Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H7N2_LEIBR

TriTrypDb:

LbrM.14.0750 , LBRM2903_140013100

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H7N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.465
CLV_C14_Caspase3-7	163	167	PF00656	0.430
CLV_NRD_NRD_1	14	16	PF00675	0.451
CLV_NRD_NRD_1	246	248	PF00675	0.756
CLV_NRD_NRD_1	253	255	PF00675	0.744
CLV_NRD_NRD_1	270	272	PF00675	0.643
CLV_NRD_NRD_1	297	299	PF00675	0.642
CLV_NRD_NRD_1	338	340	PF00675	0.692
CLV_NRD_NRD_1	361	363	PF00675	0.622
CLV_NRD_NRD_1	88	90	PF00675	0.684
CLV_PCSK_FUR_1	336	340	PF00082	0.705
CLV_PCSK_KEX2_1	14	16	PF00082	0.451
CLV_PCSK_KEX2_1	246	248	PF00082	0.756
CLV_PCSK_KEX2_1	253	255	PF00082	0.744
CLV_PCSK_KEX2_1	270	272	PF00082	0.643
CLV_PCSK_KEX2_1	297	299	PF00082	0.642
CLV_PCSK_KEX2_1	338	340	PF00082	0.692
CLV_PCSK_KEX2_1	384	386	PF00082	0.452
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.417
CLV_PCSK_SKI1_1	324	328	PF00082	0.719
CLV_Separin_Metazoa	205	209	PF03568	0.496
DEG_APCC_DBOX_1	20	28	PF00400	0.571
DEG_APCC_DBOX_1	207	215	PF00400	0.536
DEG_SCF_SKP2-CKS1_1	356	363	PF00560	0.417
DEG_SPOP_SBC_1	5	9	PF00917	0.647
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.410
DOC_MAPK_gen_1	14	24	PF00069	0.642
DOC_MAPK_gen_1	333	343	PF00069	0.422
DOC_MAPK_gen_1	362	368	PF00069	0.468
DOC_MAPK_gen_1	384	392	PF00069	0.217
DOC_MAPK_MEF2A_6	385	394	PF00069	0.231
DOC_PP2B_LxvP_1	366	369	PF13499	0.447
DOC_USP7_MATH_1	249	253	PF00917	0.500
DOC_USP7_MATH_1	274	278	PF00917	0.539
DOC_USP7_MATH_1	388	392	PF00917	0.388
DOC_USP7_MATH_1	40	44	PF00917	0.341
DOC_USP7_MATH_1	5	9	PF00917	0.619
DOC_USP7_MATH_1	75	79	PF00917	0.472
DOC_WW_Pin1_4	132	137	PF00397	0.636
DOC_WW_Pin1_4	240	245	PF00397	0.486
DOC_WW_Pin1_4	357	362	PF00397	0.419
LIG_14-3-3_CanoR_1	186	192	PF00244	0.549
LIG_14-3-3_CanoR_1	208	212	PF00244	0.429
LIG_14-3-3_CanoR_1	21	25	PF00244	0.594
LIG_14-3-3_CanoR_1	281	286	PF00244	0.449
LIG_14-3-3_CanoR_1	63	68	PF00244	0.402
LIG_APCC_ABBA_1	231	236	PF00400	0.461
LIG_BIR_III_2	170	174	PF00653	0.462
LIG_BRCT_BRCA1_1	394	398	PF00533	0.364
LIG_DLG_GKlike_1	281	288	PF00625	0.447
LIG_FHA_1	186	192	PF00498	0.561
LIG_FHA_1	384	390	PF00498	0.237
LIG_FHA_2	142	148	PF00498	0.465
LIG_FHA_2	161	167	PF00498	0.429
LIG_FHA_2	224	230	PF00498	0.445
LIG_FHA_2	349	355	PF00498	0.567
LIG_FHA_2	55	61	PF00498	0.523
LIG_LIR_Gen_1	284	293	PF02991	0.442
LIG_LIR_Nem_3	284	288	PF02991	0.450
LIG_LIR_Nem_3	395	401	PF02991	0.306
LIG_NRBOX	31	37	PF00104	0.346
LIG_PDZ_Class_2	400	405	PF00595	0.312
LIG_SH3_3	133	139	PF00018	0.448
LIG_SUMO_SIM_anti_2	386	391	PF11976	0.229
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.455
LIG_SUMO_SIM_par_1	385	391	PF11976	0.231
LIG_TRAF2_1	332	335	PF00917	0.409
LIG_WW_2	136	139	PF00397	0.445
LIG_WW_3	205	209	PF00397	0.504
MOD_CDC14_SPxK_1	243	246	PF00782	0.461
MOD_CDK_SPK_2	357	362	PF00069	0.414
MOD_CDK_SPxK_1	240	246	PF00069	0.461
MOD_CDK_SPxK_1	357	363	PF00069	0.417
MOD_CDK_SPxxK_3	240	247	PF00069	0.480
MOD_CK1_1	210	216	PF00069	0.419
MOD_CK1_1	348	354	PF00069	0.561
MOD_CK1_1	9	15	PF00069	0.709
MOD_CK2_1	325	331	PF00069	0.509
MOD_CK2_1	348	354	PF00069	0.563
MOD_GlcNHglycan	257	261	PF01048	0.748
MOD_GlcNHglycan	293	296	PF01048	0.659
MOD_GlcNHglycan	394	397	PF01048	0.279
MOD_GlcNHglycan	70	73	PF01048	0.745
MOD_GlcNHglycan	8	11	PF01048	0.445
MOD_GSK3_1	325	332	PF00069	0.548
MOD_GSK3_1	345	352	PF00069	0.384
MOD_GSK3_1	388	395	PF00069	0.325
MOD_GSK3_1	5	12	PF00069	0.712
MOD_LATS_1	158	164	PF00433	0.459
MOD_N-GLC_1	324	329	PF02516	0.650
MOD_NEK2_1	392	397	PF00069	0.316
MOD_NEK2_1	4	9	PF00069	0.661
MOD_NEK2_1	80	85	PF00069	0.458
MOD_NEK2_2	20	25	PF00069	0.579
MOD_NEK2_2	388	393	PF00069	0.388
MOD_PIKK_1	342	348	PF00454	0.422
MOD_PK_1	63	69	PF00069	0.402
MOD_PKA_2	149	155	PF00069	0.466
MOD_PKA_2	185	191	PF00069	0.539
MOD_PKA_2	20	26	PF00069	0.662
MOD_PKA_2	207	213	PF00069	0.426
MOD_PKA_2	274	280	PF00069	0.451
MOD_PKA_2	80	86	PF00069	0.432
MOD_Plk_1	324	330	PF00069	0.486
MOD_Plk_4	281	287	PF00069	0.533
MOD_Plk_4	388	394	PF00069	0.342
MOD_Plk_4	63	69	PF00069	0.498
MOD_ProDKin_1	132	138	PF00069	0.639
MOD_ProDKin_1	240	246	PF00069	0.487
MOD_ProDKin_1	357	363	PF00069	0.421
MOD_SUMO_rev_2	102	112	PF00179	0.536
MOD_SUMO_rev_2	232	242	PF00179	0.484
MOD_SUMO_rev_2	317	326	PF00179	0.509
TRG_DiLeu_BaEn_1	28	33	PF01217	0.231
TRG_ER_diArg_1	13	15	PF00400	0.616
TRG_ER_diArg_1	246	248	PF00400	0.522
TRG_ER_diArg_1	253	255	PF00400	0.515
TRG_ER_diArg_1	270	273	PF00400	0.548
TRG_ER_diArg_1	296	298	PF00400	0.434
TRG_ER_diArg_1	336	339	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I683	Leptomonas seymouri	26%	100%
A0A3S7WT04	Leishmania donovani	53%	100%
A4HW21	Leishmania infantum	52%	100%
E9APS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	95%
Q4QFQ6	Leishmania major	55%	100%