Pyr_redox_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyridine nucleotide-disulphide oxidoreductase, putative

Species:

Leishmania braziliensis

UniProt:

A4H7K4_LEIBR

TriTrypDb:

LbrM.14.0450 , LBRM2903_140009600 , LBRM2903_140009700

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7K4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0000166	nucleotide binding	3	1
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	4	1
GO:0005488	binding	1	1
GO:0009055	electron transfer activity	3	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	1
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.337
CLV_C14_Caspase3-7	261	265	PF00656	0.648
CLV_C14_Caspase3-7	399	403	PF00656	0.404
CLV_MEL_PAP_1	529	535	PF00089	0.379
CLV_NRD_NRD_1	104	106	PF00675	0.273
CLV_NRD_NRD_1	151	153	PF00675	0.313
CLV_NRD_NRD_1	227	229	PF00675	0.310
CLV_NRD_NRD_1	333	335	PF00675	0.512
CLV_PCSK_KEX2_1	104	106	PF00082	0.280
CLV_PCSK_KEX2_1	115	117	PF00082	0.257
CLV_PCSK_KEX2_1	172	174	PF00082	0.416
CLV_PCSK_KEX2_1	227	229	PF00082	0.436
CLV_PCSK_KEX2_1	333	335	PF00082	0.573
CLV_PCSK_KEX2_1	346	348	PF00082	0.502
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.287
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.416
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.535
CLV_PCSK_PC7_1	111	117	PF00082	0.287
CLV_PCSK_SKI1_1	304	308	PF00082	0.615
CLV_PCSK_SKI1_1	442	446	PF00082	0.351
DEG_APCC_DBOX_1	303	311	PF00400	0.593
DEG_Nend_Nbox_1	1	3	PF02207	0.512
DEG_SPOP_SBC_1	263	267	PF00917	0.661
DEG_SPOP_SBC_1	281	285	PF00917	0.500
DOC_MAPK_gen_1	101	109	PF00069	0.357
DOC_MAPK_MEF2A_6	20	29	PF00069	0.651
DOC_MAPK_MEF2A_6	204	211	PF00069	0.318
DOC_MAPK_MEF2A_6	475	482	PF00069	0.393
DOC_PP1_RVXF_1	375	382	PF00149	0.400
DOC_PP2B_LxvP_1	278	281	PF13499	0.482
DOC_PP2B_LxvP_1	29	32	PF13499	0.628
DOC_PP4_FxxP_1	515	518	PF00568	0.426
DOC_USP7_MATH_1	192	196	PF00917	0.182
DOC_USP7_MATH_1	263	267	PF00917	0.670
DOC_USP7_MATH_1	282	286	PF00917	0.751
DOC_USP7_MATH_1	289	293	PF00917	0.600
DOC_WW_Pin1_4	265	270	PF00397	0.662
DOC_WW_Pin1_4	372	377	PF00397	0.488
DOC_WW_Pin1_4	486	491	PF00397	0.351
LIG_14-3-3_CanoR_1	247	255	PF00244	0.332
LIG_14-3-3_CanoR_1	387	392	PF00244	0.568
LIG_14-3-3_CanoR_1	406	411	PF00244	0.334
LIG_Actin_WH2_2	102	117	PF00022	0.272
LIG_Actin_WH2_2	120	137	PF00022	0.272
LIG_BIR_III_4	484	488	PF00653	0.317
LIG_CSL_BTD_1	310	313	PF09270	0.386
LIG_EH1_1	4	12	PF00400	0.560
LIG_EH1_1	404	412	PF00400	0.334
LIG_eIF4E_1	405	411	PF01652	0.338
LIG_FHA_1	119	125	PF00498	0.287
LIG_FHA_1	31	37	PF00498	0.447
LIG_FHA_1	356	362	PF00498	0.490
LIG_FHA_1	455	461	PF00498	0.502
LIG_FHA_1	540	546	PF00498	0.445
LIG_FHA_1	81	87	PF00498	0.298
LIG_FHA_2	201	207	PF00498	0.339
LIG_FHA_2	247	253	PF00498	0.288
LIG_FHA_2	70	76	PF00498	0.302
LIG_LIR_Apic_2	514	518	PF02991	0.412
LIG_LIR_Gen_1	139	148	PF02991	0.308
LIG_LIR_Gen_1	362	371	PF02991	0.370
LIG_LIR_Nem_3	139	145	PF02991	0.308
LIG_LIR_Nem_3	362	368	PF02991	0.357
LIG_LIR_Nem_3	443	448	PF02991	0.357
LIG_LIR_Nem_3	76	82	PF02991	0.272
LIG_PCNA_PIPBox_1	106	115	PF02747	0.416
LIG_PCNA_yPIPBox_3	333	343	PF02747	0.610
LIG_PDZ_Class_1	545	550	PF00595	0.520
LIG_Pex14_2	365	369	PF04695	0.356
LIG_Rb_pABgroove_1	63	71	PF01858	0.291
LIG_SH2_CRK	142	146	PF00017	0.272
LIG_SH2_CRK	325	329	PF00017	0.413
LIG_SH2_STAP1	142	146	PF00017	0.272
LIG_SH2_STAT3	521	524	PF00017	0.442
LIG_SH2_STAT5	113	116	PF00017	0.272
LIG_SH2_STAT5	133	136	PF00017	0.145
LIG_SH2_STAT5	367	370	PF00017	0.356
LIG_SH2_STAT5	510	513	PF00017	0.536
LIG_SH3_3	217	223	PF00018	0.287
LIG_SH3_3	251	257	PF00018	0.571
LIG_SH3_3	276	282	PF00018	0.655
LIG_SH3_3	307	313	PF00018	0.427
LIG_SH3_3	449	455	PF00018	0.371
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.424
LIG_TYR_ITIM	140	145	PF00017	0.272
LIG_TYR_ITIM	323	328	PF00017	0.402
LIG_UBA3_1	86	95	PF00899	0.320
LIG_WW_3	311	315	PF00397	0.402
MOD_CDC14_SPxK_1	268	271	PF00782	0.661
MOD_CDK_SPK_2	372	377	PF00069	0.480
MOD_CDK_SPxK_1	265	271	PF00069	0.661
MOD_CK1_1	13	19	PF00069	0.552
MOD_CK1_1	246	252	PF00069	0.282
MOD_CK1_1	265	271	PF00069	0.661
MOD_CK1_1	291	297	PF00069	0.648
MOD_CK2_1	255	261	PF00069	0.678
MOD_CK2_1	434	440	PF00069	0.399
MOD_CK2_1	497	503	PF00069	0.433
MOD_Cter_Amidation	331	334	PF01082	0.556
MOD_Cter_Amidation	344	347	PF01082	0.488
MOD_GlcNHglycan	12	15	PF01048	0.499
MOD_GlcNHglycan	164	167	PF01048	0.332
MOD_GlcNHglycan	284	287	PF01048	0.687
MOD_GlcNHglycan	491	494	PF01048	0.391
MOD_GlcNHglycan	7	10	PF01048	0.543
MOD_GSK3_1	114	121	PF00069	0.337
MOD_GSK3_1	156	163	PF00069	0.276
MOD_GSK3_1	263	270	PF00069	0.565
MOD_GSK3_1	302	309	PF00069	0.570
MOD_GSK3_1	489	496	PF00069	0.446
MOD_LATS_1	404	410	PF00433	0.340
MOD_N-GLC_1	23	28	PF02516	0.653
MOD_NEK2_1	114	119	PF00069	0.353
MOD_NEK2_1	177	182	PF00069	0.287
MOD_NEK2_1	200	205	PF00069	0.333
MOD_NEK2_1	306	311	PF00069	0.641
MOD_NEK2_1	5	10	PF00069	0.572
MOD_NEK2_1	69	74	PF00069	0.287
MOD_NEK2_2	497	502	PF00069	0.436
MOD_PIKK_1	531	537	PF00454	0.511
MOD_PK_1	334	340	PF00069	0.481
MOD_PKA_2	246	252	PF00069	0.287
MOD_PKA_2	405	411	PF00069	0.338
MOD_PKA_2	423	429	PF00069	0.337
MOD_PKA_2	531	537	PF00069	0.382
MOD_PKB_1	160	168	PF00069	0.416
MOD_Plk_1	160	166	PF00069	0.346
MOD_Plk_1	23	29	PF00069	0.652
MOD_Plk_1	289	295	PF00069	0.646
MOD_Plk_1	506	512	PF00069	0.479
MOD_Plk_1	69	75	PF00069	0.257
MOD_Plk_2-3	397	403	PF00069	0.300
MOD_Plk_4	306	312	PF00069	0.530
MOD_Plk_4	32	38	PF00069	0.491
MOD_Plk_4	334	340	PF00069	0.527
MOD_Plk_4	406	412	PF00069	0.335
MOD_Plk_4	447	453	PF00069	0.382
MOD_Plk_4	454	460	PF00069	0.426
MOD_Plk_4	64	70	PF00069	0.272
MOD_ProDKin_1	265	271	PF00069	0.663
MOD_ProDKin_1	372	378	PF00069	0.482
MOD_ProDKin_1	486	492	PF00069	0.357
MOD_SUMO_rev_2	165	174	PF00179	0.332
MOD_SUMO_rev_2	70	79	PF00179	0.334
TRG_ENDOCYTIC_2	142	145	PF00928	0.272
TRG_ENDOCYTIC_2	325	328	PF00928	0.367
TRG_ER_diArg_1	104	106	PF00400	0.287
TRG_NES_CRM1_1	472	484	PF08389	0.271
TRG_Pf-PMV_PEXEL_1	442	447	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U1	Leptomonas seymouri	75%	100%
A0A0S4KJN5	Bodo saltans	42%	100%
A0A1X0NNQ7	Trypanosomatidae	57%	100%
A0A3Q8I8R3	Leishmania donovani	89%	100%
A0A422MYM5	Trypanosoma rangeli	56%	100%
A4HVY7	Leishmania infantum	89%	100%
C9ZT37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9APN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFU0	Leishmania major	89%	100%
V5AXT2	Trypanosoma cruzi	56%	100%