UDPGT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-glucoronosyl and UDP-glucosyl transferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7K7_LEIBR

TriTrypDb:

LbrM.14.0480 , LBRM2903_140010000

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 2
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H7K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7K7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008194	UDP-glycosyltransferase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016757	glycosyltransferase activity	3	9
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	228	230	PF00675	0.576
CLV_NRD_NRD_1	349	351	PF00675	0.512
CLV_NRD_NRD_1	403	405	PF00675	0.495
CLV_NRD_NRD_1	581	583	PF00675	0.377
CLV_NRD_NRD_1	585	587	PF00675	0.397
CLV_NRD_NRD_1	608	610	PF00675	0.470
CLV_PCSK_KEX2_1	349	351	PF00082	0.497
CLV_PCSK_KEX2_1	402	404	PF00082	0.479
CLV_PCSK_KEX2_1	581	583	PF00082	0.377
CLV_PCSK_KEX2_1	585	587	PF00082	0.395
CLV_PCSK_KEX2_1	607	609	PF00082	0.446
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.493
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.481
CLV_PCSK_PC7_1	345	351	PF00082	0.512
CLV_PCSK_PC7_1	581	587	PF00082	0.403
CLV_PCSK_SKI1_1	159	163	PF00082	0.531
CLV_PCSK_SKI1_1	262	266	PF00082	0.513
CLV_PCSK_SKI1_1	486	490	PF00082	0.477
DEG_Nend_UBRbox_1	1	4	PF02207	0.677
DEG_SCF_FBW7_2	478	484	PF00400	0.340
DOC_CKS1_1	478	483	PF01111	0.340
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.440
DOC_MAPK_DCC_7	229	238	PF00069	0.326
DOC_MAPK_gen_1	229	235	PF00069	0.385
DOC_MAPK_gen_1	292	301	PF00069	0.340
DOC_MAPK_gen_1	349	357	PF00069	0.312
DOC_MAPK_gen_1	6	15	PF00069	0.513
DOC_MAPK_MEF2A_6	229	238	PF00069	0.309
DOC_MAPK_MEF2A_6	349	357	PF00069	0.312
DOC_MAPK_MEF2A_6	9	17	PF00069	0.529
DOC_MAPK_NFAT4_5	350	358	PF00069	0.340
DOC_PP2B_LxvP_1	13	16	PF13499	0.440
DOC_PP2B_LxvP_1	17	20	PF13499	0.265
DOC_PP2B_LxvP_1	323	326	PF13499	0.298
DOC_PP2B_PxIxI_1	233	239	PF00149	0.312
DOC_SPAK_OSR1_1	416	420	PF12202	0.290
DOC_USP7_MATH_1	130	134	PF00917	0.471
DOC_USP7_MATH_1	169	173	PF00917	0.362
DOC_USP7_MATH_1	612	616	PF00917	0.734
DOC_WW_Pin1_4	477	482	PF00397	0.306
DOC_WW_Pin1_4	585	590	PF00397	0.630
LIG_14-3-3_CanoR_1	100	105	PF00244	0.332
LIG_14-3-3_CanoR_1	119	127	PF00244	0.439
LIG_14-3-3_CanoR_1	262	267	PF00244	0.284
LIG_14-3-3_CanoR_1	403	413	PF00244	0.285
LIG_14-3-3_CanoR_1	416	424	PF00244	0.128
LIG_14-3-3_CanoR_1	542	547	PF00244	0.448
LIG_14-3-3_CanoR_1	608	614	PF00244	0.713
LIG_Actin_WH2_2	567	583	PF00022	0.404
LIG_APCC_ABBA_1	460	465	PF00400	0.290
LIG_CtBP_PxDLS_1	354	358	PF00389	0.340
LIG_FHA_1	103	109	PF00498	0.285
LIG_FHA_1	122	128	PF00498	0.461
LIG_FHA_1	207	213	PF00498	0.372
LIG_FHA_1	240	246	PF00498	0.227
LIG_FHA_1	373	379	PF00498	0.289
LIG_FHA_1	418	424	PF00498	0.283
LIG_FHA_1	46	52	PF00498	0.526
LIG_FHA_1	543	549	PF00498	0.437
LIG_FHA_2	155	161	PF00498	0.364
LIG_FHA_2	24	30	PF00498	0.668
LIG_FHA_2	542	548	PF00498	0.417
LIG_FHA_2	90	96	PF00498	0.363
LIG_LIR_Apic_2	136	140	PF02991	0.499
LIG_LIR_Apic_2	26	31	PF02991	0.510
LIG_LIR_Gen_1	164	175	PF02991	0.319
LIG_LIR_Gen_1	180	189	PF02991	0.239
LIG_LIR_Gen_1	197	206	PF02991	0.319
LIG_LIR_Gen_1	559	568	PF02991	0.321
LIG_LIR_Gen_1	591	601	PF02991	0.671
LIG_LIR_LC3C_4	566	571	PF02991	0.440
LIG_LIR_Nem_3	157	161	PF02991	0.341
LIG_LIR_Nem_3	164	170	PF02991	0.321
LIG_LIR_Nem_3	180	184	PF02991	0.196
LIG_LIR_Nem_3	197	202	PF02991	0.319
LIG_LIR_Nem_3	559	563	PF02991	0.316
LIG_LIR_Nem_3	591	597	PF02991	0.668
LIG_PCNA_yPIPBox_3	229	239	PF02747	0.340
LIG_Pex14_2	181	185	PF04695	0.313
LIG_Pex14_2	87	91	PF04695	0.359
LIG_PTAP_UEV_1	58	63	PF05743	0.502
LIG_PTB_Apo_2	269	276	PF02174	0.312
LIG_SH2_CRK	137	141	PF00017	0.488
LIG_SH2_CRK	312	316	PF00017	0.269
LIG_SH2_CRK	521	525	PF00017	0.355
LIG_SH2_CRK	560	564	PF00017	0.419
LIG_SH2_GRB2like	370	373	PF00017	0.233
LIG_SH2_NCK_1	306	310	PF00017	0.303
LIG_SH2_PTP2	199	202	PF00017	0.372
LIG_SH2_STAP1	306	310	PF00017	0.259
LIG_SH2_STAP1	560	564	PF00017	0.419
LIG_SH2_STAT3	348	351	PF00017	0.340
LIG_SH2_STAT5	199	202	PF00017	0.276
LIG_SH2_STAT5	222	225	PF00017	0.364
LIG_SH2_STAT5	418	421	PF00017	0.273
LIG_SH2_STAT5	578	581	PF00017	0.465
LIG_SH3_3	105	111	PF00018	0.302
LIG_SH3_3	325	331	PF00018	0.255
LIG_SH3_3	407	413	PF00018	0.313
LIG_SH3_3	455	461	PF00018	0.256
LIG_SH3_3	48	54	PF00018	0.521
LIG_SH3_3	56	62	PF00018	0.462
LIG_SH3_3	617	623	PF00018	0.725
LIG_SUMO_SIM_anti_2	425	431	PF11976	0.312
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.415
LIG_SUMO_SIM_par_1	20	26	PF11976	0.406
LIG_SUMO_SIM_par_1	544	551	PF11976	0.440
LIG_TRAF2_1	39	42	PF00917	0.551
LIG_TYR_ITIM	558	563	PF00017	0.334
LIG_UBA3_1	184	190	PF00899	0.381
LIG_WRC_WIRS_1	178	183	PF05994	0.345
MOD_CK1_1	121	127	PF00069	0.443
MOD_CK1_1	133	139	PF00069	0.448
MOD_CK1_1	282	288	PF00069	0.299
MOD_CK1_1	43	49	PF00069	0.523
MOD_CK1_1	588	594	PF00069	0.665
MOD_CK1_1	60	66	PF00069	0.417
MOD_CK1_1	600	606	PF00069	0.540
MOD_CK2_1	154	160	PF00069	0.352
MOD_CK2_1	23	29	PF00069	0.663
MOD_CK2_1	443	449	PF00069	0.223
MOD_CK2_1	541	547	PF00069	0.421
MOD_CK2_1	89	95	PF00069	0.306
MOD_Cter_Amidation	227	230	PF01082	0.569
MOD_Cter_Amidation	605	608	PF01082	0.510
MOD_GlcNHglycan	132	135	PF01048	0.663
MOD_GlcNHglycan	281	284	PF01048	0.482
MOD_GlcNHglycan	45	48	PF01048	0.732
MOD_GlcNHglycan	552	555	PF01048	0.592
MOD_GlcNHglycan	565	568	PF01048	0.371
MOD_GlcNHglycan	59	62	PF01048	0.615
MOD_GlcNHglycan	590	593	PF01048	0.449
MOD_GlcNHglycan	602	605	PF01048	0.438
MOD_GSK3_1	129	136	PF00069	0.479
MOD_GSK3_1	169	176	PF00069	0.367
MOD_GSK3_1	206	213	PF00069	0.318
MOD_GSK3_1	239	246	PF00069	0.286
MOD_GSK3_1	41	48	PF00069	0.519
MOD_GSK3_1	418	425	PF00069	0.277
MOD_GSK3_1	443	450	PF00069	0.318
MOD_GSK3_1	482	489	PF00069	0.293
MOD_GSK3_1	588	595	PF00069	0.627
MOD_N-GLC_1	130	135	PF02516	0.627
MOD_N-GLC_1	542	547	PF02516	0.598
MOD_NEK2_1	118	123	PF00069	0.410
MOD_NEK2_1	129	134	PF00069	0.413
MOD_NEK2_1	417	422	PF00069	0.273
MOD_NEK2_1	437	442	PF00069	0.090
MOD_NEK2_1	597	602	PF00069	0.663
MOD_PIKK_1	118	124	PF00454	0.459
MOD_PIKK_1	30	36	PF00454	0.527
MOD_PIKK_1	362	368	PF00454	0.340
MOD_PKA_1	402	408	PF00069	0.312
MOD_PKA_1	607	613	PF00069	0.728
MOD_PKA_2	118	124	PF00069	0.408
MOD_PKA_2	302	308	PF00069	0.328
MOD_PKA_2	402	408	PF00069	0.286
MOD_PKA_2	5	11	PF00069	0.697
MOD_PKA_2	541	547	PF00069	0.421
MOD_PKA_2	607	613	PF00069	0.690
MOD_Plk_1	163	169	PF00069	0.381
MOD_Plk_1	40	46	PF00069	0.547
MOD_Plk_1	443	449	PF00069	0.223
MOD_Plk_1	542	548	PF00069	0.395
MOD_Plk_4	113	119	PF00069	0.359
MOD_Plk_4	174	180	PF00069	0.342
MOD_Plk_4	211	217	PF00069	0.261
MOD_Plk_4	218	224	PF00069	0.244
MOD_Plk_4	282	288	PF00069	0.311
MOD_Plk_4	418	424	PF00069	0.294
MOD_Plk_4	443	449	PF00069	0.271
MOD_Plk_4	60	66	PF00069	0.462
MOD_ProDKin_1	477	483	PF00069	0.306
MOD_ProDKin_1	585	591	PF00069	0.633
MOD_SUMO_rev_2	483	488	PF00179	0.324
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.440
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.335
TRG_ENDOCYTIC_2	158	161	PF00928	0.337
TRG_ENDOCYTIC_2	199	202	PF00928	0.344
TRG_ENDOCYTIC_2	312	315	PF00928	0.244
TRG_ENDOCYTIC_2	560	563	PF00928	0.412
TRG_ENDOCYTIC_2	627	630	PF00928	0.719
TRG_ER_diArg_1	266	269	PF00400	0.317
TRG_ER_diArg_1	348	350	PF00400	0.312
TRG_ER_diArg_1	580	582	PF00400	0.571
TRG_ER_diArg_1	585	587	PF00400	0.584
TRG_NES_CRM1_1	173	186	PF08389	0.399
TRG_NLS_MonoExtN_4	605	611	PF00514	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW1	Leptomonas seymouri	54%	100%
A0A0S4KJ23	Bodo saltans	34%	100%
A0A0S4KJI1	Bodo saltans	30%	100%
A0A1X0NQB7	Trypanosomatidae	36%	100%
A0A1X0P5U1	Trypanosomatidae	26%	100%
A0A291PQG3	Dactylopius coccus	24%	100%
A0A3S5IRM5	Trypanosoma rangeli	26%	100%
A0A422MYQ6	Trypanosoma rangeli	36%	100%
O60656	Homo sapiens	26%	100%
Q28611	Oryctolagus cuniculus	22%	100%
Q9HAW8	Homo sapiens	25%	100%
V5BMC3	Trypanosoma cruzi	33%	100%