RNA methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7L7_LEIBR

TriTrypDb:

LbrM.14.0580 , LBRM2903_140011300

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7L7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0001510	RNA methylation	4	1
GO:0002128	tRNA nucleoside ribose methylation	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0030488	tRNA methylation	5	1
GO:0032259	methylation	2	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008168	methyltransferase activity	4	7
GO:0008173	RNA methyltransferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0008171	O-methyltransferase activity	5	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016300	tRNA (uracil) methyltransferase activity	6	1
GO:0016427	tRNA (cytosine) methyltransferase activity	6	1
GO:0052665	tRNA (uracil-2'-O-)-methyltransferase activity	7	1
GO:0052666	tRNA (cytosine-2'-O-)-methyltransferase activity	7	1
GO:0062105	RNA 2'-O-methyltransferase activity	5	1
GO:0106050	tRNA 2'-O-methyltransferase activity	6	1
GO:0140101	catalytic activity, acting on a tRNA	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	313	319	PF00089	0.409
CLV_NRD_NRD_1	206	208	PF00675	0.484
CLV_NRD_NRD_1	490	492	PF00675	0.416
CLV_NRD_NRD_1	80	82	PF00675	0.532
CLV_NRD_NRD_1	95	97	PF00675	0.504
CLV_PCSK_FUR_1	93	97	PF00082	0.492
CLV_PCSK_KEX2_1	164	166	PF00082	0.726
CLV_PCSK_KEX2_1	206	208	PF00082	0.523
CLV_PCSK_KEX2_1	490	492	PF00082	0.416
CLV_PCSK_KEX2_1	82	84	PF00082	0.537
CLV_PCSK_KEX2_1	95	97	PF00082	0.412
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.726
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.425
CLV_PCSK_PC7_1	91	97	PF00082	0.415
CLV_PCSK_SKI1_1	206	210	PF00082	0.480
CLV_PCSK_SKI1_1	484	488	PF00082	0.285
CLV_PCSK_SKI1_1	507	511	PF00082	0.466
DEG_SPOP_SBC_1	66	70	PF00917	0.642
DOC_CKS1_1	237	242	PF01111	0.410
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.497
DOC_MAPK_gen_1	79	88	PF00069	0.466
DOC_MAPK_gen_1	93	101	PF00069	0.463
DOC_MAPK_MEF2A_6	349	356	PF00069	0.424
DOC_PP1_RVXF_1	516	522	PF00149	0.373
DOC_PP1_SILK_1	244	249	PF00149	0.395
DOC_PP2B_LxvP_1	101	104	PF13499	0.430
DOC_PP2B_LxvP_1	354	357	PF13499	0.425
DOC_USP7_MATH_1	380	384	PF00917	0.594
DOC_USP7_MATH_1	40	44	PF00917	0.792
DOC_USP7_MATH_1	66	70	PF00917	0.659
DOC_WW_Pin1_4	155	160	PF00397	0.582
DOC_WW_Pin1_4	222	227	PF00397	0.602
DOC_WW_Pin1_4	236	241	PF00397	0.331
DOC_WW_Pin1_4	299	304	PF00397	0.531
DOC_WW_Pin1_4	378	383	PF00397	0.679
DOC_WW_Pin1_4	43	48	PF00397	0.670
DOC_WW_Pin1_4	62	67	PF00397	0.713
LIG_14-3-3_CanoR_1	174	182	PF00244	0.679
LIG_14-3-3_CanoR_1	264	268	PF00244	0.488
LIG_14-3-3_CanoR_1	299	303	PF00244	0.530
LIG_14-3-3_CanoR_1	520	526	PF00244	0.419
LIG_BRCT_BRCA1_1	13	17	PF00533	0.348
LIG_BRCT_BRCA1_1	318	322	PF00533	0.283
LIG_FHA_1	117	123	PF00498	0.606
LIG_FHA_1	128	134	PF00498	0.392
LIG_FHA_1	268	274	PF00498	0.679
LIG_FHA_1	282	288	PF00498	0.572
LIG_FHA_1	300	306	PF00498	0.476
LIG_FHA_1	356	362	PF00498	0.284
LIG_FHA_1	474	480	PF00498	0.363
LIG_FHA_1	520	526	PF00498	0.516
LIG_FHA_2	174	180	PF00498	0.698
LIG_FHA_2	280	286	PF00498	0.527
LIG_FHA_2	299	305	PF00498	0.767
LIG_FHA_2	408	414	PF00498	0.475
LIG_Integrin_RGD_1	367	369	PF01839	0.343
LIG_LIR_Gen_1	16	25	PF02991	0.423
LIG_LIR_Gen_1	360	370	PF02991	0.389
LIG_LIR_Nem_3	16	21	PF02991	0.359
LIG_LIR_Nem_3	360	366	PF02991	0.365
LIG_LIR_Nem_3	403	409	PF02991	0.368
LIG_NRBOX	204	210	PF00104	0.401
LIG_Pex14_1	13	17	PF04695	0.332
LIG_Pex14_1	506	510	PF04695	0.451
LIG_Rb_pABgroove_1	357	365	PF01858	0.342
LIG_SH2_CRK	482	486	PF00017	0.374
LIG_SH2_NCK_1	147	151	PF00017	0.470
LIG_SH2_NCK_1	402	406	PF00017	0.480
LIG_SH2_SRC	402	405	PF00017	0.476
LIG_SH2_STAP1	336	340	PF00017	0.558
LIG_SH2_STAP1	482	486	PF00017	0.292
LIG_SH2_STAT5	441	444	PF00017	0.340
LIG_SH3_2	159	164	PF14604	0.560
LIG_SH3_3	156	162	PF00018	0.603
LIG_SH3_3	231	237	PF00018	0.374
LIG_SH3_3	270	276	PF00018	0.547
LIG_SH3_3	374	380	PF00018	0.623
LIG_SH3_3	394	400	PF00018	0.291
LIG_SH3_3	460	466	PF00018	0.378
LIG_SH3_3	97	103	PF00018	0.443
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.289
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.315
LIG_SUMO_SIM_par_1	269	274	PF11976	0.507
LIG_SUMO_SIM_par_1	386	391	PF11976	0.363
LIG_TRAF2_1	151	154	PF00917	0.527
LIG_TRAF2_1	283	286	PF00917	0.592
LIG_TRAF2_1	410	413	PF00917	0.489
LIG_TYR_ITIM	480	485	PF00017	0.360
LIG_WRC_WIRS_1	317	322	PF05994	0.441
MOD_CK1_1	127	133	PF00069	0.513
MOD_CK1_1	266	272	PF00069	0.523
MOD_CK1_1	290	296	PF00069	0.630
MOD_CK1_1	383	389	PF00069	0.440
MOD_CK1_1	43	49	PF00069	0.661
MOD_CK1_1	65	71	PF00069	0.776
MOD_CK2_1	13	19	PF00069	0.309
MOD_CK2_1	148	154	PF00069	0.518
MOD_CK2_1	173	179	PF00069	0.592
MOD_CK2_1	279	285	PF00069	0.521
MOD_CK2_1	407	413	PF00069	0.463
MOD_Cter_Amidation	2	5	PF01082	0.506
MOD_DYRK1A_RPxSP_1	299	303	PF00069	0.516
MOD_GlcNHglycan	126	129	PF01048	0.536
MOD_GlcNHglycan	171	174	PF01048	0.635
MOD_GlcNHglycan	292	295	PF01048	0.601
MOD_GlcNHglycan	322	325	PF01048	0.324
MOD_GlcNHglycan	450	453	PF01048	0.418
MOD_GlcNHglycan	52	55	PF01048	0.515
MOD_GSK3_1	123	130	PF00069	0.495
MOD_GSK3_1	169	176	PF00069	0.678
MOD_GSK3_1	218	225	PF00069	0.485
MOD_GSK3_1	263	270	PF00069	0.583
MOD_GSK3_1	277	284	PF00069	0.604
MOD_GSK3_1	305	312	PF00069	0.717
MOD_GSK3_1	316	323	PF00069	0.418
MOD_GSK3_1	39	46	PF00069	0.572
MOD_GSK3_1	407	414	PF00069	0.490
MOD_GSK3_1	61	68	PF00069	0.673
MOD_N-GLC_1	222	227	PF02516	0.615
MOD_NEK2_1	320	325	PF00069	0.375
MOD_NEK2_1	473	478	PF00069	0.363
MOD_NEK2_2	13	18	PF00069	0.366
MOD_NEK2_2	336	341	PF00069	0.453
MOD_NEK2_2	521	526	PF00069	0.402
MOD_PIKK_1	277	283	PF00454	0.520
MOD_PKA_2	173	179	PF00069	0.695
MOD_PKA_2	263	269	PF00069	0.486
MOD_PKA_2	298	304	PF00069	0.533
MOD_PKA_2	519	525	PF00069	0.648
MOD_PKB_1	314	322	PF00069	0.462
MOD_Plk_2-3	148	154	PF00069	0.494
MOD_Plk_4	13	19	PF00069	0.367
MOD_Plk_4	177	183	PF00069	0.697
MOD_Plk_4	316	322	PF00069	0.444
MOD_Plk_4	380	386	PF00069	0.398
MOD_ProDKin_1	155	161	PF00069	0.583
MOD_ProDKin_1	222	228	PF00069	0.586
MOD_ProDKin_1	236	242	PF00069	0.328
MOD_ProDKin_1	299	305	PF00069	0.532
MOD_ProDKin_1	378	384	PF00069	0.663
MOD_ProDKin_1	43	49	PF00069	0.670
MOD_ProDKin_1	62	68	PF00069	0.714
MOD_SUMO_rev_2	193	200	PF00179	0.435
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.467
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.460
TRG_ENDOCYTIC_2	114	117	PF00928	0.429
TRG_ENDOCYTIC_2	482	485	PF00928	0.372
TRG_ER_diArg_1	205	207	PF00400	0.510
TRG_ER_diArg_1	313	316	PF00400	0.444
TRG_ER_diArg_1	490	492	PF00400	0.525
TRG_ER_diArg_1	518	521	PF00400	0.444
TRG_ER_diArg_1	88	91	PF00400	0.496
TRG_ER_diArg_1	92	95	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC5	Leptomonas seymouri	47%	100%
A0A3S7WSX9	Leishmania donovani	69%	100%
A4HW02	Leishmania infantum	69%	100%
E9APQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QFS5	Leishmania major	69%	96%