LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania braziliensis
UniProt:
A4H7M2_LEIBR
TriTrypDb:
LbrM.14.0630 , LBRM2903_140011800 *
Length:
286

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 45
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 34
NetGPI no yes: 0, no: 35
Cellular components
Term Name Level Count
GO:0016020 membrane 2 32
GO:0110165 cellular anatomical entity 1 33
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4H7M2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7M2

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 36
GO:0006629 lipid metabolic process 3 36
GO:0006631 fatty acid metabolic process 4 36
GO:0006633 fatty acid biosynthetic process 5 36
GO:0008152 metabolic process 1 36
GO:0008610 lipid biosynthetic process 4 36
GO:0009058 biosynthetic process 2 36
GO:0009987 cellular process 1 36
GO:0016053 organic acid biosynthetic process 4 36
GO:0019752 carboxylic acid metabolic process 5 36
GO:0032787 monocarboxylic acid metabolic process 6 36
GO:0043436 oxoacid metabolic process 4 36
GO:0044237 cellular metabolic process 2 36
GO:0044238 primary metabolic process 2 36
GO:0044249 cellular biosynthetic process 3 36
GO:0044255 cellular lipid metabolic process 3 36
GO:0044281 small molecule metabolic process 2 36
GO:0044283 small molecule biosynthetic process 3 36
GO:0046394 carboxylic acid biosynthetic process 5 36
GO:0071704 organic substance metabolic process 2 36
GO:0072330 monocarboxylic acid biosynthetic process 6 36
GO:1901576 organic substance biosynthetic process 3 36
GO:0000038 very long-chain fatty acid metabolic process 5 4
GO:0001676 long-chain fatty acid metabolic process 5 3
GO:0006643 membrane lipid metabolic process 4 4
GO:0006665 sphingolipid metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0019367 fatty acid elongation, saturated fatty acid 7 4
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 4
GO:0030148 sphingolipid biosynthetic process 5 4
GO:0030497 fatty acid elongation 6 4
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 4
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 4
GO:0042759 long-chain fatty acid biosynthetic process 6 3
GO:0042761 very long-chain fatty acid biosynthetic process 6 4
GO:0046467 membrane lipid biosynthetic process 4 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 36
GO:0004312 fatty acid synthase activity 5 36
GO:0009922 fatty acid elongase activity 6 36
GO:0016740 transferase activity 2 36
GO:0016746 acyltransferase activity 3 36
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 36
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 36

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 267 269 PF00675 0.286
CLV_NRD_NRD_1 282 284 PF00675 0.461
DEG_Nend_UBRbox_3 1 3 PF02207 0.365
DOC_AGCK_PIF_1 153 158 PF00069 0.418
DOC_CDC14_PxL_1 79 87 PF14671 0.292
DOC_CYCLIN_yCln2_LP_2 193 199 PF00134 0.536
DOC_MAPK_MEF2A_6 195 203 PF00069 0.459
DOC_MAPK_MEF2A_6 243 250 PF00069 0.322
DOC_PP1_RVXF_1 108 114 PF00149 0.326
DOC_PP4_FxxP_1 40 43 PF00568 0.335
DOC_USP7_UBL2_3 191 195 PF12436 0.478
LIG_APCC_ABBA_1 253 258 PF00400 0.389
LIG_BRCT_BRCA1_1 256 260 PF00533 0.282
LIG_BRCT_BRCA1_2 256 262 PF00533 0.374
LIG_EH1_1 172 180 PF00400 0.360
LIG_FHA_1 106 112 PF00498 0.228
LIG_FHA_1 127 133 PF00498 0.460
LIG_FHA_1 147 153 PF00498 0.268
LIG_FHA_1 205 211 PF00498 0.411
LIG_FHA_1 242 248 PF00498 0.418
LIG_FHA_2 98 104 PF00498 0.273
LIG_LIR_Gen_1 128 139 PF02991 0.474
LIG_LIR_Gen_1 143 153 PF02991 0.368
LIG_LIR_Gen_1 216 224 PF02991 0.422
LIG_LIR_Nem_3 143 148 PF02991 0.333
LIG_LIR_Nem_3 149 154 PF02991 0.310
LIG_LIR_Nem_3 177 183 PF02991 0.321
LIG_LIR_Nem_3 187 193 PF02991 0.463
LIG_LIR_Nem_3 216 221 PF02991 0.320
LIG_LIR_Nem_3 71 76 PF02991 0.298
LIG_Pex14_1 3 7 PF04695 0.355
LIG_Pex14_2 141 145 PF04695 0.373
LIG_Pex14_2 256 260 PF04695 0.283
LIG_SH2_PTP2 200 203 PF00017 0.482
LIG_SH2_PTP2 218 221 PF00017 0.250
LIG_SH2_PTP2 264 267 PF00017 0.526
LIG_SH2_STAP1 107 111 PF00017 0.253
LIG_SH2_STAT3 156 159 PF00017 0.326
LIG_SH2_STAT3 7 10 PF00017 0.217
LIG_SH2_STAT5 107 110 PF00017 0.285
LIG_SH2_STAT5 151 154 PF00017 0.299
LIG_SH2_STAT5 173 176 PF00017 0.355
LIG_SH2_STAT5 180 183 PF00017 0.302
LIG_SH2_STAT5 200 203 PF00017 0.545
LIG_SH2_STAT5 218 221 PF00017 0.277
LIG_SH2_STAT5 249 252 PF00017 0.319
LIG_SH2_STAT5 254 257 PF00017 0.307
LIG_SH2_STAT5 264 267 PF00017 0.440
LIG_SH2_STAT5 30 33 PF00017 0.298
LIG_SH2_STAT5 35 38 PF00017 0.296
LIG_SH3_3 275 281 PF00018 0.621
LIG_SH3_3 78 84 PF00018 0.355
LIG_SUMO_SIM_anti_2 55 60 PF11976 0.348
LIG_TYR_ITSM 147 154 PF00017 0.337
LIG_UBA3_1 117 122 PF00899 0.326
LIG_UBA3_1 255 262 PF00899 0.325
LIG_UBA3_1 85 91 PF00899 0.332
LIG_WRC_WIRS_1 98 103 PF05994 0.291
MOD_CK1_1 140 146 PF00069 0.236
MOD_CK1_1 235 241 PF00069 0.297
MOD_CK1_1 71 77 PF00069 0.267
MOD_CK2_1 97 103 PF00069 0.303
MOD_CMANNOS 63 66 PF00535 0.384
MOD_GlcNHglycan 215 218 PF01048 0.373
MOD_GlcNHglycan 234 237 PF01048 0.527
MOD_GlcNHglycan 70 73 PF01048 0.352
MOD_GSK3_1 222 229 PF00069 0.260
MOD_GSK3_1 230 237 PF00069 0.290
MOD_N-GLC_1 137 142 PF02516 0.148
MOD_NEK2_1 106 111 PF00069 0.231
MOD_NEK2_1 118 123 PF00069 0.304
MOD_NEK2_1 126 131 PF00069 0.317
MOD_NEK2_1 174 179 PF00069 0.303
MOD_NEK2_1 199 204 PF00069 0.490
MOD_NEK2_1 213 218 PF00069 0.295
MOD_NEK2_1 38 43 PF00069 0.322
MOD_NEK2_1 68 73 PF00069 0.300
MOD_NEK2_1 94 99 PF00069 0.278
MOD_PIKK_1 204 210 PF00454 0.377
MOD_PIKK_1 241 247 PF00454 0.382
MOD_Plk_1 137 143 PF00069 0.348
MOD_Plk_1 273 279 PF00069 0.543
MOD_Plk_4 126 132 PF00069 0.309
MOD_Plk_4 137 143 PF00069 0.455
MOD_Plk_4 147 153 PF00069 0.287
MOD_Plk_4 160 166 PF00069 0.203
MOD_Plk_4 174 180 PF00069 0.278
MOD_Plk_4 189 195 PF00069 0.469
TRG_DiLeu_BaLyEn_6 81 86 PF01217 0.439
TRG_ENDOCYTIC_2 151 154 PF00928 0.318
TRG_ENDOCYTIC_2 180 183 PF00928 0.325
TRG_ENDOCYTIC_2 200 203 PF00928 0.407
TRG_ENDOCYTIC_2 218 221 PF00928 0.389
TRG_ENDOCYTIC_2 35 38 PF00928 0.291
TRG_ENDOCYTIC_2 76 79 PF00928 0.339
TRG_NES_CRM1_1 245 258 PF08389 0.438
TRG_Pf-PMV_PEXEL_1 87 92 PF00026 0.389

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 34% 96%
A0A0N0P7D1 Leptomonas seymouri 32% 86%
A0A0N0P7D6 Leptomonas seymouri 43% 99%
A0A0N0P7R2 Leptomonas seymouri 36% 94%
A0A0N1HZJ8 Leptomonas seymouri 30% 88%
A0A0N1I9H5 Leptomonas seymouri 72% 100%
A0A0N1IIZ8 Leptomonas seymouri 24% 93%
A0A0N1ILQ4 Leptomonas seymouri 36% 98%
A0A0N1IM10 Leptomonas seymouri 54% 100%
A0A0N1PDR8 Leptomonas seymouri 33% 100%
A0A0N1PFE8 Leptomonas seymouri 59% 100%
A0A0S4IS29 Bodo saltans 36% 100%
A0A0S4IVJ6 Bodo saltans 32% 90%
A0A0S4IVS6 Bodo saltans 31% 100%
A0A0S4IW98 Bodo saltans 32% 90%
A0A0S4JH58 Bodo saltans 26% 95%
A0A1X0NNK7 Trypanosomatidae 35% 100%
A0A1X0NNL0 Trypanosomatidae 44% 95%
A0A1X0NNM4 Trypanosomatidae 38% 100%
A0A1X0NNM5 Trypanosomatidae 30% 93%
A0A1X0NP89 Trypanosomatidae 30% 90%
A0A3Q8I8T7 Leishmania donovani 28% 73%
A0A3Q8I9T2 Leishmania donovani 31% 76%
A0A3Q8I9U9 Leishmania donovani 32% 88%
A0A3Q8I9X8 Leishmania donovani 33% 85%
A0A3Q8IC05 Leishmania donovani 33% 94%
A0A3Q8ID51 Leishmania donovani 30% 72%
A0A3Q8IIA9 Leishmania donovani 59% 100%
A0A3R7KG78 Trypanosoma rangeli 30% 100%
A0A3R7MJR2 Trypanosoma rangeli 41% 100%
A0A3R7NSQ3 Trypanosoma rangeli 47% 99%
A0A3S5H6R7 Leishmania donovani 55% 100%
A0A3S5H6R8 Leishmania donovani 35% 97%
A0A3S7WSY8 Leishmania donovani 83% 100%
A0A3S7WSZ1 Leishmania donovani 32% 96%
A0A3S7WT03 Leishmania donovani 33% 96%
A0A3S7WT05 Leishmania donovani 24% 94%
A0A3S7WT16 Leishmania donovani 28% 89%
A0A422NNP1 Trypanosoma rangeli 30% 95%
A4H4G1 Leishmania braziliensis 28% 100%
A4H7M1 Leishmania braziliensis 22% 100%
A4H7M3 Leishmania braziliensis 55% 100%
A4H7M4 Leishmania braziliensis 60% 100%
A4H7M5 Leishmania braziliensis 34% 97%
A4H7M6 Leishmania braziliensis 31% 96%
A4H7M7 Leishmania braziliensis 31% 89%
A4H7M8 Leishmania braziliensis 32% 75%
A4H7M9 Leishmania braziliensis 29% 70%
A4H7N0 Leishmania braziliensis 35% 96%
A4HW06 Leishmania infantum 24% 94%
A4HW07 Leishmania infantum 83% 100%
A4HW08 Leishmania infantum 55% 100%
A4HW09 Leishmania infantum 59% 100%
A4HW10 Leishmania infantum 35% 97%
A4HW12 Leishmania infantum 34% 85%
A4HW13 Leishmania infantum 32% 88%
A4HW14 Leishmania infantum 28% 89%
A4HW15 Leishmania infantum 31% 76%
A4HW16 Leishmania infantum 30% 76%
A4HW17 Leishmania infantum 29% 73%
A4HW18 Leishmania infantum 33% 94%
B4QVX4 Drosophila simulans 22% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 95%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 93%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 76%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 75%
E9AGL0 Leishmania infantum 32% 96%
E9AGL2 Leishmania infantum 32% 96%
E9APQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 94%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 76%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 97%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 96%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 96%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 85%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 88%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 89%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 74%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 95%
G5EEE5 Caenorhabditis elegans 26% 99%
O35949 Mus musculus 30% 100%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 92%
P40319 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 83%
P49191 Caenorhabditis elegans 30% 89%
Q03574 Caenorhabditis elegans 33% 98%
Q20303 Caenorhabditis elegans 33% 100%
Q32NI8 Xenopus laevis 26% 97%
Q4QFQ9 Leishmania major 33% 100%
Q4QFR0 Leishmania major 28% 100%
Q4QFR2 Leishmania major 32% 100%
Q4QFR3 Leishmania major 29% 100%
Q4QFR4 Leishmania major 32% 100%
Q4QFR5 Leishmania major 33% 100%
Q4QFR6 Leishmania major 34% 100%
Q4QFR7 Leishmania major 35% 100%
Q4QFR8 Leishmania major 59% 100%
Q4QFR9 Leishmania major 55% 99%
Q4QFS0 Leishmania major 84% 98%
Q4QFS1 Leishmania major 26% 100%
Q5M8U1 Xenopus tropicalis 28% 97%
Q5ZJR8 Gallus gallus 33% 100%
Q6PC64 Danio rerio 32% 100%
Q7LKX0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 78%
Q86JM5 Dictyostelium discoideum 27% 97%
Q920L5 Mus musculus 35% 100%
Q920L6 Rattus norvegicus 35% 100%
Q9EQC4 Mus musculus 24% 92%
Q9GZR5 Homo sapiens 24% 91%
Q9H5J4 Homo sapiens 35% 100%
Q9HB03 Homo sapiens 30% 100%
Q9VV87 Drosophila melanogaster 32% 91%
Q9XVQ9 Caenorhabditis elegans 28% 100%
V5BE99 Trypanosoma cruzi 31% 100%
V5BIX9 Trypanosoma cruzi 42% 100%
V5BND3 Trypanosoma cruzi 31% 95%
V5DF68 Trypanosoma cruzi 45% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS