Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7M4_LEIBR

TriTrypDb:

LbrM.14.0650 , LBRM2903_140012000

Length:

284

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 23
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	23
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H7M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7M4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	25
GO:0006629	lipid metabolic process	3	25
GO:0006631	fatty acid metabolic process	4	25
GO:0006633	fatty acid biosynthetic process	5	25
GO:0008152	metabolic process	1	25
GO:0008610	lipid biosynthetic process	4	25
GO:0009058	biosynthetic process	2	25
GO:0009987	cellular process	1	25
GO:0016053	organic acid biosynthetic process	4	25
GO:0019752	carboxylic acid metabolic process	5	25
GO:0032787	monocarboxylic acid metabolic process	6	25
GO:0043436	oxoacid metabolic process	4	25
GO:0044237	cellular metabolic process	2	25
GO:0044238	primary metabolic process	2	25
GO:0044249	cellular biosynthetic process	3	25
GO:0044255	cellular lipid metabolic process	3	25
GO:0044281	small molecule metabolic process	2	25
GO:0044283	small molecule biosynthetic process	3	25
GO:0046394	carboxylic acid biosynthetic process	5	25
GO:0071704	organic substance metabolic process	2	25
GO:0072330	monocarboxylic acid biosynthetic process	6	25
GO:1901576	organic substance biosynthetic process	3	25
GO:0000038	very long-chain fatty acid metabolic process	5	3
GO:0001676	long-chain fatty acid metabolic process	5	3
GO:0006643	membrane lipid metabolic process	4	3
GO:0006665	sphingolipid metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0019367	fatty acid elongation, saturated fatty acid	7	3
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	3
GO:0030148	sphingolipid biosynthetic process	5	3
GO:0030497	fatty acid elongation	6	3
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	3
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	3
GO:0042759	long-chain fatty acid biosynthetic process	6	3
GO:0042761	very long-chain fatty acid biosynthetic process	6	3
GO:0046467	membrane lipid biosynthetic process	4	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901566	organonitrogen compound biosynthetic process	4	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004312	fatty acid synthase activity	5	25
GO:0009922	fatty acid elongase activity	6	25
GO:0016740	transferase activity	2	25
GO:0016746	acyltransferase activity	3	25
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	25
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.277
CLV_NRD_NRD_1	137	139	PF00675	0.321
CLV_NRD_NRD_1	264	266	PF00675	0.301
CLV_NRD_NRD_1	90	92	PF00675	0.423
CLV_PCSK_KEX2_1	137	139	PF00082	0.282
CLV_PCSK_KEX2_1	90	92	PF00082	0.377
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.321
CLV_PCSK_SKI1_1	57	61	PF00082	0.287
DEG_Nend_UBRbox_2	1	3	PF02207	0.361
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.522
DOC_MAPK_MEF2A_6	196	204	PF00069	0.484
DOC_PP4_FxxP_1	40	43	PF00568	0.317
DOC_USP7_UBL2_3	192	196	PF12436	0.521
LIG_AP2alpha_1	126	130	PF02296	0.396
LIG_APCC_ABBA_1	250	255	PF00400	0.375
LIG_BRCT_BRCA1_1	253	257	PF00533	0.340
LIG_BRCT_BRCA1_2	253	259	PF00533	0.364
LIG_EH1_1	173	181	PF00400	0.342
LIG_eIF4E_1	79	85	PF01652	0.245
LIG_FHA_1	127	133	PF00498	0.466
LIG_FHA_1	148	154	PF00498	0.281
LIG_FHA_1	206	212	PF00498	0.411
LIG_FHA_1	233	239	PF00498	0.350
LIG_FHA_1	79	85	PF00498	0.236
LIG_FHA_2	8	14	PF00498	0.297
LIG_LIR_Apic_2	37	43	PF02991	0.367
LIG_LIR_Gen_1	144	154	PF02991	0.371
LIG_LIR_Gen_1	163	174	PF02991	0.189
LIG_LIR_Gen_1	178	189	PF02991	0.330
LIG_LIR_Nem_3	128	133	PF02991	0.446
LIG_LIR_Nem_3	144	149	PF02991	0.347
LIG_LIR_Nem_3	163	169	PF02991	0.202
LIG_LIR_Nem_3	178	184	PF02991	0.330
LIG_LIR_Nem_3	188	194	PF02991	0.459
LIG_LIR_Nem_3	74	79	PF02991	0.310
LIG_PCNA_PIPBox_1	1	10	PF02747	0.383
LIG_Pex14_2	126	130	PF04695	0.396
LIG_Pex14_2	142	146	PF04695	0.373
LIG_Pex14_2	152	156	PF04695	0.342
LIG_Pex14_2	216	220	PF04695	0.245
LIG_Pex14_2	253	257	PF04695	0.313
LIG_REV1ctd_RIR_1	104	114	PF16727	0.156
LIG_SH2_CRK	79	83	PF00017	0.311
LIG_SH2_PTP2	201	204	PF00017	0.330
LIG_SH2_PTP2	261	264	PF00017	0.549
LIG_SH2_STAP1	154	158	PF00017	0.352
LIG_SH2_STAP1	181	185	PF00017	0.402
LIG_SH2_STAT5	174	177	PF00017	0.364
LIG_SH2_STAT5	181	184	PF00017	0.322
LIG_SH2_STAT5	201	204	PF00017	0.359
LIG_SH2_STAT5	215	218	PF00017	0.329
LIG_SH2_STAT5	246	249	PF00017	0.333
LIG_SH2_STAT5	251	254	PF00017	0.312
LIG_SH2_STAT5	261	264	PF00017	0.434
LIG_SH2_STAT5	30	33	PF00017	0.320
LIG_SH2_STAT5	35	38	PF00017	0.310
LIG_SH2_STAT5	7	10	PF00017	0.354
LIG_SH3_3	272	278	PF00018	0.654
LIG_UBA3_1	117	122	PF00899	0.337
LIG_UBA3_1	252	259	PF00899	0.305
LIG_WRC_WIRS_1	35	40	PF05994	0.381
MOD_CMANNOS	63	66	PF00535	0.375
MOD_Cter_Amidation	135	138	PF01082	0.282
MOD_GlcNHglycan	50	53	PF01048	0.356
MOD_GSK3_1	175	182	PF00069	0.379
MOD_GSK3_1	273	280	PF00069	0.639
MOD_N-GLC_1	231	236	PF02516	0.414
MOD_NEK2_1	118	123	PF00069	0.315
MOD_NEK2_1	126	131	PF00069	0.324
MOD_NEK2_1	175	180	PF00069	0.316
MOD_NEK2_1	200	205	PF00069	0.501
MOD_NEK2_1	214	219	PF00069	0.307
MOD_NEK2_1	48	53	PF00069	0.489
MOD_NEK2_1	61	66	PF00069	0.478
MOD_NEK2_2	71	76	PF00069	0.394
MOD_PIKK_1	205	211	PF00454	0.367
MOD_Plk_1	270	276	PF00069	0.559
MOD_Plk_4	126	132	PF00069	0.307
MOD_Plk_4	141	147	PF00069	0.307
MOD_Plk_4	16	22	PF00069	0.261
MOD_Plk_4	161	167	PF00069	0.162
MOD_Plk_4	175	181	PF00069	0.235
MOD_Plk_4	190	196	PF00069	0.459
MOD_Plk_4	216	222	PF00069	0.176
MOD_Plk_4	34	40	PF00069	0.314
TRG_ENDOCYTIC_2	154	157	PF00928	0.333
TRG_ENDOCYTIC_2	181	184	PF00928	0.344
TRG_ENDOCYTIC_2	201	204	PF00928	0.137
TRG_ENDOCYTIC_2	215	218	PF00928	0.329
TRG_ENDOCYTIC_2	35	38	PF00928	0.304
TRG_ENDOCYTIC_2	79	82	PF00928	0.359
TRG_ER_diArg_1	89	91	PF00400	0.177
TRG_ER_diLys_1	281	284	PF00400	0.634
TRG_NES_CRM1_1	242	255	PF08389	0.434
TRG_NLS_MonoExtC_3	136	141	PF00514	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	29%	95%
A0A0N0P7D1	Leptomonas seymouri	35%	85%
A0A0N0P7D6	Leptomonas seymouri	41%	98%
A0A0N0P7R2	Leptomonas seymouri	36%	93%
A0A0N1HZJ8	Leptomonas seymouri	30%	88%
A0A0N1I9H5	Leptomonas seymouri	58%	100%
A0A0N1IIZ8	Leptomonas seymouri	25%	93%
A0A0N1ILQ4	Leptomonas seymouri	36%	97%
A0A0N1IM10	Leptomonas seymouri	47%	99%
A0A0N1PDR8	Leptomonas seymouri	32%	100%
A0A0N1PFE8	Leptomonas seymouri	81%	100%
A0A0S4IS29	Bodo saltans	38%	100%
A0A0S4IVJ6	Bodo saltans	31%	89%
A0A0S4IVS6	Bodo saltans	34%	100%
A0A0S4IW98	Bodo saltans	37%	90%
A0A1X0NNK7	Trypanosomatidae	33%	100%
A0A1X0NNL0	Trypanosomatidae	42%	94%
A0A1X0NNM4	Trypanosomatidae	35%	99%
A0A1X0NNM5	Trypanosomatidae	31%	92%
A0A1X0NP89	Trypanosomatidae	28%	89%
A0A3Q8I9U9	Leishmania donovani	30%	87%
A0A3Q8I9X8	Leishmania donovani	35%	85%
A0A3Q8IC05	Leishmania donovani	31%	93%
A0A3Q8ID51	Leishmania donovani	28%	72%
A0A3Q8IIA9	Leishmania donovani	88%	100%
A0A3R7KG78	Trypanosoma rangeli	30%	100%
A0A3R7MJR2	Trypanosoma rangeli	35%	100%
A0A3R7NSQ3	Trypanosoma rangeli	43%	99%
A0A3S5H6R7	Leishmania donovani	48%	100%
A0A3S5H6R8	Leishmania donovani	34%	97%
A0A3S7WSY8	Leishmania donovani	59%	100%
A0A3S7WSZ1	Leishmania donovani	32%	95%
A0A3S7WT03	Leishmania donovani	33%	95%
A0A3S7WT05	Leishmania donovani	22%	93%
A0A3S7WT16	Leishmania donovani	30%	88%
A0A422NNP1	Trypanosoma rangeli	30%	95%
A4H7M1	Leishmania braziliensis	22%	98%
A4H7M2	Leishmania braziliensis	60%	100%
A4H7M3	Leishmania braziliensis	49%	99%
A4H7M5	Leishmania braziliensis	33%	97%
A4H7M6	Leishmania braziliensis	32%	95%
A4H7M7	Leishmania braziliensis	31%	88%
A4H7M9	Leishmania braziliensis	28%	70%
A4H7N0	Leishmania braziliensis	33%	96%
A4HW06	Leishmania infantum	22%	93%
A4HW07	Leishmania infantum	59%	100%
A4HW08	Leishmania infantum	48%	100%
A4HW09	Leishmania infantum	88%	100%
A4HW10	Leishmania infantum	34%	97%
A4HW12	Leishmania infantum	35%	85%
A4HW13	Leishmania infantum	30%	87%
A4HW14	Leishmania infantum	30%	88%
A4HW16	Leishmania infantum	28%	76%
A4HW18	Leishmania infantum	31%	94%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	94%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	93%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	76%
E9AGL0	Leishmania infantum	33%	95%
E9AGL2	Leishmania infantum	33%	95%
E9APQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	93%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	76%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	97%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	95%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	95%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	85%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	87%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	88%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	74%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	94%
G5EEE5	Caenorhabditis elegans	28%	99%
O35949	Mus musculus	33%	100%
P49191	Caenorhabditis elegans	33%	89%
Q20300	Caenorhabditis elegans	30%	100%
Q32NI8	Xenopus laevis	26%	96%
Q4QFQ9	Leishmania major	30%	100%
Q4QFR1	Leishmania major	28%	100%
Q4QFR2	Leishmania major	27%	100%
Q4QFR3	Leishmania major	30%	100%
Q4QFR4	Leishmania major	30%	100%
Q4QFR5	Leishmania major	36%	100%
Q4QFR6	Leishmania major	33%	100%
Q4QFR7	Leishmania major	36%	100%
Q4QFR8	Leishmania major	90%	100%
Q4QFR9	Leishmania major	47%	99%
Q4QFS0	Leishmania major	58%	99%
Q4QFS1	Leishmania major	24%	93%
Q5M8U1	Xenopus tropicalis	25%	96%
Q5ZJR8	Gallus gallus	34%	100%
Q6PC64	Danio rerio	38%	100%
Q920L5	Mus musculus	34%	100%
Q920L6	Rattus norvegicus	38%	100%
Q9H5J4	Homo sapiens	34%	100%
Q9HB03	Homo sapiens	35%	100%
Q9VV87	Drosophila melanogaster	33%	90%
Q9XVQ9	Caenorhabditis elegans	30%	100%
V5BE99	Trypanosoma cruzi	31%	99%
V5BIX9	Trypanosoma cruzi	36%	100%
V5BND3	Trypanosoma cruzi	30%	95%
V5DF68	Trypanosoma cruzi	42%	98%