1	288	295	PF00069	0.641
MOD_GSK3_1	331	338	PF00069	0.656
MOD_GSK3_1	344	351	PF00069	0.613
MOD_GSK3_1	370	377	PF00069	0.709
MOD_GSK3_1	393	400	PF00069	0.677
MOD_GSK3_1	406	413	PF00069	0.698
MOD_GSK3_1	46	53	PF00069	0.697
MOD_GSK3_1	56	63	PF00069	0.768
MOD_GSK3_1	85	92	PF00069	0.517
MOD_N-GLC_1	160	165	PF02516	0.691
MOD_N-GLC_1	320	325	PF02516	0.684
MOD_NEK2_1	102	107	PF00069	0.425
MOD_NEK2_1	194	199	PF00069	0.683
MOD_NEK2_1	86	91	PF00069	0.611
MOD_PIKK_1	180	186	PF00454	0.692
MOD_PIKK_1	202	208	PF00454	0.688
MOD_PK_1	393	399	PF00069	0.488
MOD_PKA_1	12	18	PF00069	0.686
MOD_PKA_1	20	26	PF00069	0.485
MOD_PKA_1	202	208	PF00069	0.688
MOD_PKA_2	112	118	PF00069	0.441
MOD_PKA_2	38	44	PF00069	0.746
MOD_Plk_1	194	200	PF00069	0.688
MOD_Plk_1	71	77	PF00069	0.641
MOD_ProDKin_1	138	144	PF00069	0.674
MOD_ProDKin_1	204	210	PF00069	0.648
MOD_ProDKin_1	240	246	PF00069	0.577
MOD_ProDKin_1	266	272	PF00069	0.665
MOD_ProDKin_1	332	338	PF00069	0.661
MOD_ProDKin_1	63	69	PF00069	0.681
MOD_SUMO_for_1	119	122	PF00179	0.651
MOD_SUMO_rev_2	110	119	PF00179	0.608
MOD_SUMO_rev_2	143	152	PF00179	0.704
TRG_NLS_MonoExtC_3	19	25	PF00514	0.713
TRG_NLS_MonoExtN_4	17	24	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE22	Leptomonas seymouri	42%	100%
A0A1X0NNK6	Trypanosomatidae	32%	89%
A0A3R7RMH8	Trypanosoma rangeli	30%	100%
A0A3S7WT08	Leishmania donovani	68%	99%
A4HW24	Leishmania infantum	68%	99%
C9ZT09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
E9APS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	96%
Q4QFQ3	Leishmania major	68%	97%