CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-terminal conserved domain of Nudc./CS domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7K5_LEIBR

TriTrypDb:

LbrM.14.0460 , LBRM2903_140009800

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H7K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7K5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.709
CLV_C14_Caspase3-7	18	22	PF00656	0.407
CLV_C14_Caspase3-7	273	277	PF00656	0.519
CLV_NRD_NRD_1	108	110	PF00675	0.503
CLV_NRD_NRD_1	125	127	PF00675	0.502
CLV_NRD_NRD_1	309	311	PF00675	0.637
CLV_NRD_NRD_1	32	34	PF00675	0.255
CLV_NRD_NRD_1	45	47	PF00675	0.547
CLV_NRD_NRD_1	63	65	PF00675	0.554
CLV_PCSK_KEX2_1	45	47	PF00082	0.603
CLV_PCSK_SKI1_1	143	147	PF00082	0.787
CLV_PCSK_SKI1_1	168	172	PF00082	0.358
CLV_PCSK_SKI1_1	251	255	PF00082	0.538
DEG_SPOP_SBC_1	79	83	PF00917	0.491
DOC_CYCLIN_RxL_1	104	114	PF00134	0.418
DOC_MAPK_gen_1	190	198	PF00069	0.456
DOC_MAPK_MEF2A_6	190	198	PF00069	0.466
DOC_MAPK_MEF2A_6	5	13	PF00069	0.455
DOC_PIKK_1	268	275	PF02985	0.525
DOC_PP4_FxxP_1	38	41	PF00568	0.455
DOC_USP7_MATH_1	267	271	PF00917	0.522
DOC_USP7_MATH_1	44	48	PF00917	0.510
DOC_USP7_MATH_1	79	83	PF00917	0.564
DOC_WW_Pin1_4	208	213	PF00397	0.475
LIG_14-3-3_CanoR_1	280	284	PF00244	0.475
LIG_14-3-3_CanoR_1	33	41	PF00244	0.455
LIG_14-3-3_CanoR_1	45	49	PF00244	0.427
LIG_14-3-3_CanoR_1	80	88	PF00244	0.664
LIG_APCC_Cbox_2	53	59	PF00515	0.412
LIG_deltaCOP1_diTrp_1	248	254	PF00928	0.504
LIG_DLG_GKlike_1	5	13	PF00625	0.522
LIG_FHA_1	234	240	PF00498	0.467
LIG_FHA_2	228	234	PF00498	0.455
LIG_FHA_2	297	303	PF00498	0.478
LIG_LIR_Apic_2	35	41	PF02991	0.455
LIG_LIR_Gen_1	3	14	PF02991	0.305
LIG_LIR_Nem_3	217	222	PF02991	0.455
LIG_LIR_Nem_3	248	253	PF02991	0.363
LIG_LIR_Nem_3	25	31	PF02991	0.486
LIG_PCNA_yPIPBox_3	304	313	PF02747	0.566
LIG_Pex14_1	250	254	PF04695	0.495
LIG_SH2_CRK	219	223	PF00017	0.497
LIG_SH2_STAP1	166	170	PF00017	0.290
LIG_SH2_STAT5	169	172	PF00017	0.522
LIG_SH2_STAT5	55	58	PF00017	0.609
LIG_SH3_3	177	183	PF00018	0.484
LIG_SUMO_SIM_anti_2	81	89	PF11976	0.569
LIG_SUMO_SIM_par_1	235	240	PF11976	0.465
LIG_TRAF2_1	174	177	PF00917	0.465
LIG_TRAF2_1	58	61	PF00917	0.359
LIG_UBA3_1	203	208	PF00899	0.399
LIG_WRC_WIRS_1	24	29	PF05994	0.455
MOD_CK1_1	29	35	PF00069	0.475
MOD_CK1_1	78	84	PF00069	0.580
MOD_CK2_1	171	177	PF00069	0.455
MOD_CK2_1	296	302	PF00069	0.486
MOD_CK2_1	80	86	PF00069	0.529
MOD_GlcNHglycan	77	80	PF01048	0.670
MOD_GSK3_1	233	240	PF00069	0.474
MOD_GSK3_1	32	39	PF00069	0.469
MOD_GSK3_1	75	82	PF00069	0.680
MOD_NEK2_1	171	176	PF00069	0.481
MOD_NEK2_1	319	324	PF00069	0.474
MOD_NEK2_2	249	254	PF00069	0.498
MOD_NEK2_2	44	49	PF00069	0.340
MOD_PIKK_1	169	175	PF00454	0.455
MOD_PIKK_1	319	325	PF00454	0.534
MOD_PIKK_1	36	42	PF00454	0.479
MOD_PKA_2	279	285	PF00069	0.473
MOD_PKA_2	296	302	PF00069	0.362
MOD_PKA_2	32	38	PF00069	0.455
MOD_PKA_2	44	50	PF00069	0.422
MOD_PKA_2	79	85	PF00069	0.681
MOD_Plk_4	23	29	PF00069	0.434
MOD_Plk_4	233	239	PF00069	0.470
MOD_Plk_4	249	255	PF00069	0.400
MOD_Plk_4	5	11	PF00069	0.497
MOD_ProDKin_1	208	214	PF00069	0.475
MOD_SUMO_rev_2	119	125	PF00179	0.601
MOD_SUMO_rev_2	139	145	PF00179	0.439
MOD_SUMO_rev_2	232	237	PF00179	0.493
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.608
TRG_ENDOCYTIC_2	219	222	PF00928	0.497
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P482	Leptomonas seymouri	77%	99%
A0A0S4KFL2	Bodo saltans	55%	100%
A0A1X0NNN1	Trypanosomatidae	62%	100%
A0A3R7KDG6	Trypanosoma rangeli	62%	100%
A0A3S5H6R4	Leishmania donovani	85%	100%
A4HVY8	Leishmania infantum	85%	100%
C9ZT35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9APP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O35685	Mus musculus	45%	98%
Q17QG2	Bos taurus	44%	98%
Q4QFT9	Leishmania major	86%	99%
Q5RB75	Pongo abelii	30%	91%
Q5ZIN1	Gallus gallus	45%	96%
Q63525	Rattus norvegicus	45%	98%
Q8IVD9	Homo sapiens	30%	91%
Q8R1N4	Mus musculus	29%	90%
Q9LV09	Arabidopsis thaliana	39%	100%
Q9VVA6	Drosophila melanogaster	38%	98%
Q9Y266	Homo sapiens	45%	99%
V5BHT5	Trypanosoma cruzi	62%	78%