LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania braziliensis
UniProt:
A4H7N0_LEIBR
TriTrypDb:
LbrM.14.0720 , LBRM2903_140012800 *
Length:
297

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 35
NetGPI no yes: 0, no: 35
Cellular components
Term Name Level Count
GO:0016020 membrane 2 32
GO:0110165 cellular anatomical entity 1 33
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4H7N0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7N0

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 36
GO:0006629 lipid metabolic process 3 36
GO:0006631 fatty acid metabolic process 4 36
GO:0006633 fatty acid biosynthetic process 5 36
GO:0008152 metabolic process 1 36
GO:0008610 lipid biosynthetic process 4 36
GO:0009058 biosynthetic process 2 36
GO:0009987 cellular process 1 36
GO:0016053 organic acid biosynthetic process 4 36
GO:0019752 carboxylic acid metabolic process 5 36
GO:0032787 monocarboxylic acid metabolic process 6 36
GO:0043436 oxoacid metabolic process 4 36
GO:0044237 cellular metabolic process 2 36
GO:0044238 primary metabolic process 2 36
GO:0044249 cellular biosynthetic process 3 36
GO:0044255 cellular lipid metabolic process 3 36
GO:0044281 small molecule metabolic process 2 36
GO:0044283 small molecule biosynthetic process 3 36
GO:0046394 carboxylic acid biosynthetic process 5 36
GO:0071704 organic substance metabolic process 2 36
GO:0072330 monocarboxylic acid biosynthetic process 6 36
GO:1901576 organic substance biosynthetic process 3 36
GO:0000038 very long-chain fatty acid metabolic process 5 4
GO:0006643 membrane lipid metabolic process 4 4
GO:0006665 sphingolipid metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0019367 fatty acid elongation, saturated fatty acid 7 4
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 4
GO:0030148 sphingolipid biosynthetic process 5 4
GO:0030497 fatty acid elongation 6 4
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 4
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 4
GO:0042761 very long-chain fatty acid biosynthetic process 6 4
GO:0046467 membrane lipid biosynthetic process 4 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 36
GO:0004312 fatty acid synthase activity 5 36
GO:0009922 fatty acid elongase activity 6 36
GO:0016740 transferase activity 2 36
GO:0016746 acyltransferase activity 3 36
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 36
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 36

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 191 193 PF00675 0.244
CLV_NRD_NRD_1 235 237 PF00675 0.442
CLV_NRD_NRD_1 268 270 PF00675 0.446
CLV_PCSK_KEX2_1 235 237 PF00082 0.442
CLV_PCSK_KEX2_1 262 264 PF00082 0.298
CLV_PCSK_KEX2_1 268 270 PF00082 0.451
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.315
CLV_PCSK_PC1ET2_1 268 270 PF00082 0.478
CLV_PCSK_PC7_1 258 264 PF00082 0.138
DEG_MDM2_SWIB_1 64 72 PF02201 0.180
DOC_CYCLIN_yClb5_NLxxxL_5 65 74 PF00134 0.316
DOC_MAPK_gen_1 137 143 PF00069 0.414
DOC_MAPK_gen_1 235 242 PF00069 0.230
DOC_MAPK_MEF2A_6 235 244 PF00069 0.200
DOC_PP1_RVXF_1 136 143 PF00149 0.426
DOC_PP2B_LxvP_1 161 164 PF13499 0.140
DOC_PP4_FxxP_1 47 50 PF00568 0.303
DOC_USP7_MATH_1 279 283 PF00917 0.634
LIG_14-3-3_CanoR_1 269 276 PF00244 0.548
LIG_Actin_RPEL_3 189 208 PF02755 0.452
LIG_Actin_WH2_2 179 194 PF00022 0.305
LIG_AP2alpha_1 28 32 PF02296 0.348
LIG_BIR_II_1 1 5 PF00653 0.321
LIG_BIR_III_3 1 5 PF00653 0.396
LIG_EH1_1 173 181 PF00400 0.278
LIG_FHA_1 128 134 PF00498 0.285
LIG_FHA_1 148 154 PF00498 0.272
LIG_FHA_1 212 218 PF00498 0.297
LIG_FHA_1 69 75 PF00498 0.357
LIG_FHA_1 78 84 PF00498 0.355
LIG_FHA_1 98 104 PF00498 0.309
LIG_GBD_Chelix_1 112 120 PF00786 0.349
LIG_LIR_Gen_1 129 140 PF02991 0.271
LIG_LIR_Gen_1 220 228 PF02991 0.309
LIG_LIR_Gen_1 247 257 PF02991 0.289
LIG_LIR_Gen_1 29 40 PF02991 0.267
LIG_LIR_Nem_3 111 117 PF02991 0.250
LIG_LIR_Nem_3 129 135 PF02991 0.311
LIG_LIR_Nem_3 178 184 PF02991 0.301
LIG_LIR_Nem_3 220 226 PF02991 0.300
LIG_LIR_Nem_3 247 252 PF02991 0.277
LIG_LIR_Nem_3 25 31 PF02991 0.309
LIG_LIR_Nem_3 254 259 PF02991 0.274
LIG_Pex14_1 115 119 PF04695 0.243
LIG_Pex14_1 156 160 PF04695 0.200
LIG_Pex14_2 252 256 PF04695 0.293
LIG_Pex14_2 28 32 PF04695 0.259
LIG_Pex14_2 64 68 PF04695 0.169
LIG_SH2_CRK 223 227 PF00017 0.289
LIG_SH2_CRK 37 41 PF00017 0.194
LIG_SH2_PTP2 42 45 PF00017 0.301
LIG_SH2_SRC 160 163 PF00017 0.140
LIG_SH2_STAP1 219 223 PF00017 0.358
LIG_SH2_STAT5 160 163 PF00017 0.235
LIG_SH2_STAT5 174 177 PF00017 0.285
LIG_SH2_STAT5 181 184 PF00017 0.317
LIG_SH2_STAT5 219 222 PF00017 0.296
LIG_SH2_STAT5 225 228 PF00017 0.250
LIG_SH2_STAT5 248 251 PF00017 0.297
LIG_SH2_STAT5 260 263 PF00017 0.450
LIG_SH2_STAT5 31 34 PF00017 0.240
LIG_SH2_STAT5 42 45 PF00017 0.285
LIG_SH2_STAT5 63 66 PF00017 0.502
LIG_SH3_3 191 197 PF00018 0.424
LIG_Sin3_3 2 9 PF02671 0.267
LIG_SUMO_SIM_par_1 70 76 PF11976 0.248
LIG_SUMO_SIM_par_1 79 85 PF11976 0.237
LIG_TYR_ITIM 35 40 PF00017 0.227
LIG_UBA3_1 116 123 PF00899 0.350
LIG_UBA3_1 255 262 PF00899 0.284
LIG_UBA3_1 44 51 PF00899 0.315
LIG_WRC_WIRS_1 218 223 PF05994 0.335
LIG_WRC_WIRS_1 74 79 PF05994 0.284
MOD_CK1_1 224 230 PF00069 0.218
MOD_CK1_1 73 79 PF00069 0.372
MOD_CK2_1 103 109 PF00069 0.368
MOD_GlcNHglycan 164 167 PF01048 0.435
MOD_GlcNHglycan 263 266 PF01048 0.327
MOD_GlcNHglycan 37 40 PF01048 0.234
MOD_GSK3_1 217 224 PF00069 0.250
MOD_GSK3_1 73 80 PF00069 0.311
MOD_N-GLC_1 290 295 PF02516 0.521
MOD_N-GLC_1 68 73 PF02516 0.259
MOD_N-GLC_2 288 290 PF02516 0.301
MOD_NEK2_1 103 108 PF00069 0.229
MOD_NEK2_1 119 124 PF00069 0.305
MOD_NEK2_1 127 132 PF00069 0.309
MOD_NEK2_1 133 138 PF00069 0.299
MOD_NEK2_1 175 180 PF00069 0.301
MOD_NEK2_1 185 190 PF00069 0.367
MOD_NEK2_1 221 226 PF00069 0.360
MOD_NEK2_1 244 249 PF00069 0.286
MOD_NEK2_1 251 256 PF00069 0.282
MOD_NEK2_1 35 40 PF00069 0.214
MOD_NEK2_1 70 75 PF00069 0.311
MOD_NEK2_1 77 82 PF00069 0.295
MOD_NEK2_1 96 101 PF00069 0.231
MOD_PIKK_1 14 20 PF00454 0.271
MOD_PKA_1 268 274 PF00069 0.569
MOD_PKA_2 234 240 PF00069 0.159
MOD_PKA_2 268 274 PF00069 0.673
MOD_Plk_1 103 109 PF00069 0.241
MOD_Plk_1 279 285 PF00069 0.688
MOD_Plk_1 68 74 PF00069 0.229
MOD_Plk_4 127 133 PF00069 0.244
MOD_Plk_4 147 153 PF00069 0.322
MOD_Plk_4 175 181 PF00069 0.284
MOD_Plk_4 217 223 PF00069 0.278
MOD_Plk_4 244 250 PF00069 0.286
MOD_Plk_4 251 257 PF00069 0.287
MOD_Plk_4 70 76 PF00069 0.316
MOD_Plk_4 82 88 PF00069 0.282
TRG_ENDOCYTIC_2 146 149 PF00928 0.303
TRG_ENDOCYTIC_2 160 163 PF00928 0.271
TRG_ENDOCYTIC_2 183 186 PF00928 0.295
TRG_ENDOCYTIC_2 223 226 PF00928 0.284
TRG_ENDOCYTIC_2 248 251 PF00928 0.283
TRG_ENDOCYTIC_2 31 34 PF00928 0.250
TRG_ENDOCYTIC_2 37 40 PF00928 0.284
TRG_ENDOCYTIC_2 42 45 PF00928 0.289
TRG_ER_diLys_1 294 297 PF00400 0.711
TRG_Pf-PMV_PEXEL_1 105 109 PF00026 0.525

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 28% 100%
A0A0N0P5E5 Leptomonas seymouri 68% 99%
A0A0N0P7D1 Leptomonas seymouri 40% 89%
A0A0N0P7D6 Leptomonas seymouri 32% 100%
A0A0N0P7R2 Leptomonas seymouri 43% 97%
A0A0N1HZJ8 Leptomonas seymouri 37% 92%
A0A0N1I9H5 Leptomonas seymouri 35% 100%
A0A0N1ILQ4 Leptomonas seymouri 36% 100%
A0A0N1IM10 Leptomonas seymouri 29% 100%
A0A0N1PDR8 Leptomonas seymouri 52% 100%
A0A0S4IS29 Bodo saltans 48% 100%
A0A0S4IVJ6 Bodo saltans 33% 93%
A0A0S4IVS6 Bodo saltans 41% 100%
A0A0S4IW98 Bodo saltans 42% 94%
A0A0S4J4C4 Bodo saltans 26% 100%
A0A0S4JH58 Bodo saltans 28% 99%
A0A1X0NNK7 Trypanosomatidae 58% 100%
A0A1X0NNL0 Trypanosomatidae 34% 98%
A0A1X0NNM4 Trypanosomatidae 37% 100%
A0A1X0NNM5 Trypanosomatidae 42% 96%
A0A1X0NP89 Trypanosomatidae 36% 93%
A0A3Q8I8T7 Leishmania donovani 36% 76%
A0A3Q8I9T2 Leishmania donovani 34% 79%
A0A3Q8I9U9 Leishmania donovani 37% 91%
A0A3Q8I9X8 Leishmania donovani 39% 89%
A0A3Q8IC05 Leishmania donovani 72% 97%
A0A3Q8ID51 Leishmania donovani 34% 75%
A0A3Q8IIA9 Leishmania donovani 32% 100%
A0A3R7KG78 Trypanosoma rangeli 57% 100%
A0A3R7MJR2 Trypanosoma rangeli 41% 100%
A0A3R7NSQ3 Trypanosoma rangeli 39% 100%
A0A3S5H5M3 Leishmania donovani 32% 100%
A0A3S5H6R7 Leishmania donovani 33% 100%
A0A3S5H6R8 Leishmania donovani 38% 100%
A0A3S7WSY8 Leishmania donovani 35% 100%
A0A3S7WSZ1 Leishmania donovani 39% 99%
A0A3S7WT03 Leishmania donovani 42% 99%
A0A3S7WT16 Leishmania donovani 36% 92%
A0A422NNP1 Trypanosoma rangeli 45% 99%
A0JNC4 Bos taurus 31% 100%
A4H4G1 Leishmania braziliensis 34% 100%
A4H7M2 Leishmania braziliensis 35% 100%
A4H7M3 Leishmania braziliensis 34% 100%
A4H7M4 Leishmania braziliensis 33% 100%
A4H7M5 Leishmania braziliensis 35% 100%
A4H7M6 Leishmania braziliensis 38% 100%
A4H7M7 Leishmania braziliensis 36% 100%
A4H7M8 Leishmania braziliensis 33% 100%
A4H7M9 Leishmania braziliensis 35% 100%
A4HSN8 Leishmania infantum 32% 100%
A4HW07 Leishmania infantum 35% 100%
A4HW08 Leishmania infantum 33% 100%
A4HW09 Leishmania infantum 32% 100%
A4HW10 Leishmania infantum 34% 100%
A4HW12 Leishmania infantum 38% 89%
A4HW13 Leishmania infantum 39% 91%
A4HW14 Leishmania infantum 36% 92%
A4HW15 Leishmania infantum 34% 79%
A4HW16 Leishmania infantum 34% 79%
A4HW17 Leishmania infantum 36% 76%
A4HW18 Leishmania infantum 72% 98%
B4QVX4 Drosophila simulans 29% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 99%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 97%
D4A612 Rattus norvegicus 32% 100%
D4ADY9 Rattus norvegicus 30% 100%
E8NHR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 79%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 78%
E9AGL0 Leishmania infantum 42% 99%
E9AGL2 Leishmania infantum 39% 99%
E9AKM3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 79%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 99%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 99%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 89%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 91%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 92%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 77%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 99%
G5EEE5 Caenorhabditis elegans 33% 100%
O35949 Mus musculus 35% 100%
P25358 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 86%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 96%
P40319 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 86%
P49191 Caenorhabditis elegans 36% 93%
Q03574 Caenorhabditis elegans 35% 100%
Q1HRV8 Aedes aegypti 31% 83%
Q20300 Caenorhabditis elegans 31% 100%
Q20303 Caenorhabditis elegans 33% 100%
Q2KJD9 Bos taurus 28% 99%
Q32NI8 Xenopus laevis 27% 100%
Q3S8M4 Macaca mulatta 30% 95%
Q4QFQ9 Leishmania major 71% 100%
Q4QFR0 Leishmania major 37% 100%
Q4QFR1 Leishmania major 35% 100%
Q4QFR2 Leishmania major 36% 100%
Q4QFR3 Leishmania major 36% 100%
Q4QFR4 Leishmania major 37% 100%
Q4QFR5 Leishmania major 41% 100%
Q4QFR6 Leishmania major 44% 100%
Q4QFR7 Leishmania major 39% 100%
Q4QFR8 Leishmania major 34% 100%
Q4QFR9 Leishmania major 34% 100%
Q4QFS0 Leishmania major 36% 100%
Q4QJ85 Leishmania major 32% 100%
Q4R516 Macaca fascicularis 28% 99%
Q5M8U1 Xenopus tropicalis 25% 100%
Q5RFL5 Pongo abelii 29% 99%
Q5ZJR8 Gallus gallus 37% 100%
Q6PC64 Danio rerio 39% 100%
Q7LKX0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 81%
Q8BHI7 Mus musculus 28% 99%
Q920L5 Mus musculus 38% 100%
Q920L6 Rattus norvegicus 37% 100%
Q920L7 Rattus norvegicus 27% 99%
Q95K73 Macaca fascicularis 30% 95%
Q9BW60 Homo sapiens 32% 100%
Q9D2Y9 Mus musculus 30% 100%
Q9EQC4 Mus musculus 32% 95%
Q9GZR5 Homo sapiens 30% 95%
Q9H5J4 Homo sapiens 37% 100%
Q9HB03 Homo sapiens 31% 100%
Q9JLJ4 Mus musculus 32% 100%
Q9JLJ5 Mus musculus 32% 100%
Q9NXB9 Homo sapiens 33% 100%
Q9NYP7 Homo sapiens 28% 99%
Q9UTF7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 89%
Q9VH58 Drosophila melanogaster 30% 100%
Q9VHX7 Drosophila melanogaster 27% 90%
Q9VV87 Drosophila melanogaster 37% 94%
Q9XVQ9 Caenorhabditis elegans 36% 100%
V5BE99 Trypanosoma cruzi 58% 100%
V5BIX9 Trypanosoma cruzi 40% 100%
V5BND3 Trypanosoma cruzi 44% 99%
V5DF68 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS