LeishMANIAdb
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Cystathionine beta-lyase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cystathionine beta-lyase-like protein
Gene product:
cystathionine beta-lyase-like protein
Species:
Leishmania braziliensis
UniProt:
A4H7K6_LEIBR
TriTrypDb:
LbrM.14.0470 , LBRM2903_140009900
Length:
514

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H7K6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7K6

Function

Biological processes
Term Name Level Count
GO:0000096 sulfur amino acid metabolic process 4 8
GO:0000097 sulfur amino acid biosynthetic process 5 8
GO:0006082 organic acid metabolic process 3 8
GO:0006520 amino acid metabolic process 3 8
GO:0006534 cysteine metabolic process 5 8
GO:0006555 methionine metabolic process 5 8
GO:0006790 sulfur compound metabolic process 3 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0008652 amino acid biosynthetic process 4 8
GO:0009058 biosynthetic process 2 8
GO:0009066 aspartate family amino acid metabolic process 5 8
GO:0009067 aspartate family amino acid biosynthetic process 6 8
GO:0009069 serine family amino acid metabolic process 5 8
GO:0009086 methionine biosynthetic process 6 8
GO:0009092 homoserine metabolic process 6 8
GO:0009987 cellular process 1 8
GO:0016053 organic acid biosynthetic process 4 8
GO:0019346 transsulfuration 6 8
GO:0019752 carboxylic acid metabolic process 5 8
GO:0043436 oxoacid metabolic process 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044249 cellular biosynthetic process 3 8
GO:0044272 sulfur compound biosynthetic process 4 8
GO:0044281 small molecule metabolic process 2 8
GO:0044283 small molecule biosynthetic process 3 8
GO:0046394 carboxylic acid biosynthetic process 5 8
GO:0050667 homocysteine metabolic process 5 8
GO:0071265 L-methionine biosynthetic process 7 8
GO:0071266 'de novo' L-methionine biosynthetic process 8 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
GO:1901566 organonitrogen compound biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 8
GO:1901605 alpha-amino acid metabolic process 4 8
GO:1901607 alpha-amino acid biosynthetic process 5 8
GO:0009070 serine family amino acid biosynthetic process 6 1
GO:0019343 cysteine biosynthetic process via cystathionine 7 1
GO:0019344 cysteine biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004121 cystathionine beta-lyase activity 4 8
GO:0005488 binding 1 8
GO:0016829 lyase activity 2 8
GO:0016846 carbon-sulfur lyase activity 3 8
GO:0019842 vitamin binding 3 8
GO:0030170 pyridoxal phosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0070279 vitamin B6 binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8
GO:0004123 cystathionine gamma-lyase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 242 244 PF00675 0.321
CLV_NRD_NRD_1 30 32 PF00675 0.650
CLV_PCSK_KEX2_1 107 109 PF00082 0.628
CLV_PCSK_KEX2_1 433 435 PF00082 0.351
CLV_PCSK_PC1ET2_1 107 109 PF00082 0.628
CLV_PCSK_PC1ET2_1 433 435 PF00082 0.351
CLV_PCSK_SKI1_1 218 222 PF00082 0.351
CLV_PCSK_SKI1_1 230 234 PF00082 0.351
CLV_PCSK_SKI1_1 243 247 PF00082 0.399
CLV_PCSK_SKI1_1 443 447 PF00082 0.358
CLV_PCSK_SKI1_1 69 73 PF00082 0.630
DEG_APCC_DBOX_1 47 55 PF00400 0.429
DEG_APCC_DBOX_1 68 76 PF00400 0.623
DEG_SPOP_SBC_1 7 11 PF00917 0.533
DOC_AGCK_PIF_2 154 159 PF00069 0.351
DOC_MAPK_gen_1 357 366 PF00069 0.351
DOC_MAPK_gen_1 382 390 PF00069 0.224
DOC_MAPK_gen_1 440 449 PF00069 0.367
DOC_MAPK_HePTP_8 354 366 PF00069 0.351
DOC_MAPK_MEF2A_6 357 366 PF00069 0.351
DOC_MAPK_MEF2A_6 382 390 PF00069 0.224
DOC_MAPK_MEF2A_6 443 451 PF00069 0.351
DOC_PP1_RVXF_1 228 234 PF00149 0.224
DOC_PP1_RVXF_1 332 339 PF00149 0.351
DOC_PP4_FxxP_1 146 149 PF00568 0.351
DOC_USP7_MATH_1 185 189 PF00917 0.351
DOC_USP7_MATH_1 63 67 PF00917 0.516
DOC_WW_Pin1_4 256 261 PF00397 0.351
DOC_WW_Pin1_4 289 294 PF00397 0.351
DOC_WW_Pin1_4 8 13 PF00397 0.669
LIG_14-3-3_CanoR_1 218 227 PF00244 0.351
LIG_14-3-3_CanoR_1 31 37 PF00244 0.611
LIG_14-3-3_CanoR_1 357 363 PF00244 0.351
LIG_14-3-3_CanoR_1 415 424 PF00244 0.405
LIG_14-3-3_CanoR_1 482 486 PF00244 0.405
LIG_Actin_WH2_2 186 203 PF00022 0.330
LIG_Actin_WH2_2 279 297 PF00022 0.477
LIG_BRCT_BRCA1_1 434 438 PF00533 0.351
LIG_BRCT_BRCA1_1 89 93 PF00533 0.646
LIG_BRCT_BRCA1_2 89 95 PF00533 0.646
LIG_Clathr_ClatBox_1 254 258 PF01394 0.351
LIG_FHA_1 118 124 PF00498 0.454
LIG_FHA_1 222 228 PF00498 0.363
LIG_FHA_1 237 243 PF00498 0.356
LIG_FHA_1 259 265 PF00498 0.351
LIG_FHA_1 309 315 PF00498 0.351
LIG_FHA_1 359 365 PF00498 0.351
LIG_FHA_1 427 433 PF00498 0.405
LIG_FHA_1 496 502 PF00498 0.405
LIG_FHA_2 166 172 PF00498 0.326
LIG_FHA_2 71 77 PF00498 0.610
LIG_LIR_Apic_2 143 149 PF02991 0.351
LIG_LIR_Apic_2 90 94 PF02991 0.728
LIG_LIR_Gen_1 351 359 PF02991 0.351
LIG_LIR_Gen_1 96 106 PF02991 0.607
LIG_LIR_Nem_3 152 157 PF02991 0.317
LIG_LIR_Nem_3 351 356 PF02991 0.351
LIG_LIR_Nem_3 96 102 PF02991 0.619
LIG_MYND_2 477 481 PF01753 0.224
LIG_Pex14_2 233 237 PF04695 0.351
LIG_SH2_CRK 392 396 PF00017 0.405
LIG_SH2_CRK 91 95 PF00017 0.655
LIG_SH2_SRC 157 160 PF00017 0.405
LIG_SH2_STAT3 81 84 PF00017 0.586
LIG_SH2_STAT5 81 84 PF00017 0.579
LIG_SH3_2 103 108 PF14604 0.623
LIG_SH3_3 100 106 PF00018 0.622
LIG_SH3_3 126 132 PF00018 0.469
LIG_SH3_3 244 250 PF00018 0.463
LIG_SH3_3 257 263 PF00018 0.276
LIG_TRAF2_1 74 77 PF00917 0.603
LIG_TYR_ITIM 390 395 PF00017 0.351
LIG_UBA3_1 56 64 PF00899 0.646
LIG_Vh1_VBS_1 205 223 PF01044 0.234
MOD_CDC14_SPxK_1 292 295 PF00782 0.351
MOD_CDK_SPxK_1 289 295 PF00069 0.351
MOD_CK1_1 306 312 PF00069 0.405
MOD_CK1_1 404 410 PF00069 0.351
MOD_CK1_1 416 422 PF00069 0.351
MOD_CK1_1 423 429 PF00069 0.351
MOD_CK1_1 450 456 PF00069 0.389
MOD_CK1_1 465 471 PF00069 0.273
MOD_CK2_1 165 171 PF00069 0.326
MOD_CK2_1 402 408 PF00069 0.365
MOD_CK2_1 453 459 PF00069 0.351
MOD_CK2_1 70 76 PF00069 0.532
MOD_GlcNHglycan 161 164 PF01048 0.351
MOD_GlcNHglycan 187 190 PF01048 0.365
MOD_GlcNHglycan 308 311 PF01048 0.351
MOD_GlcNHglycan 418 421 PF01048 0.351
MOD_GlcNHglycan 60 63 PF01048 0.636
MOD_GSK3_1 159 166 PF00069 0.351
MOD_GSK3_1 192 199 PF00069 0.351
MOD_GSK3_1 218 225 PF00069 0.292
MOD_GSK3_1 282 289 PF00069 0.351
MOD_GSK3_1 416 423 PF00069 0.244
MOD_GSK3_1 428 435 PF00069 0.351
MOD_GSK3_1 58 65 PF00069 0.695
MOD_GSK3_1 97 104 PF00069 0.663
MOD_N-GLC_1 67 72 PF02516 0.657
MOD_NEK2_1 184 189 PF00069 0.351
MOD_NEK2_1 196 201 PF00069 0.351
MOD_NEK2_1 378 383 PF00069 0.405
MOD_NEK2_1 413 418 PF00069 0.405
MOD_NEK2_1 445 450 PF00069 0.351
MOD_NEK2_2 303 308 PF00069 0.405
MOD_PIKK_1 117 123 PF00454 0.455
MOD_PIKK_1 218 224 PF00454 0.351
MOD_PIKK_1 32 38 PF00454 0.440
MOD_PIKK_1 413 419 PF00454 0.372
MOD_PIKK_1 49 55 PF00454 0.507
MOD_PIKK_1 495 501 PF00454 0.405
MOD_PK_1 360 366 PF00069 0.351
MOD_PKA_2 30 36 PF00069 0.616
MOD_PKA_2 481 487 PF00069 0.351
MOD_Plk_1 286 292 PF00069 0.351
MOD_Plk_1 303 309 PF00069 0.351
MOD_Plk_1 67 73 PF00069 0.709
MOD_Plk_4 142 148 PF00069 0.351
MOD_Plk_4 169 175 PF00069 0.405
MOD_Plk_4 192 198 PF00069 0.351
MOD_Plk_4 286 292 PF00069 0.351
MOD_Plk_4 420 426 PF00069 0.351
MOD_Plk_4 453 459 PF00069 0.351
MOD_ProDKin_1 256 262 PF00069 0.351
MOD_ProDKin_1 289 295 PF00069 0.351
MOD_ProDKin_1 8 14 PF00069 0.671
MOD_SUMO_for_1 327 330 PF00179 0.351
MOD_SUMO_rev_2 329 336 PF00179 0.405
TRG_DiLeu_BaEn_1 459 464 PF01217 0.351
TRG_DiLeu_BaEn_4 408 414 PF01217 0.477
TRG_DiLeu_BaEn_4 77 83 PF01217 0.582
TRG_DiLeu_BaLyEn_6 215 220 PF01217 0.351
TRG_DiLeu_BaLyEn_6 250 255 PF01217 0.224
TRG_ENDOCYTIC_2 213 216 PF00928 0.316
TRG_ENDOCYTIC_2 392 395 PF00928 0.351
TRG_ENDOCYTIC_2 99 102 PF00928 0.636
TRG_NES_CRM1_1 226 240 PF08389 0.224
TRG_NES_CRM1_1 370 383 PF08389 0.351
TRG_Pf-PMV_PEXEL_1 218 222 PF00026 0.351
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.321
TRG_Pf-PMV_PEXEL_1 253 258 PF00026 0.296
TRG_Pf-PMV_PEXEL_1 474 479 PF00026 0.405

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0D2YG02 Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) 29% 100%
A0A0J6G7P5 Pseudomonas deceptionensis 36% 100%
A0A0N0P3U0 Leptomonas seymouri 88% 100%
A0A0N0P8H0 Leptomonas seymouri 28% 100%
A0A0N1HW05 Leptomonas seymouri 32% 100%
A0A0N1PG90 Leptomonas seymouri 28% 100%
A0A0S4IZX4 Bodo saltans 30% 100%
A0A1X0NP01 Trypanosomatidae 70% 100%
A0A1X0P5N4 Trypanosomatidae 31% 100%
A0A3Q8ILD8 Leishmania donovani 27% 100%
A0A3R7R3B5 Trypanosoma rangeli 30% 100%
A0A3S7WSY5 Leishmania donovani 92% 100%
A0A3S7X9N0 Leishmania donovani 32% 100%
A2RM21 Lactococcus lactis subsp. cremoris (strain MG1363) 39% 100%
A4HKQ5 Leishmania braziliensis 27% 100%
A4HMZ0 Leishmania braziliensis 32% 100%
A4HVY9 Leishmania infantum 91% 99%
A4I885 Leishmania infantum 27% 100%
A4IBL4 Leishmania infantum 32% 100%
C9ZZ26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AFE7 Leishmania major 32% 100%
E9APP1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B343 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B6K2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O05394 Bacillus subtilis (strain 168) 40% 100%
O13326 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
O31631 Bacillus subtilis (strain 168) 34% 100%
O31632 Bacillus subtilis (strain 168) 42% 100%
O42851 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
O94350 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 100%
P00935 Escherichia coli (strain K12) 37% 100%
P06106 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P06721 Escherichia coli (strain K12) 26% 100%
P0A4K2 Lactococcus lactis subsp. lactis (strain IL1403) 39% 100%
P0C2T9 Lactococcus lactis subsp. cremoris 39% 100%
P13254 Pseudomonas putida 39% 100%
P18757 Rattus norvegicus 39% 100%
P18949 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 25% 100%
P31373 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P32929 Homo sapiens 39% 100%
P38716 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P44502 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 36% 100%
P44527 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 27% 100%
P46807 Mycobacterium leprae (strain TN) 38% 100%
P50125 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 28% 100%
P53101 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P53780 Arabidopsis thaliana 49% 100%
P55216 Caenorhabditis elegans 36% 100%
P55217 Arabidopsis thaliana 34% 91%
P55218 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 36% 100%
P56069 Helicobacter pylori (strain ATCC 700392 / 26695) 40% 100%
P66876 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 37% 100%
P94890 Leptospira meyeri 33% 100%
P9WGB4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 32% 100%
P9WGB5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 32% 100%
P9WGB6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 37% 100%
P9WGB7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 37% 100%
Q07703 Bordetella avium 32% 100%
Q19QT7 Sus scrofa 36% 100%
Q1K8G0 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 43% 100%
Q1M0P5 Helicobacter pylori 39% 100%
Q4L332 Staphylococcus haemolyticus (strain JCSC1435) 35% 100%
Q4Q511 Leishmania major 27% 100%
Q4QFT8 Leishmania major 92% 100%
Q52811 Rhizobium leguminosarum bv. viciae (strain 3841) 28% 100%
Q55DV9 Dictyostelium discoideum 39% 100%
Q58DW2 Bos taurus 38% 100%
Q59829 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 31% 100%
Q5MNH8 Epichloe uncinata 29% 100%
Q5SJ58 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 29% 100%
Q5SK88 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 30% 100%
Q60HG7 Macaca fascicularis 38% 100%
Q73GL9 Wolbachia pipientis wMel 27% 100%
Q73KL7 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 37% 100%
Q79VI4 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 33% 100%
Q7MX71 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 37% 100%
Q826W3 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 34% 100%
Q83A83 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 38% 100%
Q8J0B2 Epichloe uncinata 28% 100%
Q8L0X4 Fusobacterium nucleatum subsp. polymorphum 35% 100%
Q8RDT4 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) 35% 100%
Q8VCN5 Mus musculus 39% 100%
Q92441 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 30% 100%
Q9C876 Arabidopsis thaliana 35% 100%
Q9SGU9 Arabidopsis thaliana 30% 100%
Q9WZY4 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 30% 100%
Q9X0Z7 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 32% 100%
Q9ZMW7 Helicobacter pylori (strain J99 / ATCC 700824) 39% 100%
S0DUX5 Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) 29% 100%
V5DUQ5 Trypanosoma cruzi 30% 100%
W7MS09 Gibberella moniliformis (strain M3125 / FGSC 7600) 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS