Ion transport protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ion transport protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7L2_LEIBR

TriTrypDb:

LbrM.14.0530 , LBRM2903_140010700

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4H7L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7L2

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005227	calcium activated cation channel activity	6	11
GO:0005261	monoatomic cation channel activity	5	11
GO:0005267	potassium channel activity	6	11
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.355
CLV_NRD_NRD_1	379	381	PF00675	0.414
CLV_NRD_NRD_1	410	412	PF00675	0.359
CLV_NRD_NRD_1	478	480	PF00675	0.467
CLV_NRD_NRD_1	527	529	PF00675	0.401
CLV_PCSK_KEX2_1	409	411	PF00082	0.366
CLV_PCSK_KEX2_1	478	480	PF00082	0.467
CLV_PCSK_KEX2_1	59	61	PF00082	0.489
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.525
CLV_PCSK_SKI1_1	174	178	PF00082	0.257

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A8	Leptomonas seymouri	67%	100%
A0A0S4IWT9	Bodo saltans	35%	100%
A0A1X0NNP7	Trypanosomatidae	44%	100%
A0A3S7WSZ6	Leishmania donovani	80%	100%
A0A422NNK5	Trypanosoma rangeli	42%	100%
A4HVZ6	Leishmania infantum	80%	100%
E9APP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QFT1	Leishmania major	79%	100%
V5BNC5	Trypanosoma cruzi	41%	100%

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