Polynucleotide 5'-triphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA capping enzyme, beta chain, putative

Species:

Leishmania braziliensis

UniProt:

A4H7K3_LEIBR

TriTrypDb:

LbrM.14.0440 , LBRM2903_140009500

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H7K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7K3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004651	polynucleotide 5'-phosphatase activity	6	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.686
CLV_NRD_NRD_1	288	290	PF00675	0.520
CLV_PCSK_KEX2_1	122	124	PF00082	0.549
CLV_PCSK_KEX2_1	288	290	PF00082	0.520
CLV_PCSK_KEX2_1	319	321	PF00082	0.537
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.549
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.537
CLV_PCSK_SKI1_1	190	194	PF00082	0.498
CLV_PCSK_SKI1_1	195	199	PF00082	0.499
CLV_PCSK_SKI1_1	20	24	PF00082	0.433
DEG_APCC_DBOX_1	19	27	PF00400	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.569
DOC_CKS1_1	278	283	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.682
DOC_MAPK_gen_1	212	222	PF00069	0.450
DOC_MAPK_gen_1	52	60	PF00069	0.682
DOC_MAPK_MEF2A_6	111	118	PF00069	0.600
DOC_MAPK_MEF2A_6	195	203	PF00069	0.624
DOC_MAPK_MEF2A_6	215	224	PF00069	0.448
DOC_MAPK_MEF2A_6	37	44	PF00069	0.546
DOC_MAPK_MEF2A_6	52	60	PF00069	0.434
DOC_PP2B_LxvP_1	352	355	PF13499	0.578
DOC_PP2B_LxvP_1	56	59	PF13499	0.693
DOC_USP7_MATH_1	147	151	PF00917	0.542
DOC_USP7_MATH_1	211	215	PF00917	0.508
DOC_USP7_MATH_1	325	329	PF00917	0.554
DOC_WD40_RPTOR_TOS_1	303	308	PF00400	0.383
DOC_WW_Pin1_4	259	264	PF00397	0.724
DOC_WW_Pin1_4	277	282	PF00397	0.468
DOC_WW_Pin1_4	61	66	PF00397	0.526
LIG_CtBP_PxDLS_1	157	161	PF00389	0.433
LIG_CtBP_PxDLS_1	200	204	PF00389	0.683
LIG_CtBP_PxDLS_1	246	250	PF00389	0.462
LIG_eIF4E_2	244	250	PF01652	0.614
LIG_FHA_1	159	165	PF00498	0.568
LIG_FHA_1	196	202	PF00498	0.511
LIG_FHA_1	269	275	PF00498	0.589
LIG_FHA_1	278	284	PF00498	0.615
LIG_FHA_1	300	306	PF00498	0.542
LIG_FHA_1	331	337	PF00498	0.593
LIG_FHA_1	342	348	PF00498	0.503
LIG_FHA_2	34	40	PF00498	0.587
LIG_FHA_2	354	360	PF00498	0.706
LIG_GBD_Chelix_1	18	26	PF00786	0.457
LIG_LIR_Apic_2	240	246	PF02991	0.557
LIG_LIR_Gen_1	366	373	PF02991	0.666
LIG_LIR_Nem_3	366	371	PF02991	0.680
LIG_Pex14_1	318	322	PF04695	0.526
LIG_SH2_CRK	128	132	PF00017	0.655
LIG_SH2_CRK	155	159	PF00017	0.674
LIG_SH2_CRK	368	372	PF00017	0.467
LIG_SH2_STAP1	368	372	PF00017	0.467
LIG_SH2_STAT3	88	91	PF00017	0.298
LIG_SH2_STAT5	252	255	PF00017	0.752
LIG_SH2_STAT5	330	333	PF00017	0.553
LIG_SH2_STAT5	379	382	PF00017	0.564
LIG_SH3_3	140	146	PF00018	0.704
LIG_SH3_3	220	226	PF00018	0.323
LIG_SH3_3	254	260	PF00018	0.656
LIG_SH3_3	59	65	PF00018	0.651
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.432
LIG_SUMO_SIM_par_1	156	161	PF11976	0.515
LIG_SUMO_SIM_par_1	198	205	PF11976	0.644
LIG_SUMO_SIM_par_1	57	64	PF11976	0.573
MOD_CK1_1	168	174	PF00069	0.320
MOD_CK1_1	235	241	PF00069	0.620
MOD_CK2_1	33	39	PF00069	0.586
MOD_CK2_1	353	359	PF00069	0.696
MOD_Cter_Amidation	120	123	PF01082	0.328
MOD_GlcNHglycan	108	111	PF01048	0.432
MOD_GlcNHglycan	167	170	PF01048	0.567
MOD_GlcNHglycan	327	330	PF01048	0.513
MOD_GlcNHglycan	333	336	PF01048	0.554
MOD_GSK3_1	158	165	PF00069	0.639
MOD_GSK3_1	191	198	PF00069	0.327
MOD_GSK3_1	211	218	PF00069	0.418
MOD_GSK3_1	226	233	PF00069	0.483
MOD_GSK3_1	264	271	PF00069	0.701
MOD_GSK3_1	273	280	PF00069	0.602
MOD_GSK3_1	293	300	PF00069	0.423
MOD_GSK3_1	325	332	PF00069	0.520
MOD_GSK3_1	337	344	PF00069	0.447
MOD_GSK3_1	353	360	PF00069	0.657
MOD_NEK2_1	158	163	PF00069	0.605
MOD_NEK2_1	331	336	PF00069	0.543
MOD_NEK2_1	367	372	PF00069	0.687
MOD_NEK2_1	48	53	PF00069	0.506
MOD_NEK2_2	348	353	PF00069	0.679
MOD_PIKK_1	230	236	PF00454	0.537
MOD_PIKK_1	295	301	PF00454	0.479
MOD_PIKK_1	80	86	PF00454	0.318
MOD_PK_1	139	145	PF00069	0.510
MOD_PK_1	43	49	PF00069	0.567
MOD_Plk_1	195	201	PF00069	0.379
MOD_Plk_1	348	354	PF00069	0.747
MOD_Plk_4	273	279	PF00069	0.583
MOD_Plk_4	367	373	PF00069	0.720
MOD_Plk_4	43	49	PF00069	0.567
MOD_ProDKin_1	259	265	PF00069	0.726
MOD_ProDKin_1	277	283	PF00069	0.467
MOD_ProDKin_1	61	67	PF00069	0.518
MOD_SUMO_rev_2	168	173	PF00179	0.454
TRG_DiLeu_BaEn_1	376	381	PF01217	0.521
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.566
TRG_ENDOCYTIC_2	128	131	PF00928	0.646
TRG_ENDOCYTIC_2	155	158	PF00928	0.683
TRG_ENDOCYTIC_2	368	371	PF00928	0.475
TRG_ER_diArg_1	124	127	PF00400	0.329
TRG_ER_diArg_1	216	219	PF00400	0.322
TRG_NES_CRM1_1	12	27	PF08389	0.434
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D6	Leptomonas seymouri	38%	96%
A0A1X0NNQ2	Trypanosomatidae	25%	100%
A0A3Q8ID33	Leishmania donovani	79%	92%
A0A3R7JXB6	Trypanosoma rangeli	26%	100%
A4HVY6	Leishmania infantum	79%	92%
E9APN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	88%
Q4QFU1	Leishmania major	78%	100%