Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 53 |
| NetGPI | no | yes: 0, no: 53 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 49 |
| GO:0110165 | cellular anatomical entity | 1 | 51 |
| GO:0005737 | cytoplasm | 2 | 2 |
Related structures:
AlphaFold database: A4H7M6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 54 |
| GO:0006629 | lipid metabolic process | 3 | 54 |
| GO:0006631 | fatty acid metabolic process | 4 | 54 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 54 |
| GO:0008152 | metabolic process | 1 | 54 |
| GO:0008610 | lipid biosynthetic process | 4 | 54 |
| GO:0009058 | biosynthetic process | 2 | 54 |
| GO:0009987 | cellular process | 1 | 54 |
| GO:0016053 | organic acid biosynthetic process | 4 | 54 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 54 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 54 |
| GO:0043436 | oxoacid metabolic process | 4 | 54 |
| GO:0044237 | cellular metabolic process | 2 | 54 |
| GO:0044238 | primary metabolic process | 2 | 54 |
| GO:0044249 | cellular biosynthetic process | 3 | 54 |
| GO:0044255 | cellular lipid metabolic process | 3 | 54 |
| GO:0044281 | small molecule metabolic process | 2 | 54 |
| GO:0044283 | small molecule biosynthetic process | 3 | 54 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 54 |
| GO:0071704 | organic substance metabolic process | 2 | 54 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 54 |
| GO:1901576 | organic substance biosynthetic process | 3 | 54 |
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 5 |
| GO:0006643 | membrane lipid metabolic process | 4 | 5 |
| GO:0006665 | sphingolipid metabolic process | 4 | 5 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 5 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 5 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 5 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 5 |
| GO:0030497 | fatty acid elongation | 6 | 5 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 5 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 5 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 5 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 5 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 5 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 5 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 54 |
| GO:0004312 | fatty acid synthase activity | 5 | 54 |
| GO:0009922 | fatty acid elongase activity | 6 | 54 |
| GO:0016740 | transferase activity | 2 | 54 |
| GO:0016746 | acyltransferase activity | 3 | 54 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 54 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 54 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 199 | 201 | PF00675 | 0.268 |
| CLV_PCSK_KEX2_1 | 237 | 239 | PF00082 | 0.385 |
| CLV_PCSK_PC1ET2_1 | 237 | 239 | PF00082 | 0.352 |
| CLV_PCSK_SKI1_1 | 79 | 83 | PF00082 | 0.510 |
| DEG_Nend_UBRbox_4 | 1 | 3 | PF02207 | 0.258 |
| DEG_ODPH_VHL_1 | 206 | 218 | PF01847 | 0.398 |
| DEG_SCF_FBW7_1 | 269 | 276 | PF00400 | 0.497 |
| DOC_AGCK_PIF_2 | 86 | 91 | PF00069 | 0.142 |
| DOC_CDC14_PxL_1 | 71 | 79 | PF14671 | 0.298 |
| DOC_CYCLIN_yCln2_LP_2 | 21 | 27 | PF00134 | 0.321 |
| DOC_MAPK_gen_1 | 145 | 151 | PF00069 | 0.448 |
| DOC_MAPK_MEF2A_6 | 204 | 212 | PF00069 | 0.428 |
| DOC_MAPK_MEF2A_6 | 56 | 64 | PF00069 | 0.238 |
| DOC_PP1_RVXF_1 | 144 | 151 | PF00149 | 0.459 |
| DOC_PP1_RVXF_1 | 245 | 251 | PF00149 | 0.379 |
| DOC_PP2B_LxvP_1 | 21 | 24 | PF13499 | 0.326 |
| DOC_PP2B_LxvP_1 | 36 | 39 | PF13499 | 0.265 |
| DOC_PP2B_PxIxI_1 | 207 | 213 | PF00149 | 0.389 |
| DOC_USP7_MATH_1 | 183 | 187 | PF00917 | 0.388 |
| DOC_WW_Pin1_4 | 269 | 274 | PF00397 | 0.418 |
| LIG_Actin_WH2_2 | 256 | 272 | PF00022 | 0.432 |
| LIG_BRCT_BRCA1_1 | 260 | 264 | PF00533 | 0.292 |
| LIG_EH1_1 | 154 | 162 | PF00400 | 0.338 |
| LIG_eIF4E_1 | 253 | 259 | PF01652 | 0.238 |
| LIG_FHA_1 | 136 | 142 | PF00498 | 0.291 |
| LIG_FHA_1 | 156 | 162 | PF00498 | 0.277 |
| LIG_FHA_1 | 171 | 177 | PF00498 | 0.262 |
| LIG_FHA_1 | 226 | 232 | PF00498 | 0.333 |
| LIG_FHA_2 | 85 | 91 | PF00498 | 0.331 |
| LIG_LIR_Apic_2 | 266 | 271 | PF02991 | 0.424 |
| LIG_LIR_Apic_2 | 70 | 75 | PF02991 | 0.238 |
| LIG_LIR_Gen_1 | 137 | 148 | PF02991 | 0.297 |
| LIG_LIR_Gen_1 | 255 | 264 | PF02991 | 0.309 |
| LIG_LIR_Nem_3 | 137 | 143 | PF02991 | 0.303 |
| LIG_LIR_Nem_3 | 186 | 192 | PF02991 | 0.329 |
| LIG_LIR_Nem_3 | 228 | 233 | PF02991 | 0.297 |
| LIG_LIR_Nem_3 | 255 | 259 | PF02991 | 0.294 |
| LIG_LIR_Nem_3 | 70 | 74 | PF02991 | 0.322 |
| LIG_LIR_Nem_3 | 85 | 89 | PF02991 | 0.282 |
| LIG_PCNA_yPIPBox_3 | 117 | 131 | PF02747 | 0.140 |
| LIG_Pex14_2 | 123 | 127 | PF04695 | 0.393 |
| LIG_Pex14_2 | 260 | 264 | PF04695 | 0.297 |
| LIG_Pex14_2 | 82 | 86 | PF04695 | 0.326 |
| LIG_SH2_CRK | 116 | 120 | PF00017 | 0.278 |
| LIG_SH2_CRK | 72 | 76 | PF00017 | 0.303 |
| LIG_SH2_CRK | 78 | 82 | PF00017 | 0.255 |
| LIG_SH2_GRB2like | 265 | 268 | PF00017 | 0.481 |
| LIG_SH2_PTP2 | 202 | 205 | PF00017 | 0.519 |
| LIG_SH2_STAP1 | 265 | 269 | PF00017 | 0.488 |
| LIG_SH2_STAT5 | 162 | 165 | PF00017 | 0.315 |
| LIG_SH2_STAT5 | 167 | 170 | PF00017 | 0.286 |
| LIG_SH2_STAT5 | 189 | 192 | PF00017 | 0.327 |
| LIG_SH2_STAT5 | 202 | 205 | PF00017 | 0.474 |
| LIG_SH2_STAT5 | 230 | 233 | PF00017 | 0.267 |
| LIG_SH2_STAT5 | 253 | 256 | PF00017 | 0.300 |
| LIG_SH2_STAT5 | 268 | 271 | PF00017 | 0.451 |
| LIG_SH2_STAT5 | 37 | 40 | PF00017 | 0.303 |
| LIG_SH2_STAT5 | 72 | 75 | PF00017 | 0.324 |
| LIG_SH2_STAT5 | 91 | 94 | PF00017 | 0.238 |
| LIG_SH3_1 | 202 | 208 | PF00018 | 0.539 |
| LIG_SH3_1 | 268 | 274 | PF00018 | 0.474 |
| LIG_SH3_3 | 202 | 208 | PF00018 | 0.445 |
| LIG_SH3_3 | 268 | 274 | PF00018 | 0.449 |
| LIG_SUMO_SIM_par_1 | 60 | 66 | PF11976 | 0.298 |
| LIG_TYR_ITIM | 254 | 259 | PF00017 | 0.337 |
| LIG_UBA3_1 | 126 | 131 | PF00899 | 0.331 |
| LIG_WRC_WIRS_1 | 5 | 10 | PF05994 | 0.415 |
| LIG_WRC_WIRS_1 | 64 | 69 | PF05994 | 0.355 |
| MOD_CK2_1 | 238 | 244 | PF00069 | 0.142 |
| MOD_GlcNHglycan | 275 | 278 | PF01048 | 0.474 |
| MOD_GSK3_1 | 269 | 276 | PF00069 | 0.470 |
| MOD_GSK3_1 | 63 | 70 | PF00069 | 0.312 |
| MOD_N-GLC_1 | 11 | 16 | PF02516 | 0.522 |
| MOD_N-GLC_1 | 169 | 174 | PF02516 | 0.457 |
| MOD_NEK2_1 | 127 | 132 | PF00069 | 0.313 |
| MOD_NEK2_1 | 135 | 140 | PF00069 | 0.322 |
| MOD_NEK2_1 | 252 | 257 | PF00069 | 0.311 |
| MOD_NEK2_1 | 258 | 263 | PF00069 | 0.309 |
| MOD_NEK2_1 | 60 | 65 | PF00069 | 0.316 |
| MOD_NEK2_1 | 67 | 72 | PF00069 | 0.304 |
| MOD_NEK2_1 | 77 | 82 | PF00069 | 0.253 |
| MOD_NEK2_2 | 84 | 89 | PF00069 | 0.339 |
| MOD_PIKK_1 | 11 | 17 | PF00454 | 0.204 |
| MOD_Plk_1 | 11 | 17 | PF00069 | 0.345 |
| MOD_Plk_1 | 84 | 90 | PF00069 | 0.319 |
| MOD_Plk_4 | 155 | 161 | PF00069 | 0.319 |
| MOD_Plk_4 | 183 | 189 | PF00069 | 0.298 |
| MOD_Plk_4 | 225 | 231 | PF00069 | 0.290 |
| MOD_Plk_4 | 252 | 258 | PF00069 | 0.305 |
| MOD_Plk_4 | 60 | 66 | PF00069 | 0.321 |
| MOD_Plk_4 | 67 | 73 | PF00069 | 0.321 |
| MOD_ProDKin_1 | 269 | 275 | PF00069 | 0.418 |
| TRG_DiLeu_BaEn_1 | 22 | 27 | PF01217 | 0.420 |
| TRG_DiLeu_BaLyEn_6 | 205 | 210 | PF01217 | 0.482 |
| TRG_ENDOCYTIC_2 | 104 | 107 | PF00928 | 0.282 |
| TRG_ENDOCYTIC_2 | 154 | 157 | PF00928 | 0.316 |
| TRG_ENDOCYTIC_2 | 191 | 194 | PF00928 | 0.311 |
| TRG_ENDOCYTIC_2 | 256 | 259 | PF00928 | 0.300 |
| TRG_ENDOCYTIC_2 | 31 | 34 | PF00928 | 0.288 |
| TRG_ENDOCYTIC_2 | 71 | 74 | PF00928 | 0.307 |
| TRG_ENDOCYTIC_2 | 78 | 81 | PF00928 | 0.259 |
| TRG_ER_diLys_1 | 296 | 299 | PF00400 | 0.663 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0C5PHQ7 | Tachysurus fulvidraco | 25% | 100% |
| A0A0N0P5E5 | Leptomonas seymouri | 43% | 100% |
| A0A0N0P7D1 | Leptomonas seymouri | 59% | 90% |
| A0A0N0P7D6 | Leptomonas seymouri | 29% | 100% |
| A0A0N0P7R2 | Leptomonas seymouri | 72% | 98% |
| A0A0N0P994 | Leptomonas seymouri | 25% | 83% |
| A0A0N1HZJ8 | Leptomonas seymouri | 41% | 92% |
| A0A0N1I9H5 | Leptomonas seymouri | 31% | 100% |
| A0A0N1ILQ4 | Leptomonas seymouri | 41% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 28% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 38% | 100% |
| A0A0S4IS29 | Bodo saltans | 45% | 100% |
| A0A0S4IVJ6 | Bodo saltans | 35% | 94% |
| A0A0S4IVS6 | Bodo saltans | 43% | 100% |
| A0A0S4IW98 | Bodo saltans | 45% | 94% |
| A0A0S4KMP5 | Bodo saltans | 31% | 91% |
| A0A1X0NNK7 | Trypanosomatidae | 41% | 100% |
| A0A1X0NNL0 | Trypanosomatidae | 34% | 99% |
| A0A1X0NNM4 | Trypanosomatidae | 35% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 51% | 97% |
| A0A1X0NP89 | Trypanosomatidae | 40% | 94% |
| A0A1X0NUJ4 | Trypanosomatidae | 26% | 83% |
| A0A3Q8I8T7 | Leishmania donovani | 32% | 76% |
| A0A3Q8I9T2 | Leishmania donovani | 30% | 80% |
| A0A3Q8I9U9 | Leishmania donovani | 41% | 92% |
| A0A3Q8I9X8 | Leishmania donovani | 55% | 89% |
| A0A3Q8IC05 | Leishmania donovani | 39% | 98% |
| A0A3Q8ID51 | Leishmania donovani | 30% | 75% |
| A0A3Q8IIA9 | Leishmania donovani | 34% | 100% |
| A0A3Q8IT78 | Leishmania donovani | 24% | 78% |
| A0A3R7KG78 | Trypanosoma rangeli | 44% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 39% | 100% |
| A0A3R7NSQ3 | Trypanosoma rangeli | 37% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 29% | 100% |
| A0A3S5H6R8 | Leishmania donovani | 36% | 100% |
| A0A3S7WSY8 | Leishmania donovani | 32% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 77% | 100% |
| A0A3S7WT03 | Leishmania donovani | 78% | 100% |
| A0A3S7WT16 | Leishmania donovani | 43% | 93% |
| A0A422NNP1 | Trypanosoma rangeli | 51% | 100% |
| A0JNC4 | Bos taurus | 29% | 100% |
| A1L3X0 | Homo sapiens | 31% | 100% |
| A4H7M2 | Leishmania braziliensis | 31% | 96% |
| A4H7M3 | Leishmania braziliensis | 30% | 98% |
| A4H7M4 | Leishmania braziliensis | 32% | 96% |
| A4H7M5 | Leishmania braziliensis | 35% | 96% |
| A4H7M7 | Leishmania braziliensis | 47% | 93% |
| A4H7M8 | Leishmania braziliensis | 28% | 78% |
| A4H7M9 | Leishmania braziliensis | 32% | 73% |
| A4H7N0 | Leishmania braziliensis | 38% | 100% |
| A4HKA3 | Leishmania braziliensis | 25% | 91% |
| A4HW07 | Leishmania infantum | 32% | 100% |
| A4HW08 | Leishmania infantum | 29% | 100% |
| A4HW09 | Leishmania infantum | 34% | 100% |
| A4HW10 | Leishmania infantum | 36% | 100% |
| A4HW12 | Leishmania infantum | 58% | 89% |
| A4HW13 | Leishmania infantum | 41% | 92% |
| A4HW14 | Leishmania infantum | 43% | 93% |
| A4HW15 | Leishmania infantum | 30% | 80% |
| A4HW16 | Leishmania infantum | 30% | 80% |
| A4HW17 | Leishmania infantum | 32% | 76% |
| A4HW18 | Leishmania infantum | 41% | 99% |
| A4I7T3 | Leishmania infantum | 24% | 78% |
| C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 48% | 99% |
| C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 100% |
| C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 98% |
| D4ADY9 | Rattus norvegicus | 31% | 100% |
| E8NHR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 100% |
| E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 80% |
| E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 78% |
| E9AGL0 | Leishmania infantum | 78% | 100% |
| E9AGL2 | Leishmania infantum | 77% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 80% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
| E9APR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 100% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 75% | 100% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 76% | 100% |
| E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 59% | 89% |
| E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 92% |
| E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 45% | 93% |
| E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 78% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 99% |
| E9B2P1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 78% |
| G5EEE5 | Caenorhabditis elegans | 32% | 100% |
| O35949 | Mus musculus | 32% | 100% |
| P39540 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 26% | 96% |
| P49191 | Caenorhabditis elegans | 34% | 93% |
| Q03574 | Caenorhabditis elegans | 30% | 100% |
| Q20300 | Caenorhabditis elegans | 29% | 100% |
| Q20303 | Caenorhabditis elegans | 34% | 100% |
| Q2KJD9 | Bos taurus | 25% | 100% |
| Q32NI8 | Xenopus laevis | 27% | 100% |
| Q3S8M4 | Macaca mulatta | 26% | 95% |
| Q4Q5G6 | Leishmania major | 27% | 78% |
| Q4QFQ9 | Leishmania major | 41% | 99% |
| Q4QFR0 | Leishmania major | 31% | 100% |
| Q4QFR1 | Leishmania major | 29% | 100% |
| Q4QFR2 | Leishmania major | 29% | 100% |
| Q4QFR3 | Leishmania major | 43% | 100% |
| Q4QFR4 | Leishmania major | 41% | 100% |
| Q4QFR5 | Leishmania major | 58% | 100% |
| Q4QFR6 | Leishmania major | 76% | 100% |
| Q4QFR7 | Leishmania major | 34% | 94% |
| Q4QFR8 | Leishmania major | 33% | 93% |
| Q4QFR9 | Leishmania major | 29% | 98% |
| Q4QFS0 | Leishmania major | 32% | 100% |
| Q4R516 | Macaca fascicularis | 24% | 100% |
| Q5M8U1 | Xenopus tropicalis | 26% | 100% |
| Q5RFL5 | Pongo abelii | 23% | 100% |
| Q5ZJR8 | Gallus gallus | 34% | 100% |
| Q6PC64 | Danio rerio | 36% | 100% |
| Q7LKX0 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 26% | 82% |
| Q86JM5 | Dictyostelium discoideum | 27% | 100% |
| Q8BHI7 | Mus musculus | 25% | 100% |
| Q920L5 | Mus musculus | 33% | 100% |
| Q920L6 | Rattus norvegicus | 34% | 100% |
| Q920L7 | Rattus norvegicus | 25% | 100% |
| Q95K73 | Macaca fascicularis | 26% | 95% |
| Q9BW60 | Homo sapiens | 27% | 100% |
| Q9D2Y9 | Mus musculus | 33% | 100% |
| Q9EQC4 | Mus musculus | 26% | 96% |
| Q9GZR5 | Homo sapiens | 26% | 95% |
| Q9H5J4 | Homo sapiens | 34% | 100% |
| Q9HB03 | Homo sapiens | 31% | 100% |
| Q9JLJ4 | Mus musculus | 28% | 100% |
| Q9JLJ5 | Mus musculus | 27% | 100% |
| Q9NXB9 | Homo sapiens | 27% | 100% |
| Q9NYP7 | Homo sapiens | 24% | 100% |
| Q9UTF7 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 27% | 90% |
| Q9VV87 | Drosophila melanogaster | 33% | 95% |
| Q9XVQ9 | Caenorhabditis elegans | 31% | 100% |
| V5BE99 | Trypanosoma cruzi | 41% | 100% |
| V5BIX9 | Trypanosoma cruzi | 41% | 100% |
| V5BND3 | Trypanosoma cruzi | 51% | 100% |
| V5DF68 | Trypanosoma cruzi | 36% | 100% |