Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7L8_LEIBR

TriTrypDb:

LbrM.14.0590 , LBRM2903_140011400

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7L8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.762
CLV_C14_Caspase3-7	81	85	PF00656	0.734
CLV_NRD_NRD_1	205	207	PF00675	0.529
CLV_NRD_NRD_1	231	233	PF00675	0.449
CLV_NRD_NRD_1	239	241	PF00675	0.469
CLV_NRD_NRD_1	355	357	PF00675	0.521
CLV_NRD_NRD_1	413	415	PF00675	0.660
CLV_PCSK_KEX2_1	231	233	PF00082	0.449
CLV_PCSK_KEX2_1	239	241	PF00082	0.469
CLV_PCSK_KEX2_1	355	357	PF00082	0.521
CLV_PCSK_KEX2_1	413	415	PF00082	0.689
CLV_PCSK_SKI1_1	249	253	PF00082	0.458
CLV_PCSK_SKI1_1	338	342	PF00082	0.493
CLV_PCSK_SKI1_1	356	360	PF00082	0.430
CLV_PCSK_SKI1_1	363	367	PF00082	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DEG_SCF_FBW7_2	314	321	PF00400	0.646
DEG_SPOP_SBC_1	121	125	PF00917	0.683
DOC_CDC14_PxL_1	339	347	PF14671	0.509
DOC_CKS1_1	185	190	PF01111	0.568
DOC_MAPK_gen_1	231	237	PF00069	0.479
DOC_MAPK_HePTP_8	335	347	PF00069	0.550
DOC_MAPK_MEF2A_6	338	347	PF00069	0.569
DOC_PP1_RVXF_1	273	279	PF00149	0.435
DOC_PP2B_LxvP_1	233	236	PF13499	0.419
DOC_PP2B_LxvP_1	340	343	PF13499	0.500
DOC_USP7_MATH_1	10	14	PF00917	0.494
DOC_USP7_MATH_1	121	125	PF00917	0.635
DOC_USP7_MATH_1	305	309	PF00917	0.546
DOC_USP7_MATH_1	407	411	PF00917	0.655
DOC_USP7_MATH_1	421	425	PF00917	0.621
DOC_USP7_MATH_1	46	50	PF00917	0.548
DOC_USP7_MATH_2	283	289	PF00917	0.552
DOC_WW_Pin1_4	128	133	PF00397	0.619
DOC_WW_Pin1_4	145	150	PF00397	0.626
DOC_WW_Pin1_4	184	189	PF00397	0.557
DOC_WW_Pin1_4	224	229	PF00397	0.443
DOC_WW_Pin1_4	244	249	PF00397	0.443
DOC_WW_Pin1_4	251	256	PF00397	0.401
DOC_WW_Pin1_4	314	319	PF00397	0.647
DOC_WW_Pin1_4	42	47	PF00397	0.686
DOC_WW_Pin1_4	70	75	PF00397	0.589
LIG_14-3-3_CanoR_1	14	22	PF00244	0.783
LIG_14-3-3_CanoR_1	28	33	PF00244	0.539
LIG_14-3-3_CanoR_1	75	83	PF00244	0.796
LIG_APCC_ABBAyCdc20_2	165	171	PF00400	0.428
LIG_BIR_III_4	392	396	PF00653	0.592
LIG_BRCT_BRCA1_1	225	229	PF00533	0.505
LIG_eIF4E_1	245	251	PF01652	0.464
LIG_FHA_1	216	222	PF00498	0.546
LIG_FHA_1	239	245	PF00498	0.487
LIG_FHA_1	331	337	PF00498	0.472
LIG_FHA_1	43	49	PF00498	0.707
LIG_FHA_2	203	209	PF00498	0.662
LIG_FHA_2	212	218	PF00498	0.620
LIG_FHA_2	279	285	PF00498	0.478
LIG_FHA_2	315	321	PF00498	0.644
LIG_FHA_2	357	363	PF00498	0.547
LIG_FHA_2	65	71	PF00498	0.638
LIG_FHA_2	75	81	PF00498	0.778
LIG_FHA_2	86	92	PF00498	0.737
LIG_GBD_Chelix_1	257	265	PF00786	0.376
LIG_LIR_Gen_1	154	164	PF02991	0.452
LIG_LIR_Gen_1	329	340	PF02991	0.392
LIG_LIR_Gen_1	94	103	PF02991	0.618
LIG_LIR_Nem_3	154	160	PF02991	0.363
LIG_LIR_Nem_3	315	319	PF02991	0.615
LIG_LIR_Nem_3	329	335	PF02991	0.400
LIG_LIR_Nem_3	53	58	PF02991	0.685
LIG_LIR_Nem_3	94	100	PF02991	0.514
LIG_SH2_CRK	245	249	PF00017	0.404
LIG_SH2_CRK	332	336	PF00017	0.392
LIG_SH2_NCK_1	316	320	PF00017	0.640
LIG_SH2_PTP2	155	158	PF00017	0.386
LIG_SH2_SRC	260	263	PF00017	0.396
LIG_SH2_SRC	461	464	PF00017	0.556
LIG_SH2_STAP1	332	336	PF00017	0.392
LIG_SH2_STAT3	290	293	PF00017	0.487
LIG_SH2_STAT5	155	158	PF00017	0.386
LIG_SH2_STAT5	213	216	PF00017	0.510
LIG_SH2_STAT5	260	263	PF00017	0.380
LIG_SH2_STAT5	277	280	PF00017	0.418
LIG_SH2_STAT5	316	319	PF00017	0.666
LIG_SH2_STAT5	332	335	PF00017	0.499
LIG_SH2_STAT5	339	342	PF00017	0.456
LIG_SH2_STAT5	461	464	PF00017	0.583
LIG_SH3_3	146	152	PF00018	0.667
LIG_SH3_3	68	74	PF00018	0.616
LIG_SUMO_SIM_par_1	332	337	PF11976	0.472
LIG_SUMO_SIM_par_1	37	42	PF11976	0.554
LIG_TRAF2_1	318	321	PF00917	0.637
LIG_TYR_ITIM	153	158	PF00017	0.348
LIG_TYR_ITIM	314	319	PF00017	0.647
LIG_UBA3_1	345	351	PF00899	0.484
MOD_CDK_SPK_2	184	189	PF00069	0.413
MOD_CDK_SPK_2	244	249	PF00069	0.502
MOD_CDK_SPK_2	70	75	PF00069	0.535
MOD_CDK_SPxxK_3	224	231	PF00069	0.507
MOD_CK1_1	13	19	PF00069	0.606
MOD_CK1_1	136	142	PF00069	0.658
MOD_CK1_1	220	226	PF00069	0.542
MOD_CK1_1	26	32	PF00069	0.707
MOD_CK1_1	42	48	PF00069	0.576
MOD_CK1_1	424	430	PF00069	0.691
MOD_CK2_1	128	134	PF00069	0.743
MOD_CK2_1	195	201	PF00069	0.741
MOD_CK2_1	202	208	PF00069	0.659
MOD_CK2_1	211	217	PF00069	0.680
MOD_CK2_1	278	284	PF00069	0.507
MOD_CK2_1	314	320	PF00069	0.627
MOD_CK2_1	356	362	PF00069	0.592
MOD_CK2_1	373	379	PF00069	0.531
MOD_CK2_1	63	69	PF00069	0.634
MOD_Cter_Amidation	237	240	PF01082	0.477
MOD_GlcNHglycan	16	19	PF01048	0.766
MOD_GlcNHglycan	195	198	PF01048	0.742
MOD_GlcNHglycan	287	290	PF01048	0.719
MOD_GlcNHglycan	397	400	PF01048	0.645
MOD_GlcNHglycan	48	51	PF01048	0.667
MOD_GlcNHglycan	97	100	PF01048	0.636
MOD_GSK3_1	10	17	PF00069	0.604
MOD_GSK3_1	121	128	PF00069	0.593
MOD_GSK3_1	141	148	PF00069	0.629
MOD_GSK3_1	211	218	PF00069	0.742
MOD_GSK3_1	22	29	PF00069	0.697
MOD_GSK3_1	220	227	PF00069	0.604
MOD_GSK3_1	42	49	PF00069	0.710
MOD_GSK3_1	420	427	PF00069	0.532
MOD_GSK3_1	56	63	PF00069	0.540
MOD_GSK3_1	70	77	PF00069	0.731
MOD_N-GLC_1	141	146	PF02516	0.777
MOD_NEK2_1	22	27	PF00069	0.703
MOD_NEK2_1	250	255	PF00069	0.449
MOD_NEK2_1	278	283	PF00069	0.492
MOD_NEK2_1	4	9	PF00069	0.594
MOD_NEK2_1	57	62	PF00069	0.666
MOD_NEK2_1	95	100	PF00069	0.551
MOD_NEK2_2	448	453	PF00069	0.585
MOD_PIKK_1	440	446	PF00454	0.674
MOD_PIKK_1	58	64	PF00454	0.597
MOD_PKA_1	430	436	PF00069	0.575
MOD_PKA_2	125	131	PF00069	0.760
MOD_PKA_2	13	19	PF00069	0.768
MOD_PKA_2	136	142	PF00069	0.696
MOD_PKA_2	238	244	PF00069	0.492
MOD_PKA_2	4	10	PF00069	0.529
MOD_PKA_2	424	430	PF00069	0.661
MOD_PKA_2	448	454	PF00069	0.612
MOD_PKA_2	74	80	PF00069	0.545
MOD_PKB_1	12	20	PF00069	0.582
MOD_PKB_1	418	426	PF00069	0.705
MOD_PKB_1	438	446	PF00069	0.453
MOD_Plk_1	108	114	PF00069	0.738
MOD_Plk_1	216	222	PF00069	0.488
MOD_Plk_1	319	325	PF00069	0.551
MOD_Plk_1	79	85	PF00069	0.534
MOD_Plk_2-3	211	217	PF00069	0.512
MOD_Plk_2-3	373	379	PF00069	0.666
MOD_Plk_2-3	86	92	PF00069	0.627
MOD_Plk_4	151	157	PF00069	0.485
MOD_Plk_4	217	223	PF00069	0.556
MOD_Plk_4	330	336	PF00069	0.390
MOD_ProDKin_1	128	134	PF00069	0.618
MOD_ProDKin_1	145	151	PF00069	0.620
MOD_ProDKin_1	184	190	PF00069	0.565
MOD_ProDKin_1	224	230	PF00069	0.432
MOD_ProDKin_1	244	250	PF00069	0.433
MOD_ProDKin_1	251	257	PF00069	0.397
MOD_ProDKin_1	314	320	PF00069	0.646
MOD_ProDKin_1	42	48	PF00069	0.684
MOD_ProDKin_1	70	76	PF00069	0.590
TRG_ENDOCYTIC_2	155	158	PF00928	0.365
TRG_ENDOCYTIC_2	316	319	PF00928	0.640
TRG_ENDOCYTIC_2	332	335	PF00928	0.568
TRG_ER_diArg_1	11	14	PF00400	0.676
TRG_ER_diArg_1	230	232	PF00400	0.549
TRG_ER_diArg_1	272	275	PF00400	0.419
TRG_ER_diArg_1	355	357	PF00400	0.530
TRG_ER_diArg_1	413	416	PF00400	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF5	Leptomonas seymouri	51%	100%
A0A3Q8I8S7	Leishmania donovani	74%	100%
A0A3R7RMG7	Trypanosoma rangeli	41%	100%
A4HW03	Leishmania infantum	74%	100%
C9ZT20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9APQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	93%
Q4QFS4	Leishmania major	72%	100%