Ion transport protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ion transport protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7L2_LEIBR

TriTrypDb:

LbrM.14.0530 , LBRM2903_140010700

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H7L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7L2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005227	calcium activated cation channel activity	6	11
GO:0005261	monoatomic cation channel activity	5	11
GO:0005267	potassium channel activity	6	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015079	potassium ion transmembrane transporter activity	6	11
GO:0015267	channel activity	4	11
GO:0015269	calcium-activated potassium channel activity	7	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0016286	small conductance calcium-activated potassium channel activity	8	11
GO:0022803	passive transmembrane transporter activity	3	11
GO:0022836	gated channel activity	5	11
GO:0022839	monoatomic ion gated channel activity	6	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0046873	metal ion transmembrane transporter activity	5	11
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.355
CLV_NRD_NRD_1	379	381	PF00675	0.414
CLV_NRD_NRD_1	410	412	PF00675	0.359
CLV_NRD_NRD_1	478	480	PF00675	0.467
CLV_NRD_NRD_1	527	529	PF00675	0.401
CLV_PCSK_KEX2_1	409	411	PF00082	0.366
CLV_PCSK_KEX2_1	478	480	PF00082	0.467
CLV_PCSK_KEX2_1	59	61	PF00082	0.489
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.525
CLV_PCSK_SKI1_1	174	178	PF00082	0.257
CLV_PCSK_SKI1_1	254	258	PF00082	0.295
CLV_PCSK_SKI1_1	469	473	PF00082	0.444
CLV_PCSK_SKI1_1	74	78	PF00082	0.395
CLV_PCSK_SKI1_1	93	97	PF00082	0.387
DEG_APCC_DBOX_1	412	420	PF00400	0.456
DEG_APCC_DBOX_1	519	527	PF00400	0.515
DEG_SPOP_SBC_1	246	250	PF00917	0.535
DOC_CKS1_1	194	199	PF01111	0.324
DOC_CKS1_1	30	35	PF01111	0.609
DOC_MAPK_gen_1	261	270	PF00069	0.477
DOC_MAPK_gen_1	363	372	PF00069	0.614
DOC_MAPK_gen_1	375	384	PF00069	0.566
DOC_MAPK_gen_1	390	398	PF00069	0.575
DOC_MAPK_gen_1	455	464	PF00069	0.635
DOC_MAPK_gen_1	478	486	PF00069	0.645
DOC_MAPK_HePTP_8	258	270	PF00069	0.539
DOC_MAPK_MEF2A_6	217	225	PF00069	0.324
DOC_MAPK_MEF2A_6	261	270	PF00069	0.539
DOC_MAPK_MEF2A_6	457	466	PF00069	0.633
DOC_MAPK_RevD_3	396	411	PF00069	0.435
DOC_PP1_RVXF_1	313	320	PF00149	0.257
DOC_PP2B_LxvP_1	384	387	PF13499	0.585
DOC_USP7_MATH_1	21	25	PF00917	0.680
DOC_USP7_MATH_1	28	32	PF00917	0.670
DOC_USP7_MATH_1	488	492	PF00917	0.697
DOC_USP7_MATH_1	549	553	PF00917	0.584
DOC_USP7_UBL2_3	89	93	PF12436	0.706
DOC_WW_Pin1_4	176	181	PF00397	0.318
DOC_WW_Pin1_4	193	198	PF00397	0.401
DOC_WW_Pin1_4	29	34	PF00397	0.708
DOC_WW_Pin1_4	305	310	PF00397	0.243
DOC_WW_Pin1_4	50	55	PF00397	0.576
LIG_14-3-3_CanoR_1	174	180	PF00244	0.445
LIG_14-3-3_CanoR_1	217	222	PF00244	0.427
LIG_14-3-3_CanoR_1	237	246	PF00244	0.480
LIG_14-3-3_CanoR_1	263	269	PF00244	0.449
LIG_14-3-3_CanoR_1	282	287	PF00244	0.157
LIG_14-3-3_CanoR_1	363	372	PF00244	0.557
LIG_14-3-3_CanoR_1	392	397	PF00244	0.543
LIG_14-3-3_CanoR_1	532	540	PF00244	0.602
LIG_Actin_WH2_2	98	115	PF00022	0.517
LIG_BRCT_BRCA1_1	139	143	PF00533	0.235
LIG_BRCT_BRCA1_1	178	182	PF00533	0.360
LIG_BRCT_BRCA1_1	247	251	PF00533	0.533
LIG_CaM_IQ_9	367	383	PF13499	0.588
LIG_deltaCOP1_diTrp_1	290	296	PF00928	0.243
LIG_EH1_1	183	191	PF00400	0.360
LIG_EH1_1	346	354	PF00400	0.563
LIG_EVH1_2	197	201	PF00568	0.391
LIG_FHA_1	139	145	PF00498	0.373
LIG_FHA_1	165	171	PF00498	0.529
LIG_FHA_1	253	259	PF00498	0.498
LIG_FHA_1	260	266	PF00498	0.423
LIG_FHA_1	393	399	PF00498	0.558
LIG_FHA_1	401	407	PF00498	0.487
LIG_FHA_1	42	48	PF00498	0.682
LIG_FHA_1	426	432	PF00498	0.554
LIG_FHA_1	532	538	PF00498	0.687
LIG_FHA_1	76	82	PF00498	0.583
LIG_FHA_1	94	100	PF00498	0.525
LIG_FHA_2	522	528	PF00498	0.679
LIG_LIR_Gen_1	179	190	PF02991	0.429
LIG_LIR_Gen_1	295	304	PF02991	0.279
LIG_LIR_Gen_1	325	333	PF02991	0.299
LIG_LIR_Gen_1	334	342	PF02991	0.288
LIG_LIR_Gen_1	460	471	PF02991	0.573
LIG_LIR_Gen_1	53	63	PF02991	0.609
LIG_LIR_Nem_3	290	296	PF02991	0.377
LIG_LIR_Nem_3	301	307	PF02991	0.287
LIG_LIR_Nem_3	334	340	PF02991	0.358
LIG_LIR_Nem_3	436	442	PF02991	0.655
LIG_LIR_Nem_3	460	466	PF02991	0.559
LIG_LIR_Nem_3	53	58	PF02991	0.566
LIG_LIR_Nem_3	79	85	PF02991	0.578
LIG_NRBOX	205	211	PF00104	0.260
LIG_PDZ_Class_1	551	556	PF00595	0.659
LIG_Pex14_1	322	326	PF04695	0.321
LIG_PTB_Apo_2	165	172	PF02174	0.533
LIG_PTB_Apo_2	209	216	PF02174	0.324
LIG_PTB_Apo_2	224	231	PF02174	0.345
LIG_PTB_Phospho_1	224	230	PF10480	0.374
LIG_REV1ctd_RIR_1	249	258	PF16727	0.583
LIG_SH2_CRK	219	223	PF00017	0.324
LIG_SH2_CRK	337	341	PF00017	0.488
LIG_SH2_CRK	394	398	PF00017	0.440
LIG_SH2_GRB2like	224	227	PF00017	0.425
LIG_SH2_PTP2	82	85	PF00017	0.607
LIG_SH2_STAP1	219	223	PF00017	0.324
LIG_SH2_STAP1	394	398	PF00017	0.596
LIG_SH2_STAT5	175	178	PF00017	0.499
LIG_SH2_STAT5	224	227	PF00017	0.411
LIG_SH2_STAT5	230	233	PF00017	0.600
LIG_SH2_STAT5	326	329	PF00017	0.349
LIG_SH2_STAT5	394	397	PF00017	0.635
LIG_SH2_STAT5	442	445	PF00017	0.586
LIG_SH2_STAT5	463	466	PF00017	0.604
LIG_SH2_STAT5	82	85	PF00017	0.589
LIG_SH3_3	27	33	PF00018	0.676
LIG_Sin3_3	149	156	PF02671	0.196
LIG_SUMO_SIM_anti_2	482	488	PF11976	0.660
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.533
LIG_SUMO_SIM_par_1	124	130	PF11976	0.402
LIG_SUMO_SIM_par_1	394	399	PF11976	0.585
LIG_TRAF2_1	422	425	PF00917	0.529
LIG_TYR_ITIM	302	307	PF00017	0.284
LIG_UBA3_1	150	155	PF00899	0.324
LIG_WRC_WIRS_1	232	237	PF05994	0.527
MOD_CK1_1	127	133	PF00069	0.412
MOD_CK1_1	164	170	PF00069	0.578
MOD_CK1_1	240	246	PF00069	0.624
MOD_CK1_1	295	301	PF00069	0.290
MOD_CK1_1	31	37	PF00069	0.645
MOD_CK1_1	310	316	PF00069	0.237
MOD_CK1_1	474	480	PF00069	0.619
MOD_CK1_1	7	13	PF00069	0.780
MOD_CK2_1	21	27	PF00069	0.803
MOD_CK2_1	419	425	PF00069	0.627
MOD_CK2_1	521	527	PF00069	0.611
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.627
MOD_GlcNHglycan	133	136	PF01048	0.604
MOD_GlcNHglycan	163	166	PF01048	0.361
MOD_GlcNHglycan	239	242	PF01048	0.375
MOD_GlcNHglycan	24	27	PF01048	0.471
MOD_GlcNHglycan	312	315	PF01048	0.500
MOD_GlcNHglycan	365	368	PF01048	0.309
MOD_GlcNHglycan	540	543	PF01048	0.474
MOD_GSK3_1	127	134	PF00069	0.426
MOD_GSK3_1	3	10	PF00069	0.640
MOD_GSK3_1	331	338	PF00069	0.214
MOD_GSK3_1	392	399	PF00069	0.559
MOD_GSK3_1	415	422	PF00069	0.656
MOD_GSK3_1	425	432	PF00069	0.649
MOD_GSK3_1	50	57	PF00069	0.616
MOD_GSK3_1	501	508	PF00069	0.698
MOD_GSK3_1	543	550	PF00069	0.669
MOD_N-GLC_1	138	143	PF02516	0.360
MOD_NEK2_1	124	129	PF00069	0.315
MOD_NEK2_1	137	142	PF00069	0.318
MOD_NEK2_1	143	148	PF00069	0.329
MOD_NEK2_1	247	252	PF00069	0.518
MOD_NEK2_1	292	297	PF00069	0.278
MOD_NEK2_1	331	336	PF00069	0.346
MOD_NEK2_1	358	363	PF00069	0.600
MOD_NEK2_1	396	401	PF00069	0.536
MOD_NEK2_1	423	428	PF00069	0.629
MOD_NEK2_1	443	448	PF00069	0.432
MOD_NEK2_1	472	477	PF00069	0.690
MOD_NEK2_1	551	556	PF00069	0.714
MOD_NEK2_1	68	73	PF00069	0.579
MOD_NEK2_2	54	59	PF00069	0.568
MOD_PIKK_1	521	527	PF00454	0.620
MOD_PK_1	217	223	PF00069	0.412
MOD_PKA_1	409	415	PF00069	0.537
MOD_PKA_2	28	34	PF00069	0.767
MOD_PKA_2	4	10	PF00069	0.654
MOD_PKA_2	409	415	PF00069	0.575
MOD_PKA_2	531	537	PF00069	0.589
MOD_Plk_1	138	144	PF00069	0.287
MOD_Plk_4	124	130	PF00069	0.331
MOD_Plk_4	138	144	PF00069	0.273
MOD_Plk_4	217	223	PF00069	0.383
MOD_Plk_4	247	253	PF00069	0.558
MOD_Plk_4	264	270	PF00069	0.229
MOD_Plk_4	322	328	PF00069	0.378
MOD_Plk_4	335	341	PF00069	0.370
MOD_Plk_4	392	398	PF00069	0.546
MOD_Plk_4	402	408	PF00069	0.540
MOD_Plk_4	415	421	PF00069	0.654
MOD_Plk_4	42	48	PF00069	0.628
MOD_Plk_4	480	486	PF00069	0.636
MOD_ProDKin_1	176	182	PF00069	0.318
MOD_ProDKin_1	193	199	PF00069	0.412
MOD_ProDKin_1	29	35	PF00069	0.709
MOD_ProDKin_1	305	311	PF00069	0.243
MOD_ProDKin_1	50	56	PF00069	0.575
MOD_SUMO_rev_2	422	428	PF00179	0.487
TRG_DiLeu_BaEn_1	354	359	PF01217	0.434
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.619
TRG_ENDOCYTIC_2	219	222	PF00928	0.328
TRG_ENDOCYTIC_2	232	235	PF00928	0.634
TRG_ENDOCYTIC_2	304	307	PF00928	0.284
TRG_ENDOCYTIC_2	326	329	PF00928	0.299
TRG_ENDOCYTIC_2	337	340	PF00928	0.423
TRG_ENDOCYTIC_2	394	397	PF00928	0.448
TRG_ENDOCYTIC_2	442	445	PF00928	0.590
TRG_ENDOCYTIC_2	463	466	PF00928	0.604
TRG_ENDOCYTIC_2	82	85	PF00928	0.578
TRG_ER_diArg_1	362	365	PF00400	0.589
TRG_ER_diArg_1	409	411	PF00400	0.554
TRG_NLS_MonoExtN_4	378	384	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A8	Leptomonas seymouri	67%	100%
A0A0S4IWT9	Bodo saltans	35%	100%
A0A1X0NNP7	Trypanosomatidae	44%	100%
A0A3S7WSZ6	Leishmania donovani	80%	100%
A0A422NNK5	Trypanosoma rangeli	42%	100%
A4HVZ6	Leishmania infantum	80%	100%
E9APP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QFT1	Leishmania major	79%	100%
V5BNC5	Trypanosoma cruzi	41%	100%