LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania braziliensis
UniProt:
A4H7M7_LEIBR
TriTrypDb:
LbrM.14.0690 , LBRM2903_140012400 *
Length:
322

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 56
NetGPI no yes: 0, no: 56
Cellular components
Term Name Level Count
GO:0016020 membrane 2 51
GO:0110165 cellular anatomical entity 1 53
GO:0005737 cytoplasm 2 2

Expansion

Sequence features

A4H7M7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7M7

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 57
GO:0006629 lipid metabolic process 3 57
GO:0006631 fatty acid metabolic process 4 57
GO:0006633 fatty acid biosynthetic process 5 57
GO:0008152 metabolic process 1 57
GO:0008610 lipid biosynthetic process 4 57
GO:0009058 biosynthetic process 2 57
GO:0009987 cellular process 1 57
GO:0016053 organic acid biosynthetic process 4 57
GO:0019752 carboxylic acid metabolic process 5 57
GO:0032787 monocarboxylic acid metabolic process 6 57
GO:0043436 oxoacid metabolic process 4 57
GO:0044237 cellular metabolic process 2 57
GO:0044238 primary metabolic process 2 57
GO:0044249 cellular biosynthetic process 3 57
GO:0044255 cellular lipid metabolic process 3 57
GO:0044281 small molecule metabolic process 2 57
GO:0044283 small molecule biosynthetic process 3 57
GO:0046394 carboxylic acid biosynthetic process 5 57
GO:0071704 organic substance metabolic process 2 57
GO:0072330 monocarboxylic acid biosynthetic process 6 57
GO:1901576 organic substance biosynthetic process 3 57
GO:0000038 very long-chain fatty acid metabolic process 5 6
GO:0006643 membrane lipid metabolic process 4 6
GO:0006665 sphingolipid metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0019367 fatty acid elongation, saturated fatty acid 7 6
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 6
GO:0030148 sphingolipid biosynthetic process 5 6
GO:0030497 fatty acid elongation 6 6
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 6
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 6
GO:0042761 very long-chain fatty acid biosynthetic process 6 6
GO:0046467 membrane lipid biosynthetic process 4 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 57
GO:0004312 fatty acid synthase activity 5 57
GO:0009922 fatty acid elongase activity 6 57
GO:0016740 transferase activity 2 57
GO:0016746 acyltransferase activity 3 57
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 57
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 57

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.364
CLV_NRD_NRD_1 299 301 PF00675 0.251
CLV_PCSK_SKI1_1 277 281 PF00082 0.461
CLV_PCSK_SKI1_1 48 52 PF00082 0.303
DEG_Nend_UBRbox_3 1 3 PF02207 0.383
DEG_ODPH_VHL_1 237 249 PF01847 0.403
DOC_CDC14_PxL_1 78 86 PF14671 0.297
DOC_MAPK_gen_1 176 182 PF00069 0.450
DOC_MAPK_gen_1 51 60 PF00069 0.379
DOC_MAPK_MEF2A_6 235 243 PF00069 0.425
DOC_PP1_RVXF_1 175 182 PF00149 0.460
DOC_USP7_MATH_1 306 310 PF00917 0.659
DOC_USP7_UBL2_3 301 305 PF12436 0.462
DOC_WW_Pin1_4 105 110 PF00397 0.370
LIG_14-3-3_CanoR_1 300 308 PF00244 0.431
LIG_Actin_WH2_2 89 104 PF00022 0.322
LIG_BRCT_BRCA1_1 13 17 PF00533 0.203
LIG_BRCT_BRCA1_1 290 294 PF00533 0.281
LIG_BRCT_BRCA1_1 45 49 PF00533 0.188
LIG_BRCT_BRCA1_2 45 51 PF00533 0.188
LIG_EH1_1 185 193 PF00400 0.326
LIG_EH1_1 212 220 PF00400 0.293
LIG_eIF4E_1 283 289 PF01652 0.259
LIG_FHA_1 167 173 PF00498 0.291
LIG_FHA_1 187 193 PF00498 0.276
LIG_FHA_1 3 9 PF00498 0.380
LIG_FHA_1 312 318 PF00498 0.625
LIG_FHA_1 87 93 PF00498 0.260
LIG_GBD_Chelix_1 33 41 PF00786 0.304
LIG_LIR_Gen_1 14 24 PF02991 0.314
LIG_LIR_Gen_1 168 179 PF02991 0.304
LIG_LIR_Gen_1 242 251 PF02991 0.377
LIG_LIR_Gen_1 285 294 PF02991 0.312
LIG_LIR_Gen_1 70 79 PF02991 0.300
LIG_LIR_Nem_3 14 20 PF02991 0.279
LIG_LIR_Nem_3 168 174 PF02991 0.306
LIG_LIR_Nem_3 217 223 PF02991 0.329
LIG_LIR_Nem_3 242 246 PF02991 0.325
LIG_LIR_Nem_3 285 289 PF02991 0.295
LIG_LIR_Nem_3 70 75 PF02991 0.315
LIG_MLH1_MIPbox_1 290 294 PF16413 0.339
LIG_PCNA_PIPBox_1 1 10 PF02747 0.390
LIG_Pex14_2 290 294 PF04695 0.295
LIG_Pex14_2 68 72 PF04695 0.270
LIG_REV1ctd_RIR_1 291 301 PF16727 0.358
LIG_SH2_CRK 79 83 PF00017 0.305
LIG_SH2_NCK_1 85 89 PF00017 0.344
LIG_SH2_PTP2 233 236 PF00017 0.511
LIG_SH2_PTP2 38 41 PF00017 0.330
LIG_SH2_STAT3 261 264 PF00017 0.337
LIG_SH2_STAT5 103 106 PF00017 0.381
LIG_SH2_STAT5 193 196 PF00017 0.317
LIG_SH2_STAT5 220 223 PF00017 0.330
LIG_SH2_STAT5 233 236 PF00017 0.474
LIG_SH2_STAT5 258 261 PF00017 0.333
LIG_SH2_STAT5 283 286 PF00017 0.301
LIG_SH2_STAT5 298 301 PF00017 0.450
LIG_SH2_STAT5 38 41 PF00017 0.293
LIG_SH2_STAT5 79 82 PF00017 0.326
LIG_SH3_1 233 239 PF00018 0.540
LIG_SH3_3 233 239 PF00018 0.444
LIG_SH3_3 85 91 PF00018 0.314
LIG_SUMO_SIM_anti_2 276 282 PF11976 0.146
LIG_TYR_ITIM 284 289 PF00017 0.342
LIG_TYR_ITIM 36 41 PF00017 0.254
LIG_WRC_WIRS_1 240 245 PF05994 0.385
MOD_CK1_1 133 139 PF00069 0.261
MOD_CK1_1 273 279 PF00069 0.293
MOD_CK1_1 70 76 PF00069 0.343
MOD_CK2_1 91 97 PF00069 0.348
MOD_CMANNOS 195 198 PF00535 0.188
MOD_GlcNHglycan 203 206 PF01048 0.455
MOD_GlcNHglycan 69 72 PF01048 0.352
MOD_GlcNHglycan 93 96 PF01048 0.458
MOD_GSK3_1 11 18 PF00069 0.346
MOD_GSK3_1 130 137 PF00069 0.251
MOD_GSK3_1 197 204 PF00069 0.348
MOD_GSK3_1 269 276 PF00069 0.297
MOD_GSK3_1 307 314 PF00069 0.620
MOD_N-GLC_1 105 110 PF02516 0.532
MOD_NEK2_1 134 139 PF00069 0.256
MOD_NEK2_1 158 163 PF00069 0.318
MOD_NEK2_1 166 171 PF00069 0.326
MOD_NEK2_1 201 206 PF00069 0.270
MOD_NEK2_1 214 219 PF00069 0.284
MOD_NEK2_1 282 287 PF00069 0.313
MOD_NEK2_1 288 293 PF00069 0.312
MOD_NEK2_1 67 72 PF00069 0.315
MOD_PIKK_1 2 8 PF00454 0.392
MOD_PKA_1 300 306 PF00069 0.429
MOD_PKA_2 130 136 PF00069 0.266
MOD_PKA_2 299 305 PF00069 0.491
MOD_Plk_1 134 140 PF00069 0.278
MOD_Plk_1 15 21 PF00069 0.360
MOD_Plk_4 186 192 PF00069 0.318
MOD_Plk_4 214 220 PF00069 0.299
MOD_Plk_4 250 256 PF00069 0.290
MOD_Plk_4 282 288 PF00069 0.305
MOD_ProDKin_1 105 111 PF00069 0.370
TRG_DiLeu_BaLyEn_6 236 241 PF01217 0.477
TRG_ENDOCYTIC_2 185 188 PF00928 0.309
TRG_ENDOCYTIC_2 222 225 PF00928 0.315
TRG_ENDOCYTIC_2 286 289 PF00928 0.300
TRG_ENDOCYTIC_2 38 41 PF00928 0.289
TRG_ENDOCYTIC_2 78 81 PF00928 0.309
TRG_ENDOCYTIC_2 85 88 PF00928 0.260
TRG_ER_diArg_1 294 297 PF00400 0.423
TRG_ER_diLys_1 319 322 PF00400 0.618

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 24% 100%
A0A0N0P5E5 Leptomonas seymouri 37% 100%
A0A0N0P7D1 Leptomonas seymouri 44% 96%
A0A0N0P7D6 Leptomonas seymouri 27% 100%
A0A0N0P7R2 Leptomonas seymouri 46% 100%
A0A0N1HZJ8 Leptomonas seymouri 39% 99%
A0A0N1I9H5 Leptomonas seymouri 29% 100%
A0A0N1ILQ4 Leptomonas seymouri 37% 100%
A0A0N1IM10 Leptomonas seymouri 29% 100%
A0A0N1PDR8 Leptomonas seymouri 36% 100%
A0A0S4IS29 Bodo saltans 43% 100%
A0A0S4IVJ6 Bodo saltans 31% 100%
A0A0S4IVS6 Bodo saltans 37% 100%
A0A0S4IW98 Bodo saltans 41% 100%
A0A1X0NNK7 Trypanosomatidae 42% 100%
A0A1X0NNL0 Trypanosomatidae 39% 100%
A0A1X0NNM4 Trypanosomatidae 36% 100%
A0A1X0NNM5 Trypanosomatidae 54% 100%
A0A1X0NP89 Trypanosomatidae 44% 100%
A0A3Q8I8T7 Leishmania donovani 31% 82%
A0A3Q8I9T2 Leishmania donovani 29% 86%
A0A3Q8I9U9 Leishmania donovani 40% 99%
A0A3Q8I9X8 Leishmania donovani 46% 96%
A0A3Q8IC05 Leishmania donovani 37% 100%
A0A3Q8ID51 Leishmania donovani 29% 81%
A0A3Q8IIA9 Leishmania donovani 30% 100%
A0A3R7KG78 Trypanosoma rangeli 41% 100%
A0A3R7MJR2 Trypanosoma rangeli 36% 100%
A0A3R7NSQ3 Trypanosoma rangeli 35% 100%
A0A3S5H6R7 Leishmania donovani 30% 100%
A0A3S5H6R8 Leishmania donovani 34% 100%
A0A3S7WSY8 Leishmania donovani 30% 100%
A0A3S7WSZ1 Leishmania donovani 43% 100%
A0A3S7WT03 Leishmania donovani 45% 100%
A0A3S7WT16 Leishmania donovani 78% 100%
A0A422NNP1 Trypanosoma rangeli 50% 100%
A0A422NYI1 Trypanosoma rangeli 27% 100%
A1L3X0 Homo sapiens 29% 100%
A4H7M2 Leishmania braziliensis 31% 93%
A4H7M3 Leishmania braziliensis 30% 90%
A4H7M4 Leishmania braziliensis 31% 90%
A4H7M5 Leishmania braziliensis 33% 100%
A4H7M6 Leishmania braziliensis 47% 97%
A4H7M8 Leishmania braziliensis 29% 85%
A4H7M9 Leishmania braziliensis 30% 79%
A4H7N0 Leishmania braziliensis 36% 100%
A4HW07 Leishmania infantum 30% 100%
A4HW08 Leishmania infantum 30% 100%
A4HW09 Leishmania infantum 30% 100%
A4HW10 Leishmania infantum 34% 100%
A4HW12 Leishmania infantum 46% 96%
A4HW13 Leishmania infantum 40% 99%
A4HW14 Leishmania infantum 78% 100%
A4HW15 Leishmania infantum 29% 86%
A4HW16 Leishmania infantum 29% 86%
A4HW17 Leishmania infantum 31% 82%
A4HW18 Leishmania infantum 36% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D4ADY9 Rattus norvegicus 28% 100%
E8NHR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 86%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 84%
E9AGL0 Leishmania infantum 45% 100%
E9AGL2 Leishmania infantum 43% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 86%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 96%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 99%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 84%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
G5EEE5 Caenorhabditis elegans 30% 100%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P49191 Caenorhabditis elegans 33% 100%
Q03574 Caenorhabditis elegans 31% 100%
Q20300 Caenorhabditis elegans 27% 100%
Q3S8M4 Macaca mulatta 24% 100%
Q4QFQ9 Leishmania major 38% 99%
Q4QFR0 Leishmania major 31% 100%
Q4QFR1 Leishmania major 29% 100%
Q4QFR2 Leishmania major 29% 100%
Q4QFR3 Leishmania major 77% 100%
Q4QFR4 Leishmania major 39% 100%
Q4QFR5 Leishmania major 47% 100%
Q4QFR6 Leishmania major 44% 99%
Q4QFR7 Leishmania major 35% 100%
Q4QFR8 Leishmania major 31% 89%
Q4QFR9 Leishmania major 31% 90%
Q4QFS0 Leishmania major 30% 94%
Q4QFS1 Leishmania major 26% 100%
Q5ZJR8 Gallus gallus 31% 100%
Q6PC64 Danio rerio 33% 100%
Q86JM5 Dictyostelium discoideum 30% 100%
Q920L5 Mus musculus 31% 100%
Q920L6 Rattus norvegicus 31% 100%
Q95K73 Macaca fascicularis 24% 100%
Q9D2Y9 Mus musculus 29% 100%
Q9GZR5 Homo sapiens 25% 100%
Q9H5J4 Homo sapiens 31% 100%
Q9HB03 Homo sapiens 30% 100%
Q9VV87 Drosophila melanogaster 32% 100%
Q9XVQ9 Caenorhabditis elegans 30% 100%
V5BE99 Trypanosoma cruzi 42% 100%
V5BIX9 Trypanosoma cruzi 40% 100%
V5BND3 Trypanosoma cruzi 49% 100%
V5DF68 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS