Ion_trans_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ion channel, putative

Species:

Leishmania braziliensis

UniProt:

A4H7L1_LEIBR

TriTrypDb:

LbrM.14.0520 , LBRM2903_140010600

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H7L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7L1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0005216	monoatomic ion channel activity	4	13
GO:0005227	calcium activated cation channel activity	6	13
GO:0005261	monoatomic cation channel activity	5	13
GO:0005267	potassium channel activity	6	13
GO:0008324	monoatomic cation transmembrane transporter activity	4	13
GO:0015075	monoatomic ion transmembrane transporter activity	3	13
GO:0015079	potassium ion transmembrane transporter activity	6	13
GO:0015267	channel activity	4	13
GO:0015269	calcium-activated potassium channel activity	7	13
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	13
GO:0016286	small conductance calcium-activated potassium channel activity	8	13
GO:0022803	passive transmembrane transporter activity	3	13
GO:0022836	gated channel activity	5	13
GO:0022839	monoatomic ion gated channel activity	6	13
GO:0022857	transmembrane transporter activity	2	13
GO:0022890	inorganic cation transmembrane transporter activity	4	13
GO:0046873	metal ion transmembrane transporter activity	5	13
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.304
CLV_NRD_NRD_1	340	342	PF00675	0.330
CLV_NRD_NRD_1	399	401	PF00675	0.490
CLV_NRD_NRD_1	485	487	PF00675	0.377
CLV_PCSK_FUR_1	314	318	PF00082	0.355
CLV_PCSK_KEX2_1	168	170	PF00082	0.401
CLV_PCSK_KEX2_1	313	315	PF00082	0.327
CLV_PCSK_KEX2_1	316	318	PF00082	0.363
CLV_PCSK_KEX2_1	340	342	PF00082	0.303
CLV_PCSK_KEX2_1	399	401	PF00082	0.507
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.401
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.371
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.404
CLV_PCSK_SKI1_1	406	410	PF00082	0.540
CLV_PCSK_SKI1_1	448	452	PF00082	0.586
DEG_MDM2_SWIB_1	202	209	PF02201	0.388
DEG_Nend_UBRbox_2	1	3	PF02207	0.604
DEG_SCF_FBW7_1	370	377	PF00400	0.715
DEG_SPOP_SBC_1	393	397	PF00917	0.698
DEG_SPOP_SBC_1	462	466	PF00917	0.566
DOC_CYCLIN_yCln2_LP_2	274	280	PF00134	0.444
DOC_MAPK_gen_1	313	324	PF00069	0.544
DOC_MAPK_MEF2A_6	117	126	PF00069	0.455
DOC_MAPK_MEF2A_6	316	324	PF00069	0.621
DOC_MAPK_NFAT4_5	317	325	PF00069	0.447
DOC_PP4_MxPP_1	128	131	PF00568	0.394
DOC_USP7_MATH_1	103	107	PF00917	0.634
DOC_USP7_MATH_1	170	174	PF00917	0.626
DOC_USP7_MATH_1	20	24	PF00917	0.510
DOC_USP7_MATH_1	413	417	PF00917	0.688
DOC_USP7_MATH_1	437	441	PF00917	0.736
DOC_USP7_MATH_1	461	465	PF00917	0.727
DOC_WW_Pin1_4	109	114	PF00397	0.501
DOC_WW_Pin1_4	21	26	PF00397	0.573
DOC_WW_Pin1_4	273	278	PF00397	0.548
DOC_WW_Pin1_4	370	375	PF00397	0.663
DOC_WW_Pin1_4	384	389	PF00397	0.677
DOC_WW_Pin1_4	409	414	PF00397	0.667
DOC_WW_Pin1_4	430	435	PF00397	0.653
DOC_WW_Pin1_4	457	462	PF00397	0.706
DOC_WW_Pin1_4	98	103	PF00397	0.560
LIG_14-3-3_CanoR_1	160	167	PF00244	0.549
LIG_14-3-3_CanoR_1	169	175	PF00244	0.494
LIG_14-3-3_CanoR_1	248	255	PF00244	0.296
LIG_14-3-3_CanoR_1	29	34	PF00244	0.615
LIG_14-3-3_CanoR_1	317	323	PF00244	0.502
LIG_14-3-3_CanoR_1	335	340	PF00244	0.518
LIG_14-3-3_CanoR_1	352	358	PF00244	0.612
LIG_14-3-3_CanoR_1	366	371	PF00244	0.652
LIG_14-3-3_CanoR_1	399	405	PF00244	0.699
LIG_14-3-3_CanoR_1	448	456	PF00244	0.691
LIG_14-3-3_CanoR_1	457	461	PF00244	0.669
LIG_14-3-3_CanoR_1	494	503	PF00244	0.725
LIG_Actin_WH2_2	357	373	PF00022	0.623
LIG_Actin_WH2_2	444	459	PF00022	0.592
LIG_APCC_ABBA_1	402	407	PF00400	0.702
LIG_BRCT_BRCA1_1	320	324	PF00533	0.545
LIG_CaM_IQ_9	300	316	PF13499	0.519
LIG_Clathr_ClatBox_1	30	34	PF01394	0.624
LIG_CtBP_PxDLS_1	444	448	PF00389	0.589
LIG_FHA_1	161	167	PF00498	0.603
LIG_FHA_1	248	254	PF00498	0.284
LIG_FHA_1	25	31	PF00498	0.547
LIG_FHA_1	286	292	PF00498	0.620
LIG_FHA_1	375	381	PF00498	0.602
LIG_FHA_1	498	504	PF00498	0.750
LIG_FHA_2	354	360	PF00498	0.618
LIG_FHA_2	464	470	PF00498	0.596
LIG_FHA_2	473	479	PF00498	0.528
LIG_LIR_Gen_1	136	146	PF02991	0.375
LIG_LIR_Gen_1	151	158	PF02991	0.268
LIG_LIR_Gen_1	321	329	PF02991	0.529
LIG_LIR_Gen_1	401	410	PF02991	0.709
LIG_LIR_Nem_3	136	142	PF02991	0.363
LIG_LIR_Nem_3	144	149	PF02991	0.286
LIG_LIR_Nem_3	151	157	PF02991	0.234
LIG_LIR_Nem_3	223	229	PF02991	0.253
LIG_LIR_Nem_3	231	237	PF02991	0.262
LIG_LIR_Nem_3	321	327	PF02991	0.648
LIG_LIR_Nem_3	401	405	PF02991	0.706
LIG_LIR_Nem_3	94	99	PF02991	0.518
LIG_MYND_3	442	446	PF01753	0.686
LIG_OCRL_FandH_1	178	190	PF00620	0.461
LIG_Pex14_1	245	249	PF04695	0.304
LIG_Pex14_2	202	206	PF04695	0.448
LIG_SH2_PTP2	152	155	PF00017	0.310
LIG_SH2_SRC	152	155	PF00017	0.342
LIG_SH2_SRC	221	224	PF00017	0.361
LIG_SH2_STAP1	237	241	PF00017	0.327
LIG_SH2_STAT5	114	117	PF00017	0.388
LIG_SH2_STAT5	152	155	PF00017	0.284
LIG_SH2_STAT5	157	160	PF00017	0.356
LIG_SH2_STAT5	188	191	PF00017	0.489
LIG_SH2_STAT5	226	229	PF00017	0.253
LIG_SH2_STAT5	310	313	PF00017	0.555
LIG_SH2_STAT5	355	358	PF00017	0.619
LIG_SH3_3	96	102	PF00018	0.584
LIG_SUMO_SIM_par_1	271	276	PF11976	0.549
LIG_SUMO_SIM_par_1	29	34	PF11976	0.629
LIG_SUMO_SIM_par_1	74	79	PF11976	0.294
LIG_TYR_ITIM	235	240	PF00017	0.248
LIG_WRC_WIRS_1	143	148	PF05994	0.327
MOD_CDK_SPK_2	389	394	PF00069	0.698
MOD_CK1_1	101	107	PF00069	0.617
MOD_CK1_1	135	141	PF00069	0.253
MOD_CK1_1	162	168	PF00069	0.607
MOD_CK1_1	24	30	PF00069	0.529
MOD_CK1_1	365	371	PF00069	0.639
MOD_CK1_1	435	441	PF00069	0.707
MOD_CK1_1	465	471	PF00069	0.700
MOD_CK2_1	211	217	PF00069	0.251
MOD_CK2_1	273	279	PF00069	0.551
MOD_CK2_1	495	501	PF00069	0.704
MOD_Cter_Amidation	397	400	PF01082	0.465
MOD_GlcNHglycan	380	383	PF01048	0.534
MOD_GSK3_1	109	116	PF00069	0.394
MOD_GSK3_1	144	151	PF00069	0.426
MOD_GSK3_1	156	163	PF00069	0.501
MOD_GSK3_1	20	27	PF00069	0.637
MOD_GSK3_1	207	214	PF00069	0.304
MOD_GSK3_1	281	288	PF00069	0.562
MOD_GSK3_1	353	360	PF00069	0.601
MOD_GSK3_1	362	369	PF00069	0.654
MOD_GSK3_1	370	377	PF00069	0.661
MOD_GSK3_1	380	387	PF00069	0.610
MOD_GSK3_1	389	396	PF00069	0.604
MOD_GSK3_1	409	416	PF00069	0.688
MOD_GSK3_1	457	464	PF00069	0.737
MOD_GSK3_1	465	472	PF00069	0.637
MOD_GSK3_1	497	504	PF00069	0.665
MOD_GSK3_1	97	104	PF00069	0.582
MOD_NEK2_1	156	161	PF00069	0.437
MOD_NEK2_1	207	212	PF00069	0.304
MOD_NEK2_1	227	232	PF00069	0.187
MOD_NEK2_1	285	290	PF00069	0.539
MOD_NEK2_1	327	332	PF00069	0.498
MOD_NEK2_1	357	362	PF00069	0.596
MOD_NEK2_1	380	385	PF00069	0.722
MOD_NEK2_1	456	461	PF00069	0.783
MOD_NEK2_1	477	482	PF00069	0.605
MOD_NEK2_1	76	81	PF00069	0.297
MOD_NEK2_2	55	60	PF00069	0.340
MOD_PIKK_1	160	166	PF00454	0.572
MOD_PIKK_1	24	30	PF00454	0.688
MOD_PKA_2	159	165	PF00069	0.599
MOD_PKA_2	247	253	PF00069	0.338
MOD_PKA_2	351	357	PF00069	0.584
MOD_PKA_2	365	371	PF00069	0.632
MOD_PKA_2	398	404	PF00069	0.770
MOD_PKA_2	456	462	PF00069	0.673
MOD_PKA_2	472	478	PF00069	0.495
MOD_Plk_1	217	223	PF00069	0.338
MOD_Plk_1	346	352	PF00069	0.485
MOD_Plk_1	357	363	PF00069	0.501
MOD_Plk_1	477	483	PF00069	0.653
MOD_Plk_2-3	217	223	PF00069	0.279
MOD_Plk_4	162	168	PF00069	0.537
MOD_Plk_4	207	213	PF00069	0.242
MOD_Plk_4	240	246	PF00069	0.287
MOD_Plk_4	281	287	PF00069	0.501
MOD_Plk_4	346	352	PF00069	0.531
MOD_Plk_4	479	485	PF00069	0.665
MOD_ProDKin_1	109	115	PF00069	0.418
MOD_ProDKin_1	21	27	PF00069	0.566
MOD_ProDKin_1	273	279	PF00069	0.547
MOD_ProDKin_1	370	376	PF00069	0.664
MOD_ProDKin_1	384	390	PF00069	0.679
MOD_ProDKin_1	409	415	PF00069	0.668
MOD_ProDKin_1	430	436	PF00069	0.654
MOD_ProDKin_1	457	463	PF00069	0.706
MOD_ProDKin_1	98	104	PF00069	0.561
MOD_SUMO_for_1	312	315	PF00179	0.535
MOD_SUMO_rev_2	401	410	PF00179	0.673
TRG_DiLeu_BaEn_2	445	451	PF01217	0.590
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.490
TRG_ENDOCYTIC_2	152	155	PF00928	0.271
TRG_ENDOCYTIC_2	188	191	PF00928	0.453
TRG_ENDOCYTIC_2	226	229	PF00928	0.224
TRG_ENDOCYTIC_2	237	240	PF00928	0.248
TRG_ER_diArg_1	3	6	PF00400	0.523
TRG_ER_diArg_1	339	341	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	337	342	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W7	Leptomonas seymouri	61%	98%
A0A0S4IWT9	Bodo saltans	30%	95%
A0A0S4IZM8	Bodo saltans	34%	100%
A0A1X0NNP7	Trypanosomatidae	29%	94%
A0A1X0NP80	Trypanosomatidae	36%	100%
A0A3Q8I9U0	Leishmania donovani	76%	100%
A0A422NNJ1	Trypanosoma rangeli	36%	100%
A4HVZ5	Leishmania infantum	76%	100%
E9APP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QFT2	Leishmania major	76%	100%
V5BNC5	Trypanosoma cruzi	28%	98%