LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania braziliensis
UniProt:
A4H7M9_LEIBR
TriTrypDb:
LbrM.14.0710 , LBRM2903_140012500
Length:
407

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 27
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 71
NetGPI no yes: 0, no: 72
Cellular components
Term Name Level Count
GO:0016020 membrane 2 63
GO:0110165 cellular anatomical entity 1 66
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

A4H7M9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7M9

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 73
GO:0006629 lipid metabolic process 3 73
GO:0006631 fatty acid metabolic process 4 73
GO:0006633 fatty acid biosynthetic process 5 73
GO:0008152 metabolic process 1 73
GO:0008610 lipid biosynthetic process 4 73
GO:0009058 biosynthetic process 2 73
GO:0009987 cellular process 1 73
GO:0016053 organic acid biosynthetic process 4 73
GO:0019752 carboxylic acid metabolic process 5 73
GO:0032787 monocarboxylic acid metabolic process 6 73
GO:0043436 oxoacid metabolic process 4 73
GO:0044237 cellular metabolic process 2 73
GO:0044238 primary metabolic process 2 73
GO:0044249 cellular biosynthetic process 3 73
GO:0044255 cellular lipid metabolic process 3 73
GO:0044281 small molecule metabolic process 2 73
GO:0044283 small molecule biosynthetic process 3 73
GO:0046394 carboxylic acid biosynthetic process 5 73
GO:0071704 organic substance metabolic process 2 73
GO:0072330 monocarboxylic acid biosynthetic process 6 73
GO:1901576 organic substance biosynthetic process 3 73
GO:0000038 very long-chain fatty acid metabolic process 5 10
GO:0006643 membrane lipid metabolic process 4 10
GO:0006665 sphingolipid metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0019367 fatty acid elongation, saturated fatty acid 7 10
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 10
GO:0030148 sphingolipid biosynthetic process 5 10
GO:0030497 fatty acid elongation 6 10
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 10
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 10
GO:0042761 very long-chain fatty acid biosynthetic process 6 10
GO:0046467 membrane lipid biosynthetic process 4 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901566 organonitrogen compound biosynthetic process 4 10
GO:0001676 long-chain fatty acid metabolic process 5 2
GO:0042759 long-chain fatty acid biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 73
GO:0004312 fatty acid synthase activity 5 73
GO:0009922 fatty acid elongase activity 6 73
GO:0016740 transferase activity 2 73
GO:0016746 acyltransferase activity 3 73
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 73
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 73

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 28 32 PF00656 0.476
CLV_NRD_NRD_1 186 188 PF00675 0.360
CLV_NRD_NRD_1 370 372 PF00675 0.440
CLV_NRD_NRD_1 376 378 PF00675 0.455
CLV_NRD_NRD_1 58 60 PF00675 0.326
CLV_PCSK_KEX2_1 360 362 PF00082 0.306
CLV_PCSK_KEX2_1 402 404 PF00082 0.364
CLV_PCSK_KEX2_1 57 59 PF00082 0.319
CLV_PCSK_PC1ET2_1 360 362 PF00082 0.310
CLV_PCSK_PC1ET2_1 402 404 PF00082 0.364
CLV_PCSK_SKI1_1 145 149 PF00082 0.470
CLV_PCSK_SKI1_1 27 31 PF00082 0.604
DOC_CKS1_1 15 20 PF01111 0.434
DOC_CKS1_1 172 177 PF01111 0.475
DOC_CYCLIN_RxL_1 351 359 PF00134 0.414
DOC_CYCLIN_yClb5_NLxxxL_5 68 77 PF00134 0.354
DOC_MAPK_MEF2A_6 246 254 PF00069 0.467
DOC_MAPK_RevD_3 43 59 PF00069 0.184
DOC_PP1_RVXF_1 186 193 PF00149 0.473
DOC_PP4_FxxP_1 49 52 PF00568 0.329
DOC_USP7_MATH_1 3 7 PF00917 0.327
DOC_USP7_MATH_1 311 315 PF00917 0.201
DOC_USP7_UBL2_3 98 102 PF12436 0.155
DOC_WW_Pin1_4 126 131 PF00397 0.321
DOC_WW_Pin1_4 14 19 PF00397 0.376
DOC_WW_Pin1_4 171 176 PF00397 0.476
DOC_WW_Pin1_4 274 279 PF00397 0.262
LIG_14-3-3_CanoR_1 145 150 PF00244 0.303
LIG_14-3-3_CanoR_1 187 193 PF00244 0.562
LIG_14-3-3_CanoR_1 57 63 PF00244 0.475
LIG_Actin_WH2_2 229 244 PF00022 0.434
LIG_BIR_II_1 1 5 PF00653 0.350
LIG_BIR_III_2 31 35 PF00653 0.169
LIG_BRCT_BRCA1_1 214 218 PF00533 0.271
LIG_BRCT_BRCA1_1 321 325 PF00533 0.205
LIG_deltaCOP1_diTrp_1 9 14 PF00928 0.471
LIG_EH1_1 223 231 PF00400 0.302
LIG_eIF4E_1 231 237 PF01652 0.430
LIG_FHA_1 172 178 PF00498 0.326
LIG_FHA_1 2 8 PF00498 0.431
LIG_FHA_1 307 313 PF00498 0.192
LIG_FHA_1 59 65 PF00498 0.356
LIG_FHA_1 72 78 PF00498 0.388
LIG_FHA_2 92 98 PF00498 0.320
LIG_KLC1_Yacidic_2 355 359 PF13176 0.398
LIG_LIR_Apic_2 124 128 PF02991 0.166
LIG_LIR_Apic_2 155 161 PF02991 0.348
LIG_LIR_Gen_1 162 172 PF02991 0.317
LIG_LIR_Gen_1 179 190 PF02991 0.314
LIG_LIR_Gen_1 209 218 PF02991 0.348
LIG_LIR_Gen_1 267 276 PF02991 0.397
LIG_LIR_Gen_1 344 353 PF02991 0.326
LIG_LIR_Nem_3 162 168 PF02991 0.258
LIG_LIR_Nem_3 179 185 PF02991 0.329
LIG_LIR_Nem_3 209 213 PF02991 0.331
LIG_LIR_Nem_3 228 234 PF02991 0.336
LIG_LIR_Nem_3 267 272 PF02991 0.351
LIG_LIR_Nem_3 283 289 PF02991 0.276
LIG_LIR_Nem_3 344 348 PF02991 0.297
LIG_LIR_Nem_3 35 39 PF02991 0.408
LIG_LIR_Nem_3 83 87 PF02991 0.368
LIG_Pex14_1 206 210 PF04695 0.253
LIG_Pex14_2 285 289 PF04695 0.194
LIG_Pex14_2 349 353 PF04695 0.322
LIG_Pex14_2 96 100 PF04695 0.320
LIG_PTB_Apo_2 120 127 PF02174 0.169
LIG_PTB_Apo_2 279 286 PF02174 0.197
LIG_PTB_Apo_2 292 299 PF02174 0.172
LIG_PTB_Phospho_1 120 126 PF10480 0.169
LIG_PTB_Phospho_1 292 298 PF10480 0.180
LIG_REV1ctd_RIR_1 283 291 PF16727 0.185
LIG_SH2_CRK 158 162 PF00017 0.341
LIG_SH2_CRK 165 169 PF00017 0.440
LIG_SH2_CRK 345 349 PF00017 0.220
LIG_SH2_GRB2like 280 283 PF00017 0.194
LIG_SH2_GRB2like 300 303 PF00017 0.149
LIG_SH2_PTP2 210 213 PF00017 0.297
LIG_SH2_PTP2 265 268 PF00017 0.418
LIG_SH2_SRC 126 129 PF00017 0.348
LIG_SH2_SRC 298 301 PF00017 0.157
LIG_SH2_STAP1 149 153 PF00017 0.257
LIG_SH2_STAP1 165 169 PF00017 0.266
LIG_SH2_STAP1 280 284 PF00017 0.330
LIG_SH2_STAP1 39 43 PF00017 0.450
LIG_SH2_STAT3 149 152 PF00017 0.174
LIG_SH2_STAT3 85 88 PF00017 0.173
LIG_SH2_STAT5 165 168 PF00017 0.305
LIG_SH2_STAT5 171 174 PF00017 0.327
LIG_SH2_STAT5 204 207 PF00017 0.343
LIG_SH2_STAT5 210 213 PF00017 0.259
LIG_SH2_STAT5 231 234 PF00017 0.343
LIG_SH2_STAT5 265 268 PF00017 0.327
LIG_SH2_STAT5 269 272 PF00017 0.316
LIG_SH2_STAT5 298 301 PF00017 0.192
LIG_SH2_STAT5 345 348 PF00017 0.314
LIG_SH2_STAT5 357 360 PF00017 0.466
LIG_SH2_STAT5 44 47 PF00017 0.319
LIG_SH2_STAT5 66 69 PF00017 0.549
LIG_SH2_STAT5 85 88 PF00017 0.297
LIG_SH3_3 208 214 PF00018 0.173
LIG_SH3_3 244 250 PF00018 0.451
LIG_SH3_3 31 37 PF00018 0.338
LIG_SUMO_SIM_anti_2 74 79 PF11976 0.183
LIG_SUMO_SIM_par_1 44 50 PF11976 0.268
LIG_SUMO_SIM_par_1 73 79 PF11976 0.291
LIG_TRFH_1 210 214 PF08558 0.166
LIG_TRFH_1 274 278 PF08558 0.202
LIG_UBA3_1 168 173 PF00899 0.363
LIG_UBA3_1 348 354 PF00899 0.320
MOD_CK1_1 2 8 PF00069 0.274
MOD_CK1_1 225 231 PF00069 0.245
MOD_CK1_1 305 311 PF00069 0.199
MOD_CK1_1 330 336 PF00069 0.319
MOD_CK1_1 393 399 PF00069 0.570
MOD_CK1_1 76 82 PF00069 0.354
MOD_CK2_1 3 9 PF00069 0.346
MOD_CK2_1 91 97 PF00069 0.379
MOD_GlcNHglycan 1 4 PF01048 0.500
MOD_GlcNHglycan 161 164 PF01048 0.498
MOD_GlcNHglycan 214 217 PF01048 0.457
MOD_GlcNHglycan 24 27 PF01048 0.535
MOD_GSK3_1 1 8 PF00069 0.391
MOD_GSK3_1 106 113 PF00069 0.343
MOD_GSK3_1 159 166 PF00069 0.304
MOD_GSK3_1 218 225 PF00069 0.319
MOD_GSK3_1 302 309 PF00069 0.199
MOD_GSK3_1 327 334 PF00069 0.303
MOD_GSK3_1 393 400 PF00069 0.562
MOD_GSK3_1 76 83 PF00069 0.330
MOD_LATS_1 20 26 PF00433 0.229
MOD_N-GLC_1 222 227 PF02516 0.224
MOD_N-GLC_1 71 76 PF02516 0.279
MOD_NEK2_1 1 6 PF00069 0.353
MOD_NEK2_1 100 105 PF00069 0.317
MOD_NEK2_1 134 139 PF00069 0.274
MOD_NEK2_1 177 182 PF00069 0.354
MOD_NEK2_1 21 26 PF00069 0.369
MOD_NEK2_1 218 223 PF00069 0.367
MOD_NEK2_1 241 246 PF00069 0.530
MOD_NEK2_1 264 269 PF00069 0.339
MOD_NEK2_1 341 346 PF00069 0.311
MOD_NEK2_1 73 78 PF00069 0.331
MOD_NEK2_1 90 95 PF00069 0.285
MOD_NEK2_2 106 111 PF00069 0.355
MOD_NEK2_2 280 285 PF00069 0.316
MOD_NEK2_2 91 96 PF00069 0.342
MOD_PKA_1 58 64 PF00069 0.352
MOD_PKA_2 110 116 PF00069 0.338
MOD_PKA_2 241 247 PF00069 0.410
MOD_PKA_2 58 64 PF00069 0.499
MOD_Plk_1 222 228 PF00069 0.206
MOD_Plk_1 71 77 PF00069 0.302
MOD_Plk_4 177 183 PF00069 0.294
MOD_Plk_4 188 194 PF00069 0.469
MOD_Plk_4 206 212 PF00069 0.293
MOD_Plk_4 225 231 PF00069 0.277
MOD_Plk_4 267 273 PF00069 0.305
MOD_Plk_4 280 286 PF00069 0.281
MOD_Plk_4 302 308 PF00069 0.199
MOD_Plk_4 363 369 PF00069 0.680
MOD_Plk_4 73 79 PF00069 0.320
MOD_Plk_4 80 86 PF00069 0.316
MOD_Plk_4 91 97 PF00069 0.251
MOD_ProDKin_1 126 132 PF00069 0.321
MOD_ProDKin_1 14 20 PF00069 0.379
MOD_ProDKin_1 171 177 PF00069 0.476
MOD_ProDKin_1 274 280 PF00069 0.262
TRG_ENDOCYTIC_2 165 168 PF00928 0.273
TRG_ENDOCYTIC_2 196 199 PF00928 0.331
TRG_ENDOCYTIC_2 210 213 PF00928 0.300
TRG_ENDOCYTIC_2 233 236 PF00928 0.332
TRG_ENDOCYTIC_2 265 268 PF00928 0.371
TRG_ENDOCYTIC_2 269 272 PF00928 0.361
TRG_ENDOCYTIC_2 345 348 PF00928 0.302
TRG_ENDOCYTIC_2 39 42 PF00928 0.316
TRG_ENDOCYTIC_2 84 87 PF00928 0.338
TRG_ER_diArg_1 57 59 PF00400 0.409
TRG_NLS_Bipartite_1 360 381 PF00514 0.590
TRG_NLS_MonoExtC_3 376 382 PF00514 0.519

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 33% 100%
A0A0N0P7D1 Leptomonas seymouri 30% 100%
A0A0N0P7R2 Leptomonas seymouri 34% 100%
A0A0N1HZJ8 Leptomonas seymouri 30% 100%
A0A0N1I9H5 Leptomonas seymouri 29% 100%
A0A0S4IVS6 Bodo saltans 32% 100%
A0A1X0NNK7 Trypanosomatidae 35% 100%
A0A1X0NNL0 Trypanosomatidae 27% 100%
A0A1X0NNM5 Trypanosomatidae 35% 100%
A0A1X0NP89 Trypanosomatidae 30% 100%
A0A3Q8I8T7 Leishmania donovani 82% 100%
A0A3Q8I9T2 Leishmania donovani 63% 100%
A0A3Q8I9U9 Leishmania donovani 30% 100%
A0A3Q8I9X8 Leishmania donovani 32% 100%
A0A3Q8IC05 Leishmania donovani 35% 100%
A0A3Q8ID51 Leishmania donovani 62% 100%
A0A3Q8IIA9 Leishmania donovani 28% 100%
A0A3R7KG78 Trypanosoma rangeli 36% 100%
A0A3R7MJR2 Trypanosoma rangeli 27% 100%
A0A3R7NSQ3 Trypanosoma rangeli 26% 100%
A0A3S5H6R8 Leishmania donovani 33% 100%
A0A3S7WSY8 Leishmania donovani 28% 100%
A0A3S7WSZ1 Leishmania donovani 30% 100%
A0A3S7WT03 Leishmania donovani 31% 100%
A0A3S7WT16 Leishmania donovani 32% 100%
A0A422NNP1 Trypanosoma rangeli 32% 100%
A4H7M2 Leishmania braziliensis 29% 100%
A4H7M4 Leishmania braziliensis 28% 100%
A4H7M6 Leishmania braziliensis 32% 88%
A4H7M7 Leishmania braziliensis 30% 97%
A4H7M8 Leishmania braziliensis 63% 100%
A4H7N0 Leishmania braziliensis 35% 100%
A4HW07 Leishmania infantum 28% 100%
A4HW09 Leishmania infantum 28% 100%
A4HW10 Leishmania infantum 33% 100%
A4HW12 Leishmania infantum 31% 100%
A4HW13 Leishmania infantum 29% 100%
A4HW14 Leishmania infantum 32% 100%
A4HW15 Leishmania infantum 63% 100%
A4HW16 Leishmania infantum 63% 100%
A4HW17 Leishmania infantum 81% 100%
A4HW18 Leishmania infantum 33% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 100%
E9AGL0 Leishmania infantum 32% 100%
E9AGL2 Leishmania infantum 30% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
Q4QFQ9 Leishmania major 34% 80%
Q4QFR0 Leishmania major 82% 100%
Q4QFR1 Leishmania major 62% 100%
Q4QFR2 Leishmania major 64% 100%
Q4QFR3 Leishmania major 32% 96%
Q4QFR4 Leishmania major 31% 94%
Q4QFR5 Leishmania major 30% 93%
Q4QFR6 Leishmania major 30% 80%
Q4QFR8 Leishmania major 28% 100%
Q4QFS0 Leishmania major 28% 100%
Q9VV87 Drosophila melanogaster 24% 100%
Q9XVQ9 Caenorhabditis elegans 26% 100%
V5BE99 Trypanosoma cruzi 36% 100%
V5BIX9 Trypanosoma cruzi 25% 100%
V5BND3 Trypanosoma cruzi 31% 100%
V5DF68 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS