Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H7L3_LEIBR

TriTrypDb:

LbrM.14.0540 , LBRM2903_140010800

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H7L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.674
CLV_NRD_NRD_1	332	334	PF00675	0.502
CLV_NRD_NRD_1	42	44	PF00675	0.689
CLV_PCSK_KEX2_1	227	229	PF00082	0.674
CLV_PCSK_KEX2_1	330	332	PF00082	0.490
CLV_PCSK_KEX2_1	42	44	PF00082	0.715
CLV_PCSK_KEX2_1	457	459	PF00082	0.621
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.481
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.577
CLV_PCSK_SKI1_1	107	111	PF00082	0.670
CLV_PCSK_SKI1_1	127	131	PF00082	0.757
CLV_PCSK_SKI1_1	168	172	PF00082	0.678
CLV_PCSK_SKI1_1	466	470	PF00082	0.517
CLV_PCSK_SKI1_1	83	87	PF00082	0.612
DOC_CYCLIN_RxL_1	80	89	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.372
DOC_MAPK_gen_1	224	232	PF00069	0.478
DOC_MAPK_MEF2A_6	267	275	PF00069	0.415
DOC_MAPK_MEF2A_6	52	59	PF00069	0.479
DOC_MAPK_MEF2A_6	9	16	PF00069	0.496
DOC_PP1_RVXF_1	166	173	PF00149	0.476
DOC_PP1_SILK_1	453	458	PF00149	0.773
DOC_PP2B_LxvP_1	109	112	PF13499	0.507
DOC_PP2B_LxvP_1	20	23	PF13499	0.522
DOC_PP2B_LxvP_1	273	276	PF13499	0.372
DOC_PP2B_PxIxI_1	54	60	PF00149	0.468
DOC_PP4_FxxP_1	349	352	PF00568	0.733
DOC_PP4_FxxP_1	477	480	PF00568	0.726
DOC_USP7_MATH_1	194	198	PF00917	0.400
DOC_USP7_MATH_1	203	207	PF00917	0.499
DOC_USP7_MATH_1	243	247	PF00917	0.410
DOC_USP7_MATH_1	345	349	PF00917	0.753
DOC_USP7_MATH_1	407	411	PF00917	0.766
DOC_USP7_MATH_1	442	446	PF00917	0.732
DOC_USP7_MATH_1	451	455	PF00917	0.710
DOC_USP7_MATH_1	64	68	PF00917	0.483
DOC_USP7_UBL2_3	300	304	PF12436	0.641
DOC_USP7_UBL2_3	326	330	PF12436	0.606
DOC_WW_Pin1_4	197	202	PF00397	0.439
DOC_WW_Pin1_4	31	36	PF00397	0.459
DOC_WW_Pin1_4	341	346	PF00397	0.693
DOC_WW_Pin1_4	353	358	PF00397	0.696
DOC_WW_Pin1_4	392	397	PF00397	0.681
DOC_WW_Pin1_4	4	9	PF00397	0.504
DOC_WW_Pin1_4	435	440	PF00397	0.757
LIG_14-3-3_CanoR_1	151	157	PF00244	0.495
LIG_14-3-3_CanoR_1	333	341	PF00244	0.696
LIG_14-3-3_CanoR_1	346	350	PF00244	0.838
LIG_14-3-3_CanoR_1	424	429	PF00244	0.740
LIG_14-3-3_CanoR_1	458	465	PF00244	0.726
LIG_14-3-3_CanoR_1	484	488	PF00244	0.777
LIG_BIR_III_2	32	36	PF00653	0.450
LIG_BIR_III_4	218	222	PF00653	0.544
LIG_BRCT_BRCA1_1	122	126	PF00533	0.553
LIG_BRCT_BRCA1_1	426	430	PF00533	0.696
LIG_BRCT_BRCA1_1	469	473	PF00533	0.692
LIG_BRCT_BRCA1_1	66	70	PF00533	0.484
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.423
LIG_EH_1	141	145	PF12763	0.392
LIG_FHA_1	173	179	PF00498	0.476
LIG_FHA_1	212	218	PF00498	0.535
LIG_FHA_1	24	30	PF00498	0.611
LIG_FHA_1	258	264	PF00498	0.418
LIG_FHA_1	300	306	PF00498	0.633
LIG_FHA_1	318	324	PF00498	0.622
LIG_FHA_1	345	351	PF00498	0.673
LIG_FHA_1	51	57	PF00498	0.407
LIG_FHA_2	232	238	PF00498	0.529
LIG_GBD_Chelix_1	283	291	PF00786	0.356
LIG_LIR_Apic_2	347	352	PF02991	0.758
LIG_LIR_Apic_2	476	480	PF02991	0.729
LIG_LIR_Gen_1	114	122	PF02991	0.460
LIG_LIR_Gen_1	141	152	PF02991	0.412
LIG_LIR_Nem_3	123	129	PF02991	0.540
LIG_LIR_Nem_3	141	147	PF02991	0.446
LIG_NRBOX	14	20	PF00104	0.578
LIG_PDZ_Class_2	484	489	PF00595	0.752
LIG_Pex14_1	116	120	PF04695	0.498
LIG_Pex14_2	181	185	PF04695	0.481
LIG_Pex14_2	473	477	PF04695	0.693
LIG_Pex14_2	70	74	PF04695	0.473
LIG_PTB_Apo_2	102	109	PF02174	0.514
LIG_SH2_GRB2like	182	185	PF00017	0.484
LIG_SH2_SRC	235	238	PF00017	0.476
LIG_SH2_STAP1	225	229	PF00017	0.478
LIG_SH2_STAP1	428	432	PF00017	0.696
LIG_SH2_STAT5	182	185	PF00017	0.489
LIG_SH2_STAT5	235	238	PF00017	0.488
LIG_SH2_STAT5	295	298	PF00017	0.473
LIG_SH2_STAT5	37	40	PF00017	0.451
LIG_SH3_3	347	353	PF00018	0.658
LIG_SH3_3	378	384	PF00018	0.705
LIG_SH3_4	300	307	PF00018	0.643
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.492
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.415
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.383
LIG_SUMO_SIM_par_1	213	218	PF11976	0.445
LIG_SUMO_SIM_par_1	26	32	PF11976	0.491
LIG_SUMO_SIM_par_1	275	280	PF11976	0.332
LIG_SUMO_SIM_par_1	53	61	PF11976	0.482
LIG_UBA3_1	119	127	PF00899	0.411
LIG_UBA3_1	292	300	PF00899	0.372
LIG_WRC_WIRS_1	365	370	PF05994	0.664
LIG_WRC_WIRS_1	78	83	PF05994	0.394
MOD_CDK_SPK_2	341	346	PF00069	0.697
MOD_CDK_SPK_2	4	9	PF00069	0.475
MOD_CK1_1	197	203	PF00069	0.468
MOD_CK1_1	337	343	PF00069	0.758
MOD_CK1_1	344	350	PF00069	0.706
MOD_CK1_1	369	375	PF00069	0.732
MOD_CK1_1	395	401	PF00069	0.823
MOD_CK1_1	431	437	PF00069	0.779
MOD_CK1_1	438	444	PF00069	0.730
MOD_CK1_1	459	465	PF00069	0.847
MOD_CK1_1	467	473	PF00069	0.739
MOD_CK2_1	231	237	PF00069	0.473
MOD_CK2_1	86	92	PF00069	0.458
MOD_GlcNHglycan	122	125	PF01048	0.679
MOD_GlcNHglycan	245	248	PF01048	0.688
MOD_GlcNHglycan	279	282	PF01048	0.332
MOD_GlcNHglycan	336	339	PF01048	0.552
MOD_GlcNHglycan	368	371	PF01048	0.524
MOD_GlcNHglycan	419	422	PF01048	0.518
MOD_GlcNHglycan	430	433	PF01048	0.517
MOD_GlcNHglycan	440	443	PF01048	0.577
MOD_GlcNHglycan	444	447	PF01048	0.588
MOD_GlcNHglycan	466	469	PF01048	0.569
MOD_GSK3_1	337	344	PF00069	0.729
MOD_GSK3_1	364	371	PF00069	0.743
MOD_GSK3_1	390	397	PF00069	0.725
MOD_GSK3_1	424	431	PF00069	0.812
MOD_GSK3_1	433	440	PF00069	0.736
MOD_GSK3_1	456	463	PF00069	0.879
MOD_LATS_1	422	428	PF00433	0.757
MOD_N-GLC_1	183	188	PF02516	0.677
MOD_N-GLC_1	194	199	PF02516	0.673
MOD_N-GLC_1	211	216	PF02516	0.736
MOD_N-GLC_1	254	259	PF02516	0.605
MOD_N-GLC_1	415	420	PF02516	0.532
MOD_N-GLC_1	64	69	PF02516	0.703
MOD_N-GLC_1	86	91	PF02516	0.690
MOD_N-GLC_1	95	100	PF02516	0.675
MOD_NEK2_1	120	125	PF00069	0.410
MOD_NEK2_1	14	19	PF00069	0.543
MOD_NEK2_1	185	190	PF00069	0.478
MOD_NEK2_1	254	259	PF00069	0.455
MOD_NEK2_1	368	373	PF00069	0.679
MOD_NEK2_1	430	435	PF00069	0.690
MOD_NEK2_1	456	461	PF00069	0.768
MOD_NEK2_1	86	91	PF00069	0.592
MOD_PIKK_1	395	401	PF00454	0.758
MOD_PKA_1	457	463	PF00069	0.743
MOD_PKA_2	345	351	PF00069	0.827
MOD_PKA_2	407	413	PF00069	0.771
MOD_PKA_2	423	429	PF00069	0.842
MOD_PKA_2	457	463	PF00069	0.886
MOD_PKA_2	483	489	PF00069	0.722
MOD_Plk_1	194	200	PF00069	0.505
MOD_Plk_1	211	217	PF00069	0.532
MOD_Plk_1	269	275	PF00069	0.398
MOD_Plk_1	451	457	PF00069	0.694
MOD_Plk_1	86	92	PF00069	0.492
MOD_Plk_4	115	121	PF00069	0.489
MOD_Plk_4	125	131	PF00069	0.520
MOD_Plk_4	23	29	PF00069	0.563
MOD_Plk_4	231	237	PF00069	0.482
MOD_Plk_4	279	285	PF00069	0.280
MOD_Plk_4	345	351	PF00069	0.714
MOD_Plk_4	407	413	PF00069	0.811
MOD_Plk_4	451	457	PF00069	0.762
MOD_Plk_4	58	64	PF00069	0.465
MOD_Plk_4	66	72	PF00069	0.459
MOD_Plk_4	77	83	PF00069	0.457
MOD_Plk_4	86	92	PF00069	0.524
MOD_ProDKin_1	197	203	PF00069	0.440
MOD_ProDKin_1	31	37	PF00069	0.458
MOD_ProDKin_1	341	347	PF00069	0.694
MOD_ProDKin_1	353	359	PF00069	0.694
MOD_ProDKin_1	392	398	PF00069	0.680
MOD_ProDKin_1	4	10	PF00069	0.497
MOD_ProDKin_1	435	441	PF00069	0.759
MOD_SUMO_for_1	303	306	PF00179	0.744
MOD_SUMO_rev_2	318	328	PF00179	0.581
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.447
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.725
TRG_ENDOCYTIC_2	182	185	PF00928	0.476
TRG_ENDOCYTIC_2	229	232	PF00928	0.574
TRG_ER_diArg_1	227	229	PF00400	0.474
TRG_ER_diArg_1	331	333	PF00400	0.716
TRG_NLS_MonoCore_2	329	334	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W9	Leptomonas seymouri	35%	100%
A0A3Q8I9R5	Leishmania donovani	28%	100%
A0A3S7WSX8	Leishmania donovani	71%	100%
A4HVZ7	Leishmania infantum	28%	100%
A4HVZ8	Leishmania infantum	71%	100%
E9APQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QFS9	Leishmania major	67%	94%