Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7L9_LEIBR

TriTrypDb:

LbrM.14.0600 , LBRM2903_140011500

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.675
CLV_C14_Caspase3-7	360	364	PF00656	0.424
CLV_C14_Caspase3-7	440	444	PF00656	0.548
CLV_C14_Caspase3-7	69	73	PF00656	0.629
CLV_C14_Caspase3-7	8	12	PF00656	0.605
CLV_NRD_NRD_1	192	194	PF00675	0.526
CLV_NRD_NRD_1	229	231	PF00675	0.478
CLV_NRD_NRD_1	236	238	PF00675	0.467
CLV_NRD_NRD_1	28	30	PF00675	0.559
CLV_NRD_NRD_1	356	358	PF00675	0.460
CLV_NRD_NRD_1	383	385	PF00675	0.680
CLV_NRD_NRD_1	400	402	PF00675	0.565
CLV_NRD_NRD_1	493	495	PF00675	0.557
CLV_NRD_NRD_1	501	503	PF00675	0.585
CLV_PCSK_FUR_1	354	358	PF00082	0.460
CLV_PCSK_FUR_1	398	402	PF00082	0.582
CLV_PCSK_FUR_1	498	502	PF00082	0.484
CLV_PCSK_KEX2_1	229	231	PF00082	0.478
CLV_PCSK_KEX2_1	241	243	PF00082	0.468
CLV_PCSK_KEX2_1	28	30	PF00082	0.559
CLV_PCSK_KEX2_1	356	358	PF00082	0.460
CLV_PCSK_KEX2_1	372	374	PF00082	0.488
CLV_PCSK_KEX2_1	383	385	PF00082	0.541
CLV_PCSK_KEX2_1	400	402	PF00082	0.719
CLV_PCSK_KEX2_1	493	495	PF00082	0.557
CLV_PCSK_KEX2_1	500	502	PF00082	0.588
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.504
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.488
CLV_PCSK_PC7_1	237	243	PF00082	0.424
CLV_PCSK_SKI1_1	230	234	PF00082	0.509
CLV_PCSK_SKI1_1	238	242	PF00082	0.474
CLV_PCSK_SKI1_1	384	388	PF00082	0.556
CLV_PCSK_SKI1_1	493	497	PF00082	0.559
CLV_PCSK_SKI1_1	59	63	PF00082	0.627
DEG_SCF_FBW7_1	45	52	PF00400	0.548
DEG_SPOP_SBC_1	107	111	PF00917	0.559
DEG_SPOP_SBC_1	148	152	PF00917	0.638
DEG_SPOP_SBC_1	170	174	PF00917	0.530
DEG_SPOP_SBC_1	321	325	PF00917	0.506
DOC_CKS1_1	78	83	PF01111	0.541
DOC_CYCLIN_RxL_1	223	236	PF00134	0.449
DOC_PP2B_LxvP_1	338	341	PF13499	0.534
DOC_USP7_MATH_1	107	111	PF00917	0.577
DOC_USP7_MATH_1	321	325	PF00917	0.577
DOC_USP7_MATH_1	408	412	PF00917	0.532
DOC_USP7_MATH_1	452	456	PF00917	0.531
DOC_USP7_MATH_1	47	51	PF00917	0.628
DOC_USP7_MATH_1	87	91	PF00917	0.656
DOC_WW_Pin1_4	171	176	PF00397	0.716
DOC_WW_Pin1_4	178	183	PF00397	0.515
DOC_WW_Pin1_4	33	38	PF00397	0.706
DOC_WW_Pin1_4	444	449	PF00397	0.776
DOC_WW_Pin1_4	45	50	PF00397	0.579
DOC_WW_Pin1_4	77	82	PF00397	0.676
DOC_WW_Pin1_4	83	88	PF00397	0.681
LIG_14-3-3_CanoR_1	28	37	PF00244	0.660
LIG_14-3-3_CanoR_1	304	312	PF00244	0.633
LIG_14-3-3_CanoR_1	383	389	PF00244	0.570
LIG_14-3-3_CanoR_1	479	483	PF00244	0.571
LIG_BRCT_BRCA1_1	173	177	PF00533	0.675
LIG_BRCT_BRCA1_1	388	392	PF00533	0.450
LIG_FHA_1	213	219	PF00498	0.484
LIG_FHA_1	313	319	PF00498	0.649
LIG_FHA_1	404	410	PF00498	0.524
LIG_FHA_1	494	500	PF00498	0.567
LIG_FHA_2	115	121	PF00498	0.726
LIG_FHA_2	438	444	PF00498	0.547
LIG_FHA_2	463	469	PF00498	0.482
LIG_FHA_2	67	73	PF00498	0.633
LIG_LIR_Gen_1	174	185	PF02991	0.726
LIG_LIR_Gen_1	293	303	PF02991	0.491
LIG_LIR_Gen_1	453	461	PF02991	0.539
LIG_LIR_Gen_1	468	478	PF02991	0.612
LIG_LIR_Nem_3	174	180	PF02991	0.675
LIG_LIR_Nem_3	293	299	PF02991	0.486
LIG_LIR_Nem_3	453	459	PF02991	0.699
LIG_LIR_Nem_3	468	474	PF02991	0.624
LIG_MYND_1	336	340	PF01753	0.541
LIG_RPA_C_Fungi	299	311	PF08784	0.499
LIG_SH2_SRC	334	337	PF00017	0.554
LIG_SH2_STAT5	287	290	PF00017	0.583
LIG_SH2_STAT5	296	299	PF00017	0.505
LIG_SH2_STAT5	334	337	PF00017	0.594
LIG_SH2_STAT5	77	80	PF00017	0.633
LIG_SH3_3	142	148	PF00018	0.614
LIG_SH3_3	338	344	PF00018	0.606
LIG_SH3_3	385	391	PF00018	0.607
LIG_SH3_3	39	45	PF00018	0.556
LIG_SH3_3	75	81	PF00018	0.543
LIG_SH3_3	96	102	PF00018	0.604
LIG_TRAF2_1	290	293	PF00917	0.482
MOD_CDK_SPK_2	33	38	PF00069	0.553
MOD_CK1_1	108	114	PF00069	0.606
MOD_CK1_1	152	158	PF00069	0.648
MOD_CK1_1	178	184	PF00069	0.650
MOD_CK1_1	188	194	PF00069	0.558
MOD_CK1_1	298	304	PF00069	0.653
MOD_CK1_1	325	331	PF00069	0.543
MOD_CK1_1	411	417	PF00069	0.610
MOD_CK1_1	462	468	PF00069	0.521
MOD_CK2_1	147	153	PF00069	0.596
MOD_CK2_1	462	468	PF00069	0.486
MOD_CK2_1	500	506	PF00069	0.551
MOD_GlcNHglycan	142	145	PF01048	0.568
MOD_GlcNHglycan	166	169	PF01048	0.531
MOD_GlcNHglycan	388	391	PF01048	0.451
MOD_GlcNHglycan	410	413	PF01048	0.509
MOD_GlcNHglycan	417	420	PF01048	0.782
MOD_GlcNHglycan	431	434	PF01048	0.616
MOD_GlcNHglycan	51	54	PF01048	0.643
MOD_GSK3_1	105	112	PF00069	0.653
MOD_GSK3_1	13	20	PF00069	0.552
MOD_GSK3_1	147	154	PF00069	0.657
MOD_GSK3_1	171	178	PF00069	0.579
MOD_GSK3_1	184	191	PF00069	0.571
MOD_GSK3_1	212	219	PF00069	0.685
MOD_GSK3_1	24	31	PF00069	0.669
MOD_GSK3_1	255	262	PF00069	0.416
MOD_GSK3_1	310	317	PF00069	0.607
MOD_GSK3_1	321	328	PF00069	0.535
MOD_GSK3_1	403	410	PF00069	0.555
MOD_GSK3_1	411	418	PF00069	0.495
MOD_GSK3_1	444	451	PF00069	0.545
MOD_GSK3_1	45	52	PF00069	0.634
MOD_GSK3_1	459	466	PF00069	0.630
MOD_GSK3_1	53	60	PF00069	0.748
MOD_GSK3_1	73	80	PF00069	0.621
MOD_GSK3_1	83	90	PF00069	0.538
MOD_GSK3_1	97	104	PF00069	0.697
MOD_N-GLC_1	57	62	PF02516	0.557
MOD_NEK2_1	13	18	PF00069	0.601
MOD_NEK2_1	140	145	PF00069	0.572
MOD_NEK2_1	394	399	PF00069	0.573
MOD_NEK2_2	452	457	PF00069	0.573
MOD_NEK2_2	87	92	PF00069	0.540
MOD_PIKK_1	175	181	PF00454	0.593
MOD_PIKK_1	205	211	PF00454	0.525
MOD_PIKK_1	28	34	PF00454	0.718
MOD_PIKK_1	339	345	PF00454	0.528
MOD_PIKK_1	47	53	PF00454	0.513
MOD_PKA_1	28	34	PF00069	0.561
MOD_PKA_1	493	499	PF00069	0.564
MOD_PKA_1	500	506	PF00069	0.539
MOD_PKA_2	22	28	PF00069	0.578
MOD_PKA_2	325	331	PF00069	0.496
MOD_PKA_2	40	46	PF00069	0.555
MOD_PKA_2	478	484	PF00069	0.609
MOD_PKA_2	493	499	PF00069	0.410
MOD_PKA_2	500	506	PF00069	0.529
MOD_PKB_1	498	506	PF00069	0.457
MOD_PKB_1	64	72	PF00069	0.550
MOD_Plk_1	255	261	PF00069	0.498
MOD_Plk_1	326	332	PF00069	0.496
MOD_Plk_1	452	458	PF00069	0.543
MOD_Plk_1	467	473	PF00069	0.627
MOD_Plk_1	57	63	PF00069	0.549
MOD_Plk_4	13	19	PF00069	0.522
MOD_Plk_4	295	301	PF00069	0.499
MOD_Plk_4	467	473	PF00069	0.627
MOD_Plk_4	478	484	PF00069	0.496
MOD_Plk_4	73	79	PF00069	0.546
MOD_ProDKin_1	171	177	PF00069	0.715
MOD_ProDKin_1	178	184	PF00069	0.520
MOD_ProDKin_1	33	39	PF00069	0.707
MOD_ProDKin_1	444	450	PF00069	0.778
MOD_ProDKin_1	45	51	PF00069	0.584
MOD_ProDKin_1	77	83	PF00069	0.676
MOD_SUMO_rev_2	236	243	PF00179	0.501
MOD_SUMO_rev_2	367	374	PF00179	0.490
TRG_DiLeu_BaEn_1	9	14	PF01217	0.437
TRG_DiLeu_BaEn_4	278	284	PF01217	0.566
TRG_DiLeu_BaEn_4	292	298	PF01217	0.474
TRG_DiLeu_BaEn_4	369	375	PF01217	0.486
TRG_ENDOCYTIC_2	247	250	PF00928	0.446
TRG_ENDOCYTIC_2	296	299	PF00928	0.496
TRG_ER_diArg_1	21	24	PF00400	0.587
TRG_ER_diArg_1	228	230	PF00400	0.479
TRG_ER_diArg_1	28	30	PF00400	0.600
TRG_ER_diArg_1	354	357	PF00400	0.461
TRG_ER_diArg_1	382	384	PF00400	0.659
TRG_ER_diArg_1	398	401	PF00400	0.557
TRG_ER_diArg_1	492	494	PF00400	0.560
TRG_ER_diArg_1	498	501	PF00400	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X0	Leptomonas seymouri	38%	97%
A0A3S7WSY4	Leishmania donovani	59%	86%
A4HW04	Leishmania infantum	59%	86%
E9APQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QFS3	Leishmania major	63%	100%