Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7M8_LEIBR

TriTrypDb:

LbrM.14.0700 , LBRM2903_140012500

Length:

381

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 78
NetGPI	no	yes: 0, no: 79

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	69
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A4H7M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7M8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	80
GO:0006629	lipid metabolic process	3	80
GO:0006631	fatty acid metabolic process	4	80
GO:0006633	fatty acid biosynthetic process	5	80
GO:0008152	metabolic process	1	80
GO:0008610	lipid biosynthetic process	4	80
GO:0009058	biosynthetic process	2	80
GO:0009987	cellular process	1	80
GO:0016053	organic acid biosynthetic process	4	80
GO:0019752	carboxylic acid metabolic process	5	80
GO:0032787	monocarboxylic acid metabolic process	6	80
GO:0043436	oxoacid metabolic process	4	80
GO:0044237	cellular metabolic process	2	80
GO:0044238	primary metabolic process	2	80
GO:0044249	cellular biosynthetic process	3	80
GO:0044255	cellular lipid metabolic process	3	80
GO:0044281	small molecule metabolic process	2	80
GO:0044283	small molecule biosynthetic process	3	80
GO:0046394	carboxylic acid biosynthetic process	5	80
GO:0071704	organic substance metabolic process	2	80
GO:0072330	monocarboxylic acid biosynthetic process	6	80
GO:1901576	organic substance biosynthetic process	3	80
GO:0000038	very long-chain fatty acid metabolic process	5	11
GO:0006643	membrane lipid metabolic process	4	11
GO:0006665	sphingolipid metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0019367	fatty acid elongation, saturated fatty acid	7	11
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	11
GO:0030148	sphingolipid biosynthetic process	5	11
GO:0030497	fatty acid elongation	6	11
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	11
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	11
GO:0042761	very long-chain fatty acid biosynthetic process	6	11
GO:0046467	membrane lipid biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:0001676	long-chain fatty acid metabolic process	5	3
GO:0042759	long-chain fatty acid biosynthetic process	6	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	80
GO:0004312	fatty acid synthase activity	5	80
GO:0009922	fatty acid elongase activity	6	80
GO:0016740	transferase activity	2	80
GO:0016746	acyltransferase activity	3	80
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	80
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.403
CLV_NRD_NRD_1	181	183	PF00675	0.342
CLV_PCSK_KEX2_1	116	118	PF00082	0.404
CLV_PCSK_KEX2_1	130	132	PF00082	0.379
CLV_PCSK_KEX2_1	355	357	PF00082	0.324
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.395
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.326
CLV_PCSK_SKI1_1	16	20	PF00082	0.581
CLV_PCSK_SKI1_1	24	28	PF00082	0.595
DEG_Nend_UBRbox_2	1	3	PF02207	0.431
DOC_CKS1_1	167	172	PF01111	0.482
DOC_CYCLIN_RxL_1	346	354	PF00134	0.405
DOC_MAPK_MEF2A_6	241	249	PF00069	0.501
DOC_MAPK_MEF2A_6	54	61	PF00069	0.456
DOC_MAPK_NFAT4_5	54	62	PF00069	0.403
DOC_PP1_RVXF_1	129	136	PF00149	0.312
DOC_PP1_RVXF_1	181	188	PF00149	0.499
DOC_PP4_FxxP_1	46	49	PF00568	0.367
DOC_USP7_MATH_1	104	108	PF00917	0.175
DOC_USP7_MATH_1	207	211	PF00917	0.338
DOC_USP7_MATH_1	306	310	PF00917	0.222
DOC_WW_Pin1_4	137	142	PF00397	0.386
DOC_WW_Pin1_4	166	171	PF00397	0.472
DOC_WW_Pin1_4	269	274	PF00397	0.232
LIG_14-3-3_CanoR_1	182	188	PF00244	0.567
LIG_14-3-3_CanoR_1	364	371	PF00244	0.621
LIG_14-3-3_CanoR_1	92	100	PF00244	0.297
LIG_Actin_WH2_2	224	239	PF00022	0.465
LIG_BRCT_BRCA1_1	209	213	PF00533	0.279
LIG_BRCT_BRCA1_1	316	320	PF00533	0.226
LIG_EH1_1	218	226	PF00400	0.334
LIG_eIF4E_1	226	232	PF01652	0.432
LIG_FHA_1	156	162	PF00498	0.313
LIG_FHA_1	167	173	PF00498	0.345
LIG_FHA_1	274	280	PF00498	0.288
LIG_FHA_1	302	308	PF00498	0.213
LIG_FHA_1	78	84	PF00498	0.361
LIG_FHA_2	365	371	PF00498	0.546
LIG_GBD_Chelix_1	194	202	PF00786	0.219
LIG_KLC1_Yacidic_2	350	354	PF13176	0.419
LIG_LIR_Apic_2	150	156	PF02991	0.324
LIG_LIR_Gen_1	174	185	PF02991	0.337
LIG_LIR_Gen_1	196	207	PF02991	0.449
LIG_LIR_Gen_1	262	271	PF02991	0.385
LIG_LIR_Gen_1	339	348	PF02991	0.339
LIG_LIR_Gen_1	38	49	PF02991	0.315
LIG_LIR_Nem_3	174	180	PF02991	0.342
LIG_LIR_Nem_3	196	202	PF02991	0.379
LIG_LIR_Nem_3	223	229	PF02991	0.350
LIG_LIR_Nem_3	262	267	PF02991	0.357
LIG_LIR_Nem_3	278	284	PF02991	0.283
LIG_LIR_Nem_3	28	33	PF02991	0.333
LIG_LIR_Nem_3	339	343	PF02991	0.326
LIG_LIR_Nem_3	38	44	PF02991	0.333
LIG_LIR_Nem_3	76	81	PF02991	0.378
LIG_LIR_Nem_3	9	13	PF02991	0.309
LIG_Pex14_1	10	14	PF04695	0.423
LIG_Pex14_1	201	205	PF04695	0.274
LIG_Pex14_2	280	284	PF04695	0.215
LIG_Pex14_2	344	348	PF04695	0.345
LIG_PTB_Apo_2	274	281	PF02174	0.218
LIG_PTB_Apo_2	287	294	PF02174	0.194
LIG_PTB_Phospho_1	287	293	PF10480	0.202
LIG_REV1ctd_RIR_1	278	286	PF16727	0.207
LIG_SH2_CRK	153	157	PF00017	0.321
LIG_SH2_CRK	340	344	PF00017	0.492
LIG_SH2_CRK	36	40	PF00017	0.359
LIG_SH2_CRK	78	82	PF00017	0.338
LIG_SH2_GRB2like	275	278	PF00017	0.386
LIG_SH2_GRB2like	295	298	PF00017	0.170
LIG_SH2_NCK_1	36	40	PF00017	0.476
LIG_SH2_PTP2	199	202	PF00017	0.430
LIG_SH2_PTP2	260	263	PF00017	0.443
LIG_SH2_SRC	293	296	PF00017	0.179
LIG_SH2_SRC	47	50	PF00017	0.449
LIG_SH2_STAP1	275	279	PF00017	0.353
LIG_SH2_STAP1	36	40	PF00017	0.424
LIG_SH2_STAT3	122	125	PF00017	0.192
LIG_SH2_STAT3	143	146	PF00017	0.194
LIG_SH2_STAT5	105	108	PF00017	0.200
LIG_SH2_STAT5	143	146	PF00017	0.319
LIG_SH2_STAT5	166	169	PF00017	0.373
LIG_SH2_STAT5	199	202	PF00017	0.364
LIG_SH2_STAT5	226	229	PF00017	0.356
LIG_SH2_STAT5	260	263	PF00017	0.351
LIG_SH2_STAT5	264	267	PF00017	0.337
LIG_SH2_STAT5	275	278	PF00017	0.284
LIG_SH2_STAT5	293	296	PF00017	0.213
LIG_SH2_STAT5	340	343	PF00017	0.340
LIG_SH2_STAT5	352	355	PF00017	0.481
LIG_SH2_STAT5	47	50	PF00017	0.344
LIG_SH2_STAT5	51	54	PF00017	0.505
LIG_SH2_STAT5	63	66	PF00017	0.572
LIG_SH3_3	239	245	PF00018	0.480
LIG_SH3_3	28	34	PF00018	0.364
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.204
LIG_TRFH_1	269	273	PF08558	0.244
LIG_UBA3_1	163	168	PF00899	0.379
LIG_UBA3_1	343	349	PF00899	0.355
MOD_CK1_1	220	226	PF00069	0.251
MOD_CK1_1	300	306	PF00069	0.240
MOD_CK1_1	325	331	PF00069	0.423
MOD_CK1_1	73	79	PF00069	0.382
MOD_CK2_1	364	370	PF00069	0.408
MOD_GlcNHglycan	106	109	PF01048	0.394
MOD_GlcNHglycan	209	212	PF01048	0.326
MOD_GlcNHglycan	94	97	PF01048	0.309
MOD_GSK3_1	269	276	PF00069	0.286
MOD_GSK3_1	297	304	PF00069	0.240
MOD_GSK3_1	322	329	PF00069	0.384
MOD_GSK3_1	70	77	PF00069	0.372
MOD_N-GLC_1	217	222	PF02516	0.243
MOD_N-GLC_1	68	73	PF02516	0.318
MOD_NEK2_1	172	177	PF00069	0.366
MOD_NEK2_1	217	222	PF00069	0.386
MOD_NEK2_1	236	241	PF00069	0.406
MOD_NEK2_1	259	264	PF00069	0.355
MOD_NEK2_1	336	341	PF00069	0.326
MOD_NEK2_1	70	75	PF00069	0.346
MOD_NEK2_2	275	280	PF00069	0.427
MOD_PKA_2	236	242	PF00069	0.255
MOD_PKA_2	53	59	PF00069	0.380
MOD_PKB_1	364	372	PF00069	0.373
MOD_Plk_1	217	223	PF00069	0.227
MOD_Plk_1	68	74	PF00069	0.330
MOD_Plk_4	172	178	PF00069	0.315
MOD_Plk_4	183	189	PF00069	0.339
MOD_Plk_4	201	207	PF00069	0.315
MOD_Plk_4	220	226	PF00069	0.299
MOD_Plk_4	262	268	PF00069	0.330
MOD_Plk_4	275	281	PF00069	0.358
MOD_Plk_4	297	303	PF00069	0.240
MOD_Plk_4	358	364	PF00069	0.624
MOD_Plk_4	70	76	PF00069	0.348
MOD_Plk_4	9	15	PF00069	0.326
MOD_ProDKin_1	137	143	PF00069	0.472
MOD_ProDKin_1	166	172	PF00069	0.472
MOD_ProDKin_1	269	275	PF00069	0.257
MOD_SUMO_for_1	135	138	PF00179	0.181
MOD_SUMO_for_1	18	21	PF00179	0.422
MOD_SUMO_rev_2	369	374	PF00179	0.626
MOD_SUMO_rev_2	375	380	PF00179	0.611
TRG_ENDOCYTIC_2	191	194	PF00928	0.346
TRG_ENDOCYTIC_2	199	202	PF00928	0.361
TRG_ENDOCYTIC_2	205	208	PF00928	0.368
TRG_ENDOCYTIC_2	228	231	PF00928	0.348
TRG_ENDOCYTIC_2	260	263	PF00928	0.394
TRG_ENDOCYTIC_2	264	267	PF00928	0.378
TRG_ENDOCYTIC_2	340	343	PF00928	0.324
TRG_ENDOCYTIC_2	36	39	PF00928	0.342
TRG_ENDOCYTIC_2	78	81	PF00928	0.375
TRG_ER_diArg_1	363	366	PF00400	0.632
TRG_ER_diArg_1	57	60	PF00400	0.267
TRG_ER_diArg_1	91	94	PF00400	0.209
TRG_ER_diLys_1	378	381	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	31%	100%
A0A0N0P7D1	Leptomonas seymouri	31%	100%
A0A0N0P7D6	Leptomonas seymouri	28%	100%
A0A0N0P7R2	Leptomonas seymouri	34%	100%
A0A0N1HZJ8	Leptomonas seymouri	29%	100%
A0A0N1IM10	Leptomonas seymouri	28%	100%
A0A0N1PDR8	Leptomonas seymouri	27%	100%
A0A0S4IS29	Bodo saltans	32%	100%
A0A0S4IVJ6	Bodo saltans	33%	100%
A0A0S4IVS6	Bodo saltans	31%	100%
A0A1X0NNK7	Trypanosomatidae	35%	100%
A0A1X0NNL0	Trypanosomatidae	29%	100%
A0A1X0NNM5	Trypanosomatidae	32%	100%
A0A1X0NP89	Trypanosomatidae	27%	100%
A0A3Q8I8T7	Leishmania donovani	61%	97%
A0A3Q8I9T2	Leishmania donovani	84%	100%
A0A3Q8I9U9	Leishmania donovani	31%	100%
A0A3Q8I9X8	Leishmania donovani	30%	100%
A0A3Q8IC05	Leishmania donovani	33%	100%
A0A3Q8ID51	Leishmania donovani	69%	96%
A0A3Q8IIA9	Leishmania donovani	28%	100%
A0A3R7KG78	Trypanosoma rangeli	30%	100%
A0A3R7MJR2	Trypanosoma rangeli	30%	100%
A0A3S5H6R7	Leishmania donovani	29%	100%
A0A3S5H6R8	Leishmania donovani	33%	100%
A0A3S7WSY8	Leishmania donovani	32%	100%
A0A3S7WSZ1	Leishmania donovani	27%	100%
A0A3S7WT03	Leishmania donovani	29%	100%
A0A3S7WT16	Leishmania donovani	30%	100%
A0A422NNP1	Trypanosoma rangeli	30%	100%
A4H7M2	Leishmania braziliensis	32%	100%
A4H7M3	Leishmania braziliensis	30%	100%
A4H7M6	Leishmania braziliensis	28%	81%
A4H7M7	Leishmania braziliensis	29%	96%
A4H7M9	Leishmania braziliensis	63%	94%
A4H7N0	Leishmania braziliensis	33%	100%
A4HW07	Leishmania infantum	32%	100%
A4HW08	Leishmania infantum	29%	100%
A4HW09	Leishmania infantum	28%	100%
A4HW10	Leishmania infantum	33%	100%
A4HW12	Leishmania infantum	31%	100%
A4HW13	Leishmania infantum	31%	100%
A4HW14	Leishmania infantum	29%	100%
A4HW15	Leishmania infantum	84%	100%
A4HW16	Leishmania infantum	70%	100%
A4HW17	Leishmania infantum	61%	97%
A4HW18	Leishmania infantum	33%	100%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
E9AGL0	Leishmania infantum	29%	100%
E9AGL2	Leishmania infantum	28%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4QFQ9	Leishmania major	33%	84%
Q4QFR0	Leishmania major	61%	100%
Q4QFR1	Leishmania major	70%	100%
Q4QFR2	Leishmania major	84%	100%
Q4QFR3	Leishmania major	30%	84%
Q4QFR4	Leishmania major	31%	92%
Q4QFR5	Leishmania major	29%	100%
Q4QFR6	Leishmania major	28%	82%
Q4QFR8	Leishmania major	28%	100%
Q4QFR9	Leishmania major	29%	100%
Q4QFS0	Leishmania major	32%	100%
V5BE99	Trypanosoma cruzi	30%	100%
V5BIX9	Trypanosoma cruzi	27%	100%
V5BND3	Trypanosoma cruzi	30%	100%
V5DF68	Trypanosoma cruzi	28%	100%